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11. 发明申请

US20090054818A1 SPINAL ORTHOSES 审中-公开
标题翻译：脊柱畸形
公开(公告)号：US20090054818A1
公开(公告)日：2009-02-26
申请号：US11628996
申请日：2005-06-09
申请人： Kenton R. Kaufman , Michael J. Yaszemski
发明人： Kenton R. Kaufman , Michael J. Yaszemski
IPC分类号： A61F5/00
CPC分类号： A61F5/34 , A61F5/012 , A61F5/022 , A61F5/024
摘要： A thoracolumbosacral and a lumbosacral orthosis with sagittal-coronal control are disclosed. The orthoses have two rigid anterior and posterior plastic shells. The anterior shell extends from the pelvis to the sternum. The posterior shell extends from the pelvis and terminates just inferior to the scapular spine. An interior surface of the anterior shell has pressure pads that apply pressure to locations on the patient's anterior torso and the interior surface of the posterior shell has pressure pads that apply pressure to locations on the patient's posterior torso when the anterior shell and the posterior shell are secured to the patient's torso. The pressure pads may be inflatable air bladders.
摘要翻译：公开了一种具有矢状冠状动脉控制的胸腰椎和腰骶矫形器。矫形器有两个刚性的前后塑料外壳。前囊从骨盆延伸到胸骨。后壳从骨盆延伸，终止于肩胛骨下方。前壳的内表面具有对患者前躯干上的位置施加压力的压力垫，并且后壳的内表面具有压力垫，当前壳和后壳是前壳和后壳时，压力垫对患者的后躯体上的位置施加压力固定在患者的躯干上。压垫可以是可充气的气囊。

12. 发明授权

US10568985B2 Photodegradable polycaprolactone fumarate block copolymers 有权
公开(公告)号：US10568985B2
公开(公告)日：2020-02-25
申请号：US13955279
申请日：2013-07-31
申请人： Michael Brett Runge , Michael J. Yaszemski
发明人： Michael Brett Runge , Michael J. Yaszemski
IPC分类号： A61L27/18 , C08L67/04 , C08G63/08 , A61L27/56
摘要： A polycaprolactone fumarate copolymer useful as a material for a biocompatible scaffold for tissue engineering applications is disclosed. The copolymer includes at least one caprolactone unit, at least one fumarate unit, and at least one third unit selected from the group consisting of acrylate units and styrenic units. A linking moiety forms a link between the third unit and at least one caprolactone unit or at least one fumarate unit. The linking moiety can be photodegradable. In one form, the third unit includes at least one methyl methacrylate unit. The copolymer can be used to form the wall of a nerve conduit.

13. 发明授权

US09255178B2 Photocrosslinkable poly (caprolactone fumarate) 有权
标题翻译：可交联聚（己内酯富马酸盐）
公开(公告)号：US09255178B2
公开(公告)日：2016-02-09
申请号：US11718906
申请日：2005-11-10
申请人： Shanfeng Wang , Lichun Lu , Michael J. Yaszemski
发明人： Shanfeng Wang , Lichun Lu , Michael J. Yaszemski
IPC分类号： C08G63/91 , A61L27/18 , A61L27/46 , C08G63/08 , C08L67/06
CPC分类号： C08G63/912 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/56 , C08G63/08 , C08L67/06 , C08L67/04
摘要： Fumaric acid or a salt thereof, such as a fumaryl halide (e.g. fumaryl chloride), which contains unsaturated carbon-carbon double bonds that can be used for in situ crosslinking, is copolymerized with poly(caprolactone)diol in the presence of an alkali metal salt. The resulting photocrosslinkable biocompatible and bioresorbable poly(caprolactone fumarate) biomaterial is useful in the fabrication of injectable an in-situ hardening scaffolds for application in skeletal reconstruction.
摘要翻译：富马酸或其盐，例如可用于原位交联的含有不饱和碳 - 碳双键的富马来酰卤（例如富马酰氯）与聚（己内酯）二醇在碱金属盐。所得的可光致交联的生物相容性和生物可再吸收的聚（己内酯富马酸盐）生物材料可用于制造注射用于骨骼重建中的原位硬化支架。

14. 发明授权

US07642300B2 Hydroxyapatite grafted fumarate based macromers for biodegradable composites 失效
标题翻译：羟基磷灰石接枝富马酸盐的大分子单体用于可生物降解的复合材料
公开(公告)号：US07642300B2
公开(公告)日：2010-01-05
申请号：US10562591
申请日：2004-06-29
申请人： Michael J. Yaszemski , Bradford L. Currier , Esmaiel Jabbari , Lichun Lu
发明人： Michael J. Yaszemski , Bradford L. Currier , Esmaiel Jabbari , Lichun Lu
IPC分类号： C08F297/02 , C08F297/00
CPC分类号： C08F292/00 , A61F2/28 , A61F2002/30062 , A61F2210/0004 , A61F2310/00293 , A61L27/425
摘要： A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.
摘要翻译：公开了一种组合物，其包含（i）通过使具有碳 - 碳双键的不饱和二酸和饱和二酸反应制备的大分子单体，和（ii）接枝到大分子单体上的生物活性陶瓷。在一个实施方案中，具有碳 - 碳双键的不饱和二酸是富马酸，饱和二酸与富马酸和富马酸（丙烯酸富马酸）如琥珀酸，戊二酸，己二酸，庚二酸，辛二酸，壬二酸酸，癸二酸及其混合物，生物活性陶瓷为羟基磷灰石。在另一个实施方案中，羟基磷灰石用可生物降解和可交联的大分子单体接枝，其包含与富马酸和己二酸酯单元交替的硅烷单元。

15. 发明授权

US06884432B2 Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery 有权
标题翻译：用于固定和控制药物递送的共混物，可交联的聚（富马酸丙烯酯）
公开(公告)号：US06884432B2
公开(公告)日：2005-04-26
申请号：US10423209
申请日：2003-04-25
申请人： Michael J. Yaszemski , Bradford L. Currier , Lichun Lu , Xun Zhu , Esmaiel Jabbari , Diederik H. R. Kempen
发明人： Michael J. Yaszemski , Bradford L. Currier , Lichun Lu , Xun Zhu , Esmaiel Jabbari , Diederik H. R. Kempen
IPC分类号： A61K9/16 , A61K9/60 , A61L27/54 , B32B27/00 , C08F20/00
CPC分类号： A61L27/54 , A61K9/1647 , A61L2300/414 , A61L2300/426 , A61L2300/602 , A61L2300/622 , Y10T428/2982 , Y10T428/2985 , Y10T428/2989
摘要： Microspheres for controlled release of a bioactive agent are disclosed, and in particular, blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery. The microsphere includes poly(propylene fumarate), a polymeric material other than poly(propylene fumarate) (e.g., poly(lactic-co-glycolic acid)), and a bioactive agent. The bioactive agent is selected depending on the physiological effect desired. For example, in bone regeneration applications, the bioactive agent may be selected from osteoinductive agents, peptides, growth hormones, osteoconductive agents, cytokines and mixtures thereof. The bioactive agent is dispersed in the microsphere, the microsphere has a diameter in the range of 1 to 300 micrometers, the poly(propylene fumarate) and poly(lactic-co-glycolic acid) are distributed in the microsphere, and the microsphere releases the bioactive agent in a sustained manner after an initial burst release. The microspheres may be covalently attached to a poly(propylene fumarate) scaffold for tissue regeneration applications in which the bioactive agent is released from the scaffold.
摘要翻译：公开了用于控制释放生物活性剂的微球，并且特别地，用于固定和控制药物递送的共混物，可交联聚（富马酸丙烯酯）。微球包括聚（丙烯富马酸盐），聚（丙烯富马酸酯）以外的聚合物（例如聚（乳酸 - 共 - 乙醇酸））和生物活性剂。取决于所需的生理效果来选择生物活性剂。例如，在骨再生应用中，生物活性剂可以选自骨诱导剂，肽，生长激素，骨诱导剂，细胞因子及其混合物。生物活性剂分散在微球中，微球的直径范围为1〜300微米，聚（丙烯富马酸）和聚（乳酸 - 共 - 乙醇酸）分布在微球中，微球释放出初始爆发后持续的生物活性剂。微球可以共价连接到用于组织再生应用的聚（丙烯富马酸酯）支架中，其中生物活性剂从支架中释放。

16. 发明授权

US08912247B2 Hydrophilic/hydrophobic polymer networks based on poly(caprolactone fumarate), poly(ethylene glycol fumarate), and copolymers thereof 有权
标题翻译：基于聚（己内酯富马酸酯），聚（乙二醇富马酸酯）及其共聚物的亲水/疏水聚合物网络
公开(公告)号：US08912247B2
公开(公告)日：2014-12-16
申请号：US11912188
申请日：2006-04-28
申请人： Shanfeng Wang , Lichun Lu , Michael J. Yaszemski
发明人： Shanfeng Wang , Lichun Lu , Michael J. Yaszemski
IPC分类号： A61L24/04 , C08G63/60 , C08G63/83 , C08G63/676 , A61L27/18
CPC分类号： C08G63/676 , A61L24/046 , A61L27/18 , C08G63/60 , C08G63/83 , C08L67/06
摘要： Improved methods for preparing polyethylene glycol fumarate) are disclosed. Methods for chemically crosslinking or photocross-linking hydrophilic polyethylene glycol fumarate) with hydrophobic polymers such as poly(propylene fumarate) (PPF) and poly(caprolactone fumarate) (PCLF) to form various hydrogels (FIG. 1) with controllable hydrophilicity are also disclosed. The hydrogels are useful in the fabrication of injectable and in-situ hardening scaffolds for application in skeletal reconstruction. An injectable material including the hydrogels may be useful in controlled drug release.
摘要翻译：公开了改进的制备聚乙二醇富马酸盐的方法。还公开了亲水聚乙二醇富马酸酯与疏水性聚合物如聚（富马酸丙烯酯）（PPF）和聚（己内酯富马酸酯）（PCLF）的化学交联或光交联以形成具有可控亲水性的各种水凝胶（图1）的方法）。水凝胶可用于制造用于骨骼重建的可注射和原位硬化支架。包含水凝胶的可注射材料可用于受控药物释放。

17. 发明申请

US20140039075A1 Photodegradable Polycaprolactone Fumarate Block Copolymers 审中-公开
标题翻译：可降解聚己内酯富马酸酯嵌段共聚物
公开(公告)号：US20140039075A1
公开(公告)日：2014-02-06
申请号：US13955279
申请日：2013-07-31
申请人： Michael Brett Runge , Michael J. Yaszemski
发明人： Michael Brett Runge , Michael J. Yaszemski
IPC分类号： A61L27/18
摘要： A polycaprolactone fumarate copolymer useful as a material for a biocompatible scaffold for tissue engineering applications is disclosed. The copolymer includes at least one caprolactone unit, at least one fumarate unit, and at least one third unit selected from the group consisting of acrylate units and styrenic units. A linking moiety forms a link between the third unit and at least one caprolactone unit or at least one fumarate unit. The linking moiety can be photodegradable. In one form, the third unit includes at least one methyl methacrylate unit. The copolymer can be used to form the wall of a nerve conduit.
摘要翻译：公开了可用作组织工程应用的生物相容性支架材料的聚己内酯富马酸共聚物。共聚物包括至少一种己内酯单元，至少一种富马酸酯单元和至少一种选自丙烯酸酯单元和苯乙烯单元的第三单元。连接部分形成第三单元与至少一个己内酯单元或至少一个富马酸酯单元之间的连接。连接部分可以是光降解的。在一种形式中，第三单元包括至少一种甲基丙烯酸甲酯单元。共聚物可用于形成神经管道的壁。

18. 发明授权

US07163545B2 Spinal cord surgical implant 有权
标题翻译：脊髓手术植入物
公开(公告)号：US07163545B2
公开(公告)日：2007-01-16
申请号：US10629427
申请日：2003-07-29
申请人： Michael J. Yaszemski , Jonathan A. Friedman , Michael J. Moore , Anthony J. Windebank
发明人： Michael J. Yaszemski , Jonathan A. Friedman , Michael J. Moore , Anthony J. Windebank
IPC分类号： A61B17/08
CPC分类号： A61B17/08 , A61B17/1128 , A61L27/383 , A61L27/3878 , A61L27/58 , A61L31/005 , A61L31/148 , A61L2430/32
摘要： An implant for bridging a gap in a severed spinal cord or nerve and for promoting nerve regeneration has a matrix comprising a biocompatible, biodegradable, polymeric material. The matrix has a proximal end for connection to a first end of severed spinal cord and a distal end for connection to a second end of severed spinal cord. The matrix includes internal guidance channels extending between the proximal end and the distal end to facilitate rejoining of the first end and the second end of the severed spinal cord. A bioactive agent may be dispersed in the matrix, or disposed in the channels, or included within microspheres in the channels. The channels may be arranged such that guidance channels correspond to spinal cord tracts. Alternatively, guidance channels may be spaced apart at the proximal end of the matrix and converge inward toward the axis of the matrix at the distal end.
摘要翻译：用于桥接切断的脊髓或神经中的间隙并用于促进神经再生的植入物具有包含生物相容性，可生物降解的聚合材料的基质。基质具有用于连接到切断的脊髓的第一端的近端和用于连接到切断的脊髓的第二端的远端。基体包括在近端和远端之间延伸的内部引导通道，以便于重新连接切断的脊髓的第一端和第二端。生物活性剂可以分散在基质中，或者设置在通道中，或者包含在通道中的微球体内。通道可以布置成使得引导通道对应于脊髓束。或者，引导通道可以在基体的近端处间隔开并且在远端处朝向矩阵的轴线向内收敛。

19. 发明申请

US20130331869A1 Conductive polymeric composites of polycaprolactone fumarate and polypyrrole for nerve regeneration 审中-公开
标题翻译：富马酸聚己内酯和聚吡咯的导电聚合物复合材料用于神经再生
公开(公告)号：US20130331869A1
公开(公告)日：2013-12-12
申请号：US12925182
申请日：2010-10-15
申请人： M. Brett Runge , Mahrokh Dadsetan , Michael J. Yaszemski
发明人： M. Brett Runge , Mahrokh Dadsetan , Michael J. Yaszemski
IPC分类号： A61F2/04 , A61N1/05
CPC分类号： A61F2/04 , A61L27/26 , A61L27/383 , A61L27/3834 , A61L27/54 , A61L2430/32 , A61N1/0551 , A61N1/326 , A61N1/36103 , C08L67/04 , C08L65/00
摘要： A novel electrically conductive polymer composite composed of polycaprolactone fumarate-polypyrrole (PCLF-PPy) for applications in nerve regeneration is disclosed. The synthesis and characterization of PCLF-PPy and in vitro studies showing PCLF-PPy supports both PC12 cell and Dorsal Root Ganglia neurite extension. PCLF-PPy composite materials were synthesized by polymerizing pyrrole in pre-formed scaffolds of PCLF resulting in an interpenetrating network of PCLF-PPy. PCLF-PPy composite materials possess electrical conductivity up to 6 mS cm−1 with compositions ranging from 5-13.5 percent polypyrrole of the bulk material. Surface topographies of PCLF-PPy materials show microstructures with a RMS roughness of 1195 nm and nanostructures with RMS roughness of 8 nm. PCLF-PPy derivatives were synthesized with anionic dopants to determine effects on electrical conductivity and to optimize the chemical composition for biocompatibility. In vitro studies using PC12 show PCLF-PPy composite materials induce a higher cellular viability and increased neurite extension compared to PCLF. PCLF-PPy composites doped with either naphthalene sulfonic acid or dodecyl benzene sulfonic acid are determined to be the optimal materials for electrical stimulation. In vitro studies showed significant increases in percentage of neurite bearing cells, number of neurites per cell and neurite length in the presence of ES compared to no ES. Additionally, extending neurites were observed to align in the direction of the applied current. Electrically conductive PCLF-PPy scaffolds possess material properties necessary for application as nerve conduits. Additionally, the capability to significantly enhance and direct neurite extension by passing electrical current through PCLF-PPy scaffolds renders them even more promising as future therapeutic treatments for severe nerve injuries.
摘要翻译：公开了一种用于神经再生的聚己内酯富马酸酯 - 聚吡咯（PCLF-PPy）的新型导电聚合物复合材料。 PCLF-PPy的合成和表征和体外研究显示PCLF-PPy支持PC12细胞和背根神经节神经突延伸。 PCLF-PPy复合材料通过在PCLF的预形成支架中聚合吡咯合成，得到PCLF-PPy的互穿网络。 PCLF-PPy复合材料具有高达6 mS cm-1的电导率，组成范围为散装材料的5-13.5％聚吡咯。 PCLF-PPy材料的表面形貌显示RMS粗糙度为1195 nm的微结构，RMS粗糙度为8 nm的纳米结构。用阴离子掺杂剂合成PCLF-PPy衍生物，以确定对电导率的影响，并优化生物相容性的化学成分。使用PC12的体外研究显示，与PCLF相比，PCLF-PPy复合材料诱导更高的细胞活力和增加的神经突延伸。掺入萘磺酸或十二烷基苯磺酸的PCLF-PPy复合材料被确定为电刺激的最佳材料。与没有ES相比，体外研究显示，在存在ES的情况下，轴突细胞的轴突细胞百分比，每个细胞的神经突数和神经突长度的显着增加。另外，观察到延伸的神经突沿所施加电流的方向排列。导电PCLF-PPy支架具有作为神经导管应用所需的材料特性。此外，通过使电流通过PCLF-PPy支架，显着增强和引导神经突延伸的能力使得它们作为未来治疗严重神经损伤的治疗方法更有希望。

20. 发明授权

US07816461B2 Block copolymers of polycarpolactone and poly (propylene funarate) 有权
标题翻译：聚内酯和聚（丙烯丙烯酸酯）的嵌段共聚物
公开(公告)号：US07816461B2
公开(公告)日：2010-10-19
申请号：US11718962
申请日：2005-11-18
申请人： Shanfeng Wang , Michael J. Yaszemski , Lichun Lu , Bradford L. Currier
发明人： Shanfeng Wang , Michael J. Yaszemski , Lichun Lu , Bradford L. Currier
IPC分类号： C08G63/91
CPC分类号： A61L27/56 , A61L27/18 , A61L27/46 , B33Y70/00 , B33Y80/00 , C08G63/08 , C08G63/60 , C08G2261/126 , C08J9/26 , C08J2201/024 , C08J2201/0446 , C08J2367/06 , C08L67/06
摘要： Poly(propylene fumarate) is copolymerized with poly(caprolactone) diol to produce a block copolymer of poly(propylene fumarate) and poly(caprolactone). The biocompatible and bioresorbable block copolymer of poly(propylene fumarate) and poly(caprolactone) is useful in the fabrication of injectable and in-situ hardening scaffolds for tissue and/or skeletal reconstruction. The block copolymer can be crosslinked by redox or photo-initiation, with or without an additional crosslinker. Thus, the copolymer is both self-crosslinkable (without the use of any crosslinkers) and photocrosslinkable (in the presence of photons such as UV light).
摘要翻译：聚（丙烯酸富马酸酯）与聚（己内酯）二醇共聚以制备聚（丙烯酸富马酸酯）和聚（己内酯）的嵌段共聚物。聚（丙烯酸富马酸酯）和聚（己内酯）的生物相容性和生物可吸收的嵌段共聚物可用于制备用于组织和/或骨骼重建的可注射和原位硬化支架。嵌段共聚物可以通过氧化还原或光引发交联，具有或不具有另外的交联剂。因此，共聚物既可自交联（不使用任何交联剂）和光可交联（在诸如紫外光的光子存在下）。

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