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1. 发明申请

US20130331869A1 Conductive polymeric composites of polycaprolactone fumarate and polypyrrole for nerve regeneration 审中-公开
标题翻译：富马酸聚己内酯和聚吡咯的导电聚合物复合材料用于神经再生
公开(公告)号：US20130331869A1
公开(公告)日：2013-12-12
申请号：US12925182
申请日：2010-10-15
申请人： M. Brett Runge , Mahrokh Dadsetan , Michael J. Yaszemski
发明人： M. Brett Runge , Mahrokh Dadsetan , Michael J. Yaszemski
IPC分类号： A61F2/04 , A61N1/05
CPC分类号： A61F2/04 , A61L27/26 , A61L27/383 , A61L27/3834 , A61L27/54 , A61L2430/32 , A61N1/0551 , A61N1/326 , A61N1/36103 , C08L67/04 , C08L65/00
摘要： A novel electrically conductive polymer composite composed of polycaprolactone fumarate-polypyrrole (PCLF-PPy) for applications in nerve regeneration is disclosed. The synthesis and characterization of PCLF-PPy and in vitro studies showing PCLF-PPy supports both PC12 cell and Dorsal Root Ganglia neurite extension. PCLF-PPy composite materials were synthesized by polymerizing pyrrole in pre-formed scaffolds of PCLF resulting in an interpenetrating network of PCLF-PPy. PCLF-PPy composite materials possess electrical conductivity up to 6 mS cm−1 with compositions ranging from 5-13.5 percent polypyrrole of the bulk material. Surface topographies of PCLF-PPy materials show microstructures with a RMS roughness of 1195 nm and nanostructures with RMS roughness of 8 nm. PCLF-PPy derivatives were synthesized with anionic dopants to determine effects on electrical conductivity and to optimize the chemical composition for biocompatibility. In vitro studies using PC12 show PCLF-PPy composite materials induce a higher cellular viability and increased neurite extension compared to PCLF. PCLF-PPy composites doped with either naphthalene sulfonic acid or dodecyl benzene sulfonic acid are determined to be the optimal materials for electrical stimulation. In vitro studies showed significant increases in percentage of neurite bearing cells, number of neurites per cell and neurite length in the presence of ES compared to no ES. Additionally, extending neurites were observed to align in the direction of the applied current. Electrically conductive PCLF-PPy scaffolds possess material properties necessary for application as nerve conduits. Additionally, the capability to significantly enhance and direct neurite extension by passing electrical current through PCLF-PPy scaffolds renders them even more promising as future therapeutic treatments for severe nerve injuries.
摘要翻译：公开了一种用于神经再生的聚己内酯富马酸酯 - 聚吡咯（PCLF-PPy）的新型导电聚合物复合材料。 PCLF-PPy的合成和表征和体外研究显示PCLF-PPy支持PC12细胞和背根神经节神经突延伸。 PCLF-PPy复合材料通过在PCLF的预形成支架中聚合吡咯合成，得到PCLF-PPy的互穿网络。 PCLF-PPy复合材料具有高达6 mS cm-1的电导率，组成范围为散装材料的5-13.5％聚吡咯。 PCLF-PPy材料的表面形貌显示RMS粗糙度为1195 nm的微结构，RMS粗糙度为8 nm的纳米结构。用阴离子掺杂剂合成PCLF-PPy衍生物，以确定对电导率的影响，并优化生物相容性的化学成分。使用PC12的体外研究显示，与PCLF相比，PCLF-PPy复合材料诱导更高的细胞活力和增加的神经突延伸。掺入萘磺酸或十二烷基苯磺酸的PCLF-PPy复合材料被确定为电刺激的最佳材料。与没有ES相比，体外研究显示，在存在ES的情况下，轴突细胞的轴突细胞百分比，每个细胞的神经突数和神经突长度的显着增加。另外，观察到延伸的神经突沿所施加电流的方向排列。导电PCLF-PPy支架具有作为神经导管应用所需的材料特性。此外，通过使电流通过PCLF-PPy支架，显着增强和引导神经突延伸的能力使得它们作为未来治疗严重神经损伤的治疗方法更有希望。

2. 发明申请

US20100055186A1 PHOTOCROSSLINKABLE OLIGO(POLY (ETHYLENE GLYCOL) FUMARATE) HYDROGELS FOR CELL AND DRUG DELIVERY 有权
标题翻译：紫外线（POLY（乙烯甘油）FUMARATE）水解胶囊和药物递送
公开(公告)号：US20100055186A1
公开(公告)日：2010-03-04
申请号：US11909241
申请日：2006-03-23
申请人： Mahrokh Dadsetan , Michael Yaszemski , Lichun Lu
发明人： Mahrokh Dadsetan , Michael Yaszemski , Lichun Lu
IPC分类号： A61K9/14 , C08F2/46 , A61K35/32 , A61P43/00
CPC分类号： A61K31/79 , A61L27/18 , A61L27/3817 , A61L27/3821 , B33Y70/00 , B33Y80/00 , C08F283/01 , C08F283/06 , C08L71/02 , C08F2/48 , C08F226/10
摘要： The invention provides photocrosslinkable, injectable, biodegradable oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels made from the photopolymerization of an OPF macromer with UV light and a photoinitiator. Hydrogels with varying mechanical properties and water content can be made with changes in macromer and crosslinking agent concentration in a precursor solution. The biodegradable OPF hydrogels can be injected as a fluid into a bodily defect of any shape, may incorporate various therapeutic agents, e.g., cells and/or growth factors, and may be implanted via minimally invasive arthroscopic techniques.
摘要翻译：本发明提供由OPF大分子单体与UV光和光引发剂的光聚合制备的可光交联的可注射的可生物降解的寡聚（聚（乙二醇）富马酸盐）（OPF）水凝胶。具有不同机械性能和水含量的水凝胶可以在大分子单体和前体溶液中的交联剂浓度的变化下进行。可生物降解的OPF水凝胶可以作为流体注入任何形状的身体缺陷，可以并入各种治疗剂，例如细胞和/或生长因子，并且可以通过微创关节镜技术植入。

3. 发明授权

US08343527B2 Photocrosslinkable oligo(poly (ethylene glycol) fumarate) hydrogels for cell and drug delivery 有权
标题翻译：光可交联寡聚（聚（乙二醇）富马酸盐）水凝胶用于细胞和药物递送
公开(公告)号：US08343527B2
公开(公告)日：2013-01-01
申请号：US11909241
申请日：2006-03-23
申请人： Mahrokh Dadsetan , Michael Yaszemski , Lichun Lu
发明人： Mahrokh Dadsetan , Michael Yaszemski , Lichun Lu
IPC分类号： A61F2/00 , A61K9/14 , C08F2/48 , C07K14/51
CPC分类号： A61K31/79 , A61L27/18 , A61L27/3817 , A61L27/3821 , B33Y70/00 , B33Y80/00 , C08F283/01 , C08F283/06 , C08L71/02 , C08F2/48 , C08F226/10
摘要： The invention provides photocrosslinkable, injectable, biodegradable oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels made from the photopolymerization of an OPF macromer with UV light and a photoinitiator. Hydrogels with varying mechanical properties and water content can be made with changes in macromer and crosslinking agent concentration in a precursor solution. The biodegradable OPF hydrogels can be injected as a fluid into a bodily defect of any shape, may incorporate various therapeutic agents, e.g., cells and/or growth factors, and may be implanted via minimally invasive arthroscopic techniques.
摘要翻译：本发明提供由OPF大分子单体与UV光和光引发剂的光聚合制备的可光交联的可注射的可生物降解的寡聚（聚（乙二醇）富马酸盐）（OPF）水凝胶。具有不同机械性能和水含量的水凝胶可以在大分子单体和前体溶液中的交联剂浓度的变化下进行。可生物降解的OPF水凝胶可以作为流体注入任何形状的身体缺陷，可以并入各种治疗剂，例如细胞和/或生长因子，并且可以通过微创关节镜技术植入。

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