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1. 发明申请

US20130331869A1 Conductive polymeric composites of polycaprolactone fumarate and polypyrrole for nerve regeneration 审中-公开
标题翻译：富马酸聚己内酯和聚吡咯的导电聚合物复合材料用于神经再生
公开(公告)号：US20130331869A1
公开(公告)日：2013-12-12
申请号：US12925182
申请日：2010-10-15
申请人： M. Brett Runge , Mahrokh Dadsetan , Michael J. Yaszemski
发明人： M. Brett Runge , Mahrokh Dadsetan , Michael J. Yaszemski
IPC分类号： A61F2/04 , A61N1/05
CPC分类号： A61F2/04 , A61L27/26 , A61L27/383 , A61L27/3834 , A61L27/54 , A61L2430/32 , A61N1/0551 , A61N1/326 , A61N1/36103 , C08L67/04 , C08L65/00
摘要： A novel electrically conductive polymer composite composed of polycaprolactone fumarate-polypyrrole (PCLF-PPy) for applications in nerve regeneration is disclosed. The synthesis and characterization of PCLF-PPy and in vitro studies showing PCLF-PPy supports both PC12 cell and Dorsal Root Ganglia neurite extension. PCLF-PPy composite materials were synthesized by polymerizing pyrrole in pre-formed scaffolds of PCLF resulting in an interpenetrating network of PCLF-PPy. PCLF-PPy composite materials possess electrical conductivity up to 6 mS cm−1 with compositions ranging from 5-13.5 percent polypyrrole of the bulk material. Surface topographies of PCLF-PPy materials show microstructures with a RMS roughness of 1195 nm and nanostructures with RMS roughness of 8 nm. PCLF-PPy derivatives were synthesized with anionic dopants to determine effects on electrical conductivity and to optimize the chemical composition for biocompatibility. In vitro studies using PC12 show PCLF-PPy composite materials induce a higher cellular viability and increased neurite extension compared to PCLF. PCLF-PPy composites doped with either naphthalene sulfonic acid or dodecyl benzene sulfonic acid are determined to be the optimal materials for electrical stimulation. In vitro studies showed significant increases in percentage of neurite bearing cells, number of neurites per cell and neurite length in the presence of ES compared to no ES. Additionally, extending neurites were observed to align in the direction of the applied current. Electrically conductive PCLF-PPy scaffolds possess material properties necessary for application as nerve conduits. Additionally, the capability to significantly enhance and direct neurite extension by passing electrical current through PCLF-PPy scaffolds renders them even more promising as future therapeutic treatments for severe nerve injuries.
摘要翻译：公开了一种用于神经再生的聚己内酯富马酸酯 - 聚吡咯（PCLF-PPy）的新型导电聚合物复合材料。 PCLF-PPy的合成和表征和体外研究显示PCLF-PPy支持PC12细胞和背根神经节神经突延伸。 PCLF-PPy复合材料通过在PCLF的预形成支架中聚合吡咯合成，得到PCLF-PPy的互穿网络。 PCLF-PPy复合材料具有高达6 mS cm-1的电导率，组成范围为散装材料的5-13.5％聚吡咯。 PCLF-PPy材料的表面形貌显示RMS粗糙度为1195 nm的微结构，RMS粗糙度为8 nm的纳米结构。用阴离子掺杂剂合成PCLF-PPy衍生物，以确定对电导率的影响，并优化生物相容性的化学成分。使用PC12的体外研究显示，与PCLF相比，PCLF-PPy复合材料诱导更高的细胞活力和增加的神经突延伸。掺入萘磺酸或十二烷基苯磺酸的PCLF-PPy复合材料被确定为电刺激的最佳材料。与没有ES相比，体外研究显示，在存在ES的情况下，轴突细胞的轴突细胞百分比，每个细胞的神经突数和神经突长度的显着增加。另外，观察到延伸的神经突沿所施加电流的方向排列。导电PCLF-PPy支架具有作为神经导管应用所需的材料特性。此外，通过使电流通过PCLF-PPy支架，显着增强和引导神经突延伸的能力使得它们作为未来治疗严重神经损伤的治疗方法更有希望。

2. 发明申请

US20140099278A1 BIOCOMPATIBLE POLYCAPROLACTONE FUMARATE FORMULATIONS 审中-公开
标题翻译：生物可溶性多环芳酮FUMARATE配方
公开(公告)号：US20140099278A1
公开(公告)日：2014-04-10
申请号：US14009987
申请日：2012-04-04
申请人： Michael Brett Runge , Michael J. Yaszemski
发明人： Michael Brett Runge , Michael J. Yaszemski
IPC分类号： A61L27/18 , A61L27/26
CPC分类号： A61L27/18 , A61L27/26 , C08G63/08 , C08G63/60 , C08L67/04
摘要： A polycaprolactone fumarate polymer useful as a matrix material for a biocompatible scaffold for tissue engineering applications is disclosed. The polycaprolactone fumarate polymer can be prepared by reacting caprolactone with an alkane polyol to prepare a polycaprolactone precursor, and then reacting the polycaprolactone precursor with fumaric acid or a salt thereof to prepare the polycaprolactone fumarate polymer. The use of an alkane diol, such as 1,2-propanediol, provides a linear polycaprolactone diol precursor. The use of an alkane triol, such as glycerol, provides a branched polycaprolactone triol precursor. The biocompatible polycaprolactone fumarate formulation releases no diethylene glycol or other undesirable byproducts during degradation.
摘要翻译：公开了可用作组织工程应用的生物相容性支架的基质材料的聚己内酯富马酸酯聚合物。聚己内酯富马酸酯聚合物可以通过使己内酯与烷烃多元醇反应制备聚己内酯前体，然后使聚己内酯前体与富马酸或其盐反应制备富马酸聚己内酯聚合物。使用诸如1,2-丙二醇的烷二醇提供线型聚己内酯二醇前体。使用烷烃三醇如甘油提供支链聚己内酯三醇前体。生物相容性聚己内酯富马酸盐配方在降解期间不释放二甘醇或其它不希望的副产物。

3. 发明申请

US20100119528A1 Transport of Biologically Active Molecules into a Cell, Mitochondrion, or Nucleus 审中-公开
标题翻译：将生物活性分子转运到细胞，线粒体或核中
公开(公告)号：US20100119528A1
公开(公告)日：2010-05-13
申请号：US12354142
申请日：2009-01-15
申请人： Gobinda Sarkar , Mark E. Bolander , Deendayal Mandal , Eric W. Mahlum , Michael J. Yaszemski
发明人： Gobinda Sarkar , Mark E. Bolander , Deendayal Mandal , Eric W. Mahlum , Michael J. Yaszemski
IPC分类号： A61K39/395 , C07K14/00 , C07K7/08 , C07K9/00 , C07K16/00 , A61K38/16 , A61K38/10 , A61K38/14 , A61K39/385 , C12N5/00 , C12N15/00 , A61P43/00
CPC分类号： C12N15/87 , A61K47/64 , A61K48/0041 , C07K7/06
摘要： Novel carrier peptides are described, as well as methods of using the carrier peptides to transport biologically active molecules into a cell, mitochondrion, or nucleus, e.g., by formation of a complex of the carrier peptide non-covalently bound to a biologically active molecule.
摘要翻译：描述了新颖的载体肽，以及使用载体肽将生物活性分子转运到细胞，线粒体或细胞核中的方法，例如通过形成非共价结合生物活性分子的载体肽的复合物。

4. 发明授权

US06759485B2 Biodegradable poly (propylene fumarate) networks cross linked with poly (propylene fumarate) -diacrylate macromers 有权
标题翻译：与聚（丙烯酸富马酸酯） - 二丙烯酸酯大分子单体交联的可生物降解的聚（丙烯富马酸）网络
公开(公告)号：US06759485B2
公开(公告)日：2004-07-06
申请号：US10127117
申请日：2002-04-22
申请人： Shulin He , Michael J. Yaszemski , Antonios G. Mikos
发明人： Shulin He , Michael J. Yaszemski , Antonios G. Mikos
IPC分类号： C08L6706
CPC分类号： C08L67/06 , A61L27/18 , A61L27/50 , A61L27/58 , C08G63/676 , C08G63/918 , C08G81/025 , C08L67/07 , Y10S530/812 , Y10S530/815 , C08L67/00 , C08L71/02
摘要： A network consisting essentially of poly(propylene fumarate) cross linked with diacrylate and a method for making same.
摘要翻译：基本上由二丙烯酸交联的聚（丙烯酸富马酸酯）组成的网络及其制备方法。

5. 发明授权

US10426867B2 Biocompatible polycaprolactone fumarate formulations 有权
公开(公告)号：US10426867B2
公开(公告)日：2019-10-01
申请号：US14009987
申请日：2012-04-04
申请人： Michael Brett Runge , Michael J. Yaszemski
发明人： Michael Brett Runge , Michael J. Yaszemski
IPC分类号： A61L27/18 , A61L27/26 , C08G63/08 , C08G63/60
摘要： A polycaprolactone fumarate polymer useful as a matrix material for a biocompatible scaffold for tissue engineering applications is disclosed. The polycaprolactone fumarate polymer can be prepared by reacting caprolactone with an alkane polyol to prepare a polycaprolactone precursor, and then reacting the polycaprolactone precursor with fumaric acid or a salt thereof to prepare the polycaprolactone fumarate polymer. The use of an alkane diol, such as 1,2-propanediol, provides a linear polycaprolactone diol precursor. The use of an alkane triol, such as glycerol, provides a branched polycaprolactone triol precursor. The biocompatible polycaprolactone fumarate formulation releases no diethylene glycol or other undesirable byproducts during degradation.

6. 发明申请

US20090054818A1 SPINAL ORTHOSES 审中-公开
标题翻译：脊柱畸形
公开(公告)号：US20090054818A1
公开(公告)日：2009-02-26
申请号：US11628996
申请日：2005-06-09
申请人： Kenton R. Kaufman , Michael J. Yaszemski
发明人： Kenton R. Kaufman , Michael J. Yaszemski
IPC分类号： A61F5/00
CPC分类号： A61F5/34 , A61F5/012 , A61F5/022 , A61F5/024
摘要： A thoracolumbosacral and a lumbosacral orthosis with sagittal-coronal control are disclosed. The orthoses have two rigid anterior and posterior plastic shells. The anterior shell extends from the pelvis to the sternum. The posterior shell extends from the pelvis and terminates just inferior to the scapular spine. An interior surface of the anterior shell has pressure pads that apply pressure to locations on the patient's anterior torso and the interior surface of the posterior shell has pressure pads that apply pressure to locations on the patient's posterior torso when the anterior shell and the posterior shell are secured to the patient's torso. The pressure pads may be inflatable air bladders.
摘要翻译：公开了一种具有矢状冠状动脉控制的胸腰椎和腰骶矫形器。矫形器有两个刚性的前后塑料外壳。前囊从骨盆延伸到胸骨。后壳从骨盆延伸，终止于肩胛骨下方。前壳的内表面具有对患者前躯干上的位置施加压力的压力垫，并且后壳的内表面具有压力垫，当前壳和后壳是前壳和后壳时，压力垫对患者的后躯体上的位置施加压力固定在患者的躯干上。压垫可以是可充气的气囊。

7. 发明授权

US5733951A Poly(propylene fumarate) 失效
标题翻译：聚（富马酸丙烯酯）
公开(公告)号：US5733951A
公开(公告)日：1998-03-31
申请号：US234551
申请日：1994-04-28
申请人： Michael J. Yaszemski , Richard G. Payne , Antonios G. Mikos
发明人： Michael J. Yaszemski , Richard G. Payne , Antonios G. Mikos
IPC分类号： A61L24/04 , C08G63/52 , C08G63/02 , A61F2/00 , C08K3/32
CPC分类号： C08G63/52 , A61L24/046
摘要： A novel pathway for the synthesis of poly(propylene fumarate) includes first producing bis-hydroxypropyl fumarate and then its transesterification into poly(propylene fumarate). This synthetic pathway permits production of high molecular weight poly(propylene fumarate) and enables the production of a composite material useful in orthopedic procedures.
摘要翻译：用于合成聚（富马酸丙烯酯）的新途径包括首先生产富马酸双羟丙酯，然后将其酯交换成聚（富马酸丙烯酯）。该合成途径允许生产高分子量聚（富马酸丙烯酯），并且能够生产用于矫形程序的复合材料。

8. 发明授权

US5644005A Method of making poly(propylene fumarate-coethylene oxide) 失效
标题翻译：聚（丙烯酸富马酸酯 - 环氧乙烷）的制备方法
公开(公告)号：US5644005A
公开(公告)日：1997-07-01
申请号：US637355
申请日：1996-04-24
申请人： Laura J. Suggs , Richard G. Payne , Michael J. Yaszemski , Antonios G. Mikos
发明人： Laura J. Suggs , Richard G. Payne , Michael J. Yaszemski , Antonios G. Mikos
IPC分类号： A61K47/48 , C08F283/01 , C08G63/676 , C08G81/00 , C08L71/02 , C08F20/00
CPC分类号： C08G81/00 , A61K47/48992 , C08F283/01 , C08G63/676 , C08L71/02
摘要： A biodegradable block copolymer made from the transesterfication of a poly(propylene fumarate) prepolymer and a poly(ethylene oxide) prepolymer. The block copolymer poly(propylene fumarate -co- ethylene oxide) is capable of crosslinking at body temperature. Crosslinking requires an appropriate crosslinking monomer and an initiator. The biodegradable block copolymer has utility as a vascular implant became it can be injected as a fluid into the vascular system and crosslinked in situ.
摘要翻译：由聚（丙烯富马酸酯）预聚物和聚（环氧乙烷）预聚物的酯交换制备的可生物降解的嵌段共聚物。嵌段共聚物聚（富马酸丙烯酯 - 环氧乙烷）能够在体温下交联。交联需要合适的交联单体和引发剂。可生物降解的嵌段共聚物具有作为血管植入物的效用，其可以作为流体注入血管系统并原位交联。

9. 发明授权

US10568985B2 Photodegradable polycaprolactone fumarate block copolymers 有权
公开(公告)号：US10568985B2
公开(公告)日：2020-02-25
申请号：US13955279
申请日：2013-07-31
申请人： Michael Brett Runge , Michael J. Yaszemski
发明人： Michael Brett Runge , Michael J. Yaszemski
IPC分类号： A61L27/18 , C08L67/04 , C08G63/08 , A61L27/56
摘要： A polycaprolactone fumarate copolymer useful as a material for a biocompatible scaffold for tissue engineering applications is disclosed. The copolymer includes at least one caprolactone unit, at least one fumarate unit, and at least one third unit selected from the group consisting of acrylate units and styrenic units. A linking moiety forms a link between the third unit and at least one caprolactone unit or at least one fumarate unit. The linking moiety can be photodegradable. In one form, the third unit includes at least one methyl methacrylate unit. The copolymer can be used to form the wall of a nerve conduit.

10. 发明授权

US09255178B2 Photocrosslinkable poly (caprolactone fumarate) 有权
标题翻译：可交联聚（己内酯富马酸盐）
公开(公告)号：US09255178B2
公开(公告)日：2016-02-09
申请号：US11718906
申请日：2005-11-10
申请人： Shanfeng Wang , Lichun Lu , Michael J. Yaszemski
发明人： Shanfeng Wang , Lichun Lu , Michael J. Yaszemski
IPC分类号： C08G63/91 , A61L27/18 , A61L27/46 , C08G63/08 , C08L67/06
CPC分类号： C08G63/912 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/56 , C08G63/08 , C08L67/06 , C08L67/04
摘要： Fumaric acid or a salt thereof, such as a fumaryl halide (e.g. fumaryl chloride), which contains unsaturated carbon-carbon double bonds that can be used for in situ crosslinking, is copolymerized with poly(caprolactone)diol in the presence of an alkali metal salt. The resulting photocrosslinkable biocompatible and bioresorbable poly(caprolactone fumarate) biomaterial is useful in the fabrication of injectable an in-situ hardening scaffolds for application in skeletal reconstruction.
摘要翻译：富马酸或其盐，例如可用于原位交联的含有不饱和碳 - 碳双键的富马来酰卤（例如富马酰氯）与聚（己内酯）二醇在碱金属盐。所得的可光致交联的生物相容性和生物可再吸收的聚（己内酯富马酸盐）生物材料可用于制造注射用于骨骼重建中的原位硬化支架。

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