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1. 发明授权

US07163545B2 Spinal cord surgical implant 有权
标题翻译：脊髓手术植入物
公开(公告)号：US07163545B2
公开(公告)日：2007-01-16
申请号：US10629427
申请日：2003-07-29
申请人： Michael J. Yaszemski , Jonathan A. Friedman , Michael J. Moore , Anthony J. Windebank
发明人： Michael J. Yaszemski , Jonathan A. Friedman , Michael J. Moore , Anthony J. Windebank
IPC分类号： A61B17/08
CPC分类号： A61B17/08 , A61B17/1128 , A61L27/383 , A61L27/3878 , A61L27/58 , A61L31/005 , A61L31/148 , A61L2430/32
摘要： An implant for bridging a gap in a severed spinal cord or nerve and for promoting nerve regeneration has a matrix comprising a biocompatible, biodegradable, polymeric material. The matrix has a proximal end for connection to a first end of severed spinal cord and a distal end for connection to a second end of severed spinal cord. The matrix includes internal guidance channels extending between the proximal end and the distal end to facilitate rejoining of the first end and the second end of the severed spinal cord. A bioactive agent may be dispersed in the matrix, or disposed in the channels, or included within microspheres in the channels. The channels may be arranged such that guidance channels correspond to spinal cord tracts. Alternatively, guidance channels may be spaced apart at the proximal end of the matrix and converge inward toward the axis of the matrix at the distal end.
摘要翻译：用于桥接切断的脊髓或神经中的间隙并用于促进神经再生的植入物具有包含生物相容性，可生物降解的聚合材料的基质。基质具有用于连接到切断的脊髓的第一端的近端和用于连接到切断的脊髓的第二端的远端。基体包括在近端和远端之间延伸的内部引导通道，以便于重新连接切断的脊髓的第一端和第二端。生物活性剂可以分散在基质中，或者设置在通道中，或者包含在通道中的微球体内。通道可以布置成使得引导通道对应于脊髓束。或者，引导通道可以在基体的近端处间隔开并且在远端处朝向矩阵的轴线向内收敛。

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