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11. 发明申请

US20100228149A1 SENSOR DEVICE 审中-公开
标题翻译：传感器设备
公开(公告)号：US20100228149A1
公开(公告)日：2010-09-09
申请号：US12528660
申请日：2008-02-25
申请人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Shingo Kaimori , Takahiko Kitamura , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
发明人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Shingo Kaimori , Takahiko Kitamura , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
IPC分类号： A61B5/151
CPC分类号： A61B5/15194 , A61B5/14532 , A61B5/1468 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150519 , A61B5/150633 , A61B5/150702 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/1519 , A61B5/157 , A61B2562/0295
摘要： A sensor device has a needle-integrated type sensor element which is detachably mounted therein and which has a sensor chip, a lancet needle fixed to an end portion of the sensor chip, and a flow path forming element provided compressibly and restorably at the end portion of the sensor chip, to which the lancet needle is fixed. The sensor device includes a puncture mechanism (a drive spring) configured to cause the sensor element to puncture a target, and a pressing mechanism (a pressure spring) configured to urge the sensor element to the extent that the sensor element is prevented from being detached from the target by a restoring force of the flow path forming element after the target is punctured.
摘要翻译：传感器装置具有可拆卸地安装在其中的针式集成型传感器元件，其具有传感器芯片，固定到传感器芯片的端部的刺血针，以及可流动地且可修复地设置在端部处的流路形成元件传感器芯片，刺针针固定到该传感器芯片上。传感器装置包括构造成使传感器元件刺穿目标的穿刺机构（驱动弹簧）以及构造成将传感器元件推压到防止传感器元件脱离的程度的按压机构（压力弹簧）在目标被刺破之后，通过流路形成元件的恢复力从目标射出。

12. 发明申请

US20100069792A1 BIOSENSOR CARTRIDGE, BIOSENSOR DEVICE, SAMPLE COLLECTING METHOD, MANUFACTURING METHOD OF BIOSENSOR CARTRIDGE, AND NEEDLE INTEGRAL SENSOR 审中-公开
标题翻译：生物传感器盒，生物传感器装置，样品采集方法，生物传感器盒的制造方法和针状集成传感器
公开(公告)号：US20100069792A1
公开(公告)日：2010-03-18
申请号：US12513458
申请日：2007-11-01
申请人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Takahiko Kitamura , Shingo Kaimori , Akira Harada , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
发明人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Takahiko Kitamura , Shingo Kaimori , Akira Harada , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
IPC分类号： A61B5/151 , H01R43/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150549 , A61B5/150618 , A61B5/150717 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B2562/0295 , Y10T29/49002
摘要： A biosensor cartridge capable of performing puncturing in an exact position, and easily collecting and measuring a sample of a puncture hole without requiring the operation of bringing a sample collection opening close to the puncture hole is provided. When tip portion 11a of biosensor chip body 11 is pushed against a subject M, elastic body 20 protruding from a tip portion 11a of biosensor chip body 11 is compressed, and puncturing tool 12 for puncturing protrudes. Thus, the subject M can be punctured. Additionally, if a pushing force is weakened, puncturing tool 12 is extracted from the subject M by the restoring force of elastic body 20, and the sample R flows out of the puncture hole. Additionally, cover member 19 is provided around biosensor chip body 11. Thus, when puncturing is performed by thin plate-shaped biosensor cartridge 10, biosensor chip body 11 can be prevented from deforming, and puncturing can be accurately performed in a desired puncturing position.
摘要翻译：本发明提供一种生物传感器盒，其能够在精确位置进行穿刺，并且容易地收集和测量穿刺孔的样本，而不需要使样本收集开口靠近穿刺孔的操作。当生物传感器芯体11的尖端部分11a被压靠在被检体M上时，从生物传感器芯体11的尖端部分11a突出的弹性体20被压缩，并且用于穿刺的穿刺工具12突出。因此，可以对被检体M进行穿刺。此外，如果推力减弱，则通过弹性体20的恢复力从被检体M取出穿刺工具12，并且样本R流出穿刺孔。另外，盖体19设置在生物传感器芯体11周围。因此，当通过薄板状生物传感器盒10进行穿刺时，可以防止生物传感器芯体11变形，并且可以在期望的穿刺位置精确地进行穿刺。

13. 发明申请

US20100004559A1 BIOSENSOR CARTRIDGE, METHOD OF USING BIOSENSOR CARTRIDGE, BIOSENSOR DEVICE, AND NEEDLE INTEGRAL SENSOR 审中-公开
标题翻译： BIOSENSOR CARTRIDGE，使用BIOSENSOR CARTRIDGE的方法，生物传感器设备和针式集成传感器
公开(公告)号：US20100004559A1
公开(公告)日：2010-01-07
申请号：US12519916
申请日：2007-12-17
申请人： Tsuyoshi Fujimura , Hideaki Nakamura , Masao Gotoh , Isao Karube , Tomoko Ishikawa , Takahiko Kitamura , Shingo Kaimori , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
发明人： Tsuyoshi Fujimura , Hideaki Nakamura , Masao Gotoh , Isao Karube , Tomoko Ishikawa , Takahiko Kitamura , Shingo Kaimori , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
IPC分类号： A61B5/151
CPC分类号： A61B5/1519 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150549 , A61B5/150618 , A61B5/150717 , A61B5/15113 , A61B5/15117
摘要： A biosensor cartridge capable of making the collected amount of a sample required for measurement into a small quantity to reduce a user's burden, and easily collecting and measuring a sample of a puncture hole without requiring the operation of bringing a sample collection opening close to the puncture hole is provided. When one end portion of biosensor chip is pushed against subject, elastic body is compressed, and puncturing tool can protrude and perform puncturing. Additionally, if a pushing force is weakened, puncturing tool is extracted from subject by the restoring force of elastic body, and blood (sample) flows out of the puncture hole. In this case, since the puncture hole, and sample collection opening provided at biosensor chip are contained in enclosed half-open space formed by elastic body, even a small amount of blood (sample) can also be easily collected. Additionally, elastic body is formed with a groove which forms a ventilation passage, so that enclosed half-open space can be opened to the atmosphere.
摘要翻译：一种生物传感器盒，其能够将少量测量所需的样本的收集量减少到用户的负担，并且容易地收集和测量穿孔的样本，而不需要使样本收集开口靠近穿刺的操作提供孔。当生物传感器芯片的一个端部被压住物体时，弹性体被压缩，并且穿刺工具可以伸出并进行穿刺。此外，如果推力减弱，则通过弹性体的恢复力从被检体取出穿刺工具，血液（样品）从穿刺孔流出。在这种情况下，由于设置在生物传感器芯片上的穿刺孔和样本收集开口包含在由弹性体形成的封闭半开放空间中，所以即使少量的血液（样品）也可以容易地收集。此外，弹性体形成有形成通风通道的槽，使得封闭的半开放空间可以打开到大气。

14. 发明申请

US20090299225A1 BIOSENSOR CHIP 审中-公开
标题翻译：生物传感器芯片
公开(公告)号：US20090299225A1
公开(公告)日：2009-12-03
申请号：US12297387
申请日：2007-04-17
申请人： Takahiko Kitamura , Shingo Kaimori , Akira Harada , Toshifumi Hosoya , Tsuyoshi Fujimura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
发明人： Takahiko Kitamura , Shingo Kaimori , Akira Harada , Toshifumi Hosoya , Tsuyoshi Fujimura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
IPC分类号： A61B5/151
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150229 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150511 , A61B5/150549 , A61B5/150717 , A61B5/15186
摘要： There is provided a biosensor chip where the collecting amount necessary for the measurement is made small whereby burden of a user is reduced and, at the same time, a sample at a puncture opening is able to be easily collected and measured without an operation of making the sample collection opening nearer the puncture opening. When an end of a main body chip is pushed onto a test body, an elastic body installed at an end of the main body chip is compressed and a device for puncture is produced whereby the test body is able to be punctured. When the pushing force is made weak, the device for puncture is pulled out from the test body due to resilience of the elastic body and a sample is flown out from the puncture opening. At that time, since the puncture opening and the sample collection opening installed in the main body chip are enclosed in a tightly-closed space formed by the elastic body, even small amount of the sample is able to be easily collected by the sample collection opening without conducting the positioning of the sample collection opening.
摘要翻译：提供了一种生物传感器芯片，其中使得测量所需的收集量变小，从而减少了使用者的负担，并且同时，能够容易地收集和测量穿刺开口处的样本而不进行操作样品收集开口更靠近穿刺孔。当主体芯片的一端被推到测试体上时，安装在主体芯片的端部的弹性体被压缩，并且产生用于穿刺的装置，由此能够刺破测试体。当推力变弱时，由于弹性体的弹性，用于穿刺的装置从测试体被拉出，并且样品从穿刺孔流出。此时，由于安装在主体芯片上的穿刺开口和样本收集开口被包围在由弹性体形成的紧密封闭的空间中，所以即使少量的样本能够容易地被样本收集开口收集而不进行样品收集开口的定位。

15. 发明申请

US20090124876A1 NEEDLE INTEGRATED BIOSENSOR 审中-公开
标题翻译：针式集成生物传感器
公开(公告)号：US20090124876A1
公开(公告)日：2009-05-14
申请号：US11994010
申请日：2006-06-27
申请人： Hideaki Nakamura , Masao Gotoh , Isao Karube
发明人： Hideaki Nakamura , Masao Gotoh , Isao Karube
IPC分类号： A61B5/157 , A61B5/055
CPC分类号： A61B10/0045 , A61B5/150022 , A61B5/150099 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , A61B5/150572 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B5/15194 , A61B5/157 , A61B2562/0295
摘要： There is a needle integrated biosensor, including: a biosensor including at least two electrodes, and a puncture needle to collect a body fluid by piercing a skin of a person to be tested, the biosensor and the puncture needle being integrated, wherein the puncture needle is able to be kept hygienic without the need of a protective cover or the like for the puncture needle.There is a needle integrated biosensor, including: a biosensor including at least two electrodes, and a puncture needle to collect a body fluid by piercing a skin of a person to be tested, the biosensor and the puncture needle being integrated, wherein a soft material is attached to the front end of the puncture needle so that the front end of the puncture needle is protected.
摘要翻译：针组合生物传感器包括：生物传感器，包括至少两个电极;以及穿刺针，用于通过刺穿待测试人员的皮肤来收集体液，所述生物传感器和穿刺针是一体的，其中所述穿刺针能够保持卫生，而不需要用于穿刺针的保护罩等。针组合式生物传感器包括：生物传感器，包括至少两个电极;以及穿刺针，用于通过刺穿待测试人的皮肤，生物传感器和穿刺针一体地收集体液，其中柔软材料附着在穿刺针的前端，使得穿刺针的前端受到保护。

16. 发明申请

US20070000776A1 Biosensor and production method therefor 审中-公开
标题翻译：生物传感器及其生产方法
公开(公告)号：US20070000776A1
公开(公告)日：2007-01-04
申请号：US10565830
申请日：2004-04-15
申请人： Isao Karube , Masao Gotoh , Hideaki Nakamura
发明人： Isao Karube , Masao Gotoh , Hideaki Nakamura
IPC分类号： G01N33/487
CPC分类号： G01N27/3272
摘要： A downsized biosensor in which an electrode is formed on one sheet of electrically-insulated substrate, and a sheet of flat substrate is worked three-dimensionally so as to dispose the electrode on the inner side of the substrate to provide a two-dimensional or three-dimensional electrode disposition, whereby a sample introduced by capillary phenomenon can be measured quantitatively in a small space. A production method of a biosensor comprising the steps of bending a plate member so as to position an electrode formed on the surface of the electrically-insulated plane member on the inner side, and disposing the electrode in a space surrounded by a substrate and a cover to thereby form the substrate and the cover from one sheet of plate member.
摘要翻译：在一片电绝缘基板上形成电极的小型生物传感器，三维地加工一层平面基板，以将电极设置在基板的内侧，以提供二维或三维通过毛细管现象引入的样品可以在很小的空间内定量测量。一种生物传感器的生产方法，包括以下步骤：弯曲板构件，以将形成在电绝缘平面构件的表面上的电极定位在内侧，并将电极设置在由基板和盖子从而从一片板构件形成基板和盖。

17. 发明申请

US20080194988A1 Biosensor Unified With Needle 审中-公开
标题翻译：生物传感器统一用针
公开(公告)号：US20080194988A1
公开(公告)日：2008-08-14
申请号：US11885352
申请日：2006-03-01
申请人： Hideaki Nakamura , Masao Gotoh , Isao Karube
发明人： Hideaki Nakamura , Masao Gotoh , Isao Karube
IPC分类号： A61B5/157 , G01N33/483
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/14865 , A61B5/150022 , A61B5/150099 , A61B5/150175 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150717 , A61B5/150748 , A61B5/15113 , A61B5/1519 , A61B5/15194
摘要： There is provided a biosensor unified with a needle in which, since its constitution is simple, its assembling is easy in spite of having strength, collecting of body fluid sample can be conducted surely without waste, a puncturing needle is not polluted by a reagent layer, carrying is easy due to its simple package and hygiene can be maintained even after use. There is also provided a biosensor unified with a needle in which an assembling is easy without deteriorating its strength and collecting a body fluid sample can be surely conducted without waste where a puncturing needle is not polluted with a reagent layer.A biosensor unified with a needle where a puncturing needle for collecting a body fluid by puncturing the skin of a person to be tested and a main body of a biosensor for conducting the analysis of the body fluid are constituted in a unified manner and the puncturing needle is constituted in such a manner that it penetrates by driving the main body of the biosensor in a vertical direction by an external driving means and punctures the skin. In a biosensor unified with a needle which is constituted in such a manner that a biosensor comprising electrically insulating substrate and cover, a spacer installed in a space sandwiched between them, an electrode and a reagent layer and a puncturing needle for penetrating the skin of a person to be tested and collecting the body fluid are unified, a biosensor unified with a needle which is characterized in that a cover part forming an opening for collecting the blood installed at the end of the longitudinal direction of a biosensor has one penetrating hole for a puncturing needle.
摘要翻译：提供了一种与针一体化的生物传感器，其结构简单，即使具有强度，组装也容易，可以可靠地进行收集体液样品而不浪费，刺针不被试剂层污染携带方便，即使使用后也能保持简单的包装和卫生。还提供了一种用针组装的生物传感器，其中容易组装而不会降低其强度，并且可以可靠地进行收集体液样品，而不会在没有用试剂层污染穿刺针的情况下进行收集。一种统一的生物传感器，其中通过刺穿待测试人的皮肤收集体液的穿刺针和用于进行体液分析的生物传感器的主体一体地构成，并且穿刺针以通过外部驱动装置在垂直方向上驱动生物传感器主体而穿透皮肤的方式构成。在与针状物一体化的生物传感器中，其构成为包括电绝缘基板和盖的生物传感器，安装在夹在它们之间的空间中的间隔件，电极和试剂层以及用于穿透皮肤的穿刺针被检测体和收集体液的人是统一的，与针统一的生物传感器，其特征在于，形成用于收集安装在生物传感器的纵向方向末端的血液的开口的盖部分具有一个用于穿刺针。

18. 发明申请

US20050247573A1 Biosensors 审中-公开
公开(公告)号：US20050247573A1
公开(公告)日：2005-11-10
申请号：US11087015
申请日：2005-03-22
申请人： Hideaki Nakamura , Shouji Shinohara , Masao Gotoh , Isao Karube
发明人： Hideaki Nakamura , Shouji Shinohara , Masao Gotoh , Isao Karube
IPC分类号： G01N27/26 , G01N33/487
CPC分类号： G01N27/3272
摘要： The biosensors of the present invention comprise an electrically insulating substrate, an electrically insulating cover connected to the substrate via a spacer layer, a reaction-detecting section formed on the substrate at a region sandwiched between the substrate and cover, and comprising at least one set of electrodes, and an external terminal to be connected to the reaction-detecting section, and a sealed sample-feeding path defined between the substrate and cover by the spacer layer, where the sample-feeding path has a portion intersecting the electrodes, as well as a cutting plane line provided at an outermost surface of the substrate or cover, which is a boundary between a sensor portion comprising electrodes and a sealed cap portion which does not comprise electrodes, and the cutting plane line is present at a position where, when the sealed cap portion is cut along the cutting plane line, the cut surface does not cross the electrodes and does cross the sample-feeding path, so that a sample-inlet port and an air-discharge port leading from the sample-feeding path are exposed through the cut surface. In addition, the biosensors for simultaneously measuring multiple items of the present invention comprise: a substrate; a cover connected to the substrate via a spacer layer; and a number of biosensor units comprising substrates each containing at least one biosensor unit which comprises a reaction-detecting section including one electrode system and one reagent layer on the substrate, and a sample-feeding path including the reagent layer, wherein each of the biosensor units comprise one reagent layer on one sample-feeding path, a cutting plane line for dividing each of the biosensor unit-comprising substrates is provided at a top surface of the substrate or cover, the cutting plane line and sample-feeding path are placed such that, when the substrate or cover is cut along the cutting plane line, a sample-inlet port for supplying a sample solution is open to a cut surface of each biosensor unit-comprising substrate as a cut port of the sample-feeding path.

19. 发明申请

US20090093695A1 BIOSENSOR 审中-公开
标题翻译：生物传感器
公开(公告)号：US20090093695A1
公开(公告)日：2009-04-09
申请号：US11993911
申请日：2006-06-27
申请人： Hideaki Nakamura , Masao Gotoh , Isao Karube
发明人： Hideaki Nakamura , Masao Gotoh , Isao Karube
IPC分类号： A61B5/1468 , G01N27/26 , G01N33/49
CPC分类号： A61B5/157 , A61B5/0002 , A61B5/14532 , A61B5/1486 , A61B5/14865 , A61B5/150022 , A61B5/150099 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B5/15194 , G01N27/3272
摘要： There is provided a biosensor (which is integrated with a needle) with a high precision where an assembling is easy and reproducibility of the prepared biosensor (integrated with a needle) is good.There is provided with a biosensor comprising: two sheets of electrically insulating substrates connected by a connecting part, and an electrode and a spacer formed on one of or both of the two sheets of electrically insulating substrates, wherein the two sheets of the electrically insulating substrates are folded along the connecting part, and the electrode and the spacer are positioned between the electrically insulating substrates. In this biosensor (integrated with a needle), a biosensor (integrated with a needle) is able to be easily prepared by folding two sheets of electrically insulating substrates which are connected by a connecting part and, therefore, it achieves excellent effects that the product is able to be easily manufactured without such a troublesome step where each biosensor material is correctly layered and that the biosensor (integrated with a needle) manufactured as such has a good reproducibility and a high precision.
摘要翻译：提供了具有高精度的生物传感器（其与针一体化），其中组装容易且制备的生物传感器（与针一体化）的再现性良好。设置有生物传感器，其包括：通过连接部连接的两片电绝缘基板，以及形成在两片电绝缘基板之一或两者上的电极和间隔件，其中两片电绝缘基板沿着连接部分折叠，并且电极和间隔件位于电绝缘基板之间。在该生物传感器（与针集成）中，通过折叠通过连接部连接的两片电绝缘基板，能够容易地制造生物传感器（与针一体化），因此实现了良好的效果，能够容易地制造没有这样的麻烦的步骤，其中每个生物传感器材料被正确分层，并且制造的生物传感器（与针一体化）具有良好的再现性和高精度。

20. 发明授权

US08012430B2 Methods for producing microchannel chips, microchannel chips, methods for separating biomolecules using the microchannel chips, and electrophoretic apparatus having the microchannel chips 失效
标题翻译：用于生产微通道芯片的方法，微通道芯片，使用微通道芯片分离生物分子的方法，以及具有微通道芯片的电泳装置
公开(公告)号：US08012430B2
公开(公告)日：2011-09-06
申请号：US10591335
申请日：2005-03-03
申请人： Kenji Yokoyama , Satoshi Koide , Koji Sakairi , Kazuyoshi Yano , Isao Karube
发明人： Kenji Yokoyama , Satoshi Koide , Koji Sakairi , Kazuyoshi Yano , Isao Karube
IPC分类号： B01L3/00 , G01N27/453
CPC分类号： B32B27/08 , B01D67/0006 , B01D67/0062 , B01D2323/40 , B01J2219/00783 , B01J2219/00804 , B01J2219/00837 , B01J2219/00853 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2400/0421 , B29C65/02 , B29C66/53461 , B29C66/71 , B29L2031/756 , B32B3/26 , B32B2255/26 , B82Y30/00 , G01N21/05 , G01N27/44791 , G01N2021/0346 , B29K2023/06 , B29K2023/12 , B29K2025/06 , B29K2033/08 , B29K2033/12 , B29K2067/003 , B29K2069/00
摘要： The methods for producing microchannel chips of the present invention comprise the steps of shielding substrate surfaces on which groove-like channels have been formed, using a mask that exposes the channels, and then forming polymer membranes on the exposed surfaces of the substrates; and the step of laminating cover materials onto the side of the substrate surfaces on which the channels have been formed.
摘要翻译：用于制造本发明的微通道芯片的方法包括使用暴露通道的掩模，然后在基板的暴露表面上形成聚合物膜来屏蔽已经形成沟槽状沟道的基板表面的步骤。以及将覆盖材料层压到其上形成有通道的基板表面的侧面上的步骤。

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