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1. 发明申请

US20100004559A1 BIOSENSOR CARTRIDGE, METHOD OF USING BIOSENSOR CARTRIDGE, BIOSENSOR DEVICE, AND NEEDLE INTEGRAL SENSOR 审中-公开
标题翻译： BIOSENSOR CARTRIDGE，使用BIOSENSOR CARTRIDGE的方法，生物传感器设备和针式集成传感器
公开(公告)号：US20100004559A1
公开(公告)日：2010-01-07
申请号：US12519916
申请日：2007-12-17
申请人： Tsuyoshi Fujimura , Hideaki Nakamura , Masao Gotoh , Isao Karube , Tomoko Ishikawa , Takahiko Kitamura , Shingo Kaimori , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
发明人： Tsuyoshi Fujimura , Hideaki Nakamura , Masao Gotoh , Isao Karube , Tomoko Ishikawa , Takahiko Kitamura , Shingo Kaimori , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
IPC分类号： A61B5/151
CPC分类号： A61B5/1519 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150549 , A61B5/150618 , A61B5/150717 , A61B5/15113 , A61B5/15117
摘要： A biosensor cartridge capable of making the collected amount of a sample required for measurement into a small quantity to reduce a user's burden, and easily collecting and measuring a sample of a puncture hole without requiring the operation of bringing a sample collection opening close to the puncture hole is provided. When one end portion of biosensor chip is pushed against subject, elastic body is compressed, and puncturing tool can protrude and perform puncturing. Additionally, if a pushing force is weakened, puncturing tool is extracted from subject by the restoring force of elastic body, and blood (sample) flows out of the puncture hole. In this case, since the puncture hole, and sample collection opening provided at biosensor chip are contained in enclosed half-open space formed by elastic body, even a small amount of blood (sample) can also be easily collected. Additionally, elastic body is formed with a groove which forms a ventilation passage, so that enclosed half-open space can be opened to the atmosphere.
摘要翻译：一种生物传感器盒，其能够将少量测量所需的样本的收集量减少到用户的负担，并且容易地收集和测量穿孔的样本，而不需要使样本收集开口靠近穿刺的操作提供孔。当生物传感器芯片的一个端部被压住物体时，弹性体被压缩，并且穿刺工具可以伸出并进行穿刺。此外，如果推力减弱，则通过弹性体的恢复力从被检体取出穿刺工具，血液（样品）从穿刺孔流出。在这种情况下，由于设置在生物传感器芯片上的穿刺孔和样本收集开口包含在由弹性体形成的封闭半开放空间中，所以即使少量的血液（样品）也可以容易地收集。此外，弹性体形成有形成通风通道的槽，使得封闭的半开放空间可以打开到大气。

2. 发明申请

US20090299225A1 BIOSENSOR CHIP 审中-公开
标题翻译：生物传感器芯片
公开(公告)号：US20090299225A1
公开(公告)日：2009-12-03
申请号：US12297387
申请日：2007-04-17
申请人： Takahiko Kitamura , Shingo Kaimori , Akira Harada , Toshifumi Hosoya , Tsuyoshi Fujimura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
发明人： Takahiko Kitamura , Shingo Kaimori , Akira Harada , Toshifumi Hosoya , Tsuyoshi Fujimura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
IPC分类号： A61B5/151
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150229 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150511 , A61B5/150549 , A61B5/150717 , A61B5/15186
摘要： There is provided a biosensor chip where the collecting amount necessary for the measurement is made small whereby burden of a user is reduced and, at the same time, a sample at a puncture opening is able to be easily collected and measured without an operation of making the sample collection opening nearer the puncture opening. When an end of a main body chip is pushed onto a test body, an elastic body installed at an end of the main body chip is compressed and a device for puncture is produced whereby the test body is able to be punctured. When the pushing force is made weak, the device for puncture is pulled out from the test body due to resilience of the elastic body and a sample is flown out from the puncture opening. At that time, since the puncture opening and the sample collection opening installed in the main body chip are enclosed in a tightly-closed space formed by the elastic body, even small amount of the sample is able to be easily collected by the sample collection opening without conducting the positioning of the sample collection opening.
摘要翻译：提供了一种生物传感器芯片，其中使得测量所需的收集量变小，从而减少了使用者的负担，并且同时，能够容易地收集和测量穿刺开口处的样本而不进行操作样品收集开口更靠近穿刺孔。当主体芯片的一端被推到测试体上时，安装在主体芯片的端部的弹性体被压缩，并且产生用于穿刺的装置，由此能够刺破测试体。当推力变弱时，由于弹性体的弹性，用于穿刺的装置从测试体被拉出，并且样品从穿刺孔流出。此时，由于安装在主体芯片上的穿刺开口和样本收集开口被包围在由弹性体形成的紧密封闭的空间中，所以即使少量的样本能够容易地被样本收集开口收集而不进行样品收集开口的定位。

3. 发明申请

US20090093695A1 BIOSENSOR 审中-公开
标题翻译：生物传感器
公开(公告)号：US20090093695A1
公开(公告)日：2009-04-09
申请号：US11993911
申请日：2006-06-27
申请人： Hideaki Nakamura , Masao Gotoh , Isao Karube
发明人： Hideaki Nakamura , Masao Gotoh , Isao Karube
IPC分类号： A61B5/1468 , G01N27/26 , G01N33/49
CPC分类号： A61B5/157 , A61B5/0002 , A61B5/14532 , A61B5/1486 , A61B5/14865 , A61B5/150022 , A61B5/150099 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B5/15194 , G01N27/3272
摘要： There is provided a biosensor (which is integrated with a needle) with a high precision where an assembling is easy and reproducibility of the prepared biosensor (integrated with a needle) is good.There is provided with a biosensor comprising: two sheets of electrically insulating substrates connected by a connecting part, and an electrode and a spacer formed on one of or both of the two sheets of electrically insulating substrates, wherein the two sheets of the electrically insulating substrates are folded along the connecting part, and the electrode and the spacer are positioned between the electrically insulating substrates. In this biosensor (integrated with a needle), a biosensor (integrated with a needle) is able to be easily prepared by folding two sheets of electrically insulating substrates which are connected by a connecting part and, therefore, it achieves excellent effects that the product is able to be easily manufactured without such a troublesome step where each biosensor material is correctly layered and that the biosensor (integrated with a needle) manufactured as such has a good reproducibility and a high precision.
摘要翻译：提供了具有高精度的生物传感器（其与针一体化），其中组装容易且制备的生物传感器（与针一体化）的再现性良好。设置有生物传感器，其包括：通过连接部连接的两片电绝缘基板，以及形成在两片电绝缘基板之一或两者上的电极和间隔件，其中两片电绝缘基板沿着连接部分折叠，并且电极和间隔件位于电绝缘基板之间。在该生物传感器（与针集成）中，通过折叠通过连接部连接的两片电绝缘基板，能够容易地制造生物传感器（与针一体化），因此实现了良好的效果，能够容易地制造没有这样的麻烦的步骤，其中每个生物传感器材料被正确分层，并且制造的生物传感器（与针一体化）具有良好的再现性和高精度。

4. 发明申请

US20080129280A1 Coupled Member Made of a Plurality of Sensor Chips and Manufacturing Method Thereof 审中-公开
标题翻译：传感器芯片制造的耦合构件及其制造方法
公开(公告)号：US20080129280A1
公开(公告)日：2008-06-05
申请号：US11795902
申请日：2006-01-23
申请人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Hideaki Nakamura , Masao Gotoh , Fumiyo Kurusu , Tomoko Ishikawa , Isao Karube
发明人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Hideaki Nakamura , Masao Gotoh , Fumiyo Kurusu , Tomoko Ishikawa , Isao Karube
IPC分类号： G01N27/327
CPC分类号： B82Y5/00 , G01N33/4875 , Y10T29/49002
摘要： A coupled member made of a plurality of sensor chips is featured by that adjacent sensor chips are coupled to each other under cuttable condition; the respective sensor chips can be cut and piece-separated from the coupled member in a higher efficiency; and even after the sensor chips are piece-separated, these sensor chips can be readily and quickly stored in containers thereof; and furthermore, the sensor chips can be easily checked and failure chips can be readily removed. More specifically, a method for manufacturing a coupled member made of the plurality of sensor chips is provided in which such sensor chips are coupled to each other under cuttable conditions, while each of these sensor chips includes: a base plate; a cover layer; a hollow reaction portion provided between the base plate and the cover layer; a sensing member provided in the hollow reaction portion; an output terminal for outputting a signal sensed by the sensing member to the outside; and a sample introducing port for introducing a sample to the hollow reaction portion.
摘要翻译：由多个传感器芯片制成的耦合构件的特征在于相邻的传感器芯片在可切割的状态下彼此耦合; 相应的传感器芯片可以以更高的效率从耦合部件切割和分离; 并且即使在传感器芯片被分离之后，这些传感器芯片也可以容易且快速地存储在容器中; 此外，可以容易地检测传感器芯片，并且可以容易地去除故障芯片。更具体地说，提供了一种用于制造由多个传感器芯片制成的耦合构件的方法，其中这些传感器芯片在可切割的条件下彼此耦合，而这些传感器芯片中的每一个包括：基板; 覆盖层; 设置在所述基板和所述覆盖层之间的中空反应部; 设置在所述中空反应部中的检测部件; 输出端子，用于将由感测构件感测的信号输出到外部; 以及用于将样品引入中空反应部的样品引入口。

5. 外观设计

USD548347S1 Device for measuring constituents in the blood 有权
标题翻译：用于测量血液中成分的装置
公开(公告)号：USD548347S1
公开(公告)日：2007-08-07
申请号：US29253418
申请日：2006-02-07
申请人： Moriyasu Ichino , Toshifumi Hosoya , Kazuhiro Kuwa , Nobuyuki Matsumura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
设计人： Moriyasu Ichino , Toshifumi Hosoya , Kazuhiro Kuwa , Nobuyuki Matsumura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa

6. 发明申请

US20090123335A1 Sensor Chip and Sensor System 审中-公开
标题翻译：传感器芯片和传感器系统
公开(公告)号：US20090123335A1
公开(公告)日：2009-05-14
申请号：US11885945
申请日：2006-10-25
申请人： Hideaki Nakamura , Masao Gotoh , Tomoko Ishikawa , Isao Karube , Toshifumi Hosoya , Shingo Kaimori , Moriyasu Ichino
发明人： Hideaki Nakamura , Masao Gotoh , Tomoko Ishikawa , Isao Karube , Toshifumi Hosoya , Shingo Kaimori , Moriyasu Ichino
IPC分类号： G01N31/22
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438
摘要： It is intended to provide a sensor chip that enables detection of a deterioration state of a reagent applied on a reaction portion when measuring a concentration of a measurement object substance and a sensor system that enables a correct measurement by using the sensor chip for detecting the reagent deterioration state. A sensor chip including two substrates opposed to each other, a spacer layer sandwiched between the substrates, a multiple reaction portions provided in the spacer layer, and detection electrode units disposed on surfaces of the substrates facing to the spacer layer and exposed to the reaction portions, wherein an identical reagent A is applied on two or more of the reaction portions, and another reagent B that reacts with the reagent A is applied on at least one of the two reaction portions and a sensor system including the sensor chip and a measurement unit for comparing current values from the two or more reaction portions on which the identical reagent A is applied.
摘要翻译：本发明旨在提供一种传感器芯片，其能够检测在测量对象物质的浓度的反应部分上施加的试剂的劣化状态，以及能够通过使用用于检测试剂的传感器芯片进行正确测量的传感器系统劣化状态。一种传感器芯片，包括彼此相对的两个基板，夹在基板之间的间隔层，设置在间隔层中的多个反作用部分和设置在面向间隔层的基板的表面上并暴露于反应部分的检测电极单元其中相同的试剂A施加在两个或更多个反应部分上，另一个与试剂A反应的试剂B施加在两个反应部分中的至少一个上，以及包括传感器芯片和测量单元的传感器系统用于比较来自施加相同试剂A的两个或更多个反应部分的电流值。

7. 发明申请

US20090050986A1 Method for Fabricating Sensor Chip, and Sensor Chip 审中-公开
标题翻译：制造传感器芯片和传感器芯片的方法
公开(公告)号：US20090050986A1
公开(公告)日：2009-02-26
申请号：US11795903
申请日：2006-01-23
申请人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Hideaki Nakamura , Masao Gotoh , Fumiyo Kurusu , Tomoko Ishikawa , Isao Karube
发明人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Hideaki Nakamura , Masao Gotoh , Fumiyo Kurusu , Tomoko Ishikawa , Isao Karube
IPC分类号： H01L29/00 , H01L21/50
CPC分类号： B01J19/0046 , B01J2219/00518 , B01J2219/00527 , B01J2219/00533 , B01J2219/00621 , B01J2219/00657 , B01J2219/0072 , B01J2219/00725
摘要： A method for fabricating a sensor chip having a substrate, a cover layer, a spacer layer interposed between the substrate and the cover layer, and a hollow reaction section provided in the spacer layer, the method comprising the steps of: affixing two or more adhesive or bonding tapes onto a sheet where a plurality of substrates are to be formed or onto a plurality of substrates, to thus form a spacer layer; and forming a hollow reaction section from one or a plurality of gaps between the tapes, whereby volumetric variations or positional displacements of the hollow reaction section can be reduced. A sensor chip which can be fabricated by this method.
摘要翻译：一种用于制造具有衬底，覆盖层，插入在衬底和覆盖层之间的间隔层的传感器芯片的方法和设置在间隔层中的中空反应部分，该方法包括以下步骤：将两个或更多个粘合剂或将带粘合到要形成多个基底的片上或多个基底上，从而形成间隔层; 并且从带之间的一个或多个间隙形成中空反应部分，从而可以减小中空反应部分的体积变化或位置位移。可通过该方法制造的传感器芯片。

8. 发明申请

US20080194988A1 Biosensor Unified With Needle 审中-公开
标题翻译：生物传感器统一用针
公开(公告)号：US20080194988A1
公开(公告)日：2008-08-14
申请号：US11885352
申请日：2006-03-01
申请人： Hideaki Nakamura , Masao Gotoh , Isao Karube
发明人： Hideaki Nakamura , Masao Gotoh , Isao Karube
IPC分类号： A61B5/157 , G01N33/483
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/14865 , A61B5/150022 , A61B5/150099 , A61B5/150175 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150717 , A61B5/150748 , A61B5/15113 , A61B5/1519 , A61B5/15194
摘要： There is provided a biosensor unified with a needle in which, since its constitution is simple, its assembling is easy in spite of having strength, collecting of body fluid sample can be conducted surely without waste, a puncturing needle is not polluted by a reagent layer, carrying is easy due to its simple package and hygiene can be maintained even after use. There is also provided a biosensor unified with a needle in which an assembling is easy without deteriorating its strength and collecting a body fluid sample can be surely conducted without waste where a puncturing needle is not polluted with a reagent layer.A biosensor unified with a needle where a puncturing needle for collecting a body fluid by puncturing the skin of a person to be tested and a main body of a biosensor for conducting the analysis of the body fluid are constituted in a unified manner and the puncturing needle is constituted in such a manner that it penetrates by driving the main body of the biosensor in a vertical direction by an external driving means and punctures the skin. In a biosensor unified with a needle which is constituted in such a manner that a biosensor comprising electrically insulating substrate and cover, a spacer installed in a space sandwiched between them, an electrode and a reagent layer and a puncturing needle for penetrating the skin of a person to be tested and collecting the body fluid are unified, a biosensor unified with a needle which is characterized in that a cover part forming an opening for collecting the blood installed at the end of the longitudinal direction of a biosensor has one penetrating hole for a puncturing needle.
摘要翻译：提供了一种与针一体化的生物传感器，其结构简单，即使具有强度，组装也容易，可以可靠地进行收集体液样品而不浪费，刺针不被试剂层污染携带方便，即使使用后也能保持简单的包装和卫生。还提供了一种用针组装的生物传感器，其中容易组装而不会降低其强度，并且可以可靠地进行收集体液样品，而不会在没有用试剂层污染穿刺针的情况下进行收集。一种统一的生物传感器，其中通过刺穿待测试人的皮肤收集体液的穿刺针和用于进行体液分析的生物传感器的主体一体地构成，并且穿刺针以通过外部驱动装置在垂直方向上驱动生物传感器主体而穿透皮肤的方式构成。在与针状物一体化的生物传感器中，其构成为包括电绝缘基板和盖的生物传感器，安装在夹在它们之间的空间中的间隔件，电极和试剂层以及用于穿透皮肤的穿刺针被检测体和收集体液的人是统一的，与针统一的生物传感器，其特征在于，形成用于收集安装在生物传感器的纵向方向末端的血液的开口的盖部分具有一个用于穿刺针。

9. 发明申请

US20050247573A1 Biosensors 审中-公开
公开(公告)号：US20050247573A1
公开(公告)日：2005-11-10
申请号：US11087015
申请日：2005-03-22
申请人： Hideaki Nakamura , Shouji Shinohara , Masao Gotoh , Isao Karube
发明人： Hideaki Nakamura , Shouji Shinohara , Masao Gotoh , Isao Karube
IPC分类号： G01N27/26 , G01N33/487
CPC分类号： G01N27/3272
摘要： The biosensors of the present invention comprise an electrically insulating substrate, an electrically insulating cover connected to the substrate via a spacer layer, a reaction-detecting section formed on the substrate at a region sandwiched between the substrate and cover, and comprising at least one set of electrodes, and an external terminal to be connected to the reaction-detecting section, and a sealed sample-feeding path defined between the substrate and cover by the spacer layer, where the sample-feeding path has a portion intersecting the electrodes, as well as a cutting plane line provided at an outermost surface of the substrate or cover, which is a boundary between a sensor portion comprising electrodes and a sealed cap portion which does not comprise electrodes, and the cutting plane line is present at a position where, when the sealed cap portion is cut along the cutting plane line, the cut surface does not cross the electrodes and does cross the sample-feeding path, so that a sample-inlet port and an air-discharge port leading from the sample-feeding path are exposed through the cut surface. In addition, the biosensors for simultaneously measuring multiple items of the present invention comprise: a substrate; a cover connected to the substrate via a spacer layer; and a number of biosensor units comprising substrates each containing at least one biosensor unit which comprises a reaction-detecting section including one electrode system and one reagent layer on the substrate, and a sample-feeding path including the reagent layer, wherein each of the biosensor units comprise one reagent layer on one sample-feeding path, a cutting plane line for dividing each of the biosensor unit-comprising substrates is provided at a top surface of the substrate or cover, the cutting plane line and sample-feeding path are placed such that, when the substrate or cover is cut along the cutting plane line, a sample-inlet port for supplying a sample solution is open to a cut surface of each biosensor unit-comprising substrate as a cut port of the sample-feeding path.

10. 发明申请

US20100228149A1 SENSOR DEVICE 审中-公开
标题翻译：传感器设备
公开(公告)号：US20100228149A1
公开(公告)日：2010-09-09
申请号：US12528660
申请日：2008-02-25
申请人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Shingo Kaimori , Takahiko Kitamura , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
发明人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Shingo Kaimori , Takahiko Kitamura , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
IPC分类号： A61B5/151
CPC分类号： A61B5/15194 , A61B5/14532 , A61B5/1468 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150519 , A61B5/150633 , A61B5/150702 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/1519 , A61B5/157 , A61B2562/0295
摘要： A sensor device has a needle-integrated type sensor element which is detachably mounted therein and which has a sensor chip, a lancet needle fixed to an end portion of the sensor chip, and a flow path forming element provided compressibly and restorably at the end portion of the sensor chip, to which the lancet needle is fixed. The sensor device includes a puncture mechanism (a drive spring) configured to cause the sensor element to puncture a target, and a pressing mechanism (a pressure spring) configured to urge the sensor element to the extent that the sensor element is prevented from being detached from the target by a restoring force of the flow path forming element after the target is punctured.
摘要翻译：传感器装置具有可拆卸地安装在其中的针式集成型传感器元件，其具有传感器芯片，固定到传感器芯片的端部的刺血针，以及可流动地且可修复地设置在端部处的流路形成元件传感器芯片，刺针针固定到该传感器芯片上。传感器装置包括构造成使传感器元件刺穿目标的穿刺机构（驱动弹簧）以及构造成将传感器元件推压到防止传感器元件脱离的程度的按压机构（压力弹簧）在目标被刺破之后，通过流路形成元件的恢复力从目标射出。

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