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11. 发明授权

US06495736B1 Compositions and methods for increasing bone mineralization 有权
标题翻译：增加骨矿化的组合物和方法
公开(公告)号：US06495736B1
公开(公告)日：2002-12-17
申请号：US09668037
申请日：2000-09-21
申请人： Mary E. Brunkow , David J. Galas , Brian Kovacevich , John T. Mulligan , Bryan W. Paeper , Jeffrey Van Ness , David G. Winkler
发明人： Mary E. Brunkow , David J. Galas , Brian Kovacevich , John T. Mulligan , Bryan W. Paeper , Jeffrey Van Ness , David G. Winkler
IPC分类号： A01K67027
CPC分类号： G01N33/74 , A01K2217/05 , A01K2217/075 , A61K38/18 , A61K39/3955 , A61K45/06 , A61K48/00 , C07K14/475 , C07K14/51 , C07K16/18 , C07K16/22 , C07K2317/11 , C07K2317/23 , C07K2319/00 , C12N2799/021 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6872 , G01N33/84 , G01N2333/47 , G01N2333/495 , G01N2333/51 , G01N2500/02 , G01N2500/20
摘要： A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
摘要翻译：公开了一种新型的TGF-β结合蛋白类或家族。还公开了用于选择用于增加骨矿化的分子的测定法和利用这种分子的方法。

12. 发明授权

US06489445B1 Polypeptides associated with alterations in bone density 有权
标题翻译：与骨密度变化相关的多肽
公开(公告)号：US06489445B1
公开(公告)日：2002-12-03
申请号：US09668529
申请日：2000-09-21
申请人： Mary E. Brunkow , David J. Galas , Brian Kovacevich , John T. Mulligan , Bryan W. Paeper , Jeffrey Van Ness , David G. Winkler
发明人： Mary E. Brunkow , David J. Galas , Brian Kovacevich , John T. Mulligan , Bryan W. Paeper , Jeffrey Van Ness , David G. Winkler
IPC分类号： C07K100
CPC分类号： G01N33/74 , A01K2217/05 , A01K2217/075 , A61K38/18 , A61K39/3955 , A61K45/06 , A61K48/00 , C07K14/475 , C07K14/51 , C07K16/18 , C07K16/22 , C07K2317/11 , C07K2317/23 , C07K2319/00 , C12N2799/021 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6872 , G01N33/84 , G01N2333/47 , G01N2333/495 , G01N2333/51 , G01N2500/02 , G01N2500/20
摘要： Compositions and methods for increasing bone density using antibodies directed to a novel class or family human of TGF-&bgr; binding proteins are disclosed. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis. The disclosed compositions include polypeptides, and their encoding polynucleotides, which specifically bind to at least one human bone morphogenic protein (BMP) selected from BMP-5 and BMP-6.
摘要翻译：公开了使用针对TGF-β结合蛋白的新型类或家族人的抗体增加骨密度的组合物和方法。所公开的组合物可用于例如诊断，预防和/或治疗与骨密度丧失相关的疾病，例如骨质疏松症。所公开的组合物包括与至少一种选自BMP-5和BMP-6的人骨形态发生蛋白（BMP）特异性结合的多肽及其编码多核苷酸。

13. 发明授权

US06312893B1 Methods and compositions for determining the sequence of nucleic acid molecules 失效
标题翻译：用于确定核酸分子序列的方法和组合物
公开(公告)号：US06312893B1
公开(公告)日：2001-11-06
申请号：US08898180
申请日：1997-07-22
申请人： Jeffrey Van Ness , John C. Tabone , J. Jeffry Howbert , John T. Mulligan
发明人： Jeffrey Van Ness , John C. Tabone , J. Jeffry Howbert , John T. Mulligan
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07B2200/11 , C07D211/78 , C07H21/04 , C12Q1/6872 , C12Q1/6874 , C40B40/00 , Y10T436/24 , C12Q2565/629 , C12Q2563/167
摘要： Methods and compounds, including compositions therefrom, are provided for determining the sequence of nucleic acid molecules. The methods permit the determination of multiple nucleic acid sequences simultaneously. The compounds are used as tags to generate tagged nucleic acid fragments which are complementary to a selected target nucleic acid molecule. Each tag is correlative with a particular nucleotide and, in a preferred embodiment, is detectable by mass spectrometry. Following separation of the tagged fragments by sequential length, the tags are cleaved from the tagged fragments. In a preferred embodiment, the tags are detected by mass spectrometry and the sequence of the nucleic acid molecule is determined therefrom. The individual steps of the methods can be used in automated format, e.g., by the incorporation into systems.
摘要翻译：提供方法和化合物，包括其组合物，用于确定核酸分子的序列。该方法允许同时测定多个核酸序列。该化合物用作标签以产生与选定的靶核酸分子互补的标记的核酸片段。每个标签与特定核苷酸相关，并且在优选实施方案中可通过质谱法检测。在通过连续长度分离标记的片段之后，从标记的片段切割标签。在优选的实施方案中，通过质谱检测标签，并由此确定核酸分子的序列。方法的各个步骤可以以自动格式使用，例如通过并入系统。

14. 发明授权

US07977312B2 Compositions and methods for increasing bone mineralization 有权
标题翻译：增加骨矿化的组合物和方法
公开(公告)号：US07977312B2
公开(公告)日：2011-07-12
申请号：US11931812
申请日：2007-10-31
申请人： Mary E. Brunkow , David J. Galas , Brian Kovacevich , John T. Mulligan , Bryan W. Paeper , Jeffrey Van Ness , David J. Winkler
发明人： Mary E. Brunkow , David J. Galas , Brian Kovacevich , John T. Mulligan , Bryan W. Paeper , Jeffrey Van Ness , David J. Winkler
IPC分类号： A61K38/00 , C07K14/00 , C07K7/00
CPC分类号： G01N33/74 , A01K2217/05 , A01K2217/075 , A61K38/18 , A61K39/3955 , A61K45/06 , A61K48/00 , C07K14/475 , C07K14/51 , C07K16/18 , C07K16/22 , C07K2317/11 , C07K2317/23 , C07K2319/00 , C12N2799/021 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6872 , G01N33/84 , G01N2333/47 , G01N2333/495 , G01N2333/51 , G01N2500/02 , G01N2500/20
摘要： A novel class or family of TGF-β binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
摘要翻译：一种新型的TGF- 公开了结合蛋白。还公开了用于选择用于增加骨矿化的分子的测定法和利用这种分子的方法。

15. 发明申请

US20080182788A1 Compositions and Methods for Increasing Bone Mineralization 有权
标题翻译：增加骨矿化的组成和方法
公开(公告)号：US20080182788A1
公开(公告)日：2008-07-31
申请号：US11931812
申请日：2007-10-31
申请人： Mary E. Brunkow , David J. Galas , Brian Kovacevich , John T. Mulligan , Bryan W. Paeper , Jeffrey Van Ness , David G. Winkler
发明人： Mary E. Brunkow , David J. Galas , Brian Kovacevich , John T. Mulligan , Bryan W. Paeper , Jeffrey Van Ness , David G. Winkler
IPC分类号： A61K38/00 , C07K14/00 , C07K7/00 , A61P19/00 , G01N33/566
CPC分类号： G01N33/74 , A01K2217/05 , A01K2217/075 , A61K38/18 , A61K39/3955 , A61K45/06 , A61K48/00 , C07K14/475 , C07K14/51 , C07K16/18 , C07K16/22 , C07K2317/11 , C07K2317/23 , C07K2319/00 , C12N2799/021 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6872 , G01N33/84 , G01N2333/47 , G01N2333/495 , G01N2333/51 , G01N2500/02 , G01N2500/20
摘要： A novel class or family of TGF-β binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
摘要翻译：公开了一种新型的TGF-β结合蛋白类或家族。还公开了用于选择用于增加骨矿化的分子的测定法和利用这种分子的方法。

16. 发明授权

US07164992B1 Method and system for polynucleotide synthesis 有权
标题翻译：多核苷酸合成方法和系统
公开(公告)号：US07164992B1
公开(公告)日：2007-01-16
申请号：US10104986
申请日：2002-03-22
申请人： John T. Mulligan , John C. Tabone , R. Gregg Brickner
发明人： John T. Mulligan , John C. Tabone , R. Gregg Brickner
IPC分类号： G06F19/00 , G11C17/00 , G05B15/00
CPC分类号： G06F19/702 , G06F19/10
摘要： Methods and systems for automated polynucleotide synthesis design are provided. Example embodiments provide an Automated Polynucleotide Synthesis Design System (“APSDS”), which automatically generates a synthesis design for a designated target sequence specification. In one embodiment, the APSDS comprises a synthesis design engine, user interface support, a synthesis rules data repository, and a synthesis data repository. The APSDS automatically generates a synthesis design by receiving a target sequence(s) specification, generating a potential synthesis design, evaluating the potential design against synthesis rules, and when the evaluation indicates that the potential design is not successful according to the synthesis rules, adjusting the design to generate a new potential synthesis design and repeating the process of evaluating and adjusting until a potential synthesis design is found that satisfies the synthesis rules or until no solution is found.
摘要翻译：提供了自动多核苷酸合成设计的方法和系统。实施例提供自动多核苷酸合成设计系统（“APSDS”），其自动产生用于指定的靶序列规范的合成设计。在一个实施例中，APSDS包括合成设计引擎，用户界面支持，综合规则数据存储库和综合数据存储库。 APSDS通过接收目标序列规范自动生成合成设计，产生潜在的合成设计，根据综合规则评估潜在设计，以及当评估根据合成规则表明潜在设计不成功时，调整设计产生新的潜在合成设计，并重复评估和调整的过程，直到找到满足合成规则或直到找不到解决方案的潜在合成设计为止。

17. 发明授权

US06815212B2 Methods and compositions for enhancing sensitivity in the analysis of biological-based assays 有权
标题翻译：用于增强基于生物学测定分析的灵敏度的方法和组合物
公开(公告)号：US06815212B2
公开(公告)日：2004-11-09
申请号：US10000467
申请日：2001-10-24
申请人： Jeffrey Van Ness , John C. Tabone , J. Jeffry Howbert , John T. Mulligan
发明人： Jeffrey Van Ness , John C. Tabone , J. Jeffry Howbert , John T. Mulligan
IPC分类号： G01N2400
CPC分类号： C12Q1/6872 , Y10T436/24 , C12Q2563/167
摘要： Methods are provided for detecting the binding of a first member to a second member of a ligand pair, comprising the steps of (a) combining a set of first tagged members with a biological sample which may contain one or more second members, under conditions, and for a time sufficient to permit binding of a first member to a second member, wherein said tag is correlative with a particular first member and detectable by non-fluorescent spectrometry, or potentiometry, (b) separating bound first and second members from unbound members, (c) cleaving the tag from the tagged first member, and (d) detecting the tag by non-fluorescent spectrometry, or potentiometry, and therefrom detecting the binding of the first member to the second member.

18. 发明授权

US06583112B1 Gene products related to werner's syndrome 失效
标题翻译：与维纳综合征相关的基因产物
公开(公告)号：US06583112B1
公开(公告)日：2003-06-24
申请号：US09618166
申请日：2000-07-17
申请人： Ying-Hui Fu , Chang-En Yu , Junko Oshima , John T. Mulligan , Gerard D. Schellenberg
发明人： Ying-Hui Fu , Chang-En Yu , Junko Oshima , John T. Mulligan , Gerard D. Schellenberg
IPC分类号： C07K1400
CPC分类号： C07K14/47 , A01K2217/05 , C12N9/90 , C12N2799/021
摘要： The present invention discloses nucleic acid molecules encoding WRN gene products, expression vectors and host cells suitable for expressing such products.
摘要翻译：本发明公开了编码WRN基因产物，表达载体和适于表达这些产物的宿主细胞的核酸分子。

19. 发明授权

US6027890A Methods and compositions for enhancing sensitivity in the analysis of biological-based assays 失效
标题翻译：用于增强基于生物学测定分析的灵敏度的方法和组合物
公开(公告)号：US6027890A
公开(公告)日：2000-02-22
申请号：US898501
申请日：1997-07-22
申请人： Jeffrey Van Ness , John C. Tabone , J. Jeffry Howbert , John T. Mulligan
发明人： Jeffrey Van Ness , John C. Tabone , J. Jeffry Howbert , John T. Mulligan
IPC分类号： A01N43/04 , A61K38/00 , C07C69/74 , C12Q1/68 , G01N24/00 , G01N33/53 , G01N33/542
CPC分类号： C12Q1/6872 , Y10T436/24
摘要： Methods are provided for detecting the binding of a first member to a second member of a ligand pair, comprising the steps of (a) combining a set of first tagged members with a biological sample which may contain one or more second members, under conditions, and for a time sufficient to permit binding of a first member to a second member, wherein said tag is correlative with a particular first member and detectable by non-fluorescent spectrometry, or potentiometry, (b) separating bound first and second members from unbound members, (c) cleaving the tag from the tagged first member, and (d) detecting the tag by non-fluorescent spectrometry, or potentiometry, and therefrom detecting the binding of the first member to the second member.
摘要翻译：提供了用于检测第一成员与配体对的第二成员的结合的方法，其包括以下步骤：（a）在一些条件下，将一组第一标记成员与可包含一个或多个第二成员的生物样品组合，并且足以允许第一构件与第二构件结合的时间，其中所述标签与特定第一构件相关并且可通过非荧光光谱法或电位法检测，（b）将结合的第一和第二构件与未结合的成员分离，（c）从标记的第一构件切割标签，以及（d）通过非荧光光谱法或电位法检测标签，从而检测第一构件与第二构件的结合。

20. 发明授权

US08705518B1 Apparatus and method for controlling services and operations in converged communications networks 有权
标题翻译：用于控制融合通信网络中的业务和操作的装置和方法
公开(公告)号：US08705518B1
公开(公告)日：2014-04-22
申请号：US10785714
申请日：2004-02-24
申请人： Siroos Afshar , Susan Roberta Bailey , Bisrat Bulcha , Marian Rogers Croak , Enrique G. Cuevas , Joubine Dustzadeh , Steve Fisher , Samuel Glazer , Burwell Goode , Barbara Joanne Kittredge , Karen McGregor-Barnes , John T. Mulligan , Magda K. Nassar , Radhika R. Roy , Larry Arnise Russell , Anand Singh
发明人： Siroos Afshar , Susan Roberta Bailey , Bisrat Bulcha , Marian Rogers Croak , Enrique G. Cuevas , Joubine Dustzadeh , Steve Fisher , Samuel Glazer , Burwell Goode , Barbara Joanne Kittredge , Karen McGregor-Barnes , John T. Mulligan , Magda K. Nassar , Radhika R. Roy , Larry Arnise Russell , Anand Singh
IPC分类号： H04L12/66
CPC分类号： H04L65/1036 , H04L65/1046 , H04L65/1069
摘要： Method and apparatus for providing integrated network and operations control for a converged communications network providing all service types on a common architecture.
摘要翻译：用于为融合通信网络提供集成网络和操作控制的方法和装置，其在公共架构上提供所有服务类型。

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