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1. 发明授权

US6090620A Genes and gene products related to Werner's syndrome 失效
标题翻译：与维纳综合征相关的基因和基因产物
公开(公告)号：US6090620A
公开(公告)日：2000-07-18
申请号：US781891
申请日：1996-12-27
申请人： Ying-Hui Fu , Chang-En Yu , Junko Oshima , John T. Mulligan , Gerard D. Schellenberg
发明人： Ying-Hui Fu , Chang-En Yu , Junko Oshima , John T. Mulligan , Gerard D. Schellenberg
IPC分类号： A01K67/027 , A01K67/00 , C07H21/04 , C07K14/00 , C07K14/47 , C07K16/18 , C12N5/10 , C12N9/64 , C12N9/90 , C12N15/09 , C12N15/861 , C12N15/867 , C12P21/08 , C12Q1/68 , C12N5/00 , C12N15/00 , C12N15/63
CPC分类号： C07K14/47 , C12N9/90 , A01K2217/05 , C12N2799/021
摘要： The present invention discloses nucleic acid molecules encoding WRN gene products, expresion vectors, viral vectors, and host cells suitable for expressing such products.
摘要翻译：本发明公开了编码WRN基因产物，表达载体，病毒载体和适于表达该产物的宿主细胞的核酸分子。

2. 发明授权

US07285641B2 Antibodies against gene products related to Werner's Syndrome 失效
标题翻译：抗Werner综合征基因产物抗体
公开(公告)号：US07285641B2
公开(公告)日：2007-10-23
申请号：US10374077
申请日：2003-02-25
申请人： Ying-Hui Fu , Chang-En Yu , Junko Oshima , John T Mulligan , Gerard D Schellenberg
发明人： Ying-Hui Fu , Chang-En Yu , Junko Oshima , John T Mulligan , Gerard D Schellenberg
IPC分类号： C07K16/00
CPC分类号： C07K14/47 , A01K2217/05 , C12N9/90 , C12N2799/021
摘要： The present invention discloses antibodies that specifically bind to a WRN gene product or a portion thereof.
摘要翻译：本发明公开了特异性结合WRN基因产物或其一部分的抗体。

3. 发明授权

US06583112B1 Gene products related to werner's syndrome 失效
标题翻译：与维纳综合征相关的基因产物
公开(公告)号：US06583112B1
公开(公告)日：2003-06-24
申请号：US09618166
申请日：2000-07-17
申请人： Ying-Hui Fu , Chang-En Yu , Junko Oshima , John T. Mulligan , Gerard D. Schellenberg
发明人： Ying-Hui Fu , Chang-En Yu , Junko Oshima , John T. Mulligan , Gerard D. Schellenberg
IPC分类号： C07K1400
CPC分类号： C07K14/47 , A01K2217/05 , C12N9/90 , C12N2799/021
摘要： The present invention discloses nucleic acid molecules encoding WRN gene products, expression vectors and host cells suitable for expressing such products.
摘要翻译：本发明公开了编码WRN基因产物，表达载体和适于表达这些产物的宿主细胞的核酸分子。

4. 发明授权

US5449604A Chromosome 14 and familial Alzheimers disease genetic markers and assays 失效
标题翻译：染色体14和家族性阿尔茨海默病遗传标记和测定
公开(公告)号：US5449604A
公开(公告)日：1995-09-12
申请号：US964151
申请日：1992-10-21
申请人： Gerard D. Schellenberg , Thomas D. Bird , Ellen M. Wijsman
发明人： Gerard D. Schellenberg , Thomas D. Bird , Ellen M. Wijsman
IPC分类号： C07K14/47 , C12Q1/68 , C12P19/34
CPC分类号： C07K14/4711 , C12Q1/6827 , C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , Y10S128/925
摘要： Method for isolating a DNA segment indicative of an Alzheimer's disease trait in a family population, wherein said family population consists essentially of a plurality of blood relatives of an individual having a chromosome 14 Alzheimer's disease trait, by: preparing a test sample of immobilized separated genomic DNA fragments from a plurality of the blood relatives, contacting each of the test samples with a test oligonucleotide under conditions permitting hybridization of complementary single stranded DNA molecules, wherein the test oligonucleotide is complementary with at least a portion of a genetic marker located between band q11.2 and band q32.1 in chromosome 14, identifying a plurality of hybridized molecules so formed as alleles of the genetic marker in the family population, identifying one of the genetic marker alleles as indicative of the Alzheimer's disease trait in the family population by either determining by pedigree analysis a segregation value for each of the genetic markers alleles and the Alzheimer's disease trait, and selecting an indicative genetic marker allele that co-segregates with the Alzheimer's disease trait in the family population, or measuring genetic linkage between each of the genetic marker alleles and the Alzheimer's disease trait, and selecting a genetic marker allele as indicative of the Alzheimer's disease trait in the family population if the selected genetic marker allele has a maximal LOD score of at least 3 at a recombination fraction of about 0.0 to about 0.1 for genetic linkage with the Alzheimer's disease trait in the family population, and isolating a chromosome 14 DNA segment containing the indicative genetic marker allele.
摘要翻译：用于分离指示家族群体中的阿尔茨海默病性状的DNA片段的方法，其中所述家族群体基本上由具有14型阿尔茨海默氏病特征的个体的多个血亲属组成，通过：制备固定化分离的基因组的测试样品来自多个血液亲属的DNA片段，在允许互补单链DNA分子杂交的条件下，使每个测试样品与测试寡核苷酸接触，其中所述测试寡核苷酸与至少部分位于条带q11之间的遗传标记物互补染色体14中的.2和带q32.1，鉴定如在家族群体中如遗传标记的等位基因形成的多个杂交分子，通过以下任一种鉴定家族群体中的一种遗传标记等位基因作为阿尔茨海默病特征的指示通过谱系分析确定每种遗传的分离值标记等位基因和阿尔茨海默氏病特征，并选择与家族群体中的阿尔茨海默病特征共分离的指示性遗传标记等位基因，或测量每个遗传标记等位基因和阿尔茨海默氏病性状之间的遗传连锁，并选择遗传如果所选择的遗传标记等位基因在与家族群体中的阿尔茨海默病性状的遗传连锁的约0.0至约0.1的重组部分具有至少3的最大LOD评分，则家族群体中的阿尔茨海默氏病性状的标记等位基因并分离含有指示性遗传标记等位基因的染色体14DNA片段。

5. 发明授权

US06468791B1 Chromosone 1 gene and gene products related to Alzheimer's Disease 失效
标题翻译： Chromosone 1基因和与阿尔茨海默病相关的基因产物
公开(公告)号：US06468791B1
公开(公告)日：2002-10-22
申请号：US09375318
申请日：1999-08-16
申请人： Rudolph E. Tanzi , Gerard D. Schellenberg , Wilma Wasco , Ephrat Levy-Lahad , Thomas D. Bird , David J. Galas
发明人： Rudolph E. Tanzi , Gerard D. Schellenberg , Wilma Wasco , Ephrat Levy-Lahad , Thomas D. Bird , David J. Galas
IPC分类号： C12N1500
CPC分类号： C07K14/4711 , A01K2217/05 , A01K2267/0312 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The present invention discloses nucleic acid molecules encoding AD4 gene products, expression vectors and host cells suitable for expressing such gene products. Also disclosed are methods for treating, preventing, and diagnosing Alzheimer's Disease.
摘要翻译：本发明公开了编码AD4基因产物，表达载体和适合表达该基因产物的宿主细胞的核酸分子。还公开了治疗，预防和诊断阿尔茨海默氏病的方法。

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