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11. 发明授权

US06199970B1 Acoustic ink jet printhead design and method of operation utilizing ink cross-flow 有权
标题翻译：声喷墨打印头的设计和操作方法利用油墨交叉流动
公开(公告)号：US06199970B1
公开(公告)日：2001-03-13
申请号：US09361035
申请日：1999-07-23
申请人： Joy Roy , Michael C. Weisberg , Jerry Elkin , Babur B. Hadimioglu
发明人： Joy Roy , Michael C. Weisberg , Jerry Elkin , Babur B. Hadimioglu
IPC分类号： B41J2135
CPC分类号： B41J2/14008 , B41J2202/08
摘要： A droplet emitter with an array of droplet emitting devices constructed such that a flowing liquid used create the droplets can flow through the droplet emitter at higher flow rates. The higher flow rates prevent excess heat absorption during the droplet emission process and allow for excess heat generated by control electronics to be transferred to the flowing liquid after droplet emission but before it leaves the droplet emitter. This prevents excess heat build-up within the droplet emitter and allows for higher more accurate droplet emission.
摘要翻译：具有液滴发射器件阵列的液滴发射器被构造成使得所使用的流动液体产生液滴可以以更高的流速流过液滴发射器。较高的流速可以防止在液滴喷射过程中过多的吸热，并且允许控制电子产生的多余的热量在液滴发射之后但在其离开液滴发射器之前转移到流动的液体。这可以防止液滴发射器内的过多的热量积聚，并允许更高精度的液滴发射。

12. 发明授权

US08318094B1 Substrate analysis systems 有权
标题翻译：基板分析系统
公开(公告)号：US08318094B1
公开(公告)日：2012-11-27
申请号：US13162433
申请日：2011-06-16
申请人： Hovig Bayandorian , Yujuan Cheng , John Dixon , Kevin Hester , Yanqiao Huang , Paul Lundquist , Joy Roy , Stephen Turner , Peiqian Zhao , Cheng Frank Zhong
发明人： Hovig Bayandorian , Yujuan Cheng , John Dixon , Kevin Hester , Yanqiao Huang , Paul Lundquist , Joy Roy , Stephen Turner , Peiqian Zhao , Cheng Frank Zhong
IPC分类号： G01N31/00
CPC分类号： G01N21/645 , G01N35/0099 , G01N2021/6417 , G01N2035/00039 , Y10T436/11
摘要： This invention provides systems for analyzing substrates. Also provided by the invention are improved optical systems for enhanced multiplex illumination, optical systems with compact multi-wavelength illumination architectures, optical systems for enhanced detection of optical signals, and optical systems for reduced autofluorescence background noise.
摘要翻译：本发明提供了用于分析衬底的系统。本发明还提供了用于增强多重照明的改进的光学系统，具有紧凑的多波长照明结构的光学系统，用于增强光信号的检测的光学系统以及用于减少自发荧光背景噪声的光学系统。

13. 发明申请

US20060132531A1 Fluidic structures 有权
公开(公告)号：US20060132531A1
公开(公告)日：2006-06-22
申请号：US11014356
申请日：2004-12-16
申请人： John Fitch , Scott Elrod , Jurgen Daniel , James Stasiak , Steven Buhler , Babur Hadimioglu , Joy Roy , Michael Weisberg , James Zesch
发明人： John Fitch , Scott Elrod , Jurgen Daniel , James Stasiak , Steven Buhler , Babur Hadimioglu , Joy Roy , Michael Weisberg , James Zesch
IPC分类号： B01L3/00
CPC分类号： B01L3/0268 , B01L2200/12 , B01L2300/0819 , B01L2400/0433 , B01L2400/0605 , B01L2400/084
摘要： Various fluidic techniques can employ ducting structures, such as microstructures, that extend between other components, such as plate-like structures. A ducting structure can, for example, include an inlet opening toward or near one plate-like structure, an outlet opening toward or near another plate-like structure, and a duct in which fluid flows after being received through the inlet opening and before being provided through the outlet opening. In some implementations, a ducting structure is photo-defined, such as by exposing a photoimageable structure and then removing either exposed or unexposed regions. In some implementations, a ducting structure is a freestanding polymer microstructure. In some implementations, ducting structures are microstructures that extend approximately the same length between first and second plate-like structures, and have a ratio of length to maximum cavity diameter of approximately two or more. A printhead implementation includes an array of such microstructures supported between drive side and drop side assemblies.

14. 发明授权

US06484975B1 Method and apparatus to achieve uniform ink temperatures in printheads 有权
标题翻译：在打印头中实现均匀油墨温度的方法和设备
公开(公告)号：US06484975B1
公开(公告)日：2002-11-26
申请号：US09428825
申请日：1999-10-28
申请人： Scott A. Elrod , Joy Roy , Richard G. Stearns , John S. Fitch
发明人： Scott A. Elrod , Joy Roy , Richard G. Stearns , John S. Fitch
IPC分类号： B41J29377
CPC分类号： B41J2/14008 , B41J2202/08
摘要： A system for improving the uniformity of ink droplets delivered from a plurality of droplet sources on a printhead is described. The system includes a cooling system that compensates for nonuniform heating effects in a printhead which results in nonuniform temperatures. The distribution of the cooling system, and the effectiveness of the cooling system is set to maintain an approximately uniform ink temperature across the printhead.
摘要翻译：描述了一种用于改善从打印头上的多个液滴源输送的墨滴的均匀性的系统。该系统包括一个冷却系统，其补偿打印头中不均匀的加热效应，这导致不均匀的温度。冷却系统的分布和冷却系统的有效性被设定为保持打印头两端的大致均匀的油墨温度。

15. 发明授权

US06428159B1 Apparatus for achieving high quality aqueous ink-jet printing on plain paper at high print speeds 有权
标题翻译：用于以高打印速度在普通纸上实现高质量水性喷墨打印的装置
公开(公告)号：US06428159B1
公开(公告)日：2002-08-06
申请号：US09357015
申请日：1999-07-19
申请人： Joy Roy , Babur Hadimioglu , Richard N. Ellson , Robert Sprague , James B. Kruger , John Lennon
发明人： Joy Roy , Babur Hadimioglu , Richard N. Ellson , Robert Sprague , James B. Kruger , John Lennon
IPC分类号： B41J201
CPC分类号： B41J11/002
摘要： An apparatus for ink-jet printing on a recording medium is provided which includes the steps of jetting aqueous ink drops on paper in the form of an image. The aqueous ink used is a slow-drying (high-surface tension) ink which does not penetrate the paper/paper fibers for a relatively long time. Prior to penetration of the paper/paper fibers, the water in the droplet is quickly evaporated from the ink while still resident on the paper surface. The evaporation process is substantially completed prior to an additional liquid ink being jetted onto the same or adjoining location of the recording medium. The evaporation is rapid enough to prevent the resident ink from substantially migrating/wicking to any adjacent location or into the recording medium. Further the drying energy is transferred to the resident ink spots from the same direction as the printheads ensuring less energy requirement.
摘要翻译：提供了一种用于在记录介质上进行喷墨打印的设备，其包括以图像形式将水性墨滴喷射在纸上的步骤。使用的水性油墨是一种慢干（高表面张力）油墨，其不会在相对长的时间内渗透纸/纸纤维。在纸/纸纤维渗透之前，液滴中的水从墨水中迅速蒸发，同时仍然驻留在纸张表面上。在附加的液体墨水喷射到记录介质的相同或相邻位置之前，蒸发过程基本上完成。蒸发速度足够快以防止驻留的墨水基本上迁移/吸附到任何相邻位置或记录介质中。此外，干燥能量从与打印头相同的方向转移到驻留的墨点，确保较少的能量需求。

16. 发明授权

US06283580B1 Method of operation of an acoustic ink jet droplet emitter utilizing high liquid flow rates 有权
标题翻译：使用高液体流速的声学喷墨液滴发射器的操作方法
公开(公告)号：US06283580B1
公开(公告)日：2001-09-04
申请号：US09359520
申请日：1999-07-23
申请人： Joy Roy , Michael C. Weisberg , Jerry Elkin , Babur B. Hadimioglu
发明人： Joy Roy , Michael C. Weisberg , Jerry Elkin , Babur B. Hadimioglu
IPC分类号： B41S2135
CPC分类号： B41J2/14008 , B41J2202/08
摘要： A method of operation of an acoustic droplet emitter with an array of droplet emitting utilizing high liquid flow rates. The higher flow rates prevent excess heat absorption during the droplet emission process and allow for excess heat generated by control electronics to be transferred to the flowing liquid after droplet emission but before it leaves the droplet emitter. This prevents excess heat build-up within the droplet emitter and allows for higher more accurate droplet emission.
摘要翻译：一种使用高液体流速的具有液滴发射阵列的声液滴发射器的操作方法。较高的流速可以防止在液滴喷射过程中过多的吸热，并且允许控制电子产生的多余的热量在液滴发射之后但在其离开液滴发射器之前转移到流动的液体。这可以防止液滴发射器内的过多的热量积聚，并允许更高精度的液滴发射。

17. 发明授权

US08597590B2 Systems and methods for multiple analyte detection 有权
标题翻译：多个分析物检测的系统和方法
公开(公告)号：US08597590B2
公开(公告)日：2013-12-03
申请号：US12789363
申请日：2010-05-27
申请人： Min Yue , David M. Liu , Joy Roy , Yuh-Min Chiang , Joon Mo Yang , Dennis Lehto , Charles S. Vann , Nigel P. Beard , Ian A. Harding , John R. Van Camp , Alexander Dromaretsky , Sergey V. Ermakov , Mark F. Oldham , Maryam Shariati , Umberto Ulmanella
发明人： Min Yue , David M. Liu , Joy Roy , Yuh-Min Chiang , Joon Mo Yang , Dennis Lehto , Charles S. Vann , Nigel P. Beard , Ian A. Harding , John R. Van Camp , Alexander Dromaretsky , Sergey V. Ermakov , Mark F. Oldham , Maryam Shariati , Umberto Ulmanella
IPC分类号： G01N21/75
CPC分类号： C12Q1/6806 , B01J2219/00317 , B01J2219/00722 , B01L3/502707 , B01L3/502723 , B01L3/50853 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/041 , B01L2300/048 , B01L2300/0636 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/087 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0694 , G01N35/028 , Y10T436/2575
摘要： Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
摘要翻译：用于多个分析物检测的系统和方法包括用于分配包括基底的生物样品的系统，其中所述基底包括多个样品室，用于每个样品室的样品引入通道和用于每个样品室的排气通道。该系统可以进一步包括包含在每个样品室中并被配置用于进入基底的生物样品的核酸分析的预加载试剂和被配置为与基底接触以密封每个样品室以便基本上防止每个样品室中包含的样品从每个样品室流出。底物可以由检测相容和测定相容的材料构成。

18. 发明申请

US20110020179A1 Systems and Methods for Multiple Analyte Detection 有权
标题翻译：多重分析物检测的系统和方法
公开(公告)号：US20110020179A1
公开(公告)日：2011-01-27
申请号：US12789363
申请日：2010-05-27
申请人： Min Yue , David M. Liu , Yuh-Min Chiang , Joon-Mo Yang , Dennis Lehto , Charles S. Vann , Nigel P. Beard , Ian A. Harding , John Van Camp , Alexander Dromaretsky , Sergey V. Ermakov , Mark F. Oldham , Joy Roy , Maryam Shariati , Umberto Ulmanella
发明人： Min Yue , David M. Liu , Yuh-Min Chiang , Joon-Mo Yang , Dennis Lehto , Charles S. Vann , Nigel P. Beard , Ian A. Harding , John Van Camp , Alexander Dromaretsky , Sergey V. Ermakov , Mark F. Oldham , Joy Roy , Maryam Shariati , Umberto Ulmanella
IPC分类号： G01N33/00
CPC分类号： C12Q1/6806 , B01J2219/00317 , B01J2219/00722 , B01L3/502707 , B01L3/502723 , B01L3/50853 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/041 , B01L2300/048 , B01L2300/0636 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/087 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0694 , G01N35/028 , Y10T436/2575
摘要： Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
摘要翻译：用于多个分析物检测的系统和方法包括用于分配包括基底的生物样品的系统，其中所述基底包括多个样品室，用于每个样品室的样品引入通道和用于每个样品室的排气通道。该系统可以进一步包括包含在每个样品室中并被配置用于进入基底的生物样品的核酸分析的预加载试剂和被配置为与基底接触以密封每个样品室以便基本上防止每个样品室中包含的样品从每个样品室流出。底物可以由检测相容和测定相容的材料构成。

19. 发明授权

US07517043B2 Fluidic structures 有权
标题翻译：流体结构
公开(公告)号：US07517043B2
公开(公告)日：2009-04-14
申请号：US11014356
申请日：2004-12-16
申请人： John S. Fitch , Scott Elrod , Jurgen Daniel , James W. Stasiak , Steven A. Buhler , Babur B. Hadimioglu , Joy Roy , Michael C. Weisberg , James C. Zesch
发明人： John S. Fitch , Scott Elrod , Jurgen Daniel , James W. Stasiak , Steven A. Buhler , Babur B. Hadimioglu , Joy Roy , Michael C. Weisberg , James C. Zesch
IPC分类号： B41J2/015
CPC分类号： B01L3/0268 , B01L2200/12 , B01L2300/0819 , B01L2400/0433 , B01L2400/0605 , B01L2400/084
摘要： Various fluidic techniques can employ ducting structures, such as microstructures, that extend between other components, such as plate-like structures. A ducting structure can, for example, include an inlet opening toward or near one plate-like structure, an outlet opening toward or near another plate-like structure, and a duct in which fluid flows after being received through the inlet opening and before being provided through the outlet opening. In some implementations, a ducting structure is photo-defined, such as by exposing a photoimageable structure and then removing either exposed or unexposed regions. In some implementations, a ducting structure is a freestanding polymer microstructure. In some implementations, ducting structures are microstructures that extend approximately the same length between first and second plate-like structures, and have a ratio of length to maximum cavity diameter of approximately two or more. A printhead implementation includes an array of such microstructures supported between drive side and drop side assemblies.
摘要翻译：各种流体技术可以采用在诸如板状结构的其他部件之间延伸的管道结构，例如微结构。管道结构可以例如包括朝向或靠近一个板状结构的入口开口，朝向或接近另一个板状结构的出口，以及在通过入口开口之后流体流动的管道通过出口开口提供。在一些实施方案中，管道结构是光限定的，例如通过曝光可光成像的结构，然后去除暴露或未曝光的区域。在一些实施方案中，管道结构是独立的聚合物微结构。在一些实施方案中，管道结构是在第一和第二板状结构之间延伸大致相同长度的微结构，并且具有大约两个或更多个长度与最大腔直径的比率。打印头实现包括支撑在驱动侧和液滴侧组件之间的这种微结构的阵列。

20. 发明授权

US06428160B2 Method for achieving high quality aqueous ink-jet printing on plain paper at high print speeds 有权
标题翻译：用于以高打印速度在普通纸上实现高质量水性喷墨打印的方法
公开(公告)号：US06428160B2
公开(公告)日：2002-08-06
申请号：US09726100
申请日：2000-11-29
申请人： Joy Roy , Babur Hadimioglu , Richard N. Ellson , Robert Sprague , James B. Kruger , John Lennon
发明人： Joy Roy , Babur Hadimioglu , Richard N. Ellson , Robert Sprague , James B. Kruger , John Lennon
IPC分类号： B41J201
CPC分类号： B41J11/002
摘要： An apparatus and method for ink-jet printing on a recording medium is provided which includes the steps of jetting aqueous ink drops on paper in the form of an image. The aqueous ink used is a slow-drying (high-surface tension) ink which does not penetrate the paper/paper fibers for a relatively long time. Prior to penetration of the paper/paper fibers, the water in the droplet is quickly evaporated from the ink while still resident on the paper surface. The evaporation process is substantially completed prior to an additional liquid ink being jetted onto the same or adjoining location of the recording medium. The evaporation is rapid enough to prevent the resident ink from substantially migrating/wicking to any adjacent location or into the recording medium. Further the drying energy is transferred to the resident ink spots from the same direction as the printheads ensuring less energy requirement.
摘要翻译：提供了一种用于在记录介质上进行喷墨印刷的设备和方法，其包括以图像形式将水性墨滴喷射在纸上的步骤。使用的水性油墨是一种慢干（高表面张力）油墨，其不会在相对长的时间内渗透纸/纸纤维。在纸/纸纤维渗透之前，液滴中的水从墨水中迅速蒸发，同时仍然驻留在纸张表面上。在附加的液体墨水喷射到记录介质的相同或相邻位置之前，蒸发过程基本上完成。蒸发速度足够快以防止驻留的墨水基本上迁移/吸附到任何相邻位置或记录介质中。此外，干燥能量从与打印头相同的方向转移到驻留的墨点，确保较少的能量需求。

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