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1. 发明授权

US08318094B1 Substrate analysis systems 有权
标题翻译：基板分析系统
公开(公告)号：US08318094B1
公开(公告)日：2012-11-27
申请号：US13162433
申请日：2011-06-16
申请人： Hovig Bayandorian , Yujuan Cheng , John Dixon , Kevin Hester , Yanqiao Huang , Paul Lundquist , Joy Roy , Stephen Turner , Peiqian Zhao , Cheng Frank Zhong
发明人： Hovig Bayandorian , Yujuan Cheng , John Dixon , Kevin Hester , Yanqiao Huang , Paul Lundquist , Joy Roy , Stephen Turner , Peiqian Zhao , Cheng Frank Zhong
IPC分类号： G01N31/00
CPC分类号： G01N21/645 , G01N35/0099 , G01N2021/6417 , G01N2035/00039 , Y10T436/11
摘要： This invention provides systems for analyzing substrates. Also provided by the invention are improved optical systems for enhanced multiplex illumination, optical systems with compact multi-wavelength illumination architectures, optical systems for enhanced detection of optical signals, and optical systems for reduced autofluorescence background noise.
摘要翻译：本发明提供了用于分析衬底的系统。本发明还提供了用于增强多重照明的改进的光学系统，具有紧凑的多波长照明结构的光学系统，用于增强光信号的检测的光学系统以及用于减少自发荧光背景噪声的光学系统。

2. 发明授权

US08993307B2 High multiplex arrays and systems 有权
标题翻译：高复用阵列和系统
公开(公告)号：US08993307B2
公开(公告)日：2015-03-31
申请号：US13552497
申请日：2012-07-18
申请人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
发明人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
IPC分类号： C12M1/34 , G01N21/64 , G01N21/25 , G02B6/13 , G02B6/136
CPC分类号： G01N21/6452 , B05D1/005 , C23C16/50 , G01N21/253 , G02B6/12002 , G02B6/131 , G02B6/132 , G02B6/136 , G02B2006/12035 , G02B2006/12061 , G02B2006/12104 , G02B2006/12164 , G02B2006/12197
摘要： Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
摘要翻译：用于分析离散反应的设备，系统和方法，以超高的多重复用，降低光学噪声，提高系统灵活性。装置包括具有集成光学部件的衬底，其通过一个或多个增加密度的反应区域增加多重能力，改善光从离散反应区域发射或收集光。集成光学部件包括反射光学元件，其重新引导照明光和从离散区域发射的光以更有效地收集发射的光。特别优选的应用包括单分子反应分析，例如聚合酶介导的模板依赖性核酸合成和序列测定。

3. 发明授权

US08247216B2 Ultra-high multiplex analytical systems and methods 有权
标题翻译：超高分辨率分析系统和方法
公开(公告)号：US08247216B2
公开(公告)日：2012-08-21
申请号：US12567526
申请日：2009-09-25
申请人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
发明人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
IPC分类号： C12M1/36 , G01N21/00 , G01J3/00
CPC分类号： G01N21/6452 , B05D1/005 , C23C16/50 , G01N21/253 , G02B6/12002 , G02B6/131 , G02B6/132 , G02B6/136 , G02B2006/12035 , G02B2006/12061 , G02B2006/12104 , G02B2006/12164 , G02B2006/12197
摘要： Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
摘要翻译：用于分析离散反应的设备，系统和方法，以超高的多重复用，降低光学噪声，提高系统灵活性。装置包括具有集成光学部件的衬底，其通过一个或多个增加密度的反应区域增加多重能力，改善光从离散反应区域发射或收集光。集成光学部件包括反射光学元件，其重新引导照明光和从离散区域发射的光以更有效地收集发射的光。特别优选的应用包括单分子反应分析，例如聚合酶介导的模板依赖性核酸合成和序列测定。

4. 发明申请

US20100099100A1 'ULTRA-HIGH MULTIPLEX ANALYTICAL SYSTEMS AND METHODS" 有权
标题翻译： “超高分辨率分析系统和方法”
公开(公告)号：US20100099100A1
公开(公告)日：2010-04-22
申请号：US12567526
申请日：2009-09-25
申请人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
发明人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
IPC分类号： C12Q1/68 , G02B6/26 , G02B5/08 , B29D11/00
CPC分类号： G01N21/6452 , B05D1/005 , C23C16/50 , G01N21/253 , G02B6/12002 , G02B6/131 , G02B6/132 , G02B6/136 , G02B2006/12035 , G02B2006/12061 , G02B2006/12104 , G02B2006/12164 , G02B2006/12197
摘要： Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
摘要翻译：用于分析离散反应的设备，系统和方法，以超高的多重复用，降低光学噪声，提高系统灵活性。装置包括具有集成光学部件的衬底，其通过一个或多个增加密度的反应区域增加多重能力，改善光从离散反应区域发射或收集光。集成光学部件包括反射光学元件，其重新引导照明光和从离散区域发射的光以更有效地收集发射的光。特别优选的应用包括单分子反应分析，例如聚合酶介导的模板依赖性核酸合成和序列测定。

5. 发明申请

US20130023039A1 HIGH MULTIPLEX ARRAYS AND SYSTEMS 审中-公开
标题翻译：高多重阵列和系统
公开(公告)号：US20130023039A1
公开(公告)日：2013-01-24
申请号：US13552497
申请日：2012-07-18
申请人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
发明人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
IPC分类号： C12M1/34
CPC分类号： G01N21/6452 , B05D1/005 , C23C16/50 , G01N21/253 , G02B6/12002 , G02B6/131 , G02B6/132 , G02B6/136 , G02B2006/12035 , G02B2006/12061 , G02B2006/12104 , G02B2006/12164 , G02B2006/12197
摘要： Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
摘要翻译：用于分析离散反应的设备，系统和方法，以超高的多重复用，降低光学噪声，提高系统灵活性。装置包括具有集成光学部件的衬底，其通过一个或多个增加密度的反应区域增加多重能力，改善光从离散反应区域发射或收集光。集成光学部件包括反射光学元件，其重新引导照明光和从离散区域发射的光以更有效地收集发射的光。特别优选的应用包括单分子反应分析，例如聚合酶介导的模板依赖性核酸合成和序列测定。

6. 发明申请

US20060221250A1 Method and system to increase X-Y resolution in a depth (Z) camera using red, blue, green (RGB) sensing 有权
标题翻译：使用红色，蓝色，绿色（RGB）感测在深度（Z）摄像机中增加X-Y分辨率的方法和系统
公开(公告)号：US20060221250A1
公开(公告)日：2006-10-05
申请号：US11444947
申请日：2006-06-01
申请人： Christopher Rossbach , Abbas Rafii , Peiqian Zhao
发明人： Christopher Rossbach , Abbas Rafii , Peiqian Zhao
IPC分类号： H04N5/21 , H04N9/77 , H04N9/64 , H04N5/14
CPC分类号： H04N9/045 , G01S17/89 , G01S17/936 , H04N5/2355 , H04N13/128
摘要： An imaging system substantially simultaneously acquires z-depth and brightness data from first sensors, and acquires higher resolution RGB data from second sensors, and fuses data from the first and second sensors to model an RGBZ image whose resolution can be as high as resolution of the second sensors. Time correlation of captured data from first and second sensors is associated with captured image data, which permits arbitrary mapping between the two data sources, ranging from 1:many to many:1. Preferably pixels from each set of sensors that image the same target point are mapped. Many z-depth sensor settings may be used to create a static environmental model. Non-correlative and correlative filtering is carried out, and up-sampling to increase z-resolution occurs, from which a three-dimensional model is constructed using registration and calibration data.
摘要翻译：成像系统基本上同时从第一传感器获取z深度和亮度数据，并且从第二传感器获取更高分辨率的RGB数据，并且将来自第一和第二传感器的数据融合以对分辨率可以高达分辨率的RGBZ图像进行建模第二传感器。来自第一和第二传感器的捕获数据的时间相关性与捕获的图像数据相关联，其允许两个数据源之间的任意映射，范围从1：多到多：1。优选地对映射相同目标点的每组传感器的像素进行映射。许多z深度传感器设置可用于创建静态环境模型。进行非相关和相关滤波，并且发生上采样以增加z分辨率，使用配准和校准数据构建三维模型。

7. 发明授权

US08139141B2 Single chip red, green, blue, distance (RGB-Z) sensor 有权
标题翻译：单芯红色，绿色，蓝色，距离（RGB-Z）传感器
公开(公告)号：US08139141B2
公开(公告)日：2012-03-20
申请号：US11044996
申请日：2005-01-26
申请人： Cyrus Bamji , Peiqian Zhao
发明人： Cyrus Bamji , Peiqian Zhao
IPC分类号： G03B13/00 , H04N9/07 , H04N5/225 , H04N13/02 , G01C3/08
CPC分类号： H04N9/045 , G01C3/08 , G01J3/2803 , G01J3/36 , G01S7/4811 , G01S7/4863 , G01S7/4912 , G01S17/023 , G01S17/89 , G01S17/936 , H04N5/2226 , H04N5/2254 , H04N5/332 , H04N9/083
摘要： An RGB-Z sensor is implementable on a single IC chip. A beam splitter such as a hot mirror receives and separates incoming first and second spectral band optical energy from a target object into preferably RGB image components and preferably NIR Z components. The RGB image and Z components are detected by respective RGB and NIR pixel detector array regions, which output respective image data and Z data. The pixel size and array resolutions of these regions need not be equal, and both array regions may be formed on a common IC chip. A display using the image data can be augmented with Z data to help recognize a target object. The resultant structure combines optical efficiency of beam splitting with the simplicity of a single IC chip implementation. A method of using the single chip red, green, blue, distance (RGB-Z) sensor is also disclosed.
摘要翻译： RGB-Z传感器可在单个IC芯片上实现。诸如热反射镜的分束器接收并将来自目标物体的进入的第一和第二光谱带光能分解成优选的RGB图像分量，并且优选地将NIR Z分量分离。 RGB图像和Z分量由相应的RGB和NIR像素检测器阵列区域检测，其输出相应的图像数据和Z数据。这些区域的像素尺寸和阵列分辨率不必相等，并且两个阵列区域可以形成在公共IC芯片上。使用图像数据的显示可以用Z数据来增强以帮助识别目标对象。所得到的结构结合了光束分离的光学效率和单个IC芯片实现的简单性。还公开了使用单芯片红，绿，蓝，距离（RGB-Z）传感器的方法。

8. 发明授权

US08134637B2 Method and system to increase X-Y resolution in a depth (Z) camera using red, blue, green (RGB) sensing 有权
标题翻译：使用红色，蓝色，绿色（RGB）感测在深度（Z）摄像机中增加X-Y分辨率的方法和系统
公开(公告)号：US08134637B2
公开(公告)日：2012-03-13
申请号：US11444947
申请日：2006-06-01
申请人： Christopher J. Rossbach , Abbas Rafii , Peiqian Zhao
发明人： Christopher J. Rossbach , Abbas Rafii , Peiqian Zhao
IPC分类号： G03B13/00 , H04N9/07 , H04N5/225 , H04N13/02 , G01C3/08
CPC分类号： H04N9/045 , G01S17/89 , G01S17/936 , H04N5/2355 , H04N13/128
摘要： An imaging system substantially simultaneously acquires z-depth and brightness data from first sensors, and acquires higher resolution RGB data from second sensors, and fuses data from the first and second sensors to model an RGBZ image whose resolution can be as high as resolution of the second sensors. Time correlation of captured data from first and second sensors is associated with captured image data, which permits arbitrary mapping between the two data sources, ranging from 1:many to many:1. Preferably pixels from each set of sensors that image the same target point are mapped. Many z-depth sensor settings may be used to create a static environmental model. Non-correlative and correlative filtering is carried out, and up-sampling to increase z-resolution occurs, from which a three-dimensional model is constructed using registration and calibration data.
摘要翻译：成像系统基本上同时从第一传感器获取z深度和亮度数据，并且从第二传感器获取更高分辨率的RGB数据，并且将来自第一和第二传感器的数据融合以对分辨率可以高达分辨率的RGBZ图像进行建模第二传感器。来自第一和第二传感器的捕获数据的时间相关性与捕获的图像数据相关联，其允许两个数据源之间的任意映射，范围从1：多到多：1。优选地对映射相同目标点的每组传感器的像素进行映射。许多z深度传感器设置可用于创建静态环境模型。进行非相关和相关滤波，并且发生上采样以增加z分辨率，使用配准和校准数据构建三维模型。

9. 发明申请

US20050285966A1 Single chip red, green, blue, distance (RGB-Z) sensor 有权
标题翻译：单芯红色，绿色，蓝色，距离（RGB-Z）传感器
公开(公告)号：US20050285966A1
公开(公告)日：2005-12-29
申请号：US11044996
申请日：2005-01-26
申请人： Cyrus Bamji , Peiqian Zhao
发明人： Cyrus Bamji , Peiqian Zhao
IPC分类号： G01C3/08 , G01J3/28 , G01J3/36 , G01S7/481 , G01S7/486 , G01S7/491 , G01S17/89 , H04N5/225 , H04N9/04 , H04N9/07 , H04N9/083
CPC分类号： H04N9/045 , G01C3/08 , G01J3/2803 , G01J3/36 , G01S7/4811 , G01S7/4863 , G01S7/4912 , G01S17/023 , G01S17/89 , G01S17/936 , H04N5/2226 , H04N5/2254 , H04N5/332 , H04N9/083
摘要： An RGB-Z sensor is implementable on a single IC chip. A beam splitter such as a hot mirror receives and separates incoming first and second spectral band optical energy from a target object into preferably RGB image components and preferably NIR Z components. The RGB image and Z components are detected by respective RGB and NIR pixel detector array regions, which output respective image data and Z data. The pixel size and array resolutions of these regions need not be equal, and both array regions may be formed on a common IC chip. A display using the image data can be augmented with Z data to help recognize a target object. The resultant structure combines optical efficiency of beam splitting with the simplicity of a single IC chip implementation. A method of using the single chip red, green, blue, distance (RGB-Z) sensor is also disclosed.
摘要翻译： RGB-Z传感器可在单个IC芯片上实现。诸如热反射镜的分束器接收并将来自目标物体的进入的第一和第二光谱带光能分解成优选的RGB图像分量，并且优选地将NIR Z分量分离。 RGB图像和Z分量由相应的RGB和NIR像素检测器阵列区域检测，其输出相应的图像数据和Z数据。这些区域的像素尺寸和阵列分辨率不必相等，并且两个阵列区域可以形成在公共IC芯片上。使用图像数据的显示可以用Z数据来增强以帮助识别目标对象。所得到的结构结合了光束分离的光学效率和单个IC芯片实现的简单性。还公开了使用单芯片红，绿，蓝，距离（RGB-Z）传感器的方法。

10. 发明授权

US06961200B2 Optical servo track identification on tape storage media 失效
标题翻译：磁带存储介质上的光学伺服轨迹识别
公开(公告)号：US06961200B2
公开(公告)日：2005-11-01
申请号：US10140098
申请日：2002-05-07
申请人： Tzuochang Lee , Hong Chen , Peiqian Zhao
发明人： Tzuochang Lee , Hong Chen , Peiqian Zhao
IPC分类号： G02F1/01 , G11B5/584 , G11B5/596 , G11B5/78 , G11B5/84 , G11B21/10 , G11B15/18 , G11B21/02
CPC分类号： G11B21/103 , G11B5/584 , G11B5/59677
摘要： A method and a system for formatting a magnetic tape with identifiable optical servo tracks are disclosed. Multiple optically detectable servo tracks extending lengthwise parallel to the tape transport direction are written simultaneously by directing a spatial beam dot pattern unto the magnetic tape. The beam dot pattern is capable of imparting not only a unique identification, but also other information such as tape longitudinal address, and manufacturer's data to each servo track. The spatial beam dot pattern may also include two arrays of beam dots created via the use of two one-dimensional diffractive optical elements.
摘要翻译：公开了一种用于格式化具有可识别的光学伺服磁道的磁带的方法和系统。通过将空间光点图案指向磁带，同时写入沿纵向平行于磁带传送方向延伸的多个可光学检测的伺服磁道。光束点图案不仅可以赋予每个伺服轨道唯一的识别，还可以赋予诸如磁带纵向地址和制造商的数据的其他信息。空间光点图案还可以包括通过使用两个一维衍射光学元件而产生的两束光束点阵列。

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