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1. 发明授权

US08318094B1 Substrate analysis systems 有权
标题翻译：基板分析系统
公开(公告)号：US08318094B1
公开(公告)日：2012-11-27
申请号：US13162433
申请日：2011-06-16
申请人： Hovig Bayandorian , Yujuan Cheng , John Dixon , Kevin Hester , Yanqiao Huang , Paul Lundquist , Joy Roy , Stephen Turner , Peiqian Zhao , Cheng Frank Zhong
发明人： Hovig Bayandorian , Yujuan Cheng , John Dixon , Kevin Hester , Yanqiao Huang , Paul Lundquist , Joy Roy , Stephen Turner , Peiqian Zhao , Cheng Frank Zhong
IPC分类号： G01N31/00
CPC分类号： G01N21/645 , G01N35/0099 , G01N2021/6417 , G01N2035/00039 , Y10T436/11
摘要： This invention provides systems for analyzing substrates. Also provided by the invention are improved optical systems for enhanced multiplex illumination, optical systems with compact multi-wavelength illumination architectures, optical systems for enhanced detection of optical signals, and optical systems for reduced autofluorescence background noise.
摘要翻译：本发明提供了用于分析衬底的系统。本发明还提供了用于增强多重照明的改进的光学系统，具有紧凑的多波长照明结构的光学系统，用于增强光信号的检测的光学系统以及用于减少自发荧光背景噪声的光学系统。

2. 发明授权

US08993307B2 High multiplex arrays and systems 有权
标题翻译：高复用阵列和系统
公开(公告)号：US08993307B2
公开(公告)日：2015-03-31
申请号：US13552497
申请日：2012-07-18
申请人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
发明人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
IPC分类号： C12M1/34 , G01N21/64 , G01N21/25 , G02B6/13 , G02B6/136
CPC分类号： G01N21/6452 , B05D1/005 , C23C16/50 , G01N21/253 , G02B6/12002 , G02B6/131 , G02B6/132 , G02B6/136 , G02B2006/12035 , G02B2006/12061 , G02B2006/12104 , G02B2006/12164 , G02B2006/12197
摘要： Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
摘要翻译：用于分析离散反应的设备，系统和方法，以超高的多重复用，降低光学噪声，提高系统灵活性。装置包括具有集成光学部件的衬底，其通过一个或多个增加密度的反应区域增加多重能力，改善光从离散反应区域发射或收集光。集成光学部件包括反射光学元件，其重新引导照明光和从离散区域发射的光以更有效地收集发射的光。特别优选的应用包括单分子反应分析，例如聚合酶介导的模板依赖性核酸合成和序列测定。

3. 发明申请

US20130023039A1 HIGH MULTIPLEX ARRAYS AND SYSTEMS 审中-公开
标题翻译：高多重阵列和系统
公开(公告)号：US20130023039A1
公开(公告)日：2013-01-24
申请号：US13552497
申请日：2012-07-18
申请人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
发明人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
IPC分类号： C12M1/34
CPC分类号： G01N21/6452 , B05D1/005 , C23C16/50 , G01N21/253 , G02B6/12002 , G02B6/131 , G02B6/132 , G02B6/136 , G02B2006/12035 , G02B2006/12061 , G02B2006/12104 , G02B2006/12164 , G02B2006/12197
摘要： Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
摘要翻译：用于分析离散反应的设备，系统和方法，以超高的多重复用，降低光学噪声，提高系统灵活性。装置包括具有集成光学部件的衬底，其通过一个或多个增加密度的反应区域增加多重能力，改善光从离散反应区域发射或收集光。集成光学部件包括反射光学元件，其重新引导照明光和从离散区域发射的光以更有效地收集发射的光。特别优选的应用包括单分子反应分析，例如聚合酶介导的模板依赖性核酸合成和序列测定。

4. 发明授权

US08247216B2 Ultra-high multiplex analytical systems and methods 有权
标题翻译：超高分辨率分析系统和方法
公开(公告)号：US08247216B2
公开(公告)日：2012-08-21
申请号：US12567526
申请日：2009-09-25
申请人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
发明人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
IPC分类号： C12M1/36 , G01N21/00 , G01J3/00
CPC分类号： G01N21/6452 , B05D1/005 , C23C16/50 , G01N21/253 , G02B6/12002 , G02B6/131 , G02B6/132 , G02B6/136 , G02B2006/12035 , G02B2006/12061 , G02B2006/12104 , G02B2006/12164 , G02B2006/12197
摘要： Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
摘要翻译：用于分析离散反应的设备，系统和方法，以超高的多重复用，降低光学噪声，提高系统灵活性。装置包括具有集成光学部件的衬底，其通过一个或多个增加密度的反应区域增加多重能力，改善光从离散反应区域发射或收集光。集成光学部件包括反射光学元件，其重新引导照明光和从离散区域发射的光以更有效地收集发射的光。特别优选的应用包括单分子反应分析，例如聚合酶介导的模板依赖性核酸合成和序列测定。

5. 发明申请

US20100099100A1 'ULTRA-HIGH MULTIPLEX ANALYTICAL SYSTEMS AND METHODS" 有权
标题翻译： “超高分辨率分析系统和方法”
公开(公告)号：US20100099100A1
公开(公告)日：2010-04-22
申请号：US12567526
申请日：2009-09-25
申请人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
发明人： Denis Zaccarin , Paul Lundquist , Peiqian Zhao , Cheng Frank Zhong , Stephen Turner , Yanqiao Huang , Pezhman Monadgemi , Ravi Saxena , Annette Grot , Aaron Rulison
IPC分类号： C12Q1/68 , G02B6/26 , G02B5/08 , B29D11/00
CPC分类号： G01N21/6452 , B05D1/005 , C23C16/50 , G01N21/253 , G02B6/12002 , G02B6/131 , G02B6/132 , G02B6/136 , G02B2006/12035 , G02B2006/12061 , G02B2006/12104 , G02B2006/12164 , G02B2006/12197
摘要： Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
摘要翻译：用于分析离散反应的设备，系统和方法，以超高的多重复用，降低光学噪声，提高系统灵活性。装置包括具有集成光学部件的衬底，其通过一个或多个增加密度的反应区域增加多重能力，改善光从离散反应区域发射或收集光。集成光学部件包括反射光学元件，其重新引导照明光和从离散区域发射的光以更有效地收集发射的光。特别优选的应用包括单分子反应分析，例如聚合酶介导的模板依赖性核酸合成和序列测定。

6. 发明申请

US20080277595A1 Highly multiplexed confocal detection systems and methods of using same 审中-公开
标题翻译：高度多路复用共焦检测系统及其使用方法
公开(公告)号：US20080277595A1
公开(公告)日：2008-11-13
申请号：US11901273
申请日：2007-09-14
申请人： Paul Lundquist , Cheng Frank Zhong , Pegian Zhao , Stephen Turner
发明人： Paul Lundquist , Cheng Frank Zhong , Pegian Zhao , Stephen Turner
IPC分类号： G01N27/447
CPC分类号： G01N27/44721
摘要： Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high density optical systems to illuminate high density sample arrays and/or provide detection and preferably confocal detection off signals emanating from such high density arrays. Systems and methods are applied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and derivation of sequence information from such synthesis.
摘要翻译：使用高度多路复用的高密度光学系统来分析高度多路复用的样本阵列以照亮高密度样本阵列和/或提供从这种高密度阵列发出的信号的检测和优选共焦检测的系统和方法。系统和方法应用于各种不同的分析操作，包括生物和生物化学反应的分析，包括核酸合成和从这种合成得到的序列信息。

7. 发明授权

US07714303B2 Methods and systems for analyzing fluorescent materials with reduced authofluorescence 有权
标题翻译：用荧光物质分析荧光降低的方法和系统
公开(公告)号：US07714303B2
公开(公告)日：2010-05-11
申请号：US12151979
申请日：2008-05-09
申请人： Paul Lundquist , Cheng Frank Zhong , Denis Zaccarin , Stephen Turner
发明人： Paul Lundquist , Cheng Frank Zhong , Denis Zaccarin , Stephen Turner
IPC分类号： F21V9/16
CPC分类号： G01N27/447
摘要： Mitigative and remedial approaches to reduction of autofluorescence background noise are applied in analytical systems that rely upon sensitive measurement of fluorescent signals from arrays of fluorescent signal sources. Such systems are for particular use in fluorescence based sequencing by incorporation systems that rely upon small numbers or individual fluorescent molecules in detecting incorporation of nucleotides in primer extension reactions.
摘要翻译：降低自发荧光背景噪声的缓解和补救方法应用于依赖于荧光信号源阵列的荧光信号敏感测量的分析系统中。这样的系统特别用于基于荧光的测序，其通过依赖于小数目或单独的荧光分子检测引物延伸反应中核苷酸的掺入的并入系统。

8. 发明申请

US20100167413A1 METHODS AND SYSTEMS FOR ANALYZING FLUORESCENT MATERIALS WITH REDUCED AUTOFLUORESCENCE 审中-公开
标题翻译：降低自动荧光分析荧光材料的方法与系统
公开(公告)号：US20100167413A1
公开(公告)日：2010-07-01
申请号：US12451310
申请日：2008-05-09
申请人： Paul Lundquist , Cheng Frank Zhong , Denis Zaccarin , Pegian Zhao , Stephen Turner
发明人： Paul Lundquist , Cheng Frank Zhong , Denis Zaccarin , Pegian Zhao , Stephen Turner
IPC分类号： G01N21/64 , C12M1/00
CPC分类号： G01N27/44721
摘要： Mitigative and remedial approaches to reduction of autofluorescence background noise are applied in analytical systems that rely upon sensitive measurement of fluorescent signals from arrays of fluorescent signal sources. Such systems are for particular use in fluorescence based sequencing by incorporation systems that rely upon small numbers or individual fluorescent molecules in detecting incorporation of nucleotides in primer extension reactions. Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high-density optical systems to illuminate high-density sample arrays and/or provide detection and preferably confocal detection off signals emanating from such high-density arrays. Systems and methods are applied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and derivation of sequence information from such synthesis.
摘要翻译：降低自发荧光背景噪声的缓解和补救方法应用于依赖于荧光信号源阵列的荧光信号敏感测量的分析系统中。这样的系统特别用于基于荧光的测序，其通过依赖于小数目或单独的荧光分子检测引物延伸反应中核苷酸的掺入的并入系统。使用高度复用的高密度光学系统来分析高度复用的样本阵列的系统和方法，以照亮高密度样本阵列和/或提供从这种高密度阵列发出的信号的检测和优选共焦检测。系统和方法应用于各种不同的分析操作，包括生物和生物化学反应的分析，包括核酸合成和从这种合成得到的序列信息。

9. 发明申请

US20080283772A1 Methods and systems for analyzing fluorescent materials with reduced authofluorescence 有权
标题翻译：用荧光物质分析荧光降低的方法和系统
公开(公告)号：US20080283772A1
公开(公告)日：2008-11-20
申请号：US12151979
申请日：2008-05-09
申请人： Paul Lundquist , Cheng Frank Zhong , Denis Zaccarin , Stephen Turner
发明人： Paul Lundquist , Cheng Frank Zhong , Denis Zaccarin , Stephen Turner
IPC分类号： G01J1/58
CPC分类号： G01N27/447
摘要： Mitigative and remedial approaches to reduction of autofluorescence background noise are applied in analytical systems that rely upon sensitive measurement of fluorescent signals from arrays of fluorescent signal sources. Such systems are for particular use in fluorescence based sequencing by incorporation systems that rely upon small numbers or individual fluorescent molecules in detecting incorporation of nucleotides in primer extension reactions
摘要翻译：降低自发荧光背景噪声的缓解和补救方法应用于依赖于荧光信号源阵列的荧光信号敏感测量的分析系统中。这样的系统特别用于基于荧光的测序，其通过依赖于小数目或单个荧光分子检测引物延伸反应中核苷酸掺入的掺入体系

10. 发明授权

US07961314B2 Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources 有权
标题翻译：用于同时实时监测来自多个来源的光信号的方法和系统
公开(公告)号：US07961314B2
公开(公告)日：2011-06-14
申请号：US11978211
申请日：2007-10-26
申请人： Paul Lundquist , Denis Zaccarin , Yves Lacroix , Stephen Turner , John Dixon
发明人： Paul Lundquist , Denis Zaccarin , Yves Lacroix , Stephen Turner , John Dixon
IPC分类号： G01J3/30
CPC分类号： G01J3/02 , G01J3/0224 , G01J3/10 , G01J3/14 , G01J3/2803 , G01N21/6445 , G01N21/6452 , G01N21/6456 , G01N21/648 , G01N2021/6417
摘要： Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
摘要翻译：用于实时监测来自信号源阵列的光信号的方法和系统，特别是具有频谱不同信号分量的光信号源。系统包括与光学列车光学通信的信号源阵列，其将激发辐射引导到来自这种阵列的信号和从这些阵列发出的信号，并将信号映射到检测器阵列上，从而可以对这些信号进行额外的处理。

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