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11. 发明授权

US4501468A Integral optical imaging devices using grin lens systems 失效
标题翻译：使用咧嘴透镜系统的整体光学成像设备
公开(公告)号：US4501468A
公开(公告)日：1985-02-26
申请号：US520458
申请日：1983-08-04
申请人： Nicholas F. Borrelli , Donald B. Keck , David L. Morse , Paul A. Sachenik
发明人： Nicholas F. Borrelli , Donald B. Keck , David L. Morse , Paul A. Sachenik
IPC分类号： G02B27/18 , C03C23/00 , G02B3/00 , G02B5/17
CPC分类号： G02B3/0087 , C03C23/0095 , G02B3/0012 , G02B3/0056 , G02B3/0068
摘要： An integral optical imaging device is disclosed in which two or more porous glass bodies, embodying arrays of cylindrical gradient index lens systems, are rigidly maintained in a stacked relationship such that the lens systems are in register. This enhances the accumulative lens power and effective thickness of the device.
摘要翻译：公开了一种整体光学成像装置，其中体现圆柱形梯度折射率透镜系统的阵列的两个或多个多孔玻璃体被牢固地保持在堆叠关系中，使得透镜系统处于对准状态。这增强了设备的累积透镜功率和有效厚度。

12. 发明授权

US11077212B2 Molecular imaging of cancer cells in vivo 有权
公开(公告)号：US11077212B2
公开(公告)日：2021-08-03
申请号：US13813605
申请日：2011-08-24
申请人： David L. Morse , Robert J. Gillies , William Bradford Carter , Narges K. Tafreshi , Marilyn M. Bui , Steven A. Enkemann
发明人： David L. Morse , Robert J. Gillies , William Bradford Carter , Narges K. Tafreshi , Marilyn M. Bui , Steven A. Enkemann
IPC分类号： A61K49/00 , A61K51/10
摘要： Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as metastasized cancer cells, are therefore provided. Also provided are compositions and kits for use in the disclosed methods.

13. 发明授权

US4684222A Small anamorphic lenses and method 失效
标题翻译：小变形镜片和方法
公开(公告)号：US4684222A
公开(公告)日：1987-08-04
申请号：US615254
申请日：1984-05-30
申请人： Nicholas F. Borrelli , David L. Morse
发明人： Nicholas F. Borrelli , David L. Morse
IPC分类号： G02B6/42 , C03B19/00 , C03C3/085 , C03C4/04 , C03C23/00 , G02B3/00 , G02B3/04 , G02B27/09 , G02B13/08
CPC分类号： C03C23/00 , G02B3/00 , G02B3/04
摘要： Anamorphic lenses or lens arrays are formed in photosensitively crystallizable glass by selective exposure of the glass surface and thermal treatment to cause the crystallization of the glass surrounding the lenses. The lenses, which have elongated cross-sections in the plane of the exposed glass surface and raised curved surfaces resulting from the densification of the surround material, exhibit different surface curvatures over their major and minor transverse axes and thus anamorphic light-focusing properties.
摘要翻译：通过选择性地暴露玻璃表面和热处理以使透镜周围的玻璃结晶，在光敏结晶玻璃中形成变形透镜或透镜阵列。在暴露的玻璃表面的平面中具有细长横截面并且由围绕材料致密化引起的升高的曲面的透镜在它们的主横向轴和次横向轴上表现出不同的表面曲率，并因此在变形光聚焦性能方面表现出不同的表面曲率。

14. 发明授权

US4549894A Ultraviolet absorbing photochromic glass of low silver content 失效
标题翻译：紫外线吸收光银色含量低的玻璃
公开(公告)号：US4549894A
公开(公告)日：1985-10-29
申请号：US617908
申请日：1984-06-06
申请人： Roger J. Araujo , George B. Hares , David J. Kerko , David W. Morgan , David L. Morse
发明人： Roger J. Araujo , George B. Hares , David J. Kerko , David W. Morgan , David L. Morse
IPC分类号： C03C3/091 , C03C4/06
CPC分类号： C03C4/06 , C03C3/091
摘要： There is disclosed a method of producing a photochromic glass having a reduced transmittance for ultraviolet radiation while having substantially unimpaired photochromic properties. The method comprises providing a combination of 0.1-1.0% CeO.sub.2 and 0.1-1.5% Sb.sub.2 O.sub.3 and/or As.sub.2 O.sub.3 as part of the glass composition. In an embodiment utilizing minimal silver content, the glass article in thicknesses of 1.3 to 2.0 mm. can be chemically strengthened to surpass the impact specification imposed by the Federal Food and Drug Administration for eyewear, will transmit less than 0.2% of radiation having wavelengths between 290-315 nm, and will demonstrate a darkened luminous transmittance at 20.degree.-25.degree. C. below 35% and a fading rate such that after five minutes the luminous transmittance will be at least 1.75 times that of the darkened transmittance. These glasses consist essentially of:______________________________________ SiO.sub.2 55-61 Ag >0.1-
摘要翻译：公开了一种具有降低的紫外线辐射透射率而具有基本上未受损的光致变色特性的光致变色玻璃的方法。该方法包括提供0.1-1.0％CeO 2和0.1-1.5％Sb 2 O 3和/或As 2 O 3的组合作为玻璃组合物的一部分。在使用最小银含量的实施方案中，玻璃制品的厚度为1.3至2.0mm。可以化学强化超过联邦食品和药物管理局对眼镜施加的影响规格，将传播波长在290-315 nm之间的辐射不到0.2％，并将在20°-25°C显示变暗的透光率低于35％，并且褪色速率使得在5分钟后，透光率将至少为透光度变暗的1.75倍。这些玻璃基本上由以下组成：-SiO2 55-61 Ag> 0.1- <0.2- B2O3 18-21 Cl 0.2-0.6 -Al2O3 5-11 Br 0.05-0.2 -Li2O 1.5-3 CuO 0.003-0.015 -Na2O 2-5 CeO2 0.1-1.0 -K2O 4.5-8 Sb2O3 0.1-1.5 -

15. 发明授权

US4403031A Method for providing optical patterns in glass 失效
标题翻译：在玻璃中提供光学图案的方法
公开(公告)号：US4403031A
公开(公告)日：1983-09-06
申请号：US277089
申请日：1981-06-25
申请人： Nicholas F. Borrelli , David L. Morse
发明人： Nicholas F. Borrelli , David L. Morse
IPC分类号： C03B8/00 , C03B20/00 , C03C3/06 , C03C4/04 , C03C21/00 , C03C23/00 , G02B3/00 , G02B5/18 , G02B6/00 , G03C1/725 , G03C5/24
CPC分类号： G02B3/0087 , C03C23/008 , C03C23/0095 , G02B3/0012 , G02B3/0056 , Y10S430/148
摘要： Optical patterns formed by localized optical density or refractive index variations in glass are produced by impregnating a porous glass support with a photolyzable organometallic compound and selectively exposing the glass to a photolyzing light source to cause the photolytic decomposition of the organometallic compound in exposed portions of the glass. The patterns are fixed, if desired, by removing unreacted organometallic compound from the pores.
摘要翻译：通过玻璃中的局部光密度或折射率变化形成的光学图案是通过用可光致发光的有机金属化合物浸渍多孔玻璃载体并选择性地将玻璃暴露于光致变色光源来引起有机金属化合物在玻璃。如果需要，通过从孔中除去未反应的有机金属化合物，图案是固定的。

16. 发明授权

US4374931A Photochromic glass suitable for ophthalmic applications 失效
标题翻译：适用于眼科应用的光致变色玻璃
公开(公告)号：US4374931A
公开(公告)日：1983-02-22
申请号：US338042
申请日：1982-01-08
申请人： Philippe Courbin , David J. Kerko , Jean P. Mazeau , David L. Morse
发明人： Philippe Courbin , David J. Kerko , Jean P. Mazeau , David L. Morse
IPC分类号： C03C3/11 , C03C3/093 , C03C4/06 , C03C10/00 , C03C3/26 , C03C3/08 , C03C3/10
CPC分类号： C03C3/093 , C03C4/06
摘要： The present invention is concerned with the production of photochromic glass compositions consisting essentially, expressed in terms of weight percent on the oxide basis, as calculated from the batch, of______________________________________ SiO.sub.2 52-59 B.sub.2 O.sub.3 18-23 Al.sub.2 O.sub.3 6-8 Li.sub.2 O 1-2.5 Na.sub.2 O 1-3 K.sub.2 O 8-13 ZrO.sub.2 2-6 TiO.sub.2 0-3 ______________________________________ and containing, as analyzed in weight percent, of______________________________________ Ag 0.17-0.22 CuO 0.012-0.019 Cl 0.29-0.35 Br 0.06-0.12 PbO 0.1-0.15 ______________________________________ exhibiting, in 0.4 mm cross section, a clear luminous transmittance in excess of 90%, a darkened luminous transmittance below about 45% at a temperature of 25.degree. C., a darkened luminous transmittance below about 57% at a temperature of 40.degree. C., and a half fading time at both temperatures of about five minutes.
摘要翻译：本发明涉及光致变色玻璃组合物的制备，其基本上由以批量计算的基于氧化物的重量百分数表示的-SiO 2 52-59 -B 2 O 3 18-23 -Al 2 O 3 6-8 -Li 2 O 1-2.5 -Na2O 1-3-K2O 8-13-ZrO2 2-6-TiO2 0-3 - 并以重量百分比计含有-Ag 0.17-0.22 -CuO 0.012-0.019 -Cl 0.29-0.35 - Br 0.06-0.12 -PbO 0.1-0.15 - 在0.4mm的横截面中显示出超过90％的透明透光率，在25℃的温度下变暗的透光率低于约45％，更暗的透光率低于在约40℃的温度下为约57％，在约5分钟的温度下为半衰退时间。

17. 发明授权

US10406248B2 Molecular imaging of cancer cells in vivo 有权
公开(公告)号：US10406248B2
公开(公告)日：2019-09-10
申请号：US14240305
申请日：2012-09-05
申请人： David L. Morse , Robert J. Gillies , Amanda Huynh , Josef Vagner
发明人： David L. Morse , Robert J. Gillies , Amanda Huynh , Josef Vagner
IPC分类号： A61K51/00 , A61M36/14 , A61K49/00 , C07K7/06 , C07K7/08
摘要： Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as metastasized cancer cells, are therefore provided. Also provided are compositions and kits for use in the disclosed methods.

18. 发明申请

US20080261818A1 Methods of Identifying Pancreatic Cancer Cells 有权
标题翻译：鉴定胰腺癌细胞的方法
公开(公告)号：US20080261818A1
公开(公告)日：2008-10-23
申请号：US12041350
申请日：2008-03-03
申请人： Haiyong Han , Robert J. Gillies , Victor J. Hruby , David L. Morse
发明人： Haiyong Han , Robert J. Gillies , Victor J. Hruby , David L. Morse
IPC分类号： C40B30/00 , C12Q1/68
CPC分类号： G01N33/57438 , C12Q1/6886 , C12Q2600/158
摘要： Methods that identify cells as pancreatic cancer cells based on assessing the expression of combinations of target molecules expressed preferentially on pancreatic cancer cells are disclosed. Combinations were initially discovered by microarray analysis and selected based upon tumor specificity, relative lack of cross-reactivity with normal tissues, and applicability as targets of multispecific ligands. The claimed methods encompass measuring the expression of three or more specific target molecules in combination and correlating positive expression of the combination with an identification of the cell as a pancreatic cancer cell.
摘要翻译：公开了基于评估胰腺癌细胞优先表达的靶分子的组合的表达来鉴定细胞作为胰腺癌细胞的方法。组合最初通过微阵列分析发现，并且基于肿瘤特异性，与正常组织的相对缺乏交叉反应性和作为多特异性配体的靶标的适用性来选择。要求保护的方法包括组合测量三种或更多种特异性靶分子的表达，并将组合的阳性表达与作为胰腺癌细胞的细胞鉴定相关联。

19. 发明授权

US06573026B1 Femtosecond laser writing of glass, including borosilicate, sulfide, and lead glasses 有权
标题翻译：玻璃的飞秒激光写入，包括硼硅酸盐，硫化物和铅玻璃
公开(公告)号：US06573026B1
公开(公告)日：2003-06-03
申请号：US09628666
申请日：2000-07-28
申请人： Bruce G. Aitken , Nicholas F. Borrelli , David L. Morse , Alexander Streltsov
发明人： Bruce G. Aitken , Nicholas F. Borrelli , David L. Morse , Alexander Streltsov
IPC分类号： G02B618
CPC分类号： G11C13/041 , B23K26/0624 , C03C23/0025 , G02B6/13 , G02B2006/12107 , G02B2006/12147 , G02B2006/12171 , G11C13/04 , Y10S430/146
摘要： A method of writing a pattern, such as a waveguide, in a bulk glass substrate. The bulk glass substrate can be formed from, for example, borosilicate or sulfide or lead glass. A pulsed laser beam is focused within the substrate while the focus is translated relative to the substrate along a scan path at a scan speed effective to induce an increase in the refractive index of the material along the scan path. Substantially no laser induced physical damage of the material is incurred along the scan path. Various optical devices can be made using this method.
摘要翻译：在散装玻璃基板中写入诸如波导的图案的方法。散装玻璃基板可以由例如硼硅酸盐或硫化物或铅玻璃形成。脉冲激光束聚焦在衬底内，同时沿扫描路径相对于衬底平移焦点，扫描速度有效地引起材料沿着扫描路径的折射率的增加。基本上没有激光引起材料的物理损伤沿着扫描路径。可以使用这种方法制造各种光学装置。

20. 发明授权

US5937125A Detachable fiber optic connector with improved optical sub-assembly and nose block 失效
标题翻译：可拆卸光纤连接器，具有改进的光学子组件和鼻梁
公开(公告)号：US5937125A
公开(公告)日：1999-08-10
申请号：US914097
申请日：1997-08-19
申请人： Steven B. Creswick , Shawki S. Ibrahim , Donald A. Pearson, II , David L. Morse , J. Scott Bechtel
发明人： Steven B. Creswick , Shawki S. Ibrahim , Donald A. Pearson, II , David L. Morse , J. Scott Bechtel
IPC分类号： G02B6/42
CPC分类号： G02B6/4292 , G02B6/4245 , G02B6/4257 , G02B6/4272 , G02B6/4277 , G02B6/4204 , G02B6/421 , G02B6/4251 , G02B6/4265 , G02B6/4283
摘要： A detachable fiber optic connector has an improved nose block (800) which enhances cooling of power dissipating components, simplifies assembly, improves yield and reduces cost. The improved nose block (800) includes an upper tray (802) and lower tray (804) which slidingly receive an improved aluminum nitride optical subassembly (700). The subassembly (700) and nose block (800) are held together, properly aligned, and then fixated. The nose block (800) also has symmetrical protrusions (850) which allow the nose block (800) to be placed easily and precisely into mating protrusions (230, 240) in a seal ring (200). The nose block (800) provides a direct thermal pathway between power dissipating components, such as an opto-electronic component (750) and optical driver IC (730), and an aluminum package base (400). Various alternative nose blocks (810, 820, 830) are illustrated, and an alternative base (410) is also shown. The package is completely sealed to ensure field reliability, and manufactured using low cost processes.
摘要翻译：可拆卸光纤连接器具有改进的鼻梁（800），其增强了功率耗散部件的冷却，简化组装，提高产量并降低成本。改进的鼻块（800）包括滑动地接收改进的氮化铝光学子组件（700）的上托盘（802）和下托盘（804）。子组件（700）和鼻块（800）保持在一起，适当对准，然后固定。鼻块（800）还具有对称的突起（850），其允许鼻塞（800）容易且准确地放置在密封环（200）中的配合突起（230,240）中。鼻梁（800）在诸如光电子部件（750）和光学驱动器IC（730）的功率耗散部件和铝包装基座（400）之间提供直接热路径。示出了各种替代的鼻子块（810,820,830），并且还示出了替代基座（410）。该封装完全密封，以确保现场可靠性，并使用低成本工艺制造。

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