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1. 发明授权

US11077212B2 Molecular imaging of cancer cells in vivo 有权
公开(公告)号：US11077212B2
公开(公告)日：2021-08-03
申请号：US13813605
申请日：2011-08-24
申请人： David L. Morse , Robert J. Gillies , William Bradford Carter , Narges K. Tafreshi , Marilyn M. Bui , Steven A. Enkemann
发明人： David L. Morse , Robert J. Gillies , William Bradford Carter , Narges K. Tafreshi , Marilyn M. Bui , Steven A. Enkemann
IPC分类号： A61K49/00 , A61K51/10
摘要： Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as metastasized cancer cells, are therefore provided. Also provided are compositions and kits for use in the disclosed methods.

2. 发明授权

US4684222A Small anamorphic lenses and method 失效
标题翻译：小变形镜片和方法
公开(公告)号：US4684222A
公开(公告)日：1987-08-04
申请号：US615254
申请日：1984-05-30
申请人： Nicholas F. Borrelli , David L. Morse
发明人： Nicholas F. Borrelli , David L. Morse
IPC分类号： G02B6/42 , C03B19/00 , C03C3/085 , C03C4/04 , C03C23/00 , G02B3/00 , G02B3/04 , G02B27/09 , G02B13/08
CPC分类号： C03C23/00 , G02B3/00 , G02B3/04
摘要： Anamorphic lenses or lens arrays are formed in photosensitively crystallizable glass by selective exposure of the glass surface and thermal treatment to cause the crystallization of the glass surrounding the lenses. The lenses, which have elongated cross-sections in the plane of the exposed glass surface and raised curved surfaces resulting from the densification of the surround material, exhibit different surface curvatures over their major and minor transverse axes and thus anamorphic light-focusing properties.
摘要翻译：通过选择性地暴露玻璃表面和热处理以使透镜周围的玻璃结晶，在光敏结晶玻璃中形成变形透镜或透镜阵列。在暴露的玻璃表面的平面中具有细长横截面并且由围绕材料致密化引起的升高的曲面的透镜在它们的主横向轴和次横向轴上表现出不同的表面曲率，并因此在变形光聚焦性能方面表现出不同的表面曲率。

3. 发明授权

US4549894A Ultraviolet absorbing photochromic glass of low silver content 失效
标题翻译：紫外线吸收光银色含量低的玻璃
公开(公告)号：US4549894A
公开(公告)日：1985-10-29
申请号：US617908
申请日：1984-06-06
申请人： Roger J. Araujo , George B. Hares , David J. Kerko , David W. Morgan , David L. Morse
发明人： Roger J. Araujo , George B. Hares , David J. Kerko , David W. Morgan , David L. Morse
IPC分类号： C03C3/091 , C03C4/06
CPC分类号： C03C4/06 , C03C3/091
摘要： There is disclosed a method of producing a photochromic glass having a reduced transmittance for ultraviolet radiation while having substantially unimpaired photochromic properties. The method comprises providing a combination of 0.1-1.0% CeO.sub.2 and 0.1-1.5% Sb.sub.2 O.sub.3 and/or As.sub.2 O.sub.3 as part of the glass composition. In an embodiment utilizing minimal silver content, the glass article in thicknesses of 1.3 to 2.0 mm. can be chemically strengthened to surpass the impact specification imposed by the Federal Food and Drug Administration for eyewear, will transmit less than 0.2% of radiation having wavelengths between 290-315 nm, and will demonstrate a darkened luminous transmittance at 20.degree.-25.degree. C. below 35% and a fading rate such that after five minutes the luminous transmittance will be at least 1.75 times that of the darkened transmittance. These glasses consist essentially of:______________________________________ SiO.sub.2 55-61 Ag >0.1-
摘要翻译：公开了一种具有降低的紫外线辐射透射率而具有基本上未受损的光致变色特性的光致变色玻璃的方法。该方法包括提供0.1-1.0％CeO 2和0.1-1.5％Sb 2 O 3和/或As 2 O 3的组合作为玻璃组合物的一部分。在使用最小银含量的实施方案中，玻璃制品的厚度为1.3至2.0mm。可以化学强化超过联邦食品和药物管理局对眼镜施加的影响规格，将传播波长在290-315 nm之间的辐射不到0.2％，并将在20°-25°C显示变暗的透光率低于35％，并且褪色速率使得在5分钟后，透光率将至少为透光度变暗的1.75倍。这些玻璃基本上由以下组成：-SiO2 55-61 Ag> 0.1- <0.2- B2O3 18-21 Cl 0.2-0.6 -Al2O3 5-11 Br 0.05-0.2 -Li2O 1.5-3 CuO 0.003-0.015 -Na2O 2-5 CeO2 0.1-1.0 -K2O 4.5-8 Sb2O3 0.1-1.5 -

4. 发明授权

US4403031A Method for providing optical patterns in glass 失效
标题翻译：在玻璃中提供光学图案的方法
公开(公告)号：US4403031A
公开(公告)日：1983-09-06
申请号：US277089
申请日：1981-06-25
申请人： Nicholas F. Borrelli , David L. Morse
发明人： Nicholas F. Borrelli , David L. Morse
IPC分类号： C03B8/00 , C03B20/00 , C03C3/06 , C03C4/04 , C03C21/00 , C03C23/00 , G02B3/00 , G02B5/18 , G02B6/00 , G03C1/725 , G03C5/24
CPC分类号： G02B3/0087 , C03C23/008 , C03C23/0095 , G02B3/0012 , G02B3/0056 , Y10S430/148
摘要： Optical patterns formed by localized optical density or refractive index variations in glass are produced by impregnating a porous glass support with a photolyzable organometallic compound and selectively exposing the glass to a photolyzing light source to cause the photolytic decomposition of the organometallic compound in exposed portions of the glass. The patterns are fixed, if desired, by removing unreacted organometallic compound from the pores.
摘要翻译：通过玻璃中的局部光密度或折射率变化形成的光学图案是通过用可光致发光的有机金属化合物浸渍多孔玻璃载体并选择性地将玻璃暴露于光致变色光源来引起有机金属化合物在玻璃。如果需要，通过从孔中除去未反应的有机金属化合物，图案是固定的。

5. 发明授权

US4374931A Photochromic glass suitable for ophthalmic applications 失效
标题翻译：适用于眼科应用的光致变色玻璃
公开(公告)号：US4374931A
公开(公告)日：1983-02-22
申请号：US338042
申请日：1982-01-08
申请人： Philippe Courbin , David J. Kerko , Jean P. Mazeau , David L. Morse
发明人： Philippe Courbin , David J. Kerko , Jean P. Mazeau , David L. Morse
IPC分类号： C03C3/11 , C03C3/093 , C03C4/06 , C03C10/00 , C03C3/26 , C03C3/08 , C03C3/10
CPC分类号： C03C3/093 , C03C4/06
摘要： The present invention is concerned with the production of photochromic glass compositions consisting essentially, expressed in terms of weight percent on the oxide basis, as calculated from the batch, of______________________________________ SiO.sub.2 52-59 B.sub.2 O.sub.3 18-23 Al.sub.2 O.sub.3 6-8 Li.sub.2 O 1-2.5 Na.sub.2 O 1-3 K.sub.2 O 8-13 ZrO.sub.2 2-6 TiO.sub.2 0-3 ______________________________________ and containing, as analyzed in weight percent, of______________________________________ Ag 0.17-0.22 CuO 0.012-0.019 Cl 0.29-0.35 Br 0.06-0.12 PbO 0.1-0.15 ______________________________________ exhibiting, in 0.4 mm cross section, a clear luminous transmittance in excess of 90%, a darkened luminous transmittance below about 45% at a temperature of 25.degree. C., a darkened luminous transmittance below about 57% at a temperature of 40.degree. C., and a half fading time at both temperatures of about five minutes.
摘要翻译：本发明涉及光致变色玻璃组合物的制备，其基本上由以批量计算的基于氧化物的重量百分数表示的-SiO 2 52-59 -B 2 O 3 18-23 -Al 2 O 3 6-8 -Li 2 O 1-2.5 -Na2O 1-3-K2O 8-13-ZrO2 2-6-TiO2 0-3 - 并以重量百分比计含有-Ag 0.17-0.22 -CuO 0.012-0.019 -Cl 0.29-0.35 - Br 0.06-0.12 -PbO 0.1-0.15 - 在0.4mm的横截面中显示出超过90％的透明透光率，在25℃的温度下变暗的透光率低于约45％，更暗的透光率低于在约40℃的温度下为约57％，在约5分钟的温度下为半衰退时间。

6. 发明申请

US20200164093A1 Molecular Imaging of Cancer Cells In Vivo 审中-公开
公开(公告)号：US20200164093A1
公开(公告)日：2020-05-28
申请号：US16565188
申请日：2019-09-09
申请人： David L. Morse , Robert J. Gillies , Amanda Huynh , Josef Vagner
发明人： David L. Morse , Robert J. Gillies , Amanda Huynh , Josef Vagner
IPC分类号： A61K49/00 , C07K7/08 , C07K7/06
摘要： Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as metastasized cancer cells, are therefore provided. Also provided are compositions and kits for use in the disclosed methods.

7. 发明授权

US10258607B2 Method of increasing intratumoral pHe and reducing acid-mediated invasion 有权
公开(公告)号：US10258607B2
公开(公告)日：2019-04-16
申请号：US13479638
申请日：2012-05-24
申请人： Robert J. Gillies , David L. Morse , Ariosto Siqueira Silva , Arig A. Ibrahim Hashim , Robert A. Gatenby , Gary Martinez
发明人： Robert J. Gillies , David L. Morse , Ariosto Siqueira Silva , Arig A. Ibrahim Hashim , Robert A. Gatenby , Gary Martinez
IPC分类号： A61K31/4172 , A61K45/06 , A61K31/133 , A61K31/198 , A61K31/255 , A61K31/495
摘要： A method of treating cancer or inhibiting metastasis in a subject by increasing intratumoral extracellular pH is presented. The method includes administering to the subject a therapeutically effective amount of a buffer having a pKa greater than 6.1. In an advantageous embodiment the pKa of the buffer is about 7.0. Examples of buffers for increasing extracellular pH include NaHCO3, 2-imidazole-1-yl-3-ethoxycarbonylpropionic acid (IEPA), cholamine chloride, N,N-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES) and 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES). The method can further include the step of pretreating with one or more chemotherapeutic agents.

8. 发明授权

US4526873A Transparent, mullite glass-ceramics containing ZnO and method 失效
标题翻译：含有ZnO的透明莫来石玻璃陶瓷及方法
公开(公告)号：US4526873A
公开(公告)日：1985-07-02
申请号：US627073
申请日：1984-07-02
申请人： George H. Beall , Nicholas F. Borrelli , David L. Morse
发明人： George H. Beall , Nicholas F. Borrelli , David L. Morse
IPC分类号： C03C3/062 , C03C3/093 , C03C3/108 , C03C10/00 , C03C10/04 , C03C3/22 , C09K11/10
CPC分类号： C03C10/0054 , Y10S501/904
摘要： There is disclosed an improved, transparent, mullite glass-ceramic doped with Cr.sub.2 O.sub.3 to fluoresce in the 650-900 nm. region of the spectrum and having an absorption peak centered at about 600 nm. The improvement is inclusion in the composition of 2-15% by weight of ZnO and sufficient MgO, if necessary, to provide at least 5% ZnO+MgO. The ZnO or ZnO--MgO components selectively shift the absorption peak centered at 600 nm. toward the lower (blue) end of the spectrum.
摘要翻译：公开了一种改进的透明的莫来石玻璃陶瓷，掺杂有Cr 2 O 3以在650-900nm中发荧光。并具有以约600nm为中心的吸收峰。如果需要，改进是包含2-15重量％的ZnO和足够的MgO，以提供至少5％的ZnO + MgO。 ZnO或ZnO-MgO组分选择性地移动以600nm为中心的吸收峰。朝向光谱的下（蓝）端。

9. 发明授权

US4501468A Integral optical imaging devices using grin lens systems 失效
标题翻译：使用咧嘴透镜系统的整体光学成像设备
公开(公告)号：US4501468A
公开(公告)日：1985-02-26
申请号：US520458
申请日：1983-08-04
申请人： Nicholas F. Borrelli , Donald B. Keck , David L. Morse , Paul A. Sachenik
发明人： Nicholas F. Borrelli , Donald B. Keck , David L. Morse , Paul A. Sachenik
IPC分类号： G02B27/18 , C03C23/00 , G02B3/00 , G02B5/17
CPC分类号： G02B3/0087 , C03C23/0095 , G02B3/0012 , G02B3/0056 , G02B3/0068
摘要： An integral optical imaging device is disclosed in which two or more porous glass bodies, embodying arrays of cylindrical gradient index lens systems, are rigidly maintained in a stacked relationship such that the lens systems are in register. This enhances the accumulative lens power and effective thickness of the device.
摘要翻译：公开了一种整体光学成像装置，其中体现圆柱形梯度折射率透镜系统的阵列的两个或多个多孔玻璃体被牢固地保持在堆叠关系中，使得透镜系统处于对准状态。这增强了设备的累积透镜功率和有效厚度。

10. 发明授权

US4190451A Photochromic glass 失效
标题翻译：光致变色玻璃
公开(公告)号：US4190451A
公开(公告)日：1980-02-26
申请号：US14981
申请日：1979-02-28
申请人： George B. Hares , David L. Morse , Thomas P. Seward, III , Dennis W. Smith
发明人： George B. Hares , David L. Morse , Thomas P. Seward, III , Dennis W. Smith
IPC分类号： C03C3/064 , C03C3/11 , C03C4/06 , C03C21/00 , G02C7/10 , C03C3/08 , C03C3/26
CPC分类号： C03C4/06 , Y10S501/903
摘要： The instant invention is concerned with transparent photochromic glass compositions which not only exhibit desirably rapid darkening and fading characteristics, but which also demonstrate the other physical and optical properties required for use in ophthalmic applications. Such glasses utilize the presence of silver chloride and/or silver bromide crystals to impart photochromic behavior in a narrowly-defined composition range within the alkali metal aluminoborosilicate base system. Copper ions are also included in the composition to perform as a sensitizing agent. The glasses have the capability of being either thermally tempered or chemically strengthened to comply with the United States Food and Drug Administration regulations for lenses used in ophthalmic applications. Improved independence of temperature effects upon the photochromic properties can be achieved where the copper level, expressed as CuO, is maintained between about 0.004-0.02% by weight, the chloride value, expressed as Cl, is held between about 0.1-0.25% by weight, the silver content, expressed as Ag, is included between about 0.15-0.3% by weight, and the quantity of bromide, expressed as Br, is varied between about 0.1-0.2% by weight. The fading rate of the glasses is enhanced by maintaining the molar ratio of alkali metal oxides to B.sub.2 O.sub.3 between about 0.55-0.85, the molar ratio of alkali metal oxides minus Al.sub.2 O.sub.3 to B.sub.2 O.sub.3 is about 0.25-0.4, and the weight ratio Ag:(Cl+Br) is about 0.65-0.95.
摘要翻译：本发明涉及透明光致变色玻璃组合物，其不仅表现出期望的快速变暗和褪色特性，而且还显示了用于眼科应用所需的其它物理和光学性质。这种玻璃利用氯化银和/或溴化银晶体的存在，以在碱金属铝硼硅酸盐基体系内的窄范围的组成范围内赋予光致变色行为。铜离子也包括在组合物中以用作敏化剂。眼镜具有热回火或化学强化的能力，以符合美国食品和药物管理局对眼科应用中使用的镜片的规定。可以实现温度对光致变色性能的独立性，其中以CuO表示的铜含量维持在约0.004-0.02重量％之间，氯化物值（以Cl表示）保持在约0.1-0.25重量％，以Ag表示的银含量在约0.15-0.3重量％之间，以Br表示的溴的量在约0.1-0.2重量％之间变化。通过将碱金属氧化物与B 2 O 3的摩尔比保持在约0.55-0.85之间，碱金属氧化物减去Al 2 O 3与B 2 O 3的摩尔比为约0.25-0.4，并且重量比Ag Cl + Br）为约0.65-0.95。

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