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11. 发明授权

US07801271B2 Methods and devices for orthovoltage ocular radiotherapy and treatment planning 有权
标题翻译：用于正射电眼放疗和治疗计划的方法和装置
公开(公告)号：US07801271B2
公开(公告)日：2010-09-21
申请号：US12262031
申请日：2008-10-30
申请人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Junzhong Liang
发明人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Junzhong Liang
IPC分类号： A61N5/10
CPC分类号： A61N5/1037 , A61N5/1017 , A61N5/103 , A61N5/1064 , A61N2005/1091
摘要： A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.
摘要翻译：公开了一种用于规划治疗患者眼睛或其附近的视网膜上的病变的方法，代码和系统。首先建立至少两个光束路径，X射线将沿着该路径被引导到视网膜损伤处。基于光束的已知光谱和强度特性，确定沿着每个光束路径的照射的总处理时间。从对准的眼睛位置的视神经的坐标，确定眼睛移动远离对准的患者眼睛位置的方向的程度和持续时间沿着将患者的视神经移动到将在治疗期间允许的照射束的方向同时仍然将患者视神经的辐射剂量保持在预定剂量水平以下。

12. 发明申请

US20090182312A1 DEVICE AND ASSEMBLY FOR POSITIONING AND STABILIZING AN EYE 有权
标题翻译：用于定位和稳定眼睛的装置和装置
公开(公告)号：US20090182312A1
公开(公告)日：2009-07-16
申请号：US12027094
申请日：2008-02-06
申请人： Michael Gertner , Mark Arnoldussen , Matt Herron
发明人： Michael Gertner , Mark Arnoldussen , Matt Herron
IPC分类号： A61F9/007
CPC分类号： A61N5/1017 , A61B17/0231 , A61F9/008 , A61F9/00804 , A61F9/00819 , A61F9/00821 , A61F9/009 , A61F2009/00863 , A61F2009/00865 , A61F2009/00872 , A61F2009/00895
摘要： An eye contact device and assembly for stabilizing a human eye at a selected position in an external coordinate system is disclosed. The device includes an eye-contact member having an inner contact surface for contacting a front surface of an eye, and a vacuum port formed within the eye-contact member by which a negative pressure can be applied between the eye and the contact surface, to stabilize the position of the eye with respect to the device. The device, which is adapted to be biased against the patient's eye, to secure the device to the eye, may be pivotally coupled to a positioning arm, and may carry one or more beam-directing elements by which the position of the device in an external coordinate system can be determined.
摘要翻译：公开了一种用于在外部坐标系中的选定位置处稳定人眼的眼睛接触装置和组件。该装置包括具有用于接触眼睛的前表面的内接触表面的眼睛接触构件和形成在眼睛接触构件内的真空端口，通过该真空端口可以在眼睛和接触表面之间施加负压，稳定眼睛相对于装置的位置。适于被偏压抵靠患者眼睛的装置将装置固定到眼睛上的装置可以枢转地联接到定位臂，并且可以承载一个或多个光束引导元件，通过该元件将装置的位置可以确定外部坐标系。

13. 发明申请

US20090182311A1 SYSTEM AND METHOD FOR POSITIONING AND STABILIZING AN EYE 有权
标题翻译：用于定位和稳定眼睛的系统和方法
公开(公告)号：US20090182311A1
公开(公告)日：2009-07-16
申请号：US12027083
申请日：2008-02-06
申请人： Michael Gertner , Mark Arnoldussen , Matt Herron
发明人： Michael Gertner , Mark Arnoldussen , Matt Herron
IPC分类号： A61F9/007
CPC分类号： A61N5/1017 , A61B17/0231 , A61F9/008 , A61F9/00804 , A61F9/00819 , A61F9/00821 , A61F9/009 , A61F2009/00863 , A61F2009/00865 , A61F2009/00872 , A61F2009/00895
摘要： A system for securing a patient eye at a known position in an external coordinate system is disclosed. The system includes a head support for supporting the patient's head, an eye-contact device including a concave contact surface adapted to be placed against the front surface of a patient's eye, and a port in fluid communication with the contact surface, by which a vacuum can be applied to the device to remove air between the eye and the contact surface, to stabilize the position of the eye with respect to the contact device, and a biasing mechanism operatively connected to the contact device for biasing the contact device against the eye with a force sufficient to the hold the contact device against the eye, when the eye is stabilized with respect to the device by removal of air between the eye and the device's contact surface.
摘要翻译：公开了一种用于将患者眼睛固定在外部坐标系中的已知位置的系统。该系统包括用于支撑患者头部的头部支撑件，眼睛接触装置，其包括适于抵靠患者眼睛的前表面放置的凹形接触表面以及与接触表面流体连通的端口，通过该接口可以应用于装置以去除眼睛和接触表面之间的空气，以使眼睛相对于接触装置的位置稳定;以及偏置机构，其可操作地连接到接触装置，用于将接触装置偏压到眼睛上，当眼睛相对于装置通过在眼睛和装置的接触表面之间移除空气而被稳定时，该力足以将接触装置保持抵靠眼睛。

14. 发明申请

US20090161826A1 METHODS AND DEVICES FOR ORTHOVOLTAGE OCULAR RADIOTHERAPY AND TREATMENT PLANNING 有权
标题翻译： OROLOVOLTAGE OCULAR放射治疗与治疗计划的方法和装置
公开(公告)号：US20090161826A1
公开(公告)日：2009-06-25
申请号：US12262031
申请日：2008-10-30
申请人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Junzhong Liang
发明人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Junzhong Liang
IPC分类号： A61N5/10
CPC分类号： A61N5/1037 , A61N5/1017 , A61N5/103 , A61N5/1064 , A61N2005/1091
摘要： A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.
摘要翻译：公开了一种用于规划治疗患者眼睛或其附近的视网膜上的病变的方法，代码和系统。首先建立至少两个光束路径，X射线将沿着该路径被引导到视网膜损伤处。基于光束的已知光谱和强度特性，确定沿着每个光束路径的照射的总处理时间。从对准的眼睛位置的视神经的坐标，确定眼睛移动远离对准的患者眼睛位置的方向的程度和持续时间沿着将患者的视神经移动到将在治疗期间允许的照射束的方向同时仍然将患者视神经的辐射剂量保持在预定剂量水平以下。

15. 发明申请

US20070146891A1 Lenslet Array for Beam Homogenization 有权
公开(公告)号：US20070146891A1
公开(公告)日：2007-06-28
申请号：US11683968
申请日：2007-03-08
申请人： Seema Somani , Charles Munnerlyn , Mark Arnoldussen , John Osborn
发明人： Seema Somani , Charles Munnerlyn , Mark Arnoldussen , John Osborn
IPC分类号： G02B27/10
CPC分类号： G02B27/0927 , A61F9/00814 , G02B3/005 , G02B3/0068 , G02B27/0905 , G02B27/0961
摘要： Apparatus for homogenizing a laser beam includes a lenslet array. In some embodiments, the lenslets have a negative power. The lenslet array may include from 16 to 36 effective lenslets in some embodiments, or any other suitable number in alternative embodiments. Some embodiments additionally include a re-focusing lens for directing the beamlets onto a target so that the beamlets overlap and the energy distribution is homogenized. In an alternative embodiment, the lenslet array and re-focusing lens are combined in one optic.

16. 发明申请

US20060028732A1 Lenslet array for beam homogenization 有权
标题翻译：用于光束均匀化的Lenslet阵列
公开(公告)号：US20060028732A1
公开(公告)日：2006-02-09
申请号：US10913952
申请日：2004-08-06
申请人： Seema Somani , Charles Munnerlyn , Mark Arnoldussen , John Osborn
发明人： Seema Somani , Charles Munnerlyn , Mark Arnoldussen , John Osborn
IPC分类号： G02B27/10
CPC分类号： G02B27/0927 , A61F9/00814 , G02B3/005 , G02B3/0068 , G02B27/0905 , G02B27/0961
摘要： Apparatus for homogenizing a laser beam includes a lenslet array. In some embodiments, the lenslets have a negative power. The lenslet array may include from 16 to 36 effective lenslets in some embodiments, or any other suitable number in alternative embodiments. Some embodiments additionally include a re-focusing lens for directing the beamlets onto a target so that the beamlets overlap and the energy distribution is homogenized. In an alternative embodiment, the lenslet array and re-focusing lens are combined in one optic.
摘要翻译：用于使激光束均匀化的装置包括小透镜阵列。在一些实施例中，小透镜具有负功率。在一些实施例中，小透镜阵列可以包括16至36个有效小透镜，或者在替代实施例中可以包括任何其它合适的数目。一些实施例还包括用于将子束引导到靶上的再聚焦透镜，使得子束重叠并且能量分布均匀化。在替代实施例中，小透镜阵列和再聚焦透镜组合在一个光学元件中。

17. 发明授权

US08920406B2 Device and assembly for positioning and stabilizing an eye 有权
标题翻译：用于定位和稳定眼睛的装置和组件
公开(公告)号：US08920406B2
公开(公告)日：2014-12-30
申请号：US12027094
申请日：2008-02-06
申请人： Michael Gertner , Mark Arnoldussen , Matt Herron
发明人： Michael Gertner , Mark Arnoldussen , Matt Herron
IPC分类号： A61F9/009 , A61F9/01 , A61F9/008 , A61N5/10 , A61B17/02
CPC分类号： A61N5/1017 , A61B17/0231 , A61F9/008 , A61F9/00804 , A61F9/00819 , A61F9/00821 , A61F9/009 , A61F2009/00863 , A61F2009/00865 , A61F2009/00872 , A61F2009/00895
摘要： An eye contact device and assembly for stabilizing a human eye at a selected position in an external coordinate system is disclosed. The device includes an eye-contact member having an inner contact surface for contacting a front surface of an eye, and a vacuum port formed within the eye-contact member by which a negative pressure can be applied between the eye and the contact surface, to stabilize the position of the eye with respect to the device. The device, which is adapted to be biased against the patient's eye, to secure the device to the eye, may be pivotally coupled to a positioning arm, and may carry one or more beam-directing elements by which the position of the device in an external coordinate system can be determined.
摘要翻译：公开了一种用于在外部坐标系中的选定位置处稳定人眼的眼睛接触装置和组件。该装置包括具有用于接触眼睛的前表面的内接触表面的眼睛接触构件和形成在眼睛接触构件内的真空端口，通过该真空端口可以在眼睛和接触表面之间施加负压，稳定眼睛相对于装置的位置。适于被偏压抵靠患者眼睛的装置将装置固定到眼睛上的装置可以枢转地联接到定位臂，并且可以承载一个或多个光束引导元件，通过该元件将装置的位置可以确定外部坐标系。

18. 发明授权

US08512236B2 System and method for positioning and stabilizing an eye 有权
标题翻译：用于定位和稳定眼睛的系统和方法
公开(公告)号：US08512236B2
公开(公告)日：2013-08-20
申请号：US12027083
申请日：2008-02-06
申请人： Michael Gertner , Mark Arnoldussen , Matt Herron
发明人： Michael Gertner , Mark Arnoldussen , Matt Herron
IPC分类号： A61B3/10 , A61F9/007 , A61N5/01
CPC分类号： A61N5/1017 , A61B17/0231 , A61F9/008 , A61F9/00804 , A61F9/00819 , A61F9/00821 , A61F9/009 , A61F2009/00863 , A61F2009/00865 , A61F2009/00872 , A61F2009/00895
摘要： A system for securing a patient eye at a known position in an external coordinate system is disclosed. The system includes a head support for supporting the patient's head, an eye-contact device including a concave contact surface adapted to be placed against the front surface of a patient's eye, and a port in fluid communication with the contact surface, by which a vacuum can be applied to the device to remove air between the eye and the contact surface, to stabilize the position of the eye with respect to the contact device, and a biasing mechanism operatively connected to the contact device for biasing the contact device against the eye with a force sufficient to the hold the contact device against the eye, when the eye is stabilized with respect to the device by removal of air between the eye and the device's contact surface.
摘要翻译：公开了一种用于将患者眼睛固定在外部坐标系中的已知位置的系统。该系统包括用于支撑患者头部的头部支撑件，眼睛接触装置，其包括适于抵靠患者眼睛的前表面放置的凹形接触表面以及与接触表面流体连通的端口，通过该接口可以应用于装置以去除眼睛和接触表面之间的空气，以使眼睛相对于接触装置的位置稳定;以及偏置机构，其可操作地连接到接触装置，用于将接触装置偏压到眼睛上，当眼睛相对于装置通过在眼睛和装置的接触表面之间移除空气而被稳定时，该力足以将接触装置保持抵靠眼睛。

19. 发明申请

US20120076272A1 OCULAR RADIOSURGERY 有权
标题翻译：眼科放射科医师
公开(公告)号：US20120076272A1
公开(公告)日：2012-03-29
申请号：US13311372
申请日：2011-12-05
申请人： Michael GERTNER , Erik CHELL , Steven D. HANSEN , Mark ARNOLDUSSEN , Matt HERRON , Kuang-Hung PAN
发明人： Michael GERTNER , Erik CHELL , Steven D. HANSEN , Mark ARNOLDUSSEN , Matt HERRON , Kuang-Hung PAN
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61B6/506 , A61B2017/306 , A61F9/009 , A61N5/1017 , A61N5/103 , A61N2005/105 , A61N2005/1056 , A61N2005/1091
摘要： A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.
摘要翻译：描述了放射外科系统，其将治疗剂量的辐射递送到患者中的目标结构。在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。在一些实施例中，眼睛结构被放置在基于眼睛成像的全局坐标系中，其导致自动定位系统的方向。在一些实施例中，追踪眼结构的位置并与放射外科系统有关。在一些实施方案中，治疗计划用于待治疗的特定疾病和/或要避免的结构。在一些实施例中，基准有助于定位系统。在一些实施例中，使用眼睛的反射来帮助定位。在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

20. 发明申请

US20110268250A1 ORTHOVOLTAGE RADIOTHERAPY 有权
公开(公告)号：US20110268250A1
公开(公告)日：2011-11-03
申请号：US13180457
申请日：2011-07-11
申请人： Michael Gertner , Steven D. Hansen , Erik Chell , Mark Arnoldussen , Matt Herron
发明人： Michael Gertner , Steven D. Hansen , Erik Chell , Mark Arnoldussen , Matt Herron
IPC分类号： A61N5/10
CPC分类号： A61N5/1067 , A61B6/506 , A61B6/508 , A61N5/10 , A61N5/1001 , A61N5/1017 , A61N5/1045 , A61N5/1048 , A61N5/1049 , A61N5/1064 , A61N5/1065 , A61N5/1077 , A61N5/1084 , A61N2005/1019 , A61N2005/1022 , A61N2005/105 , A61N2005/1051 , A61N2005/1059 , A61N2005/1091 , A61N2005/1097
摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

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