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1. 发明授权

US07801271B2 Methods and devices for orthovoltage ocular radiotherapy and treatment planning 有权
标题翻译：用于正射电眼放疗和治疗计划的方法和装置
公开(公告)号：US07801271B2
公开(公告)日：2010-09-21
申请号：US12262031
申请日：2008-10-30
申请人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Junzhong Liang
发明人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Junzhong Liang
IPC分类号： A61N5/10
CPC分类号： A61N5/1037 , A61N5/1017 , A61N5/103 , A61N5/1064 , A61N2005/1091
摘要： A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.
摘要翻译：公开了一种用于规划治疗患者眼睛或其附近的视网膜上的病变的方法，代码和系统。首先建立至少两个光束路径，X射线将沿着该路径被引导到视网膜损伤处。基于光束的已知光谱和强度特性，确定沿着每个光束路径的照射的总处理时间。从对准的眼睛位置的视神经的坐标，确定眼睛移动远离对准的患者眼睛位置的方向的程度和持续时间沿着将患者的视神经移动到将在治疗期间允许的照射束的方向同时仍然将患者视神经的辐射剂量保持在预定剂量水平以下。

2. 发明申请

US20090161826A1 METHODS AND DEVICES FOR ORTHOVOLTAGE OCULAR RADIOTHERAPY AND TREATMENT PLANNING 有权
标题翻译： OROLOVOLTAGE OCULAR放射治疗与治疗计划的方法和装置
公开(公告)号：US20090161826A1
公开(公告)日：2009-06-25
申请号：US12262031
申请日：2008-10-30
申请人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Junzhong Liang
发明人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Junzhong Liang
IPC分类号： A61N5/10
CPC分类号： A61N5/1037 , A61N5/1017 , A61N5/103 , A61N5/1064 , A61N2005/1091
摘要： A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.
摘要翻译：公开了一种用于规划治疗患者眼睛或其附近的视网膜上的病变的方法，代码和系统。首先建立至少两个光束路径，X射线将沿着该路径被引导到视网膜损伤处。基于光束的已知光谱和强度特性，确定沿着每个光束路径的照射的总处理时间。从对准的眼睛位置的视神经的坐标，确定眼睛移动远离对准的患者眼睛位置的方向的程度和持续时间沿着将患者的视神经移动到将在治疗期间允许的照射束的方向同时仍然将患者视神经的辐射剂量保持在预定剂量水平以下。

3. 发明申请

US20090161827A1 METHODS AND DEVICES FOR DETECTING, CONTROLLING, AND PREDICTING RADIATION DELIVERY 有权
标题翻译：用于检测，控制和预测辐射传送的方法和装置
公开(公告)号：US20090161827A1
公开(公告)日：2009-06-25
申请号：US12338634
申请日：2008-12-18
申请人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Matt Herron , Igor Koruga , Junzhong Liang
发明人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Matt Herron , Igor Koruga , Junzhong Liang
IPC分类号： A61N5/10
CPC分类号： A61N5/1067 , A61F9/008 , A61F2009/00844 , A61F2009/00863 , A61N5/1017 , A61N5/1049 , A61N2005/1059 , A61N2005/1072 , A61N2005/1091
摘要： Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina. Particular methods for controlling radiation in response to motion of the target during treatment are described, such as algorithms for gating or interrupting radiation emission, both to ensure treatment goals and to avoid exposure to sensitive structures.
摘要翻译：实施例提供了用于确定诸如眼睛的患者身体部位（例如眼睛）在诸如放射治疗装置的治疗或诊断装置的外部坐标系中的对准的方法和系统，以便限定用于引导装置操作的参考轴。另外的实施例提供基于图像的方法和系统，用于相对于辐射束轴线对准，跟踪和监测身体部位和治疗目标的运动。特别的眼科实施例提供了包括眼睛接触引导装置和成像系统的方法和系统，用于对准和跟踪眼睛和眼部治疗目标相对于正电压X射线束轴线的运动，以便监测辐射对病变的应用，如视网膜的黄斑病变。描述了在处理期间响应于靶的运动来控制辐射的特定方法，例如用于门控或中断辐射发射的算法，以确保治疗目标并避免暴露于敏感结构。

4. 发明授权

US08503609B2 Methods and devices for detecting, controlling, and predicting radiation delivery 有权
标题翻译：用于检测，控制和预测辐射传播的方法和装置
公开(公告)号：US08503609B2
公开(公告)日：2013-08-06
申请号：US12877032
申请日：2010-09-07
申请人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Matt Herron , Igor Koruga , Junzhong Liang
发明人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Matt Herron , Igor Koruga , Junzhong Liang
IPC分类号： A61N5/10
CPC分类号： A61N5/1067 , A61F9/008 , A61F2009/00844 , A61F2009/00863 , A61N5/1017 , A61N5/1049 , A61N2005/1059 , A61N2005/1072 , A61N2005/1091
摘要： Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina. Particular methods for controlling radiation in response to motion of the target during treatment are described, such as algorithms for gating or interrupting radiation emission, both to ensure treatment goals and to avoid exposure to sensitive structures.
摘要翻译：实施例提供了用于确定诸如眼睛的患者身体部位（例如眼睛）在诸如放射治疗装置的治疗或诊断装置的外部坐标系中的对准的方法和系统，以便限定用于引导装置操作的参考轴。另外的实施例提供基于图像的方法和系统，用于相对于辐射束轴线对准，跟踪和监测身体部位和治疗目标的运动。特别的眼科实施例提供了包括眼睛接触引导装置和成像系统的方法和系统，用于对准和跟踪眼睛和眼部治疗目标相对于正电压X射线束轴线的运动，以便监测辐射对病变的应用，如视网膜的黄斑病变。描述了在处理期间响应于靶的运动来控制辐射的特定方法，例如用于门控或中断辐射发射的算法，以确保治疗目标并避免暴露于敏感结构。

5. 发明授权

US08494116B2 Methods and devices for orthovoltage ocular radiotherapy and treatment planning 有权
公开(公告)号：US08494116B2
公开(公告)日：2013-07-23
申请号：US12887419
申请日：2010-09-21
申请人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Junzhong Liang
发明人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Junzhong Liang
IPC分类号： A61N5/10
CPC分类号： A61N5/1037 , A61N5/1017 , A61N5/103 , A61N5/1064 , A61N2005/1091
摘要： A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.

6. 发明申请

US20110081001A1 METHODS AND DEVICES FOR ORTHOVOLTAGE OCULAR RADIOTHERAPY AND TREATMENT PLANNING 有权
标题翻译： OROLOVOLTAGE OCULAR放射治疗与治疗计划的方法和装置
公开(公告)号：US20110081001A1
公开(公告)日：2011-04-07
申请号：US12887419
申请日：2010-09-21
申请人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Junzhong Liang
发明人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Junzhong Liang
IPC分类号： A61N5/10
CPC分类号： A61N5/1037 , A61N5/1017 , A61N5/103 , A61N5/1064 , A61N2005/1091
摘要： A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.
摘要翻译：公开了一种用于规划治疗患者眼睛或其附近的视网膜上的病变的方法，代码和系统。首先建立至少两个光束路径，X射线将沿着该路径被引导到视网膜损伤处。基于光束的已知光谱和强度特性，确定沿着每个光束路径的照射的总处理时间。从对准的眼睛位置的视神经的坐标，确定眼睛移动远离对准的患者眼睛位置的方向的程度和持续时间沿着将患者的视神经移动到将在治疗期间允许的照射束的方向同时仍然将患者视神经的辐射剂量保持在预定剂量水平以下。

7. 发明申请

US20110081000A1 METHODS AND DEVICES FOR DETECTING, CONTROLLING, AND PREDICTING RADIATION DELIVERY 有权
标题翻译：用于检测，控制和预测辐射传送的方法和装置
公开(公告)号：US20110081000A1
公开(公告)日：2011-04-07
申请号：US12877032
申请日：2010-09-07
申请人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Matt Herron , Igor Koruga , Junzhong Liang
发明人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Matt Herron , Igor Koruga , Junzhong Liang
IPC分类号： A61N5/10
CPC分类号： A61N5/1067 , A61F9/008 , A61F2009/00844 , A61F2009/00863 , A61N5/1017 , A61N5/1049 , A61N2005/1059 , A61N2005/1072 , A61N2005/1091
摘要： Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina. Particular methods for controlling radiation in response to motion of the target during treatment are described, such as algorithms for gating or interrupting radiation emission, both to ensure treatment goals and to avoid exposure to sensitive structures.
摘要翻译：实施例提供了用于确定诸如眼睛的患者身体部位（例如眼睛）在诸如放射治疗装置的治疗或诊断装置的外部坐标系中的对准的方法和系统，以便限定用于引导装置操作的参考轴。另外的实施例提供基于图像的方法和系统，用于相对于辐射束轴线对准，跟踪和监测身体部位和治疗目标的运动。特别的眼科实施例提供了包括眼睛接触引导装置和成像系统的方法和系统，用于对准和跟踪眼睛和眼部治疗目标相对于正电压X射线束轴线的运动，以便监测辐射对病变的应用，如视网膜的黄斑病变。描述了在处理期间响应于靶的运动来控制辐射的特定方法，例如用于门控或中断辐射发射的算法，以确保治疗目标并避免暴露于敏感结构。

8. 发明授权

US07792249B2 Methods and devices for detecting, controlling, and predicting radiation delivery 有权
标题翻译：用于检测，控制和预测辐射传播的方法和装置
公开(公告)号：US07792249B2
公开(公告)日：2010-09-07
申请号：US12338634
申请日：2008-12-18
申请人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Matt Herron , Igor Koruga , Junzhong Liang
发明人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Matt Herron , Igor Koruga , Junzhong Liang
IPC分类号： A61N5/10
CPC分类号： A61N5/1067 , A61F9/008 , A61F2009/00844 , A61F2009/00863 , A61N5/1017 , A61N5/1049 , A61N2005/1059 , A61N2005/1072 , A61N2005/1091
摘要： Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina. Particular methods for controlling radiation in response to motion of the target during treatment are described, such as algorithms for gating or interrupting radiation emission, both to ensure treatment goals and to avoid exposure to sensitive structures.
摘要翻译：实施例提供了用于确定诸如眼睛的患者身体部位（例如眼睛）在诸如放射治疗装置的治疗或诊断装置的外部坐标系中的对准的方法和系统，以便限定用于引导装置操作的参考轴。另外的实施例提供基于图像的方法和系统，用于相对于辐射束轴线对准，跟踪和监测身体部位和治疗目标的运动。特别的眼科实施例提供了包括眼睛接触引导装置和成像系统的方法和系统，用于对准和跟踪眼睛和眼部治疗目标相对于正电压X射线束轴线的运动，以便监测辐射对病变的应用，如视网膜的黄斑病变。描述了在处理期间响应于靶的运动来控制辐射的特定方法，例如用于门控或中断辐射发射的算法，以确保治疗目标并避免暴露于敏感结构。

9. 发明授权

US07978818B2 Orthovoltage radiotherapy 有权
标题翻译：电磁放电
公开(公告)号：US07978818B2
公开(公告)日：2011-07-12
申请号：US12493136
申请日：2009-06-26
申请人： Michael Gertner , Steven D. Hansen , Erik Chell , Mark Arnoldussen , Matt Herron
发明人： Michael Gertner , Steven D. Hansen , Erik Chell , Mark Arnoldussen , Matt Herron
IPC分类号： A61N5/10 , G21K5/08 , A61B6/08
CPC分类号： A61N5/1067 , A61B6/506 , A61B6/508 , A61N5/10 , A61N5/1001 , A61N5/1017 , A61N5/1045 , A61N5/1048 , A61N5/1049 , A61N5/1064 , A61N5/1065 , A61N5/1077 , A61N5/1084 , A61N2005/1019 , A61N2005/1022 , A61N2005/105 , A61N2005/1051 , A61N2005/1059 , A61N2005/1091 , A61N2005/1097
摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilised in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.
摘要翻译：描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。在一些实施方案中，身体的其它病症或组织用辐射剂量治疗。在一些实施例中，目标组织基于眼睛成像被放置在全局坐标系中。在一些实施例中，全局坐标系统内的目标组织导致基于坐标系统内的目标组织定向的自动定位系统的方向。在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。在一些实施方案中，使用基准标记来鉴定靶组织的位置。在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

10. 发明申请

US20100172473A1 OCULAR RADIOSURGERY 有权
标题翻译：眼科放射科医师
公开(公告)号：US20100172473A1
公开(公告)日：2010-07-08
申请号：US12725406
申请日：2010-03-16
申请人： Michael Gertner , Erik Chell , Steven D. Hansen , Mark Arnoldussen , Matt Herron , Kuang-Hung Pan
发明人： Michael Gertner , Erik Chell , Steven D. Hansen , Mark Arnoldussen , Matt Herron , Kuang-Hung Pan
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61B6/506 , A61B2017/306 , A61F9/009 , A61N5/1017 , A61N5/103 , A61N2005/105 , A61N2005/1056 , A61N2005/1091
摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system. In some embodiments, the position of the ocular structure is tracked and related to the status of the radiosurgery system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, the structure is an eye and the eye is tracked by the system. In some embodiments, the eye is held in place and in some embodiments, the eye is fixed by the patient. In some embodiments, a fiducial is placed on the eye to aid in positioning. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.
摘要翻译：描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。在一些实施例中，将眼部结构置于基于眼睛成像的全局坐标系中。在一些实施例中，全局坐标系内的目镜结构导致基于坐标系内的眼睛结构而被引导的自动定位系统的方向。在一些实施例中，跟踪眼结构的位置并且与放射外科手术系统的状态相关。在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。在一些实施例中，结构是眼睛，并且眼睛被系统跟踪。在一些实施例中，眼睛被保持就位，并且在一些实施例中，眼睛被患者固定。在一些实施例中，将基准置于眼睛上以帮助定位。在一些实施例中，使用眼睛的反射来帮助定位。在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后进行递送。

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