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11. 发明授权

US4985596A Process for producing substituted phenoxyethylamines oxime 失效
标题翻译：制备取代苯氧基乙胺肟的方法
公开(公告)号：US4985596A
公开(公告)日：1991-01-15
申请号：US397179
申请日：1989-08-21
申请人： Kikuo Ataka , Koji Imaoka , Kiyotaka Yoshii , Kenji Hirotsu
发明人： Kikuo Ataka , Koji Imaoka , Kiyotaka Yoshii , Kenji Hirotsu
IPC分类号： C07C249/08 , C07C213/02 , C07C249/04 , C07C251/38 , C07C251/40
CPC分类号： C07C213/02 , C07C249/04 , C07C251/38
摘要： A process for producing a substituted phenoxyacetaldehyde oxime of the formula: ##STR1## (wherein R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification), which comprises reacting a substituted phenoxyacetaldehyde dialkylacetal of the formula: ##STR2## (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in the specification) with a hydroxylamine at a pH of from 0.1 to 1.0.

12. 发明授权

US4982008A Process for preparing p-bromophenoxyacetaldehyde dialkylacetal compounds 失效
标题翻译：制备对溴苯氧乙醛二烷基缩醛化合物的方法
公开(公告)号：US4982008A
公开(公告)日：1991-01-01
申请号：US397995
申请日：1989-08-23
申请人： Kikuo Ataka , Masahiko Kohno
发明人： Kikuo Ataka , Masahiko Kohno
IPC分类号： C07C41/48 , C07C43/315 , C07C67/00
CPC分类号： C07C41/48
摘要： There is disclosed a process for preparing a p-bromophenoxyacetaldehyde dialkylacetal derivative represented by the formula: ##STR1## wherein R.sup.1 and R.sup.2 each represent a hydrogen atom or a lower alkyl group and R.sup.3 represents an alkyl group having 1 to 6 carbon atoms,which comprises reacting a bromine to a phenoxyacetaldehyde dialkylacetal represented by the formula: ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 have the same meanings as defined above,and then the reaction mixture is treated with an alkali metal hydroxide or alcoholate dissolved in an alcohol represented by the formula:R.sup.3 OHwherein R.sup.3 has the same meaning as defined above.

13. 发明授权

US4918190A Crystalline complex compounds of propargyl alcohols and tertiary diamines, and process of separation and purification of propargyl alcohols using the same 失效
标题翻译：炔丙醇和叔二胺的结晶复合化合物，以及使用其的炔丙醇的分离和纯化方法
公开(公告)号：US4918190A
公开(公告)日：1990-04-17
申请号：US79821
申请日：1987-07-30
申请人： Fumio Toda , Koichi Tanaka , Kikuo Ataka
发明人： Fumio Toda , Koichi Tanaka , Kikuo Ataka
IPC分类号： C07C29/88 , C07B57/00 , C07C27/00 , C07C29/76 , C07C33/30 , C07C33/48 , C07C67/00 , C07D295/02 , C07D295/03 , C07D487/04
CPC分类号： C07D295/03 , C07C29/76 , C07C33/48 , C07D487/04 , C07B2200/07
摘要： Disclosed are a crystalline complex compound of a propargyl alcohol represented by Formula (I): ##STR1## wherein each of R.sub.1 and R.sub.2 represents a substituent which is different from each otherand a tertiary diamine represented by Formula (II): ##STR2## wherein A represents a group having two carbon atoms as a chain member which may be branched; each of R.sub.3, R.sub.4, R.sub.5 and R.sub.6 may be the same or different and represents an aralkyl group or an alkyl group having 1 to 6 carbon atoms; and A, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 may be bonded to each other,and a process of separation and purification of the propargyl alcohol using the crystalline complex compound described above.
摘要翻译：公开了由式（I）表示的炔丙醇的结晶配位化合物：其中R 1和R 2各自表示彼此不同的取代基和由式（II）表示的叔胺：（II）其中A表示具有两个碳原子的可作为支链的链状成员的基团; R 3，R 4，R 5和R 6可以相同或不同，表示芳烷基或碳原子数1〜6的烷基。并且A，R 3，R 4，R 5和R 6可以彼此键合，并且使用上述结晶复合化合物分离和纯化炔丙醇的方法。

14. 发明授权

US4401830A Process for preparation of 3-alkoxy-4-hydroxyphenylacetic acid 失效
标题翻译： 3-烷氧基-4-羟基苯基乙酸的制备方法
公开(公告)号：US4401830A
公开(公告)日：1983-08-30
申请号：US222155
申请日：1981-01-02
申请人： Sumio Umumura , Fumio Iwata , Kikuo Ataka , Hiroshi Shiraishi
发明人： Sumio Umumura , Fumio Iwata , Kikuo Ataka , Hiroshi Shiraishi
IPC分类号： B01J23/00 , C07B61/00 , C07C51/00 , C07C51/347 , C07C51/367 , C07C59/64 , C07C67/00 , C07C65/01
CPC分类号： C07C59/64 , C07C51/347 , C07C51/367
摘要： 3-Alkoxy-4-hydroxyphenylacetic acid useful as intermediate for preparation of pharmaceuticals is prepared by catalytic reduction with hydrogen using a palladium catalyst of corresponding 3-alkoxy-4-hydroxymandelic acid occurring as the reaction product between 2-alkoxyphenol and glyoxylic acid at high conversion and yield.
摘要翻译：用作制备药物的中间体的3-烷氧基-4-羟基苯基乙酸通过使用在高浓度下作为2-烷氧基苯酚和乙醛酸之间的反应产物而出现的相应的3-烷氧基-4-羟基扁桃酸的钯催化剂通过氢气的还原来制备转化率和产量。

15. 发明申请

US20090192297A1 CARBON MEMBRANE HAVING BIOLOGICAL MOLECULE IMMOBILIZED THEREON 审中-公开
标题翻译：具有生物分子固定化的碳膜
公开(公告)号：US20090192297A1
公开(公告)日：2009-07-30
申请号：US12278066
申请日：2007-02-02
申请人： Youichi Yoshida , Shinichiro Sadaike , Shyusei Ohya , Kikuo Ataka
发明人： Youichi Yoshida , Shinichiro Sadaike , Shyusei Ohya , Kikuo Ataka
IPC分类号： C07K17/14
CPC分类号： C12N11/14 , B01D67/0093 , B01D69/144 , B01D71/021 , B01D2323/30 , H01M4/9083 , H01M8/16 , Y02E60/527
摘要： Disclosed is a biological molecule-immobilized carbon membrane which comprises a porous carbon membrane and a biological molecule (e.g., an enzyme) immobilized on the carbon membrane, wherein the porous carbon membrane has three-dimensional cancellous pores through which fluid can permeate. The carbon membrane can have a large amount of a biological molecule (e.g., an enzyme) immobilized thereon and can also have a higher level of enzymatic activity or the like compared to a conventional one. Therefore, the carbon membrane is useful as an electrode for a bio-sensor or a bio-fuel cell.
摘要翻译：公开了一种生物分子固定的碳膜，其包含多孔碳膜和固定在碳膜上的生物分子（例如酶），其中多孔碳膜具有能够渗透流体的三维松质孔。碳膜可以具有大量固定在其上的生物分子（例如酶），并且与传统的相比可以具有更高水平的酶活性等。因此，碳膜可用作生物传感器或生物燃料电池的电极。

16. 发明授权

US5030755A Process for producing substituted phenoxyethylamines and intermediates 失效
标题翻译：制备取代苯氧基乙胺和中间体的方法
公开(公告)号：US5030755A
公开(公告)日：1991-07-09
申请号：US604757
申请日：1990-10-26
申请人： Kikuo Ataka , Koji Imaoka , Kiyotaka Yoshii , Kenji Hirotsu
发明人： Kikuo Ataka , Koji Imaoka , Kiyotaka Yoshii , Kenji Hirotsu
IPC分类号： C07C249/08 , C07C213/02 , C07C249/04 , C07C251/38 , C07C251/40
CPC分类号： C07C213/02 , C07C249/04 , C07C251/38
摘要： Disclosed are a process for producing a substituted phenoxyacetaldehyde oxime of the formula: ##STR1## (wherein R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification), which comprises allowing a substituted phenoxyacetaldehyde dialkylacetal of the formula: ##STR2## (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in the specification) to react with hydroxylamine; a process for producing a substituted phenoxyethylamine of the formula: ##STR3## (wherein R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification), which comprises reducing a substituted phenoxyacetaldehyde oxime of the formula (II) with hydrogen in the presence of a Raney-nickel catalyst; and a substituted phenoxyacetaldehyde oxime of the formula: ##STR4## (wherein R.sup.1, R.sup.2 and R.sup.6 are as defned in the specification).

17. 发明授权

US4518793A Preparation of acetone dicarboxylic acid diesters 失效
标题翻译：丙酮二羧酸二酯的制备
公开(公告)号：US4518793A
公开(公告)日：1985-05-21
申请号：US542356
申请日：1983-10-17
申请人： Shinichiro Uchiumi , Kikuo Ataka
发明人： Shinichiro Uchiumi , Kikuo Ataka
IPC分类号： B01J27/00 , B01J31/00 , C07B61/00 , C07C69/716 , C07C67/02 , C07C67/36 , C07C67/38
CPC分类号： C07C67/46 , C07C2101/14
摘要： Disclosed is a process for preparing an acetone dicarboxylic acid diester, which comprises allowing diketene, carbon monoxide and a nitrous acid ester to react in the presence of a palladium halide or a complex thereof.
摘要翻译：公开了一种制备丙酮二羧酸二酯的方法，其包括使二烯酮，一氧化碳和亚硝酸酯在卤化钯或其络合物的存在下反应。

18. 发明授权

US06916792B2 Process for preparing erythromycin compound 失效
标题翻译：红霉素化合物的制备方法
公开(公告)号：US06916792B2
公开(公告)日：2005-07-12
申请号：US10480272
申请日：2002-06-12
申请人： Hiroyuki Miyata , Akira Takama , Tatsuya Kawaguchi , Kazuma Sakata , Kikuo Ataka , Masayoshi Oku , Hiroyuki Suenaga
发明人： Hiroyuki Miyata , Akira Takama , Tatsuya Kawaguchi , Kazuma Sakata , Kikuo Ataka , Masayoshi Oku , Hiroyuki Suenaga
IPC分类号： C07H17/08 , A61K31/7048 , A61K31/70
CPC分类号： C07H17/08
摘要： The present invention is to provide a process for producing a 2′-O-acetyl-4″-formyl-8,9-anhydroerythromycin A 6,9-hemiketal compound 4, and it provide a process for producing an erythromycin compound which comprises reacting a formylating agent with a 2′-O-acetylerythromycin A compound 2 to obtain 2-′-O-acetyl-4″-O-formylerythromycin A compound 3, then, acting an acid on Compound 3 to subject to hemiketalation, and then adding an aqueous basic solution in an aqueous solution to precipitate Compound 4 as free crystals.
摘要翻译：本发明提供一种制备2'-O-乙酰基-4'-甲酰基-8,9-脱水红霉素A 6,9-半缩酮化合物4的方法，其提供了一种生产红霉素化合物的方法，其包括使甲酰化试剂与2'-O-乙酰红霉素A化合物2反应，得到2'-乙酰基-4'-O-甲酰基红霉素A化合物3，然后在酸化合物3上进行半缩合反应，然后在水溶液中加入碱性水溶液以将化合物4沉淀为游离结晶。

19. 发明授权

US06414160B1 Process for producing 4-alkoxycarbonyl-2-oxazolidinone compound 失效
标题翻译：制备4-烷氧基羰基-2-恶唑烷酮化合物的方法
公开(公告)号：US06414160B1
公开(公告)日：2002-07-02
申请号：US09480558
申请日：2000-01-10
申请人： Hiroyuki Miyata , Nobuya Satake , Takashi Honma , Kikuo Ataka
发明人： Hiroyuki Miyata , Nobuya Satake , Takashi Honma , Kikuo Ataka
IPC分类号： C07D26338
CPC分类号： C07D263/44 , C07D263/24
摘要： The present invention relates to a process for producing 4-alkoxycarbonyl-2-oxazolidinone compound represented by the formula (III): wherein R1 represents H, an alkyl group, an cycloalkyl group, an alkenyl group or a phenyl group, R2 represents H, an alkyl group, a phenyl group or an alkenyl group, R3 represents an alkyl group, a cycloalkyl group, an alkenyl group, or a phenyl group, and R4 represents H, an alkyl group, an alkenyl group, acycloalkyl group, alkynyl group, an aryl group, a 5- or 6-membered heteroaromatic ring group, an alkoxycarbonyl group, an acetyl group or a benzoyl group, which comprises reacting a 5-alkoxy-2(3H)oxazolone compound represented by the formula (I): wherein R1, R2 and R3 have the same meanings as defined above, and an aldehyde compound represented by the formula (II): R4CHO (II) wherein R4 has the same meaning as defined above, in the presence of a Lewis acid catalyst.
摘要翻译：本发明涉及式（III）表示的4-烷氧基羰基-2-恶唑烷酮化合物的制备方法：其中R1表示H，烷基，环烷基，烯基或苯基，R2表示H，烷基，苯基或烯基，R 3表示烷基，环烷基，烯基或苯基，R 4表示H，烷基，烯基，环烷基，炔基，芳基，5或6元杂芳环，烷氧基羰基，乙酰基或苯甲酰基，其包括使式（I）表示的5-烷氧基-2（3H）恶唑酮化合物：其中 R 1，R 2和R 3具有如上所定义的相同含义，和由式（II）表示的醛化合物：其中R 4具有与上述相同的含义，在路易斯酸催化剂存在下。

20. 发明授权

US06307091B1 Trifluoro-substituted benzoic acid, esters thereof and processes for preparing the same 失效
标题翻译：三氟取代的苯甲酸，其酯及其制备方法
公开(公告)号：US06307091B1
公开(公告)日：2001-10-23
申请号：US09678694
申请日：2000-10-03
申请人： Yasuhito Yamamoto , Yasuhiro Yoneda , Kikuo Ataka , Naoyuki Yokota
发明人： Yasuhito Yamamoto , Yasuhiro Yoneda , Kikuo Ataka , Naoyuki Yokota
IPC分类号： C07C6308
CPC分类号： C07C69/76 , C07C63/70
摘要： The present invention is to provided a trifluoro-substituted benzoic acid, an ester thereof, particularly 2,3,4-trifluoro-5-iodobenzonic acid, 2,3,4-trifluoro-5-trifluoromethylbenzonic acid, esters thereof, which are useful as a starting material for synthesizeing a quinolonecarboxylic acid compound useful as a medicine, an anti-bacterial agent or an antiviral agent, and processes for preparing these compounds and 2,4,5-trifluoro-3-iodobenzonic acid, 2,4,5-trifluoro-3-trifluoromethylbenzoic acid and esters thereof.
摘要翻译：本发明提供三氟取代的苯甲酸，其酯，特别是2,3,4-三氟-5-碘苯甲酸，2,3,4-三氟-5-三氟甲基苯甲酸及其酯，它们是有用的作为合成可用作药物的喹诺酮羧酸化合物的起始原料，抗菌剂或抗病毒剂，以及制备这些化合物的方法和2,4,5-三氟-3-碘苯甲酸，2,4,5 三氟-3-三氟甲基苯甲酸及其酯。

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