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11. 发明申请

US20110288059A1 NEUROACTIVE STEROID COMPOSITIONS AND METHODS OF USE THEREFOR 审中-公开
标题翻译：神经性甾体组合物及其使用方法
公开(公告)号：US20110288059A1
公开(公告)日：2011-11-24
申请号：US13191140
申请日：2011-07-26
申请人： Christine E. Marx , Jed E. Rose
发明人： Christine E. Marx , Jed E. Rose
IPC分类号： A61K31/57 , A61P25/00 , A61P25/08 , A61P25/22 , A61P25/18 , A61K31/56 , A61P25/24
CPC分类号： A61K31/57 , G01N33/6896 , G01N33/94 , G01N2800/304 , Y10T436/200833
摘要： Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder in a subject, methods for ameliorating a symptom of schizophrenia, schizoaffective disorder, or other psychotic disorder in a subject, methods for ameliorating a symptom of a depressive disorder in a subject, methods for ameliorating a symptom of bipolar disorder in a subject, methods for ameliorating a symptom of post-traumatic stress disorder or other anxiety disorder in a subject, methods for predicting a predisposition to suicide, suicidal ideation, suicidal behavior, or a combination thereof in a subject, methods for ameliorating a symptom of a pain disorder in a subject, methods for ameliorating a neurodegenerative disorder in a subject, methods for ameliorating a symptom of traumatic brain injury in a subject, methods for ameliorating a sleep disorder in a subject, and methods for improving cognitive functioning in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.
摘要翻译：提供了改善受试者神经精神障碍症状的方法。还提供了用于改善受试者戒烟所产生的至少一种身体症状或至少一种心理症状的方法，用于改善受试者中阿尔茨海默病或其他认知障碍症状的方法，改善精神分裂症症状的方法，分裂感觉障碍或其他精神病性障碍，用于改善受试者的抑郁症状的方法，改善受试者双相情感障碍症状的方法，改善创伤后应激障碍症状或其他焦虑症状的方法在一个主题中，用于预测受试者的自杀倾向，自杀意念，自杀行为或其组合的方法，改善受试者的疼痛障碍症状的方法，改善受试者的神经变性疾病的方法，方法用于改善受试者的创伤性脑损伤的症状，改善sl的方法受试者的睡眠障碍以及用于改善受试者的认知功能的方法。在一些实施方案中，所述方法包括向有需要的受试者施用有效量的神经活性类固醇组合物，其包含孕烯醇酮（PG），异哌可酮（ALLO），脱氢表雄酮（DHEA），其药学上可接受的盐，其衍生物或其组合。

12. 发明授权

US6083962A Agonist-anatagonist combination to reduce the use of nicotine and other drugs 失效
标题翻译：激动剂 - 拮抗剂组合，以减少尼古丁和其他药物的使用
公开(公告)号：US6083962A
公开(公告)日：2000-07-04
申请号：US891099
申请日：1997-04-10
申请人： Jed E. Rose , Edward D. Levin
发明人： Jed E. Rose , Edward D. Levin
IPC分类号： A24B15/16 , A24B15/18 , A24F47/00 , A61K31/44 , A61K31/465 , A61K47/48
CPC分类号： B82Y5/00 , A24B15/16 , A24B15/165 , A24B15/18 , A24F47/008 , A61K47/48738 , Y10S514/81 , Y10S514/812 , Y10S514/813 , Y10S514/922 , Y10S514/947
摘要： A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or another agonist of the drug in an amount which would normally provide the desired pharmacologic effects and at least partially satiate the needs for the drug by a user. The method also comprises administering to the subject an antagonist to the drug or its other agonist in an amount sufficient to at least partially block the pharmacologic defects of the drug or its other agonist while there is a substantial amount of the drug or other agonist present in the system of the user. In one embodiment of the invention, the drug and the antagonist are administered substantially simultaneously so as to occupy a substantial portion of the receptors of the user for that drug thereby blocking or attenuating the effects of any further intake of the drug or other agonist. In another embodiment, the drug or its other agonist is first administered and the antagonist is self-administered by a subject in a manner which mimics the use of the drug thereby counter-conditioning the drug user to the stimuli associated with the normal administration of the drug. The invention further provides a method of therapeutically treating psychophysiologic diseases and disorders involving neuronal dysregulation. The method additionally provides a pharmacologic composition for the treatment and reduction of drug dependence and which relies upon a combination of an agonist and antagonist.
摘要翻译：提供了治疗和减少药物依赖性的方法，例如尼古丁依赖性。该方法包括首先向受试者施用一定量的药物，例如尼古丁或另一种药物激动剂，其量通常将提供所需的药理作用并且至少部分地满足使用者对药物的需要。该方法还包括以足以至少部分阻断药物或其它激动剂的药理学缺陷的量向受试者施用药物或其它激动剂的拮抗剂，同时存在大量的药物或其它激动剂用户的系统。在本发明的一个实施方案中，基本上同时施用药物和拮抗剂，以占据该药物的使用者的大部分受体，从而阻断或减弱药物或其它激动剂的任何进一步摄入的影响。在另一个实施方案中，首先施用药物或其它激动剂，并且拮抗剂以模仿药物使用的方式由受试者自身给药，从而使药物使用者对与正常给药相关的刺激进行反调节药物。本发明还提供治疗性治疗涉及神经元失调的心理生理疾病和病症的方法。该方法另外提供用于治疗和降低药物依赖性并且依赖于激动剂和拮抗剂的组合的药物组合物。

13. 发明授权

US5746227A Dry powder delivery system 失效
标题翻译：干粉输送系统
公开(公告)号：US5746227A
公开(公告)日：1998-05-05
申请号：US483540
申请日：1995-06-07
申请人： Jed E. Rose , Frederique Behm , James Turner
发明人： Jed E. Rose , Frederique Behm , James Turner
IPC分类号： A24F47/00 , A61K9/00 , A61M15/00 , A61M15/06
CPC分类号： A61K9/007 , A24F47/002 , A61M11/001 , A61M15/00 , A61M15/0006 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M15/06 , A61M2202/062 , A61M2202/064 , Y10T137/5196
摘要： A method for delivering dry powder particles through the mouth of a user, in which a suction is created through an opening in a proximal end of an elongated housing for drawing air into a flow path in the housing from an opening in a distal end of the housing, the distal end including an opening in the housing with a ridge surrounding the housing, and through a resistance member in the housing for introducing a controlled pressure drop in the housing and a resistance to the drawing of air into the mouth of the user. A measured amount of dry powder particles having a therapeutic capability, is introduced into the housing so that the particles will travel downstream from the resistance member at a relatively low velocity in a non-agglomerated state, the dry powder particles being sized and coordinated with the controlled pressure drop so that the particles can be drawn into the mouth of the user and inhaled, with the resistance being sufficiently great that the particles are drawn into the mouth of the user to simulate the action of puffing on a cigarette so that at least some of the particles are deposited in the oral cavity and upper respiratory tract of the user after being drawn into the mouth.
摘要翻译：一种用于将干燥粉末颗粒输送通过使用者口腔的方法，其中通过细长壳体的近端中的开口产生吸力，用于从空腔的远端中的开口将空气吸入壳体中的流动路径所述远端包括在所述壳体中的开口，所述开口具有围绕所述壳体的脊，并且通过所述壳体中的阻力构件，用于在所述壳体中引入受控的压降并且阻止将空气抽吸到所述使用者的口中。将测量量的具有治疗能力的干粉颗粒引入壳体中，使得颗粒将以非聚集状态的相对较低的速度从阻力构件下游移动，干粉颗粒的尺寸和配合与控制的压降使得颗粒可以被吸入使用者的嘴中并被吸入，其阻力足够大，使得颗粒被吸入使用者的口中以模拟在香烟上膨化的作用，使得至少一些的颗粒在吸入口腔后沉积在使用者的口腔和上呼吸道中。

14. 发明授权

US5703101A Agonist-antagonist combination to reduce the use of nicotine and other drugs 失效
标题翻译：激动剂 - 拮抗剂组合，以减少使用尼古丁和其他药物
公开(公告)号：US5703101A
公开(公告)日：1997-12-30
申请号：US570530
申请日：1995-12-11
申请人： Jed E. Rose , Edward D. Levin
发明人： Jed E. Rose , Edward D. Levin
IPC分类号： A24B15/16 , A24B15/18 , A24F47/00 , A61K31/44 , A61K31/465 , A61K47/48
CPC分类号： B82Y5/00 , A24B15/16 , A24B15/165 , A24B15/18 , A24F47/008 , A61K47/48738 , Y10S514/81 , Y10S514/812 , Y10S514/813 , Y10S514/922 , Y10S514/947
摘要： A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or another agonist of the drug in an amount which would normally provide the desired pharmacologic effects and at least partially satiate the needs for the drug by a user. The method also comprises administering to the subject an antagonist to the drug or its other agonist in an amount sufficient to at least partially block the pharmacologic effects of the drug or its other agonist. In one embodiment of the invention, the drug and the antagonist are administered substantially simultaneously so as to occupy a substantial portion of the receptors of the user for that drug thereby blocking or attenuating the effects of any further intake of the drug or other agonist. In another embodiment, the drug or its other agonist is first administered and the antagonist is self-administered by a subject in a manner which mimics the use of the drug thereby counter-conditioning the drug user to the stimuli associated with the normal administration of the drug. The invention further provides a method of therapeutically treating psychophysiologic diseases and disorders involving neuronal dysregulation. The method additionally provides a pharmacologic composition for the treatment and reduction of drug dependence and which relied upon a combination of an agonist and an antagonist.
摘要翻译：提供了治疗和减少药物依赖性的方法，例如尼古丁依赖性。该方法包括首先向受试者施用一定量的药物，例如尼古丁或另一种药物激动剂，其量通常将提供所需的药理作用并且至少部分地满足使用者对药物的需要。该方法还包括以足以至少部分阻断药物或其其它激动剂的药理作用的量向受试者施用药物或其它激动剂的拮抗剂。在本发明的一个实施方案中，基本上同时施用药物和拮抗剂，以占据该药物的使用者的大部分受体，从而阻断或减弱药物或其它激动剂的任何进一步摄入的影响。在另一个实施方案中，首先施用药物或其它激动剂，并且拮抗剂以模仿药物使用的方式由受试者自身给药，从而使药物使用者对与正常给药相关的刺激进行反调节药物。本发明还提供治疗性治疗涉及神经元失调的心理生理疾病和病症的方法。该方法另外提供用于治疗和降低药物依赖性并且依赖于激动剂和拮抗剂的组合的药物组合物。

15. 发明授权

US5687746A Dry powder delivery system 失效
标题翻译：干粉输送系统
公开(公告)号：US5687746A
公开(公告)日：1997-11-18
申请号：US477562
申请日：1995-06-07
申请人： Jed E. Rose , Frederique Behm , James Turner
发明人： Jed E. Rose , Frederique Behm , James Turner
IPC分类号： A24F47/00 , A61K9/00 , A61M15/00 , A61M15/06 , A24B15/16 , A24D1/00
CPC分类号： A61K9/007 , A24F47/002 , A61M11/001 , A61M15/00 , A61M15/0006 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M15/06 , A61M2202/062 , A61M2202/064 , Y10T137/5196
摘要： A dry powder delivery system having an elongated tube containing a matrix having a measured mount of dry particles of therapeutic compound and a porous element having a desiccant therein is disclosed. The porous element with the desiccant can be combined with the powder-containing matrix or it can be two separate elements. The pressure drop induced by inhalation of the user causes air to flow through the tube and into contact with the particles of dry powder for discharging the particles for inhalation by the user.
摘要翻译：公开了一种干粉输送系统，其具有包含具有测量的治疗化合物的干颗粒的基质的基质的细长管和其中具有干燥剂的多孔元件。具有干燥剂的多孔元件可以与含粉末的基质组合，或者它可以是两个分开的元素。吸入使用者引起的压降导致空气流过管并与干粉颗粒接触，用于排出用户吸入的颗粒。

16. 发明授权

US4953572A Method and apparatus for aiding in the reduction of incidence of tobacco smoking 失效
标题翻译：有助于减少吸烟发生率的方法和设备
公开(公告)号：US4953572A
公开(公告)日：1990-09-04
申请号：US157948
申请日：1988-02-19
申请人： Jed E. Rose , Murray E. Jarvik , Karce D. Rose
发明人： Jed E. Rose , Murray E. Jarvik , Karce D. Rose
IPC分类号： A24F47/00 , A61K9/00 , A61K9/70 , A61K31/465
CPC分类号： A61K9/0078 , A24F47/00 , A61K31/465 , A61K9/7084
摘要： A method and a composition for aiding in the reduction of the incidence of tobacco smoking which comprises a method of administering a nicotine containing aerosol spray to the oral cavity of an individual to provide a stimulation to the respiratory tract of the smoker, somewhat similar to that provided by normal tobacco smoke. The method also comprises a composition of a low concentration nicotine aerosol spray in which the spray droplets have a size and a range of between about one micron to about ten microns in diameter and which spray preferably contains nicotine in an amount of about 0.005 miligrams to about 0.03 miligrams per inhilation.
摘要翻译：一种用于帮助减少烟草吸烟发生率的方法和组合物，其包括向个体口腔施用含有尼古丁的气溶胶喷雾剂以对吸烟者的呼吸道提供刺激的方法，其方式和组合物稍微类似于由正常烟草烟雾提供。该方法还包括低浓度尼古丁气溶胶喷雾剂的组合物，其中喷雾液滴具有直径在约1微米至约10微米之间的尺寸和范围，并且该喷雾优选含有约0.005毫克至约每次吸入0.03毫升。

17. 发明授权

US4945928A Smoking of regenerated tobacco smoke 失效
标题翻译：吸烟再生烟草烟雾
公开(公告)号：US4945928A
公开(公告)日：1990-08-07
申请号：US322689
申请日：1989-03-13
申请人： Jed E. Rose
发明人： Jed E. Rose
IPC分类号： A24B15/16 , A24B15/18 , A24F47/00
CPC分类号： B82Y5/00 , A24B15/165 , A24B15/18 , A24F47/008
摘要： A method and apparatus for regenerating tobacco smoke such that certain of the constituents may be smoked upon aerosolization thereof. The method and apparatus relies upon generating smoke from tobacco leaves or other grown plant substances and passing the smoke through a solvent, such as water. Certain of the fluidized components and certain of the gaseous components in the stream of tobacco smoke may then be captured in and preferably dissolved in the solvent. The dissolved or suspended smoke components may then be formed into an aerosol for inhalation by a user. By dissolving selected components in the solvent, many of the harmful gaseous and fluidizided constituents of a smoke stream are eliminated. Moreover, an aerosol is generated such that the particle sizes of the aerosol are sufficiently large that they are predominantly deposited in the upper respiratory tract. In this way, the smoker receives the sensations to which the smoker is normally accustomed from tobacco smoke without many of the harmful side effects of tobacco smoke.
摘要翻译：用于再生烟草烟雾的方法和装置，使得某些组分可以在其雾化时被吸烟。该方法和设备依赖于从烟草叶或其他生长的植物物质产生烟雾并使烟雾通过溶剂如水。然后烟草烟雾流中的某些流化成分和某些气体组分可被捕获并优选溶解在溶剂中。然后可将溶解或悬浮的烟雾成分形成为用于用户吸入的气溶胶。通过将选择的组分溶解在溶剂中，消除烟雾流中许多有害的气体和流体成分。此外，产生气雾剂使得气溶胶的粒度足够大，使得它们主要沉积在上呼吸道中。以这种方式，吸烟者会吸收吸烟者通常习惯于烟草烟雾的感觉，而不会产生烟草烟雾的许多有害副作用。

18. 发明授权

US4715387A Aerosol for use in the reduction of tobacco smoking 失效
标题翻译：用于减少吸烟的气溶胶
公开(公告)号：US4715387A
公开(公告)日：1987-12-29
申请号：US768966
申请日：1985-08-23
申请人： Jed E. Rose
发明人： Jed E. Rose
IPC分类号： A61M15/00 , A24F47/00
CPC分类号： A61M15/00 , A61M11/001 , A61M15/009 , A61M2202/064
摘要： A method and an apparatus and composition used in the reduction of the incidence of tobacco smoking and which comprises an aerosol for application to the oral cavity and respiratory tract of an individual. The aerosol contains a food acid, such as citric acid, which is present in non-toxic amounts and capable of being inhaled. The aerosol may be in the form of a liquid spray or a finely divided solid. The droplets or particles contained in the aerosol are of proper size and have the food acid sufficient in content to simulate the sensations in the upper respiratory tract caused by tobacco smoke. In this way, the oral cavity sensations and the respiratory tract sensations simulate those created by tobacco smoke to replace the need for tobacco smoke. In another embodiment of the invention the food acid aerosol contains tobacco smoke of proper particle size so that the food acid particles migrate to the respiratory tract and the tobacco smoke remains in the oral cavity. In still a further embodiment of the invention, the aerosol contains small particles of a carrier such as a saccharide with tobacco smoke adsorbed thereon. In still another embodiment, the aerosol can be used in combination with a transdermal application of nicotine.
摘要翻译：用于减少吸烟发生率的方法和装置和组合物，其包括用于个体口腔和呼吸道的气溶胶。气溶胶含有食物酸，如柠檬酸，其以无毒量存在且能吸入。气雾剂可以是液体喷雾或细碎固体的形式。气溶胶中包含的液滴或颗粒的尺寸适当，并且具有足够含量的食用酸以模拟由烟草烟雾引起的上呼吸道感觉。以这种方式，口腔感觉和呼吸道感觉模拟由烟草烟产生的那些，以替代烟草烟雾的需要。在本发明的另一个实施方案中，食用酸性气雾剂含有适当粒度的烟草烟雾，使得食物酸性颗粒迁移到呼吸道，并且烟草烟雾保留在口腔中。在本发明的又一个实施方案中，气溶胶含有载体如小型颗粒，例如吸附有烟草烟雾的糖。在另一个实施方案中，气溶胶可以与透皮施用尼古丁组合使用。

19. 发明申请

US20090074677A1 Neuroactive steroid compositions and methods of use therefor 审中-公开
标题翻译：神经活性类固醇组合物及其使用方法
公开(公告)号：US20090074677A1
公开(公告)日：2009-03-19
申请号：US12008259
申请日：2008-01-08
申请人： Christine E. Marx , Jed E. Rose
发明人： Christine E. Marx , Jed E. Rose
IPC分类号： A61K9/12 , A61K31/57 , C12Q1/02 , G01N33/50
CPC分类号： A61K31/57 , G01N33/6896 , G01N33/94 , G01N2800/304 , Y10T436/200833
摘要： Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder in a subject, methods for ameliorating a symptom of schizophrenia, schizoaffective disorder, or other psychotic disorder in a subject, methods for ameliorating a symptom of a depressive disorder in a subject, methods for ameliorating a symptom of bipolar disorder in a subject, methods for ameliorating a symptom of post-traumatic stress disorder or other anxiety disorder in a subject, methods for predicting a predisposition to suicide, suicidal ideation, suicidal behavior, or a combination thereof in a subject, methods for ameliorating a symptom of a pain disorder in a subject, methods for ameliorating a neurodegenerative disorder in a subject, methods for ameliorating a symptom of traumatic brain injury in a subject, methods for ameliorating a sleep disorder in a subject, and methods for improving cognitive functioning in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.
摘要翻译：提供了改善受试者神经精神障碍症状的方法。还提供了用于改善受试者戒烟所产生的至少一种身体症状或至少一种心理症状的方法，用于改善受试者中阿尔茨海默病或其他认知障碍症状的方法，改善精神分裂症症状的方法，分裂感觉障碍或其他精神病性障碍，用于改善受试者的抑郁症状的方法，改善受试者双相情感障碍症状的方法，改善创伤后应激障碍症状或其他焦虑症状的方法在一个主题中，用于预测受试者的自杀倾向，自杀意念，自杀行为或其组合的方法，改善受试者的疼痛障碍症状的方法，改善受试者的神经变性疾病的方法，方法用于改善受试者的创伤性脑损伤的症状，改善sl的方法受试者的睡眠障碍以及用于改善受试者的认知功能的方法。在一些实施方案中，所述方法包括向有需要的受试者施用有效量的神经活性类固醇组合物，其包含孕烯醇酮（PG），异哌可酮（ALLO），脱氢表雄酮（DHEA），其药学上可接受的盐，其衍生物或其组合。

20. 发明授权

US06211194B1 Solution containing nicotine 失效
标题翻译：含尼古丁的溶液
公开(公告)号：US06211194B1
公开(公告)日：2001-04-03
申请号：US09070263
申请日：1998-04-30
申请人： Eric C. Westman , Jed E. Rose , Keith F. Tomlin
发明人： Eric C. Westman , Jed E. Rose , Keith F. Tomlin
IPC分类号： A61K3144
CPC分类号： A61K31/465 , A61K9/0095 , Y10S514/81 , Y10S514/813
摘要： A nicotine method and solution which utilizes an acidic solution containing nicotine. The solution is for use to treat various medical conditions, such as to reduce the need of a user of smoking tobacco to smoke tobacco, to reduce attention deficit disorder symptoms in a person who has attention deficit disorder, and/or to reduce Alzheimer's disease symptoms in a person who has Alzheimer's disease. The solution is palatable and may be introduced into the person by the person drinking it. Subsequent to drinking, the blood plasma levels are sufficient to reduce the need to smoke tobacco, to reduce attention deficit disorder symptoms, and/or to reduce Alzheimer's disease symptoms.
摘要翻译：利用含有尼古丁的酸性溶液的尼古丁法和溶液。该解决方案用于治疗各种医疗状况，例如减少吸烟者吸烟的需要，减少患有注意力缺陷障碍的人的注意力缺陷障碍症状和/或减少阿尔茨海默病症状在有阿尔茨海默病的人中。解决方案是可口的，并且可以由饮用它的人引入人。在饮酒之后，血浆水平足以减少吸烟的需要，减少注意力缺陷障碍症状和/或减少阿尔茨海默病症状。

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