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1. 发明授权

US4953572A Method and apparatus for aiding in the reduction of incidence of tobacco smoking 失效
标题翻译：有助于减少吸烟发生率的方法和设备
公开(公告)号：US4953572A
公开(公告)日：1990-09-04
申请号：US157948
申请日：1988-02-19
申请人： Jed E. Rose , Murray E. Jarvik , Karce D. Rose
发明人： Jed E. Rose , Murray E. Jarvik , Karce D. Rose
IPC分类号： A24F47/00 , A61K9/00 , A61K9/70 , A61K31/465
CPC分类号： A61K9/0078 , A24F47/00 , A61K31/465 , A61K9/7084
摘要： A method and a composition for aiding in the reduction of the incidence of tobacco smoking which comprises a method of administering a nicotine containing aerosol spray to the oral cavity of an individual to provide a stimulation to the respiratory tract of the smoker, somewhat similar to that provided by normal tobacco smoke. The method also comprises a composition of a low concentration nicotine aerosol spray in which the spray droplets have a size and a range of between about one micron to about ten microns in diameter and which spray preferably contains nicotine in an amount of about 0.005 miligrams to about 0.03 miligrams per inhilation.
摘要翻译：一种用于帮助减少烟草吸烟发生率的方法和组合物，其包括向个体口腔施用含有尼古丁的气溶胶喷雾剂以对吸烟者的呼吸道提供刺激的方法，其方式和组合物稍微类似于由正常烟草烟雾提供。该方法还包括低浓度尼古丁气溶胶喷雾剂的组合物，其中喷雾液滴具有直径在约1微米至约10微米之间的尺寸和范围，并且该喷雾优选含有约0.005毫克至约每次吸入0.03毫升。

2. 发明授权

US4920989A Method and apparatus for aiding in the reduction of incidence of tobacco smoking 失效
标题翻译：有助于减少吸烟发生率的方法和设备
公开(公告)号：US4920989A
公开(公告)日：1990-05-01
申请号：US157536
申请日：1988-02-19
申请人： Jed E. Rose , Murray E. Jarvik , Karce D. Rose
发明人： Jed E. Rose , Murray E. Jarvik , Karce D. Rose
IPC分类号： A24F47/00 , A61K9/00 , A61K9/70 , A61K31/465
CPC分类号： A61K9/0078 , A24F47/00 , A61K31/465 , A61K9/7084
摘要： A method of aiding in the reduction of incidence of tobacco smoking. The method comprises applying a patch containing nicotine to the skin of a person with whom smoking reduction is desired and allowing the nicotine to transdermally migrate into the person's bloodstream to achieve a desired systemic nicotine level. The method also comprises the simultaneous administration of a nicotine containing aerosol spray to the oral cavity of the user in order to provide the desired sensations in the respiratory tract to which the user is accustomed from normal tobacco smoke. A combination of the spray and transdermal patch is also provided such that an occlusive patch is applied to the skin of the person with whom smoking reduction is desired and the nicotine containing aerosol spray is delivered to the oral cavity simultaneously with the application of the nicotine from the patch.
摘要翻译：一种有助于减少吸烟发生率的方法。该方法包括将含有尼古丁的贴剂涂覆到需要减少吸烟者的皮肤上，并允许尼古丁经皮移植到人的血液中以达到所需的全身尼古丁水平。该方法还包括向使用者的口腔同时施用含有尼古丁的气溶胶喷雾，以便在用户习惯于正常烟草烟雾的呼吸道中提供期望的感觉。还提供了喷雾和透皮贴剂的组合，使得将闭塞性贴剂应用于需要减少烟草的人的皮肤，并且将含尼古丁的气溶胶喷雾剂与尼古丁的应用同时递送至口腔补丁。

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