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11. 发明授权

US06395508B1 Peptide mixture and products thereof 失效
标题翻译：肽混合物及其产物
公开(公告)号：US06395508B1
公开(公告)日：2002-05-28
申请号：US09316957
申请日：1999-05-24
申请人： Seiichi Shimamura , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Yasushi Kawaguchi , Naoko Isomura , Yoko Akazome , Hiroshi Ochi , Mihoko Kawamoto
发明人： Seiichi Shimamura , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Yasushi Kawaguchi , Naoko Isomura , Yoko Akazome , Hiroshi Ochi , Mihoko Kawamoto
IPC分类号： A23C2102
CPC分类号： A61K38/018 , A23J3/08 , A23J3/343 , A23L33/18 , A61K38/01 , Y10S530/833
摘要： A method for producing a peptide mixture from a starting protein by (1) adding at least one protease to an aqueous solution of at least one starting protein to hydrolyse the starting protein, (2) measuring the amount of a free amino acid selected from the group consisting of lysine, phenylalanine, leucine and arginine produced during the hydrolysis of the starting protein, (3) calculating the amount of the free amino acid with respect to the total amount of amino acid contained in the starting protein, and (4) terminating the hydrolysis when the calculated amount of the free amino acid with respect to the total amount of the amino acid contained in the starting protein falls within a predetermined range. The inventive method provides a starting protein hydrolysate of uniform and consistent quality.
摘要翻译：（1）在至少一种起始蛋白质的水溶液中加入至少一种蛋白酶以水解起始蛋白质的方法，从起始蛋白质制备肽混合物的方法，（2）测量游离氨基酸的量在起始蛋白水解期间产生的赖氨酸，苯丙氨酸，亮氨酸和精氨酸组成的组，（3）计算游离氨基酸相对于起始蛋白质中所含氨基酸总量的量，以及（4）终止当游离氨基酸的计算量相对于起始蛋白质中含有的氨基酸总量的计算量落在预定范围内时，水解。本发明的方法提供均匀且一致质量的起始蛋白质水解产物。

12. 发明授权

US5322836A Bioactive agents, compositions and materials comprising said bioactive agents 失效
标题翻译：包含所述生物活性剂的生物活性剂，组合物和材料
公开(公告)号：US5322836A
公开(公告)日：1994-06-21
申请号：US917693
申请日：1991-03-06
申请人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
发明人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
IPC分类号： A61K38/16 , A23C9/123 , A23K1/16 , A23L1/30 , A61K38/00 , A61P1/12 , C07K14/79 , C12N1/20 , C12N1/38 , C12R1/01 , A61K37/14 , A23C9/12 , A23C17/00
CPC分类号： C12N1/38 , A23C9/1234 , A23K20/147 , C07K14/79 , A61K38/00 , Y10S530/832
摘要： Bioactive agents, having growth-promoting activity upon Bifidobacteria, consisting of one or more lactoferrin-compounds selected from the group consisting of bovine lactoferrin, bovine apolactoferrin and bovine Fe-lactoferrin, which can be used as it is as agents to promote proliferation of Bifidobacteria both in vivo and in vitro, and as additives to prepare compositions, materials and products to afford growth-promoting activity thereto, and to improve survivability of Bifidobacteria, if contained therein.
摘要翻译：由双歧杆菌生长促进活性的生物活性剂，由一种或多种选自牛乳铁蛋白，牛非球蛋白铁和牛铁铁乳蛋白的乳铁蛋白化合物组成，可作为促进双歧杆菌增殖的药剂以及用作制备组合物，材料和产品以提供生长促进活性的添加剂，以及如果其中包含双歧杆菌的生存能力的添加剂。

13. 发明授权

US5214028A Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent 失效
标题翻译：用作抗菌剂和作为酪氨酸酶抑制剂的LACTOFERRIN水解产物
公开(公告)号：US5214028A
公开(公告)日：1993-05-25
申请号：US634763
申请日：1990-12-27
申请人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
发明人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
IPC分类号： A01N63/02 , A23J3/32 , A23J3/34 , A23L3/3526 , A61K8/64 , A61K38/01 , A61Q19/02
CPC分类号： A61Q17/005 , A01N63/02 , A23J3/32 , A23J3/343 , A23L3/3526 , A61K38/40 , A61K8/64 , A61Q19/02 , A61K2800/782
摘要： Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent and which have remarkly more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.

14. 发明授权

US07424391B2 Period division statistics device, method, and program product 有权
标题翻译：期间统计设备，方法和程序产品
公开(公告)号：US07424391B2
公开(公告)日：2008-09-09
申请号：US11603621
申请日：2006-11-21
申请人： Makoto Muranaka , Hiroshi Miyakawa , Shinya Nishikawa , Maria Kita , Daisaku Tanaka
发明人： Makoto Muranaka , Hiroshi Miyakawa , Shinya Nishikawa , Maria Kita , Daisaku Tanaka
IPC分类号： G06F17/18
CPC分类号： G06Q10/10
摘要： A statistics system stores inputted statistical target information into storage. When each unit time period defined in a statistical calculation rule expires, the statistics system reads all pieces of statistical target information whose occurrence times are contained in the unit time period from storage, executes statistical calculation, and registers the statistical result to the statistical information in storage. When statistical target information is inputted, the statistics system sets a re-calculation flag to a unit time period including the occurrence time shown by the statistical target information among the respective unit time periods whose statistical results are registered in the statistical information. The statistics system reads all pieces of the statistical target information whose occurrence times are contained in the unit time period from storage for each of the flagged unit time periods, re-executing the statistical calculation, and overwrites the statistical result onto the information in storage.
摘要翻译：统计系统将输入的统计目标信息存储到存储器中。当统计计算规则中定义的每个单位时间段到期时，统计系统从存储单元读取单位时间内包含发生次数的所有统计目标信息，执行统计计算，并将统计结果登记到统计信息中存储。当输入统计目标信息时，统计系统将统计结果登记在统计信息中的各个单位时间段内的统计目标信息所显示的发生时间设定为单位时间。统计系统从每个标记单位时间段的存储单位时间内读出其发生次数所包含的所有统计目标信息，重新执行统计计算，并将统计结果重写到存储信息中。

15. 发明申请

US20070223522A1 Period division statistics device, method, and program product 有权
标题翻译：期间统计设备，方法和程序产品
公开(公告)号：US20070223522A1
公开(公告)日：2007-09-27
申请号：US11603621
申请日：2006-11-21
申请人： Makoto Muranaka , Hiroshi Miyakawa , Shinya Nishikawa , Maria Kita , Daisaku Tanaka
发明人： Makoto Muranaka , Hiroshi Miyakawa , Shinya Nishikawa , Maria Kita , Daisaku Tanaka
IPC分类号： H04J3/22
CPC分类号： G06Q10/10
摘要： A statistics system stores inputted statistical target information into storage. When each unit time period defined in a statistical calculation rule expires, the statistics system reads all pieces of statistical target information whose occurrence times are contained in the unit time period from the storage, executes statistical calculation, and registers the statistical result to the statistical information in the storage. When statistical target information is inputted, the statistics system sets a re-calculation flag to a unit time period including the occurrence time shown by the statistical target information among the respective unit time periods whose statistical results are registered in the statistical information. The statistics system reads all pieces of the statistical target information whose occurrence times are contained in the unit time period from the storage for each of the flagged unit time periods, re-executing the statistical calculation, and overwrites the statistical result onto the information in the storage.
摘要翻译：统计系统将输入的统计目标信息存储到存储器中。当统计计算规则中定义的每个单位时间段到期时，统计系统从存储单元读取单位时间内包含发生次数的所有统计目标信息，执行统计计算，并将统计结果登记到统计信息在存储中。当输入统计目标信息时，统计系统将统计结果登记在统计信息中的各个单位时间段内的统计目标信息所显示的发生时间设定为单位时间。统计系统从针对每个标记单位时间段的存储中读出在单位时间段内包含发生次数的所有统计目标信息，重新执行统计计算，并将统计结果重写为存储。

16. 发明授权

US06299928B1 Fine granular feeds for fry 有权
标题翻译：细粒饲料用于油炸
公开(公告)号：US06299928B1
公开(公告)日：2001-10-09
申请号：US09623503
申请日：2000-09-19
申请人： Toshio Takeuchi , Hirotoshi Hayasawa , Tsutomu Kudo , Hiroshi Miyakawa , Akio Yamada , Naomichi Okuma , Waichi Ishizuka , Shuzo Ishida
发明人： Toshio Takeuchi , Hirotoshi Hayasawa , Tsutomu Kudo , Hiroshi Miyakawa , Akio Yamada , Naomichi Okuma , Waichi Ishizuka , Shuzo Ishida
IPC分类号： A23J300
CPC分类号： A23K50/80 , A23K10/33 , A23K20/142 , A23K20/147 , A23K20/158 , A23K40/10 , Y02P60/871 , Y10S426/805
摘要： Fine granular feeds for fry of fishes and shellfishes capable of remarkably elevating the survival rate of fry, improving the cultivation efficiency, and causing little elution of nitrogen sources therefrom into seawater or water in feeding, which are characterized by containing at least three active components, i.e., (a) a long-chain unsaturated fatty acid calcium salt blend comprising 80% by weight or more of long-chain unsaturated fatty acid calcium salt(s) having at least 18 carbon atoms, (b) 20% by weight or less of a browned matter formed by heating molasses or saccharides, a browned matter formed by heating saccharides with amino acids or a mixture thereof at an arbitrary ratio, and (c) a mixture of peptides obtained by hydrolyzing animal protein, and being in the form of fine grains.
摘要翻译：用于鱼类和贝类的鱼粒和贝类的细粒状饲料能够显着提高鱼苗的存活率，提高培养效率，并且使得氮源从其中进入海水或进料中的水几乎不被洗脱，其特征在于含有至少三种活性成分，即（a）包含80重量％以上具有至少18个碳原子的长链不饱和脂肪酸钙盐的长链不饱和脂肪酸钙盐混合物，（b）20重量％以下通过加热糖蜜或糖形成的褐变物质，通过以任意比例用氨基酸或其混合物加热糖形成的褐变物质，和（c）通过水解动物蛋白质获得的肽的混合物，并且以细粒。

17. 发明授权

US5952193A Peptide mixture and products thereof 失效
标题翻译：肽混合物及其产物
公开(公告)号：US5952193A
公开(公告)日：1999-09-14
申请号：US817095
申请日：1997-04-14
申请人： Seiichi Shimamura , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Yasushi Kawaguchi , Naoko Isomura , Yoko Akazome , Hiroshi Ochi , Mihoko Kawamoto
发明人： Seiichi Shimamura , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Yasushi Kawaguchi , Naoko Isomura , Yoko Akazome , Hiroshi Ochi , Mihoko Kawamoto
IPC分类号： A23J3/08 , A23J3/34 , A23L1/305 , A61K38/01 , A23C21/02 , A23C21/04 , A23C21/06
CPC分类号： A61K38/018 , A23J3/08 , A23J3/343 , A23L33/18 , A61K38/01 , Y10S530/833
摘要： A method for producing a peptide mixture from whey protein by (1) adding at least one protease to an aqueous solution of at least one whey protein to hydrolyze the whey protein, (2) measuring the amount of a free amino acid selected from the group consisting of lysine, phenylalanine, leucine and arginine produced during the hydrolysis of the whey protein, (3) calculating the amount of the free amino acid with respect to the total amount of the amino acid contained in the whey protein, and (4) terminating the hydrolysis when the calculated amount of the free amino acid with respect to the total amount of the amino acid contained in the whey protein falls within a predetermined range. The inventive method provides a whey protein hydrolysate of consistent quality.
摘要翻译： PCT No.PCT / JP95 / 02109 Sec。 371日期1997年04月14日 102（e）1997年4月14日PCT 1995年10月13日PCT PCT。公开号WO96 / 11584 日期：1996年04月25日（一）通过（1）向至少一种乳清蛋白的水溶液中加入至少一种蛋白酶以水解乳清蛋白，从乳清蛋白制备肽混合物的方法，（2）测量游离氨基选自在乳清蛋白水解期间产生的赖氨酸，苯丙氨酸，亮氨酸和精氨酸的酸，（3）计算游离氨基酸相对于乳清蛋白中所含氨基酸总量的量，和（4）当游离氨基酸的计算量相对于乳清蛋白中所含氨基酸总量的计算量落在预定范围内时，终止水解。本发明的方法提供了质量一致的乳清蛋白水解产物。

18. 发明授权

US5296464A Bioactive agents and compositions for materials comprising the bioactive agent and a method for treating materials therewith 失效
标题翻译：用于包含生物活性剂的材料的生物活性剂和组合物以及用于处理材料的方法
公开(公告)号：US5296464A
公开(公告)日：1994-03-22
申请号：US780535
申请日：1991-10-21
申请人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
发明人： Mamoru Tomita , Seiichi Shimamura , Yasuo Fukuwatari , Hiroshi Miyakawa , Hitoshi Saito
IPC分类号： A01N63/02 , A23C9/152 , A23J1/20 , A23K1/16 , A23K1/175 , A23L3/3463 , A23L3/3526 , A61K38/00 , C07K14/79 , A61K37/14 , C07K15/22 , C12N1/38
CPC分类号： C07K14/79 , A01N63/02 , A23C9/1522 , A23J1/20 , A23K20/147 , A23K20/30 , A23L3/3463 , A23L3/3526 , A61K38/00
摘要： Bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin and having selective biological activities, i.e. growth-inhibitory activity against certain harmful microorganisms on one hand and growth-promoting activity upon certain useful microorganisms on the other hand; as well as compositions, products or materials therefor comprising the bioactive agents consisting of one or more lactoferrin-compounds selected from the group; and a method for treating materials, which are edible for human beings or animals or which are applicable to a portion of body of human beings or animals, with the bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin or the compositions comprising the bioactive agent consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin as an effective component.
摘要翻译：由选自Zn-，Cu-和Mn-乳铁蛋白的一种或多种乳铁蛋白化合物组成并具有选择性生物活性的生物活性剂，即一方面对某些有害微生物的生长抑制活性，以及一定程度上的生长促进活性另一方面有用的微生物; 以及其组合物，产品或材料，其包含由选自该组的一种或多种乳铁蛋白化合物组成的生物活性剂; 以及用于处理可用于人类或动物或适用于人或动物的一部分身体的材料的方法，所述生物活性剂由一种或多种选自以下的乳铁蛋白化合物组成：Zn- ，Cu-和Mn-乳铁蛋白或包含由一种或多种选自Zn-，Cu-和Mn-乳铁蛋白作为有效成分的乳铁蛋白化合物组成的生物活性剂的组合物。

19. 发明授权

US4985246A Composition of feedstuff 失效
标题翻译：饲料组成
公开(公告)号：US4985246A
公开(公告)日：1991-01-15
申请号：US924763
申请日：1986-10-30
申请人： Shigeo Okonogi , Mamoru Tomita , Seiichi Shimamura , Toshio Tomimura , Norio Ishibashi , Hiroshi Miyakawa , Koichi Sugawara
发明人： Shigeo Okonogi , Mamoru Tomita , Seiichi Shimamura , Toshio Tomimura , Norio Ishibashi , Hiroshi Miyakawa , Koichi Sugawara
IPC分类号： A23K1/16 , A23K1/00 , A61K35/74
CPC分类号： A23K10/10
摘要： A composition of feedstuff containing at least 0.5 wt. %, in solid content, of residual liquid of incubated culture broth of Bifido-bacteria and/or lactic acid bacteria which residual liquid is obtainable as the waste by-product of mass production of living or viable cell mass of the microorganisms by substantially excluding microbial cell mass from the incubated culture broth thereof.
摘要翻译：饲料的组合物含有至少0.5wt。％的固体含量的双歧杆菌和/或乳酸菌的培养培养液的残留液体，残留的液体作为大量生产微生物的活细胞或活细胞块的废弃副产物，通过基本排除微生物来自其培养的培养液的细胞质量。

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