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151. 发明申请

US20130034880A1 CHAMBER FREE NANOREACTOR SYSTEM 有权
标题翻译：无框架NANOREACTOR系统
公开(公告)号：US20130034880A1
公开(公告)日：2013-02-07
申请号：US13481858
申请日：2012-05-27
申请人： Mark F. Oldham
发明人： Mark F. Oldham
IPC分类号： C12P19/34 , C12M1/34
CPC分类号： C12Q1/6874 , B01L3/502738 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2200/0668 , B01L2200/0689 , B01L2200/10 , B01L2300/0645 , B01L2300/0816 , B01L2300/0887 , B01L2300/089 , B01L2300/12 , B01L2300/123 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B01L2400/0424 , B01L2400/0427 , B01L2400/043 , B01L2400/0478 , B01L2400/0655 , B03C1/286 , B03C1/288 , B03C1/30 , B03C5/005 , B03C5/022 , B03C5/026 , B03C2201/26 , C12Q1/6848 , C12Q1/6853 , C12Q1/6869 , C40B60/10 , G01N1/40 , G01N27/4145 , G01N27/4146 , G01N33/5438 , G01N2001/4038 , H01L29/00 , C12Q2523/307 , C12Q2563/143 , C12Q2565/543 , C12Q2563/116 , C12Q2565/607
摘要： Aspects of the invention include methods for improving the accuracy and read length of sequencing reactions by utilizing unlabeled unincorporable nucleotides, or by rephasing colony based sequencing reactions. Other aspects include systems and devices for improved measurement of biological reactions associated with bead which may be removed, utilizing current measurement methods through the counter ions associated with said beads due to the presence of reactants bound or associated with said bead, wherein electrodes for generating and measuring said current may be within the Debye length of said bead. Other aspects of the invention include methods for determining concentrations of input samples, means for reuse of an array, methods and apparatus for separating beads with different charge levels from each other.
摘要翻译：本发明的方面包括通过利用未标记的非可合并核苷酸或通过重新构建基于集落的测序反应来提高测序反应的准确性和读取长度的方法。其他方面包括用于改进与珠粒相关的生物反应测量的系统和装置，其可以通过与所述珠粒相关联的抗衡离子的电流测量方法，由于存在与所述珠粒结合或相关联的反应物，其中用于产生和测量所述电流可以在所述焊道的德拜长度内。本发明的其它方面包括用于确定输入样品的浓度的方法，用于重复使用阵列的装置，用于分离具有不同电荷水平的珠子的方法和装置。

152. 发明授权

US08349179B2 System for conditioning fluids utilizing a magnetic fluid processor 有权
标题翻译：利用磁性流体处理器调节流体的系统
公开(公告)号：US08349179B2
公开(公告)日：2013-01-08
申请号：US13488060
申请日：2012-06-04
申请人： William Steven Lopes
发明人： William Steven Lopes
IPC分类号： C02F1/48 , B01D35/06
CPC分类号： B03C1/286 , B03C1/30 , B03C2201/18 , B03C2201/32 , Y02W10/37
摘要： The invention is a system and method for conditioning fluids utilizing a magnetic fluid processor or device that includes an elongated housing comprising a core enclosed by a magnetic component in combination with an electrical return path. The process utilizes said device to affect and electron configuration within fluids by generating a magnetic field, thereby separating, for example, metals and organic or inorganic materials from fluids, in order to achieve desired fluid composition and properties.
摘要翻译：本发明是一种使用磁性流体处理器或装置来调节流体的系统和方法，所述磁性流体处理器或装置包括细长壳体，所述细长壳体包括由磁性部件包围的芯体和电气返回路径。该方法利用所述装置通过产生磁场来影响流体内的电子结构，从而例如从流体中分离出金属和有机或无机材料，以便实现所需的流体组成和性质。

153. 发明申请

US20120325726A1 IRON ORE SEPARATION DEVICE 有权
标题翻译：铁矿石分离装置
公开(公告)号：US20120325726A1
公开(公告)日：2012-12-27
申请号：US13452420
申请日：2012-04-20
申请人： Lucas Lehtinen , Shawn Henriksen , David Chappie , Travis Edward Cunningham , Danilo Bibancos
发明人： Lucas Lehtinen , Shawn Henriksen , David Chappie , Travis Edward Cunningham , Danilo Bibancos
IPC分类号： B03C1/02 , B03C1/30
CPC分类号： B03C1/286 , B03C1/03 , B03C2201/18
摘要： Slurries of magnetic and nonmagnetic particles in water are treated in a high intensity magnetic separator including at least one turntable that defines at least one circular channel therethrough in which a matrix material is positioned. Rotation of the turntable in a generally horizontal plane about a generally vertical virtual axis causes the circular channel(s) to rotate through a plurality of magnetic and nonmagnetic zones generated by magnet members. Treatment slurry is directed into the channel(s) in one or more of the magnetic zones as the turntable rotates. A tailings fraction passing through the channel(s) in a generally downward direction in the magnetic zones is collected in tailings launders. Magnetic particles attracted to the matrix material in the magnetic zones remain in the channel(s) until they pass into an adjacent nonmagnetic zone, where the magnetic particles are washed from the channel(s) into concentrate launders.
摘要翻译：在水中的磁性和非磁性颗粒的浆液在高强度的磁选机中进行处理，其包括至少一个限定了至少一个通过其中的基本材料定位的圆形通道的转台。转盘在大致水平的平面中围绕大致竖直的虚拟轴线的旋转导致圆形通道旋转穿过由磁性部件产生的多个磁性和非磁性区域。当转台旋转时，处理浆料被引导到一个或多个磁区中的通道中。在磁性区域中通常通过通道（一个或多个）通常向下的尾矿馏分被收集在尾矿清洗机中。吸引到磁性区域中的基质材料的磁性颗粒保留在通道中，直到它们进入相邻的非磁性区域，其中磁性颗粒从通道洗涤成浓缩洗涤剂。

154. 发明申请

US20120315639A1 METHOD AND APPARATUS FOR SINGLE CELL ISOLATION AND ANALYSIS 审中-公开
标题翻译：用于单细胞分离和分析的方法和装置
公开(公告)号：US20120315639A1
公开(公告)日：2012-12-13
申请号：US13483422
申请日：2012-05-30
申请人： GLENN YAGUANG DENG , Jie Zhang , Fang Tian
发明人： GLENN YAGUANG DENG , Jie Zhang , Fang Tian
IPC分类号： G01N33/574 , C12Q1/68 , C12M1/42 , G01N33/566
CPC分类号： G01N33/54333 , B03C1/0332 , B03C1/0335 , B03C1/284 , B03C1/286 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N33/538
摘要： A method and apparatus are disclosed here for rare target cell enrichment and isolation, where the captured target cells can be individually picked up and used for downstream analysis. This method and apparatus utilize antibodies conjugated microbeads to isolate target cells, use ON/OFF controls for the target cell capturing magnet and the release magnet, such that there is no need to change the cap of the capturing magnet and thus enabling automatic multiple rounds of capturing, washing and releasing cycles to increase the target cell detection sensitivity and reproducibility. A special filter is utilized to effectively remove more than 95% of free unbound microbeads, thus significantly improving the purity of the collected target cells and increasing the data quality of downstream analysis of the single target cells. Lastly, RNA expression patterns are proposed for identifying of certain target cells (e.g. circulating tumor cells and white blood cells).
摘要翻译：这里公开了用于稀有靶细胞富集和分离的方法和装置，其中捕获的靶细胞可以单独拾取并用于下游分析。该方法和装置利用抗体缀合的微珠来分离靶细胞，使用靶细胞捕获磁体和释放磁体的ON / OFF控制，使得不需要改变捕获磁体的盖，因此使得能够自动多轮捕获，洗涤和释放循环以增加靶细胞检测灵敏度和再现性。利用特殊的过滤器有效去除95％以上的游离的未结合微珠，从而显着提高收集靶细胞的纯度，提高单靶细胞下游分析的数据质量。最后，提出RNA表达模式用于鉴定某些靶细胞（例如循环肿瘤细胞和白细胞）。

155. 发明申请

US20120204910A1 DEVICE AND METHOD FOR RECOVERING MAGNETIC PARTICLES TRAPPED ON A MAGNETIC PLUG 有权
标题翻译：用于回收磁性片上的磁性颗粒的装置和方法
公开(公告)号：US20120204910A1
公开(公告)日：2012-08-16
申请号：US13504277
申请日：2010-10-22
申请人： Fabrice Colladon
发明人： Fabrice Colladon
IPC分类号： B08B5/00
CPC分类号： B03C1/284 , B03C1/032 , B03C1/286
摘要： A device for recovering magnetic particles trapped on a magnetic plug, which includes a supporting end and a magnetized element for retaining the magnetic particles in a liquid resulting from the wear of parts with which the liquid has been in contact, the recovery device including a magnetization device and an enclosure having an opening, the enclosure to receive the magnetic plug via the opening such that the magnetized element is located inside the enclosure and the supporting end is located outside the enclosure. The opening is sized such that the supporting end blocks the opening. The device also includes an injection nozzle to inject a gaseous fluid inside the enclosure, the nozzle being oriented such that the flow of gaseous fluid expels the magnetic particles retained on the magnetized element toward the bottom of the enclosure. The magnetization device traps the particles urged toward the bottom of the enclosure.
摘要翻译：一种用于回收被捕获在磁性塞子上的磁性颗粒的装置，该装置包括支撑端和用于将磁性颗粒保持在由液体已经接触的部件的磨损所导致的液体中的磁化元件，该恢复装置包括磁化装置和具有开口的外壳，所述外壳经由所述开口接收所述磁性塞，使得所述磁化元件位于所述外壳内并且所述支撑端位于所述外壳外部。开口的尺寸使得支撑端阻挡开口。该装置还包括注射喷嘴以在壳体内注入气体流体，喷嘴被定向为使得气态流体流将保留在磁化元件上的磁性颗粒朝向外壳的底部排出。磁化装置捕获朝外壳的底部被推动的颗粒。

156. 发明申请

US20120165551A1 Process and Apparatus for Online Rejuvenation of Contaminated Sulfolane Solvent 有权
标题翻译：污染环丁砜溶剂的在线再生过程和设备
公开(公告)号：US20120165551A1
公开(公告)日：2012-06-28
申请号：US13345359
申请日：2012-01-06
申请人： Ping-Wen Yen , Yuh-Sheve Ho , Hung-Tzu Chiu , Chung-Jong Hwu , June-Cheng Chang , Tzong-Bin Lin , Tsung Y. Yan , Cheng-Tsung Hong , Hung-Chung Shen
发明人： Ping-Wen Yen , Yuh-Sheve Ho , Hung-Tzu Chiu , Chung-Jong Hwu , June-Cheng Chang , Tzong-Bin Lin , Tsung Y. Yan , Cheng-Tsung Hong , Hung-Chung Shen
IPC分类号： C07D333/48 , B03C1/32
CPC分类号： B03C1/015 , B01D29/23 , B01D35/06 , B03C1/0332 , B03C1/286 , C10G21/28
摘要： A continuous online process for rejuvenating whole stream of contaminated lean sulfolane in an extraction system is provided. A rejuvenator is installed in the solvent circulation loop to remove the contaminants continuously to keep the solvent clean, effective and less corrosive. The rejuvenator includes a high pressure vessel with a removable cover and a round rack with vertical stainless steel tubes fitted in the high pressure vessel. A magnetic bar is placed in each stainless steel tube. A screen cylinder is installed outside the ring of stainless steel tubes. As the contaminated sulfolane is passed through the rejuvenator, the rejuvenator picks up contaminants. The rejuvenator can be dissembled to remove the contaminants periodically. The rejuvenator is simple in construction, reliable in operation, and low in operation and maintenance costs. With this rejuvenator, the extraction system operates at high efficiency and high capacity without the dreaded corrosion.
摘要翻译：提供了一个连续的在线过程，用于在提取系统中恢复受污染的贫环烷砜的全流。清洁剂安装在溶剂循环回路中，以连续除去污染物，保持溶剂清洁，有效，腐蚀性较差。复原器包括一个带有可拆卸盖的高压容器和一个安装在高压容器中的垂直不锈钢管的圆形支架。在每个不锈钢管中放置一个磁棒。丝网筒安装在不锈钢管外面。当受污染的环丁砜通过复原器时，复原器会吸收污染物。可以拆除复原器以定期去除污染物。振兴机构施工简单，运行可靠，运行维护成本低。采用这种复原机，提取系统运行效率高，容量大，无腐蚀。

157. 发明授权

US08186317B2 Hydraulic fluid passage with particle gettering magnet field of the invention 有权
标题翻译：带有吸气磁体的液压流体通道
公开(公告)号：US08186317B2
公开(公告)日：2012-05-29
申请号：US12653869
申请日：2009-12-21
申请人： Hamid Najmolhoda , David Seid
发明人： Hamid Najmolhoda , David Seid
IPC分类号： F01L9/02
CPC分类号： F16K31/0613 , B03C1/286 , F15B21/041 , Y10T137/794
摘要： Combination of a housing having a fluid passage and one or more solenoid actuated fluid control valves communicated to the fluid passage wherein a permanent magnet is disposed in fluid passage upstream of the fluid control valves to magnetically capture or getter ferrous particles in fluid prior to entry into the fluid control valve.
摘要翻译：具有流体通道的壳体和连通到流体通道的一个或多个螺线管致动的流体控制阀的组合，其中永久磁体设置在流体控制阀的上游的流体通道中，以在进入流体控制阀之前磁性捕获或吸入含铁颗粒的流体流体控制阀。

158. 发明申请

US20120122731A1 Screening molecular libraries using microfluidic devices 审中-公开
标题翻译：使用微流体装置筛选分子库
公开(公告)号：US20120122731A1
公开(公告)日：2012-05-17
申请号：US11655055
申请日：2007-01-17
申请人： Hyongsok Soh , Patrick Sean Daugherty , Sang-Hyun Oh
发明人： Hyongsok Soh , Patrick Sean Daugherty , Sang-Hyun Oh
IPC分类号： C40B30/10 , C40B60/12
CPC分类号： B03C1/286 , B01J2219/005 , B01J2219/00563 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00648 , B01J2219/00655 , B01J2219/00707 , B01L3/502761 , B01L3/502776 , B01L2200/0652 , B01L2300/0864 , B01L2400/043 , B01L2400/0487 , B03C1/30 , B03C2201/18
摘要： Screening in a microfluidic device is mediated by a magnetic field that in some manner displaces or otherwise activates the entities of interest. Entities of interest can be identified and/or separated from one or more other components provided to the microfluidic device. Microfluidic devices may have mechanisms that apply a defined magnetic field to a region of the microfluidic device where library members pass through sequentially and/or in parallel.
摘要翻译：在微流体装置中的筛选由磁场介导，磁场以某种方式置换或以其他方式激活感兴趣的实体。感兴趣的实体可以被识别和/或从提供给微流体装置的一个或多个其它组件分离。微流体装置可以具有将定义的磁场施加到微流体装置的区域的机制，其中库构件顺序地和/或并行穿过。

159. 发明授权

US08084271B2 Method and a device for treating microparticles 有权
标题翻译：方法和处理微粒的装置
公开(公告)号：US08084271B2
公开(公告)日：2011-12-27
申请号：US10576297
申请日：2004-10-20
申请人： Matti Korpela , Kenneth Rundt
发明人： Matti Korpela , Kenneth Rundt
IPC分类号： G01N1/18
CPC分类号： G01N1/28 , B03C1/286 , B03C2201/18 , B03C2201/26 , G01N33/54326 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： Method for handling microparticles in such a manner, that at least two treatment steps are performed for microparticles in the same vessel without moving the particles to another vessel. There are organs in the device for changing the solution without having to move the microparticles to another vessel.
摘要翻译：以这样的方式处理微粒的方法，即对同一容器中的微粒进行至少两个处理步骤，而不将颗粒移动到另一个容器。在用于改变溶液的装置中存在器官，而不必将微粒移动到另一个容器。

160. 发明申请

US20110278231A1 METHOD AND APPARATUS FOR PROCESSING MIXTURE 有权
标题翻译：处理混合物的方法和装置
公开(公告)号：US20110278231A1
公开(公告)日：2011-11-17
申请号：US13146134
申请日：2010-01-22
申请人： Shigehiro Nishijima
发明人： Shigehiro Nishijima
IPC分类号： C02F1/48
CPC分类号： B03C1/286 , B03C2201/18 , B24B1/04
摘要： The processing method for a mixture according to the present invention is a method for processing a mixture having first particles made of a magnetic material or a nonmagnetic material and second particles made of a magnetic material or a nonmagnetic material wherein the second particles are mixed in a fluid medium containing the first particles, and comprises a dispersion step of dispersing aggregates of the first particles and the second particles present in the mixture, and a magnetic separation step of providing the first particles and second particles with a magnetic force a of different magnitudes by applying a magnetic field to the mixture in parallel with or after the dispersion step, thereby separating the first particles and the second particles from each other.
摘要翻译：根据本发明的混合物的处理方法是一种处理具有由磁性材料或非磁性材料制成的第一颗粒的混合物的方法和由磁性材料或非磁性材料制成的第二颗粒，其中第二颗粒混合在包含第一颗粒的流体介质，并且包括分散步骤，分散存在于混合物中的第一颗粒和第二颗粒的聚集体，以及磁分离步骤，通过以下方式提供具有不同量值的磁力a的第一颗粒和第二颗粒：在分散步骤中或之后与混合物施加磁场，从而将第一颗粒和第二颗粒彼此分离。

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