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1. 发明申请

US20140014559A1 METHOD AND APPARATUS FOR SEPARATION OF MIXTURE 有权
标题翻译：用于分离混合物的方法和装置
公开(公告)号：US20140014559A1
公开(公告)日：2014-01-16
申请号：US14008049
申请日：2012-03-28
申请人： Shigehiro Nishijima , Fumihito Mishima , Koji Kaiso , Toshihiro Shimakawa
发明人： Shigehiro Nishijima , Fumihito Mishima , Koji Kaiso , Toshihiro Shimakawa
IPC分类号： B03C1/30
CPC分类号： B03C1/30 , B03B5/44 , B03C1/002 , B03C1/015 , B03C1/288 , B03C1/32 , B03C2201/18
摘要： Provided are a mixture separation method and a separation apparatus in which agglomeration of particles contained in the mixture is suppressed, energy required in distillation treatment of a supporting liquid is small in comparison with conventional methods, and particles that cannot be separated by conventional methods can be separated from a mixture containing the particles. The separation method and separation apparatus of the present invention separate, by type, a plurality of types of particles formed of mutually different materials by applying a magnetic field having a magnetic field gradient to the mixture containing the plurality of types of particles in the supporting liquid. Alternatively, the separation method and separation apparatus of the present invention separate a specific type of particle from such mixture. The supporting liquid is an organic solvent solution obtained by dissolving one or more types of paramagnetic compounds in an organic solvent. The plurality of types of particles includes particles of an inorganic salt, an organic acid salt, an inorganic oxide or a macromolecular compound. The organic solvent may be selected from the group consisting of alcohols, ethers, nitriles, ketones, esters, amides, sulfoxides, halomethanes and hydrocarbon solvents.
摘要翻译：提供了混合分离方法和分离装置，其中抑制了混合物中所含的颗粒的聚集，与常规方法相比，支持液的蒸馏处理所需的能量小，并且通过常规方法不能分离的颗粒可以是与含有颗粒的混合物分离。本发明的分离方法和分离装置通过将由相互不同的材料形成的多种类型的颗粒通过向包含支撑液体中的多种类型的颗粒的混合物施加具有磁场梯度的磁场而分离。或者，本发明的分离方法和分离装置将特定类型的颗粒与这种混合物分离。支持液是通过将一种或多种顺磁性化合物溶解在有机溶剂中得到的有机溶剂溶液。多种类型的颗粒包括无机盐，有机酸盐，无机氧化物或高分子化合物的颗粒。有机溶剂可以选自醇，醚，腈，酮，酯，酰胺，亚砜，卤代甲烷和烃溶剂。

2. 发明申请

US20110278231A1 METHOD AND APPARATUS FOR PROCESSING MIXTURE 有权
标题翻译：处理混合物的方法和装置
公开(公告)号：US20110278231A1
公开(公告)日：2011-11-17
申请号：US13146134
申请日：2010-01-22
申请人： Shigehiro Nishijima
发明人： Shigehiro Nishijima
IPC分类号： C02F1/48
CPC分类号： B03C1/286 , B03C2201/18 , B24B1/04
摘要： The processing method for a mixture according to the present invention is a method for processing a mixture having first particles made of a magnetic material or a nonmagnetic material and second particles made of a magnetic material or a nonmagnetic material wherein the second particles are mixed in a fluid medium containing the first particles, and comprises a dispersion step of dispersing aggregates of the first particles and the second particles present in the mixture, and a magnetic separation step of providing the first particles and second particles with a magnetic force a of different magnitudes by applying a magnetic field to the mixture in parallel with or after the dispersion step, thereby separating the first particles and the second particles from each other.
摘要翻译：根据本发明的混合物的处理方法是一种处理具有由磁性材料或非磁性材料制成的第一颗粒的混合物的方法和由磁性材料或非磁性材料制成的第二颗粒，其中第二颗粒混合在包含第一颗粒的流体介质，并且包括分散步骤，分散存在于混合物中的第一颗粒和第二颗粒的聚集体，以及磁分离步骤，通过以下方式提供具有不同量值的磁力a的第一颗粒和第二颗粒：在分散步骤中或之后与混合物施加磁场，从而将第一颗粒和第二颗粒彼此分离。

3. 发明授权

US09561511B2 Method and apparatus for separation of mixture 有权
标题翻译：分离混合物的方法和装置
公开(公告)号：US09561511B2
公开(公告)日：2017-02-07
申请号：US14239657
申请日：2012-08-24
申请人： Shigehiro Nishijima , Fumihito Mishima , Koji Kaiso , Toshihiro Shimakawa
发明人： Shigehiro Nishijima , Fumihito Mishima , Koji Kaiso , Toshihiro Shimakawa
IPC分类号： B03C1/32 , B03C1/032 , B03C1/28 , B03C1/30
CPC分类号： B03C1/32 , B03C1/032 , B03C1/034 , B03C1/286 , B03C1/30 , B03C2201/18
摘要： The present invention is a method for applying a gradient magnetic field to a paramagnetic supporting liquid containing a mixture of first particles and second particles to separate the mixture by particle type. A magnetic susceptibility of the first particles is lower than that of the liquid, and a magnetic susceptibility of the second particles is higher than that of the liquid. A gradient magnetic field is applied to the liquid in a separation tank provided with a magnetic filter and the liquid is stirred. The first particles float in the liquid by a magneto-Archimedes effect. A horizontal magnetic force acts on the first particles by the gradient magnetic field, so that the first particles travel to a region lateral to or outward from the magnetic filter and are gathered in the region. The magnetic filter is excited by the gradient magnetic field to catch the second particles.
摘要翻译：本发明是一种将梯度磁场施加到含有第一颗粒和第二颗粒的混合物的顺磁性支撑液体以通过颗粒类型分离混合物的方法。第一颗粒的磁化率低于液体的磁化率，第二颗粒的磁化率高于液体的磁化率。在设置有磁性过滤器的分离槽中对液体施加梯度磁场，并搅拌液体。第一颗粒通过磁阿基米德效应在液体中漂浮。水平磁力通过梯度磁场作用在第一颗粒上，使得第一颗粒行进到磁性过滤器的横向或向外的区域并聚集在该区域中。磁性过滤器被梯度磁场激发以捕获第二颗粒。

4. 发明申请

US20140202960A1 METHOD AND APPARATUS FOR SEPARATION OF MIXTURE 有权
标题翻译：用于分离混合物的方法和装置
公开(公告)号：US20140202960A1
公开(公告)日：2014-07-24
申请号：US14239657
申请日：2012-08-24
申请人： Shigehiro Nishijima , Fumihito Mishima , Koji Kaiso , Toshihiro Shimakawa
发明人： Shigehiro Nishijima , Fumihito Mishima , Koji Kaiso , Toshihiro Shimakawa
IPC分类号： B03C1/32
CPC分类号： B03C1/32 , B03C1/032 , B03C1/034 , B03C1/286 , B03C1/30 , B03C2201/18
摘要： Provided are a mixture separation method and a separation apparatus in which processes are performed efficiently in a short time compared to conventional methods with a low load on the apparatus configuration compared to conventional methods. The present invention is a mixture separation method or a mixture separation apparatus for separating, by applying a gradient magnetic field to a paramagnetic supporting liquid containing a mixture of first particles and second particles, the mixture by particle type. A magnetic susceptibility of the first particles is lower than a magnetic susceptibility of the supporting liquid, and a magnetic susceptibility of the second particles is higher than the magnetic susceptibility of the supporting liquid. A gradient magnetic field is applied to the supporting liquid in the separation tank (7) provided with a magnetic filter means (9) using a magnetic field generating means (11), and the supporting liquid is stirred. The first particles float in the supporting liquid by a magneto-Archimedes effect. A horizontal magnetic force acts on the first particles by the gradient magnetic field, so that the first particles travel to a region lateral to or outward from the magnetic filter means (9) and are gathered in the region. The magnetic filter means (9) is excited by the gradient magnetic field to catch the second particles.
摘要翻译：提供了一种混合分离方法和分离装置，其中与常规方法相比，与传统方法相比，具有低负载的常规方法在短时间内有效地进行处理。本发明是一种混合分离方法或混合物分离装置，通过将梯度磁场施加到含有第一颗粒和第二颗粒的混合物的顺磁性支撑液体，通过颗粒型分离。第一颗粒的磁化率低于支撑液的磁化率，第二颗粒的磁化率高于支持液的磁化率。使用磁场产生装置（11）将梯度磁场施加到设置有磁性过滤装置（9）的分离罐（7）中的支撑液体上，并搅拌支撑液体。第一颗粒通过磁阿基米德效应在支撑液体中漂浮。水平磁力通过梯度磁场作用在第一颗粒上，使得第一颗粒行进到磁性过滤装置（9）的横向或向外的区域并聚集在该区域中。磁性过滤器装置（9）被梯度磁场激发以捕获第二颗粒。

5. 发明申请

US20070299550A1 Three-Dimensional Guidance System And Method , And Drug Delivery System 审中-公开
标题翻译：三维指导系统与方法，药物输送系统
公开(公告)号：US20070299550A1
公开(公告)日：2007-12-27
申请号：US11575992
申请日：2005-08-01
申请人： Shigehiro Nishijima , Shinichi Takeda
发明人： Shigehiro Nishijima , Shinichi Takeda
IPC分类号： G05B19/18 , A61B5/05 , H01H47/00
CPC分类号： A61M37/00 , A61B34/20 , A61B34/70 , A61B34/73 , A61B2034/105 , A61B2034/2051 , A61B2034/732 , A61B2090/3954
摘要： A three-dimensional guidance system of the present invention includes a bed (1) horizontally driven by a bed drive motor (11), a position detecting sensor (6) for detecting a position of a magnetic particle carrier (8), a plurality of electromagnets (3, 4, 5) arranged to surround the bed (1), and a controller (7) for controlling a current to be supplied to the plurality of electromagnets (3, 4, 5) and a drive signal to be supplied to the bed drive motor (11). The controller (7) holds a vascular route as three-dimensional route data, and feedback-controls the current to be supplied to the plurality of electromagnets (3, 4, 5) and the drive signal to be supplied to the bed drive motor (11), based on a deviation of the current position of the magnetic particle carrier (8) detected by the position detecting sensor (6) from a target position.
摘要翻译：本发明的三维引导系统包括由床驱动电机（11）水平驱动的床（1），用于检测磁性粒子载体（8）的位置的位置检测传感器（6），多个布置成围绕床（1）的电磁体（3,4,5）以及用于控制要供给到多个电磁体（3,4,5）的电流的控制器（7）床驱动马达（11）。控制器（7）将血管路线保持为三维路径数据，并且反馈控制要提供给多个电磁体（3,4,5）的电流和要提供给床驱动电机的驱动信号基于由位置检测传感器（6）检测到的磁性粒子载体（8）的当前位置与目标位置的偏差。

6. 发明授权

US09308536B2 Method and apparatus for separation of mixture 有权
标题翻译：分离混合物的方法和装置
公开(公告)号：US09308536B2
公开(公告)日：2016-04-12
申请号：US14001002
申请日：2012-02-21
申请人： Shigehiro Nishijima , Fumihito Mishima
发明人： Shigehiro Nishijima , Fumihito Mishima
IPC分类号： B03C1/32 , B03C1/03 , B03C1/28 , B03C1/02 , B03C1/033 , B03B5/30 , B03B5/44
CPC分类号： B03C1/02 , B03B5/30 , B03B5/44 , B03C1/0335 , B03C1/288 , B03C1/32 , B03C2201/18
摘要： The present invention provides a method and an apparatus capable of continuously and accurately separating, by type, a mixture containing at least two types of particles, or capable of separating specific particles from the mixture, using a gradient magnetic field. In the present invention, a mixture containing at least two types of particles, particles of one type of which are made of a paramagnetic or diamagnetic substance, is treated. A magnetic field whose magnetic field gradient has a vertical component and a horizontal component is applied to a supporting liquid 21 stored in a separating tank 31. When the mixture is placed into the supporting liquid 21, the particles of the one type are guided such that they are positioned in the supporting liquid 21 at a predetermined height from a bottom face 39 of the separating tank 31 while horizontally traveling. Alternatively, the particles of the one type magnetically levitate at a liquid surface of the supporting liquid 21 and horizontally travel. Particles of another type of the at least two types of particles are positioned at a position vertically different from that of the particles of the one type, between the bottom face 39 of the separating tank 31 and the liquid surface of the supporting liquid 21.
摘要翻译：本发明提供一种方法和装置，其能够通过使用梯度磁场，连续且准确地分离含有至少两种类型的颗粒的混合物或能够从混合物中分离特定颗粒。在本发明中，处理包含至少两种类型的颗粒的混合物，一种类型的颗粒由顺磁性或反磁性物质制成。将磁场梯度具有垂直分量和水平分量的磁场施加到存储在分离罐31中的支撑液体21上。当将混合物放入支撑液体21中时，一种类型的颗粒被引导使得它们在水平行进的同时从分离罐31的底面39以预定高度定位在支撑液体21中。或者，一种类型的颗粒在支撑液体21的液体表面浮动并水平移动。另一种类型的至少两种类型的颗粒的颗粒定位在与分离罐31的底面39和支撑液体21的液体表面之间的一种类型的颗粒垂直不同的位置。

7. 发明授权

US09174221B2 Method and apparatus for separation of mixture 有权
标题翻译：分离混合物的方法和装置
公开(公告)号：US09174221B2
公开(公告)日：2015-11-03
申请号：US14008049
申请日：2012-03-28
申请人： Shigehiro Nishijima , Fumihito Mishima , Koji Kaiso , Toshihiro Shimakawa
发明人： Shigehiro Nishijima , Fumihito Mishima , Koji Kaiso , Toshihiro Shimakawa
IPC分类号： B03C1/30 , B03C1/00 , B03C1/015 , B03C1/28 , B03B5/44 , B03C1/32
CPC分类号： B03C1/30 , B03B5/44 , B03C1/002 , B03C1/015 , B03C1/288 , B03C1/32 , B03C2201/18
摘要： Provided are a mixture separation method and a separation apparatus in which agglomeration of particles contained in the mixture is suppressed, energy required in distillation treatment of a supporting liquid is small in comparison with conventional methods, and particles that cannot be separated by conventional methods can be separated from a mixture containing the particles. The separation method and separation apparatus of the present invention separate, by type, a plurality of types of particles formed of mutually different materials by applying a magnetic field having a magnetic field gradient to the mixture containing the plurality of types of particles in the supporting liquid. Alternatively, the separation method and separation apparatus of the present invention separate a specific type of particle from such mixture. The supporting liquid is an organic solvent solution obtained by dissolving one or more types of paramagnetic compounds in an organic solvent. The plurality of types of particles includes particles of an inorganic salt, an organic acid salt, an inorganic oxide or a macromolecular compound. The organic solvent may be selected from the group consisting of alcohols, ethers, nitriles, ketones, esters, amides, sulfoxides, halomethanes and hydrocarbon solvents.
摘要翻译：提供了混合分离方法和分离装置，其中抑制了混合物中所含的颗粒的聚集，与常规方法相比，支持液的蒸馏处理所需的能量小，并且通过常规方法不能分离的颗粒可以是与含有颗粒的混合物分离。本发明的分离方法和分离装置通过将由相互不同的材料形成的多种类型的颗粒通过向包含支撑液体中的多种类型的颗粒的混合物施加具有磁场梯度的磁场而分离。或者，本发明的分离方法和分离装置将特定类型的颗粒与这种混合物分离。支持液是通过将一种或多种顺磁性化合物溶解在有机溶剂中得到的有机溶剂溶液。多种类型的颗粒包括无机盐，有机酸盐，无机氧化物或高分子化合物的颗粒。有机溶剂可以选自醇，醚，腈，酮，酯，酰胺，亚砜，卤代甲烷和烃溶剂。

8. 发明授权

US08916049B2 Method and apparatus for processing mixture 有权
标题翻译：处理混合物的方法和装置
公开(公告)号：US08916049B2
公开(公告)日：2014-12-23
申请号：US13146134
申请日：2010-01-22
申请人： Shigehiro Nishijima
发明人： Shigehiro Nishijima
IPC分类号： B03C1/023 , C02F1/48 , C02F1/52 , C02F1/66 , B03C1/28 , B24B1/04
CPC分类号： B03C1/286 , B03C2201/18 , B24B1/04
摘要： The processing method for a mixture according to the present invention is a method for processing a mixture having first particles made of a magnetic material or a nonmagnetic material and second particles made of a magnetic material or a nonmagnetic material wherein the second particles are mixed in a fluid medium containing the first particles, and comprises a dispersion step of dispersing aggregates of the first particles and the second particles present in the mixture, and a magnetic separation step of providing the first particles and second particles with a magnetic force a of different magnitudes by applying a magnetic field to the mixture in parallel with or after the dispersion step, thereby separating the first particles and the second particles from each other.
摘要翻译：根据本发明的混合物的处理方法是一种处理具有由磁性材料或非磁性材料制成的第一颗粒的混合物的方法和由磁性材料或非磁性材料制成的第二颗粒，其中第二颗粒混合在包含第一颗粒的流体介质，并且包括分散步骤，分散存在于混合物中的第一颗粒和第二颗粒的聚集体，以及磁分离步骤，通过以下方式提供具有不同量值的磁力a的第一颗粒和第二颗粒：在分散步骤中或之后与混合物施加磁场，从而将第一颗粒和第二颗粒彼此分离。

9. 发明申请

US20130327684A1 METHOD AND APPARATUS FOR SEPARATION OF MIXTURE 有权
标题翻译：用于分离混合物的方法和装置
公开(公告)号：US20130327684A1
公开(公告)日：2013-12-12
申请号：US14001002
申请日：2012-02-21
申请人： Shigehiro Nishijima , Fumihito Mishima
发明人： Shigehiro Nishijima , Fumihito Mishima
IPC分类号： B03C1/02
CPC分类号： B03C1/02 , B03B5/30 , B03B5/44 , B03C1/0335 , B03C1/288 , B03C1/32 , B03C2201/18
摘要： The present invention provides a method and an apparatus capable of continuously and accurately separating, by type, a mixture containing at least two types of particles, or capable of separating specific particles from the mixture, using a gradient magnetic field. In the present invention, a mixture containing at least two types of particles, particles of one type of which are made of a paramagnetic or diamagnetic substance, is treated. A magnetic field whose magnetic field gradient has a vertical component and a horizontal component is applied to a supporting liquid 21 stored in a separating tank 31. When the mixture is placed into the supporting liquid 21, the particles of the one type are guided such that they are positioned in the supporting liquid 21 at a predetermined height from a bottom face 39 of the separating tank 31 while horizontally traveling. Alternatively, the particles of the one type magnetically levitate at a liquid surface of the supporting liquid 21 and horizontally travel. Particles of another type of the at least two types of particles are positioned at a position vertically different from that of the particles of the one type, between the bottom face 39 of the separating tank 31 and the liquid surface of the supporting liquid 21.
摘要翻译：本发明提供一种方法和装置，其能够通过使用梯度磁场，连续且准确地分离含有至少两种类型的颗粒的混合物或能够从混合物中分离特定颗粒。在本发明中，处理包含至少两种类型的颗粒的混合物，一种类型的颗粒由顺磁性或反磁性物质制成。将磁场梯度具有垂直分量和水平分量的磁场施加到存储在分离罐31中的支撑液体21上。当将混合物放入支撑液体21中时，一种类型的颗粒被引导使得它们在水平行进的同时从分离罐31的底面39以预定高度定位在支撑液体21中。或者，一种类型的颗粒在支撑液体21的液体表面浮动并水平移动。另一种类型的至少两种类型的颗粒的颗粒定位在与分离罐31的底面39和支撑液体21的液体表面之间的一种类型的颗粒垂直不同的位置。

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