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141. 发明申请

US20060069089A1 Fungicides 失效
公开(公告)号：US20060069089A1
公开(公告)日：2006-03-30
申请号：US10540037
申请日：2003-12-03
申请人： Patrick Crowley , Markus Dobler , Urs Mueller , John Williams
发明人： Patrick Crowley , Markus Dobler , Urs Mueller , John Williams
IPC分类号： C07D471/02 , A01N43/42
CPC分类号： C07D471/04 , A01N43/90
摘要： Fungicidal compositions of the general formula (1): wherein one of W, X, Y and Z is N and the others are CR8; R8 is H, halo, C1-4 alkyl, C1-4 alkoxy or halo(C1-4)alkyl, provided that when X is CH, Z is N, R is NHNH2, R1 is phenyl and R2 is Cl, W and Y are not both CCH3; one of R and R2 is NR3R4 and the other is halo, C1-8 alkyl, C1-8 alkoxy, C1-8 alkylthio, C2-8 alkenyl, C2-8 alkynyl or cyano; R1 is aryl, heteroaryl, morpholino, piperidino or pyrrolidino; R3 and R4 are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(C1-8)-alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)alkyl, heteroaryl, heteroaryl(C1-8)alkyl, NR5R6, provided that not v both R3 and R4 are H or NR5R6, or R3 and R4 together form a C3-7 alkylene or C3-7 alkenylene chain optionally substituted with one or more C1-4 alkyl or C1-4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R3 and R4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N—(C1-4)alkyl (especially N-methyl) ring; and R5 and R6 are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(C1-8)-alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)alkyl, heteroaryl or heteroaryl(C1-8)alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R8) being optionally substituted with halogen, cyano, C1-8 alkoxy C1-4 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 haloalkoxy, C1-6 alkylthio, tri(C1-4)alkylsilyl, C1-6 alkylamino or C1-6 alkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alkyl (especially methyl), and any of the foregoing aryl or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, halo(C1-4)alkyl, halo(C1-6)alkoxy, C1-6 alkylthio, halo(C1-4)alkylthio, hydroxy(C1-6)alkyl, C1-4 alkoxy(C1-6)alkyl, C1-6 cycloalkyl, C3-4 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, —NHCOR″′, —NHCONR″′ R″″, —CONK″′R″″, SO2R″′, —OSO2R″′, —COR″′, —CR″′═NR″ or —N═CR″′R″″, in which R″′ and R″″ are independently hydrogen, C1-4 alkyl, halo-(C1-4)alkyl, C1-4 alkoxy, halo(C1-4)alkoxy, C1-4 alkylthio, C3-4 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl groups beings optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy.

142. 发明申请

US20060063173A1 Charge switch nucleotides 有权
标题翻译：电荷开关核苷酸
公开(公告)号：US20060063173A1
公开(公告)日：2006-03-23
申请号：US11154419
申请日：2005-06-15
申请人： John Williams , Gregory Bashford , Jiyan Chen , Dan Draney , Nara Narayanan , Bambi Reynolds , Pamela Sheaff
发明人： John Williams , Gregory Bashford , Jiyan Chen , Dan Draney , Nara Narayanan , Bambi Reynolds , Pamela Sheaff
IPC分类号： C12Q1/68 , C07H19/04 , C07H21/04
CPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , C12Q1/6869 , C40B40/00 , C12Q2565/629 , C12Q2565/607 , C12Q2565/301 , C12Q2533/101
摘要： The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection channel. By electrically sorting charged molecules, the cleaved product molecules are detected in isolation without interference from unincorporated NPs and without illuminating the polymerase-DNA complex.
摘要翻译：本发明提供了使用单分子检测来测序核酸的化合物，方法和系统。使用表现出电荷转换行为的标记NP，实现了微通道分选系统中的单分子DNA测序。在操作中，随着连续的可检测部分流经检测通道，测序产物被检测成能够进行实时测序。通过电分选带电分子，分离检测产物分子而不受未结合的NP的干扰，而不照射聚合酶-DNA复合物。

143. 发明授权

US07005005B2 Soil bind and revegetation compositions and methods of making and using such compositions 失效
标题翻译：土壤结合和植被组合物以及制备和使用这些组合物的方法
公开(公告)号：US07005005B2
公开(公告)日：2006-02-28
申请号：US10723999
申请日：2003-11-26
申请人： Richard L. Maile , John Williams , Terry R. Holmes
发明人： Richard L. Maile , John Williams , Terry R. Holmes
IPC分类号： C09K17/32 , C09K3/22
CPC分类号： C09K17/40 , A01G24/00 , C05G3/04 , Y10S106/90
摘要： Soil binding and revegetation compositions useful for stabilizing soil and promoting vegetation or revegetation of soil comprise water, an endosperm, an iron compound, a strong base, and a fibrous material. The endosperm comprises the carbohydrate and protein portions of grains, seeds, or tubers. The strong base is reacted with the endosperm in the presence of water added in order to ionize the carbohydrate and protein of the endosperm and render them more soluble or dispersible in water. The iron compound promotes an electrochemical reaction that assists in the formation of a silicate crystal matrix when applied to soil. The fibrous material softens and nourishes the soil in order to promote the emergence of plant life and/or seed germination. Seeds may optionally be added to further promote vegetation or revegetation of denuded soils. A pH adjustor may be added to lower the pH of the soil binding and revegetation composition in order to improve handling ability and render the composition more compatible with soil.
摘要翻译：用于稳定土壤和促进土壤植被或植被恢复的土壤结合和植被组合物包括水，胚乳，铁化合物，强碱和纤维材料。胚乳包括谷物，种子或块茎的碳水化合物和蛋白质部分。在加入水的情况下，强碱与胚乳反应，以便电离胚乳的碳水化合物和蛋白质，并使它们更易溶于水或分散于水中。铁化合物促进电化学反应，其在施用于土壤时有助于形成硅酸盐晶体基质。纤维材料软化和滋养土壤，以促进植物生长和/或种子萌发的出现。可以任选地加入种子以进一步促进植被或植被剥蚀的土壤。可以加入pH调节剂以降低土壤结合和植被组合物的pH，以提高处理能力并使组合物更好地与土壤相容。

144. 发明申请

US20050266456A1 Field-switch sequencing 有权
标题翻译：现场开关顺序
公开(公告)号：US20050266456A1
公开(公告)日：2005-12-01
申请号：US11118031
申请日：2005-04-29
申请人： John Williams , Jon Anderson
发明人： John Williams , Jon Anderson
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6869 , B01J2219/00497 , B01J2219/005 , B01J2219/00576 , B01J2219/00648 , B01J2219/00722 , C07H21/04 , C12Q1/6818 , C12Q1/6825 , C12Q2525/113 , C12Q2525/117 , C12Q2563/107 , C12Q2563/149 , C12Q2565/518 , C12Q2523/307
摘要： The present invention provides novel compositions, methods and apparatus for DNA sequencing that can be performed, e.g., in a two-electrode chamber. The present invention also provides a method for sequencing a nucleic acid comprising immobilizing a plurality of complexes comprising a target nucleic acid, a primer nucleic acid, and a polymerase onto a surface, contacting the surface with a plurality of charged particles comprising a nucleotide phosphate by applying an electric field, reversing the electric field to transport unbound charged particles away from the surface, and detecting the incorporation of a nucleotide phosphate into a single molecule of the primer nucleic acid.
摘要翻译：本发明提供了可以例如在双电极室中进行的用于DNA测序的新型组合物，方法和装置。本发明还提供了一种对核酸进行测序的方法，包括将包含靶核酸，引物核酸和聚合酶的多种复合物固定在表面上，使表面与包含磷酸核苷酸的多个带电粒子接触，施加电场，反转电场以将未结合的带电粒子输送离开表面，以及检测将核苷酸磷酸酯掺入引物核酸的单个分子中。

145. 发明申请

US20050216461A1 Bypassing native storage operations by communicating protected data within locking messages using a lock manager independent of the storage mechanism 有权
标题翻译：通过使用独立于存储机制的锁定管理器在锁定消息内传递受保护数据来绕过本地存储操作
公开(公告)号：US20050216461A1
公开(公告)日：2005-09-29
申请号：US10811044
申请日：2004-03-27
申请人： John Williams , John Fingerhut , Jonathan Rosen
发明人： John Williams , John Fingerhut , Jonathan Rosen
IPC分类号： G06F17/30
CPC分类号： G06F9/526 , G06F17/30362 , G06F2209/522 , Y10S707/99938 , Y10S707/99939
摘要： Data is protected using locks, with the protected data sometimes being included in the locking messages, which may reduce overall processing latency, and/or reduce a bandwidth requirement for and/or number of storage operations accessing the native storage of the protected data. For example, the lock manager receives lock requests from each of the requesters, and selectively grants the lock requests. The protected data is typically communicated in the locking messages when the lock is highly contested, or at least two request for access to the data are pending. The lock manager initiates the sequence by indicating in a grant message to a requester to include the protected data in its release message. The lock manager then copies this data received in the release message to its grant message to the next requestor. If no other requesters are waiting, the grant message includes an indication not to send the protected data, and thus the requestor typically stores this protected data to storage so it can be accessed in the future.
摘要翻译：使用锁保护数据，受保护的数据有时被包括在锁定消息中，这可以减少整体处理延迟，和/或减少访问受保护数据的本机存储的存储操作的带宽需求和/或数量。例如，锁管理器从每个请求者接收锁请求，并且选择性地授予锁请求。当锁被高度争议时，或者至少两个访问数据的请求正在等待时，受保护的数据通常在锁定消息中传达。锁管理器通过在请求者的授权消息中指示将受保护数据包括在其释放消息中来发起序列。然后，锁管理器将释放消息中收到的数据复制到其授权消息给下一个请求者。如果没有其他请求者正在等待，则授权消息包括不发送受保护数据的指示，因此请求者通常将该受保护数据存储到存储器中，以便将来可以访问该保护数据。

146. 发明申请

US20050213425A1 Micro-mixer/reactor based on arrays of spatially impinging micro-jets 审中-公开
标题翻译：基于空间冲击微型射流阵列的微型混合器/反应器
公开(公告)号：US20050213425A1
公开(公告)日：2005-09-29
申请号：US11056446
申请日：2005-02-11
申请人： Wanjun Wang , Ren Yang , John Williams
发明人： Wanjun Wang , Ren Yang , John Williams
IPC分类号： B01F5/02 , B01F13/00 , B01F15/02
CPC分类号： B01F13/0059 , B01F5/0256 , B01F2215/0422 , B01F2215/0431
摘要： An inexpensive device and method of fabricating micromixers able to enhance the mixing efficiency of fluids by inducing diffusion and turbulence mixing within the micromixer, and by increasing the interfacial surface contact between fluids is disclosed. The device is a passive micromixer capable of mixing at least two different fluids (e.g., a DNA sample and a reagent) by creating impinging plumes of fluid using at least two or more arrays of micro-nozzles sized and shaped to cause the plumes to impact each other directly or interfacially. This novel, passive micromixer may be fabricated on a single substrate using a newly developed lithography technology for thick films of SU-8 resist.
摘要翻译：公开了一种廉价的装置和方法，其通过在微型混合器内引入扩散和湍流混合以及通过增加流体之间的界面表面接触来制造能够增强流体混合效率的微混合器。该装置是能够通过使用尺寸和形状使得羽流冲击的至少两个或更多个微型喷嘴阵列产生冲击的羽流而混合至少两种不同流体（例如，DNA样品和试剂）的被动微混合器彼此直接或界定。这种新型的被动微混合器可以使用新开发的用于SU-8抗蚀剂厚膜的光刻技术在单个衬底上制造。

147. 发明申请

US20050183856A1 Armored stripper rubber 有权
标题翻译：装甲脱胶橡胶
公开(公告)号：US20050183856A1
公开(公告)日：2005-08-25
申请号：US10845786
申请日：2004-05-12
申请人： John Williams
发明人： John Williams
IPC分类号： E21B33/08 , E21B19/00
CPC分类号： E21B33/085
摘要： An armored stripper rubber is provided that protects the drillstring bore of the stripper rubber from substrate infiltration, yet pivotally dilates to facilitate the passage of drillstring components through the bore while effectively maintaining a fluid-tight seal. Additionally, the stripper rubber substantially inhibits resilient contraction of the stripper rubber to an internal bore diameter smaller than a pre-selected internal diameter. The armored stripper rubber, or armadillo, substantially prevents rubber inversion and puckering under high operational well pressures. Also provided are stripper rubber inserts and insert assemblies.
摘要翻译：提供了一种装甲汽提器橡胶，其保护汽提橡胶的钻柱孔不受基底渗透，但是枢轴扩张以便于钻柱部件通过孔而通过，同时有效地保持流体密封。此外，汽提橡胶基本上抑制汽提橡胶的弹性收缩至小于预先选择的内径的内孔直径。装甲脱胶器橡胶或犰狳在高操作井压力下基本上防止橡胶倒塌和起皱。还提供了剥离橡胶插入件和插入组件。

148. 发明申请

US20050156112A1 Crystal-based coincidence timing calibration method 失效
标题翻译：基于晶体的巧合定时校准方法
公开(公告)号：US20050156112A1
公开(公告)日：2005-07-21
申请号：US11028270
申请日：2005-01-03
申请人： John Williams , Dershan Luo , Mark Limkeman , Michael Cook , David McDaniel , Edwin Oswalt , Mark Feilen
发明人： John Williams , Dershan Luo , Mark Limkeman , Michael Cook , David McDaniel , Edwin Oswalt , Mark Feilen
IPC分类号： G01T1/161 , G01T1/164 , G01T1/172 , G01T1/29
CPC分类号： G01T1/2985
摘要： A method of calibrating detectors in a detector ring of a PET scanner, each detector including a plurality of crystals, the PET scanner having a field of view, is disclosed. The method comprises collecting timing data indicative of coincidence events occurring between each pair of crystals within the field of view. The method further comprises determining a detector adjustment value for each detector, determining a crystal adjustment value for each crystal in each detector, and discretizing the crystal adjustment value for each crystal to produce a discretized crystal adjustment value for each crystal. Lastly, the method comprises calibrating each detector by applying the discretized crystal adjustment value for each crystal in each detector to the collected timing data indicative of coincidence events.
摘要翻译：公开了一种校准PET扫描器的检测器环中的检测器的方法，每个检测器包括多个晶体，PET扫描器具有视野。该方法包括收集指示在视场内的每对晶体之间发生的重合事件的定时数据。该方法还包括确定每个检测器的检测器调整值，确定每个检测器中的每个晶体的晶体调整值，以及离散每个晶体的晶体调整值以产生每个晶体的离散晶体调节值。最后，该方法包括通过将每个检测器中的每个晶体的离散晶体调整值应用于指示符合事件的收集的定时数据来校准每个检测器。

149. 发明申请

US20050135943A1 Molded compressor base 审中-公开
标题翻译：成型压缩机基座
公开(公告)号：US20050135943A1
公开(公告)日：2005-06-23
申请号：US11021802
申请日：2004-12-23
申请人： Wayne Kennedy , Scott Hix , Cosimo Caronna , John Williams , Joe Hill , Michael Young
发明人： Wayne Kennedy , Scott Hix , Cosimo Caronna , John Williams , Joe Hill , Michael Young
IPC分类号： F04B39/12 , F24F13/30 , F04B17/00 , F04B35/00
CPC分类号： F04B39/12 , F24F13/30
摘要： A molded compressor base (100) is provided for mounting a compressor without requiring mechanical fasteners. The molded compressor base (100) can be used to mount the compressor in any position ranging from a substantially horizontal position to a substantially vertical position. The molded compressor base (100) includes a mounting area that is designed and configured to secure a compressor placed in the mounting area. The mounting area can be configured for a compressor to be mounted in a substantially horizontal position, a substantially vertical position or any position in between. The molded compressor base (100) can also include one or more isolators to secure the compressor and to isolate vibrations from the compressor from the molded compressor base (100). The molded compressor base (100) can damp sound and/or vibrations generated by the compressor or the molded compressor base (100) can be coated with a sound and/or vibration damping coating.
摘要翻译：提供了一种用于安装压缩机而不需要机械紧固件的模制压缩机基座（100）。模制的压缩机基座（100）可以用于将压缩机安装在从基本上水平的位置到基本垂直的位置的任何位置。模制的压缩机基座（100）包括安装区域，其被设计和构造成固定安置在安装区域中的压缩机。安装区域可以被构造成用于将压缩机安装在基本上水平的位置，基本垂直的位置或其间的任何位置。模制的压缩机基座（100）还可以包括一个或多个隔离器以固定压缩机并且隔离来自压缩机的压缩机与模制的压缩机基座（100）的振动。模制的压缩机基座（100）可以抑制声音和/或由压缩机或模制的压缩机基座（100）产生的振动可以涂覆有声音和/或振动阻尼涂层。

150. 发明申请

US20050111923A1 Soil bind and revegetation compositions and methods of making and using such compositions 失效
标题翻译：土壤结合和植被组合物以及制备和使用这些组合物的方法
公开(公告)号：US20050111923A1
公开(公告)日：2005-05-26
申请号：US10723999
申请日：2003-11-26
申请人： Richard Maile , John Williams , Terry Holmes
发明人： Richard Maile , John Williams , Terry Holmes
IPC分类号： A01G9/10 , C05G3/04 , C09K17/00 , C09K17/40 , E02D3/12
CPC分类号： C09K17/40 , A01G24/00 , C05G3/04 , Y10S106/90
摘要： Soil binding and revegetation compositions useful for stabilizing soil and promoting vegetation or revegetation of soil comprise water, an endosperm, an iron compound, a strong base, and a fibrous material. The endosperm comprises the carbohydrate and protein portions of grains, seeds, or tubers. The strong base is reacted with the endosperm in the presence of water added in order to ionize the carbohydrate and protein of the endosperm and render them more soluble or dispersible in water. The iron compound promotes an electrochemical reaction that assists in the formation of a silicate crystal matrix when applied to soil. The fibrous material softens and nourishes the soil in order to promote the emergence of plant life and/or seed germination. Seeds may optionally be added to further promote vegetation or revegetation of denuded soils. A pH adjustor may be added to lower the pH of the soil binding and revegetation composition in order to improve handling ability and render the composition more compatible with soil.
摘要翻译：用于稳定土壤和促进土壤植被或植被恢复的土壤结合和植被组合物包括水，胚乳，铁化合物，强碱和纤维材料。胚乳包括谷物，种子或块茎的碳水化合物和蛋白质部分。在加入水的情况下，强碱与胚乳反应，以便电离胚乳的碳水化合物和蛋白质，并使它们更易溶于水或分散于水中。铁化合物促进电化学反应，其在施用于土壤时有助于形成硅酸盐晶体基质。纤维材料软化和滋养土壤，以促进植物生长和/或种子萌发的出现。可以任选地加入种子以进一步促进植被或植被剥蚀的土壤。可以加入pH调节剂以降低土壤结合和植被组合物的pH，以提高处理能力并使组合物更好地与土壤相容。

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