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    • 2. 发明申请
    • Method and apparatus for determining a hemodynamic response function for event-related functional magnetic resonance imaging
    • 用于确定事件相关功能磁共振成像的血液动力学响应函数的方法和装置
    • US20070287904A1
    • 2007-12-13
    • US11788586
    • 2007-04-20
    • Yu LiMark Limkeman
    • Yu LiMark Limkeman
    • A61B5/055
    • G01R33/4806A61B5/055A61B5/7257G01R33/58
    • Embodiments of the subject invention can involve a method of suppressing noise in hemodynamic deconvolution for event-related functional MR imaging (ER-fMRI). A typical ER-fMRI experiment measures the Blood Oxygenation Level Dependent (BOLD) response to a series of sparse, short-duration stimuli. Based on the deconvolution of a hemodynamic response function (HRF) from the BOLD signal and event stimulus function, the neuronal activation can be localized to specific brain regions and tracked on the order of a second. ER-fMRI can be used to study the temporal dynamics of neuronal network. However, in certain situations, aliasing noise can be generated in hemodynamic deconvolution due to the low sampling rate limited by the imaging speed. This aliasing noise can reduce the accuracy of temporal characterization of the HRF. In an embodiment, by incorporating the use of a phantom having one or more coil loops positioned perpendicular to the magnetic field Bo, such that DC current inputted into one of the loops will produce field distortion to Bo, an ER-fMRI experiment can be calibrated and the temporal measurement of HRF can be improved with the removal of aliasing noise.
    • 本发明的实施例可以涉及一种抑制事件相关功能MR成像(ER-fMRI)的血流动力学去卷积噪声的方法。 典型的ER-fMRI实验测量血液氧合水平依赖(BOLD)对一系列稀疏,短期刺激的反应。 基于来自BOLD信号和事件刺激函数的血液动力学响应函数(HRF)的去卷积,神经元激活可以被定位到特定的脑区域并以一秒的顺序进行跟踪。 ER-fMRI可用于研究神经元网络的时间动力学。 然而,在某些情况下,由于由成像速度限制的低采样率,可以在血流动力学反卷积中产生混叠噪声。 这种混叠噪声可以降低HRF的时间表征的准确性。 在一个实施例中,通过结合使用具有垂直于磁场B 0的一个或多个线圈环的体模,使得输入到一个环路中的DC电流将产生场失真到B < 可以校准ER-fMRI实验,并且可以通过去除混叠噪声来改善HRF的时间测量。