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1. 发明授权

US08150521B2 Methods and devices for controlling battery life in an implantable pulse generator 有权
标题翻译：用于控制可植入式脉冲发生器的电池寿命的方法和装置
公开(公告)号：US08150521B2
公开(公告)日：2012-04-03
申请号：US12049956
申请日：2008-03-17
申请人： Thomas Patrick Crowley , Jeffrey J. Hagen
发明人： Thomas Patrick Crowley , Jeffrey J. Hagen
IPC分类号： A61N1/32
CPC分类号： A61N1/36114
摘要： Methods, devices, and systems for controlling an implantable pulse generator for activation of a nerve or receptor are provided. In particular, the method, devices, and systems embodying features of the present invention control the energy output of a battery in an implantable pulse generator for stimulation of the baroreflex system of the patient.
摘要翻译：提供了用于控制用于激活神经或受体的可植入脉冲发生器的方法，装置和系统。具体地，体现本发明特征的方法，装置和系统控制可植入脉冲发生器中的电池的能量输出，用于刺激患者的压力反射系统。

2. 发明申请

US20070197472A1 N-Alkynyl-2-Heteroaryloxyalkylamides For Use As Fungicides 审中-公开
标题翻译： N-炔基-2-异丙酰氧基烷酰胺用作杀真菌剂
公开(公告)号：US20070197472A1
公开(公告)日：2007-08-23
申请号：US10558331
申请日：2004-05-28
申请人： Roger Salmon , Patrick Crowley
发明人： Roger Salmon , Patrick Crowley
IPC分类号： A01N43/82 , A01N55/00 , A01N43/76 , A01N43/50
CPC分类号： C07D263/56 , A01N43/76 , A01N43/78 , C07D277/62 , C07D277/68 , C07D277/82 , C07D413/12 , C07D417/12
摘要： Compounds of the general formula (I) are useful as fungicides wherein Het is a 5- or 6-linked group of the formula (a) or (b), and the variables are as defined in the claims.
摘要翻译：通式（I）的化合物可用作杀真菌剂，其中Het是式（a）或（b）的5-或6-连接基团，并且变量如权利要求中所定义。

3. 发明申请

US20060240988A1 Fungicides 失效
公开(公告)号：US20060240988A1
公开(公告)日：2006-10-26
申请号：US10536516
申请日：2003-11-10
申请人： Roger Salmon , Patrick Crowley , David Bacon
发明人： Roger Salmon , Patrick Crowley , David Bacon
IPC分类号： A01N37/18
CPC分类号： C07D249/08 , A01N39/04 , C07C235/20 , C07C255/30 , C07C317/28 , C07C323/41
摘要： Fungicidal compounds of the general formula (1): wherein X, Y and Z are independently H, halogen, C1-4 alkyl, halo(C1-4)alkyl, C2-4alkenyl, halo(C2-4)alkenyl, C24 alkynyl, halo(C2-4)alkynyl, C1-4 alkoxy, halo(C1-4)alkoxy, —S(O)n(C1-4)alkyl where n is 0, 1 or 2 and the alkyl group is optionally substituted with fluoro, —OS02(C1-4)alkyl where the alkyl group is optionally substituted with fluoro, cyano, nitro, C1-4 alkoxycarbonyl, —CONR′R″, —COR′, —NR′COR″ or —NR′COOR′″ where R′ and R″ are independently H or C1-4, alkyl and R′″ is C1-4 alkyl, provided that at least one of X and Z is other than H; R1 is C1-4alkyl, C2-4 alkenyl or C2-4 alkynyl in which the alkyl, alkenyl and alkynyl groups are optionally substituted on their terminal carbon atom with one, two or three halogen atoms, with a cyano group, with a C1-4 alkylcarbonyl group, with a C1-4 alkoxycarbonyl group or with a hydroxy group; R2 is H, C1-4 alkyl, C1-4 alkoxymethyl or benzyloxymethyl in which the phenyl ring of the benzyl moiety is optionally substituted with C1-4alkoxy; R3 and R4 are independently H, C1-3 alkyl, C2-3 alkenyl or C2-3 alkynyl provided that both are not H and that when both are other than H their combined total of carbon atoms does not exceed 4, or R3 and R4 join with the carbon atom to which they are attached to form a 3 or 4 membered carbocyclic ring optionally containing one 0, S or N atom and optionally substituted with halo or C1-4alkyl; and R5 is unsubstituted C3-4 alkyl, unsubstituted C3-6 cycloalkyl or C1-4 alkyl or C3-6 cycloalkyl in which the alkyl and cycloalkyl groups are substituted with halo, hydroxy, C1-6 alkoxy, cyano, C1-4 alkylcarbonyloxy, aminocarbonyloxy, mono- or di(C1-4)alkylaminocarbonyloxy, —S(O)″(C1-6)alkyl where n is 0, 1 or 2, triazolyl, tri(C1-4)alkylsilyloxy, optionally substituted phenoxy, optionally substituted thienyloxy, optionally substituted benzyloxy or optionally substituted thienyl-methoxy, in which the optionally substituted phenyl and thienyl rings of phenoxy, thienyloxy, benzyloxy and thienylmethoxy are optionally substituted with one, two or three substituents selected from halo, hydroxy, mercapto, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4alkoxy, C2-4 alkenyloxy, C2-4 alkynyloxy, halo(C1-4)alkyl, halo(C1-4)alkoxy, C1-4 alkylthio; halo(C1-4)alkylthio, hydroxy(C1-4)alkyl, C1-4 alkoxy(C1-4)alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, —NR—R′, —NHCORm, —NHCONRmR″, —CONRmR″, —S02Rm, —OS02Rm, —CORM, —CR′═NR″ or —N═CRmR″, in which R′″ and R″ are independently hydrogen, CI-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy, halo(C1-4)alkoxy, C1-4alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4alkyl or C1-4 alkoxy.

4. 发明申请

US20060148859A1 Substituted pyridyloxyalkylamides and their use as fungicides 失效
标题翻译：取代的吡啶氧基烷基酰胺及其作为杀真菌剂的用途
公开(公告)号：US20060148859A1
公开(公告)日：2006-07-06
申请号：US10536461
申请日：2003-10-23
申请人： Patrick Crowley
发明人： Patrick Crowley
IPC分类号： A01N43/40 , C07D403/02
CPC分类号： C07D213/69 , A01N43/40 , C07D213/65 , C07D213/70 , C07D213/75 , C07D213/80 , C07D213/84
摘要： Fungicidal compounds of the general formula (1), or the corresponding pyridine N-oxide, wherein X, Y, R1, R2, R3, R4 and R5 are as defined in the description.
摘要翻译：通式（1）的杀真菌化合物或相应的吡啶N-氧化物，其中X，Y，R 1，R 2，R 3， R 4，R 4和R 5如在说明书中所定义。

5. 发明申请

US20060100203A1 Fungicides based on nitrogen-containing heterocycles 审中-公开
公开(公告)号：US20060100203A1
公开(公告)日：2006-05-11
申请号：US10540039
申请日：2003-12-03
申请人： Patrick Crowley , Markus Dobler , Urs Mueller , John Williams
发明人： Patrick Crowley , Markus Dobler , Urs Mueller , John Williams
IPC分类号： A01N43/90 , A01N43/42
CPC分类号： C07D471/04
摘要： Fungicidal compounds having the general formula (1): formula (1) wherein W, Z and one of X and Y are N and the other one of X and Y is CR8; R8 is H, halo, C1-4alkyl, C1-4alkoxy, C1-4alkylthio or halo(C1-4)alkyl; R and R2 are independently H, halo, C1-8 alkyl, C1-8 alkoxy, C1-8 alkylthio, C2-8alkenyl, C2-8 alkynyl, cyano or NR3R4, provided that at least one of R and R2 is NR3R4; R1 is halo, C1-8 alkyl, C2-8 alkenyl, C2-8alkynyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)-alkyl, C1-8 alkoxy, C1-8 alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C1-4)alkyl, aryl(C1-4)alkoxy, heteroaryl(C1-4)alkyl, heteroaryl(C1-4)alkoxy, aryl(C1-4)alkylthio, heteroaryl(C1-4)alkylthio, morpholino, piperidino or pyrrolidino; R3 and R4 are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(C1-8)-alkyl, C3-8cycloalkyl, C3-8 cycloalkyl(C1-6)alkyl, heteroaryl, heteroaryl(C1-8)alkyl, NR5R6, provided that not both R3 and R4 are H or NR5R6, or R3 and R4 together form a C3-7 alkylene or C3-7 alkenylene chain optionally substituted with one or more C1-4 alkyl or C1-4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R3 and R4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C1-4)alkyl (especially N-methyl) ring; and R5 and R6 are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8-alkynyl, aryl, aryl(C1-8)alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)alkyl, heteroaryl or heteroaryl(C1-8)alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R8) being optionally substituted with halogen, cyano, C1-6 alkoxy, C1-6alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 haloalkoxy, C1-6 alkylthio, tri(C1-4)alkylsilyl, C1-6 alkylamino or C1-6 dialkylamino, any of the foregoing morpholine, thiomopholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alkyl (especially methyl), and any of the foregoing aryl or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, halo(C1-6)alkyl, halo(C1-6)alkoxy, C1-6 alkylthio, halo(C1-6)alkylthio, hydroxy(C1-6)alkyl, C1-4 alkoxy(C1-6)alkyl, C3-6 cycloalkyl, C3-6cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, —NR″′R″″, NHCOR″′, —NHCONR″′R″″, —CONR″′R″″, —SO2R″′, —OSO2R″′, —COR″′, —CR″′═NR″″ or —N═CR ″′R″″, in which R″′ and R″″ are independently hydrogen, C1-4 alkyl, halo(C1-4)alkyl, C1-4 alkoxy, halo(C1-4)alkoxy, C1-4 alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy.

6. 发明申请

US20060069089A1 Fungicides 失效
公开(公告)号：US20060069089A1
公开(公告)日：2006-03-30
申请号：US10540037
申请日：2003-12-03
申请人： Patrick Crowley , Markus Dobler , Urs Mueller , John Williams
发明人： Patrick Crowley , Markus Dobler , Urs Mueller , John Williams
IPC分类号： C07D471/02 , A01N43/42
CPC分类号： C07D471/04 , A01N43/90
摘要： Fungicidal compositions of the general formula (1): wherein one of W, X, Y and Z is N and the others are CR8; R8 is H, halo, C1-4 alkyl, C1-4 alkoxy or halo(C1-4)alkyl, provided that when X is CH, Z is N, R is NHNH2, R1 is phenyl and R2 is Cl, W and Y are not both CCH3; one of R and R2 is NR3R4 and the other is halo, C1-8 alkyl, C1-8 alkoxy, C1-8 alkylthio, C2-8 alkenyl, C2-8 alkynyl or cyano; R1 is aryl, heteroaryl, morpholino, piperidino or pyrrolidino; R3 and R4 are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(C1-8)-alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)alkyl, heteroaryl, heteroaryl(C1-8)alkyl, NR5R6, provided that not v both R3 and R4 are H or NR5R6, or R3 and R4 together form a C3-7 alkylene or C3-7 alkenylene chain optionally substituted with one or more C1-4 alkyl or C1-4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R3 and R4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N—(C1-4)alkyl (especially N-methyl) ring; and R5 and R6 are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(C1-8)-alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)alkyl, heteroaryl or heteroaryl(C1-8)alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R8) being optionally substituted with halogen, cyano, C1-8 alkoxy C1-4 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 haloalkoxy, C1-6 alkylthio, tri(C1-4)alkylsilyl, C1-6 alkylamino or C1-6 alkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alkyl (especially methyl), and any of the foregoing aryl or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, halo(C1-4)alkyl, halo(C1-6)alkoxy, C1-6 alkylthio, halo(C1-4)alkylthio, hydroxy(C1-6)alkyl, C1-4 alkoxy(C1-6)alkyl, C1-6 cycloalkyl, C3-4 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, —NHCOR″′, —NHCONR″′ R″″, —CONK″′R″″, SO2R″′, —OSO2R″′, —COR″′, —CR″′═NR″ or —N═CR″′R″″, in which R″′ and R″″ are independently hydrogen, C1-4 alkyl, halo-(C1-4)alkyl, C1-4 alkoxy, halo(C1-4)alkoxy, C1-4 alkylthio, C3-4 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl groups beings optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy.

7. 发明申请

US20050175695A1 Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods 审中-公开
标题翻译：卡维地洛游离碱，盐，无水形式或溶剂化物，相应的药物组合物，控制释放制剂和治疗或递送方法
公开(公告)号：US20050175695A1
公开(公告)日：2005-08-11
申请号：US10997836
申请日：2004-11-24
申请人： Catherine Castan , Patrick Crowley , Florence Guimberteau , Remi Meyrueix , Chooh Oh , Gerard Soula
发明人： Catherine Castan , Patrick Crowley , Florence Guimberteau , Remi Meyrueix , Chooh Oh , Gerard Soula
IPC分类号： A61K20060101 , A61K9/16 , A61K9/22 , A61K9/50 , A61K31/403
CPC分类号： A61K9/1635 , A61K9/1641 , A61K9/1658 , A61K9/2077 , A61K31/403
摘要： The present invention also relates to carvedilol free base, carvedilol salts, anhydrous forms, or solvates thereof, corresponding pharmaceutical compositions or controlled release formulations, and delivery or dosing methods of carvedilol forms to the lower gastrointestingal tract or methods to treat cardiovascular diseases, which may include, but are not limited to hypertension, congestive heart failure, atherosclerosis, and angina. The present invention relates to controlled release formulations, which comprise various carvedilol forms, which may include, but are not limited to a carvedilol free base or corresponding carvedilol salts, anhydrous forms or solvates thereof.
摘要翻译：本发明还涉及卡维地洛游离碱，卡维地洛盐，无水形式或其溶剂合物，相应的药物组合物或控释制剂，以及卡维地洛形式向下胃肠道输送或给药方法或治疗心血管疾病的方法，包括但不限于高血压，充血性心力衰竭，动脉粥样硬化和心绞痛。本发明涉及包含各种卡维地洛形式的控释制剂，其可以包括但不限于卡维地洛游离碱或相应的卡维地洛盐，无水形式或溶剂化物。

8. 发明授权

US4900349A Amide derivatives and their use as fungicides and plant growth regulators 失效
标题翻译：酰胺衍生物及其作为杀真菌剂和植物生长调节剂的用途
公开(公告)号：US4900349A
公开(公告)日：1990-02-13
申请号：US178010
申请日：1988-04-05
申请人： Stephen P. Heaney , Patrick Crowley , Lawrence G. Reynolds
发明人： Stephen P. Heaney , Patrick Crowley , Lawrence G. Reynolds
IPC分类号： C07F7/18 , A01N37/34 , A01N37/36 , A01N37/46 , A01N43/08 , A01N43/36 , A01N43/56 , A01N55/00 , A01N55/10 , B01J31/00 , C07B61/00 , C07C67/00 , C07C253/00 , C07C255/29 , C07C325/00 , C07C327/42 , C07C327/44 , C07D231/12 , C07D307/52 , C07D307/54 , C07D521/00 , C07F7/08
CPC分类号： C07D231/12 , A01N37/36 , A01N43/08 , A01N43/56 , C07C255/00 , C07D233/56 , C07D249/08 , C07D307/54 , C07F7/0812 , C07F7/0818
摘要： A compound of the general formula (I): ##STR1## wherein R is C.sub.2 -C.sub.4 alkenyl or C.sub.2 -C.sub.4 alkynyl, both optionally substituted by lower alkyl, halogen or trialkylsilyl; E is CN or CSNH.sub.2 ; and Y is C.sub.1 -C.sub.4 alkoxy, C.sub.3 -C.sub.4 alkenyloxy, C.sub.3 -C.sub.4 alkynyloxy, 1-pyrazolyl or 2-furyl. The compounds have fungicidal and plant growth regulating activity.

9. 发明授权

US3683914A Personal sanitary appliance 失效
标题翻译：个人卫生用品
公开(公告)号：US3683914A
公开(公告)日：1972-08-15
申请号：US3683914D
申请日：1971-03-19
申请人： IVAN PATRICK CROWLEY , STANDARD BANK LTD
发明人： CROWLEY IVAN PATRICK
IPC分类号： A61F5/455 , A61F13/20
CPC分类号： A61F5/455
摘要： A personal sanitary device for use in incontinent females comprises a vaginal portion for insertion in the vagina and provided with an opening for receiving secretion from the uterus and a vestibular portion provided with an opening for receiving fluid from the urethra, the openings communicating with passage means provided with a one way valve which is adapted such that the passage of fluid from the openings therethrough will maintain a subatmospheric pressure in the device which pressure causes the device to be sealingly engaged with the wearer.
摘要翻译：用于失禁女性的个人卫生装置包括用于插入阴道中并具有用于接收子宫分泌物的开口的阴道部分和设置有用于从尿道接收流体的开口的前庭部分，所述开口与通道装置连通设置有单向阀，其适于使得流体从开口通过其中将在该装置中保持低于大气压，该压力导致装置与穿着者密封地接合。

10. 发明申请

US20110316281A1 APPARATUS FOR GENERATING ELECTICITY FROM A TIDAL WATER FLOW 有权
标题翻译：从TIDAL水流中产生选择的装置
公开(公告)号：US20110316281A1
公开(公告)日：2011-12-29
申请号：US13138586
申请日：2010-03-11
申请人： Patrick James Mulvey , Timothy Patrick Crowley
发明人： Patrick James Mulvey , Timothy Patrick Crowley
IPC分类号： F03B13/26
CPC分类号： F03B13/264 , F05B2240/133 , F05B2240/40 , F05B2250/132 , F05B2250/283 , Y02E10/28
摘要： Apparatus (2) for generating electricity from a tidal water flow, which apparatus (2) comprises a plurality of units (4) which generate electricity, and a base (6) for securing the units (4) to a water bed (8), the apparatus (2) being such that: (i) the units (4) each comprise a housing (10) and a turbine generator (12) which is positioned in the housing (10) and which generates the electricity; (ii) the housing (10) has openings (14, 16) for allowing the tidal water to flow through the housing (10) and rotate the turbine generator (12) in order to cause the turbine generator (12) to generate the electricity; (iii) the housing (10) has at least six sides (18) and is symmetrical in end view; (iv) the units (4) contact each other along at least two adjacent sides (18), whereby the units (4) securely connect to each other and provide support for each other; (v) the base has an upper surface (20) with at least one recess (22) which receives a lower part of at least one of the units (4); and (vi) the recess (22) is of a complementary shape to the shape of the lower part of the unit (4) that is located in the recess (22), whereby a plurality of sides of the unit (4) engage adjacent sides of the recess (24), and whereby the unit (4) in the recess (22) securely connects to the base (6).
摘要翻译：用于从潮汐水流发电的装置（2），所述装置（2）包括多个发电单元（4）和用于将单元（4）固定到水床（8）的基座（6），所述装置（2）使得：（i）所述单元（4）各自包括壳体（10）和位于壳体（10）中并且产生电力的涡轮发电机（12）; （ii）壳体（10）具有用于允许潮汐水流过壳体（10）并使涡轮发电机（12）旋转的开口（14,16），以使涡轮发电机（12）产生电力 ; （iii）所述壳体（10）具有至少六个侧面（18）并且在端视图中是对称的; （iv）单元（4）沿着至少两个相邻侧面（18）彼此接触，由此单元（4）彼此牢固地连接并提供彼此的支撑; （v）所述基座具有上表面（20），所述上表面具有至少一个容纳所述单元（4）中的至少一个的下部的凹部（22）; 和（vi）所述凹部（22）与所述单元（4）的位于所述凹部（22）中的下部的形状互补形状，由此所述单元（4）的多个侧面相邻凹部（24）的侧面，并且由此凹部（22）中的单元（4）牢固地连接到基部（6）。

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