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1. 发明申请

US20050156112A1 Crystal-based coincidence timing calibration method 失效
标题翻译：基于晶体的巧合定时校准方法
公开(公告)号：US20050156112A1
公开(公告)日：2005-07-21
申请号：US11028270
申请日：2005-01-03
申请人： John Williams , Dershan Luo , Mark Limkeman , Michael Cook , David McDaniel , Edwin Oswalt , Mark Feilen
发明人： John Williams , Dershan Luo , Mark Limkeman , Michael Cook , David McDaniel , Edwin Oswalt , Mark Feilen
IPC分类号： G01T1/161 , G01T1/164 , G01T1/172 , G01T1/29
CPC分类号： G01T1/2985
摘要： A method of calibrating detectors in a detector ring of a PET scanner, each detector including a plurality of crystals, the PET scanner having a field of view, is disclosed. The method comprises collecting timing data indicative of coincidence events occurring between each pair of crystals within the field of view. The method further comprises determining a detector adjustment value for each detector, determining a crystal adjustment value for each crystal in each detector, and discretizing the crystal adjustment value for each crystal to produce a discretized crystal adjustment value for each crystal. Lastly, the method comprises calibrating each detector by applying the discretized crystal adjustment value for each crystal in each detector to the collected timing data indicative of coincidence events.
摘要翻译：公开了一种校准PET扫描器的检测器环中的检测器的方法，每个检测器包括多个晶体，PET扫描器具有视野。该方法包括收集指示在视场内的每对晶体之间发生的重合事件的定时数据。该方法还包括确定每个检测器的检测器调整值，确定每个检测器中的每个晶体的晶体调整值，以及离散每个晶体的晶体调整值以产生每个晶体的离散晶体调节值。最后，该方法包括通过将每个检测器中的每个晶体的离散晶体调整值应用于指示符合事件的收集的定时数据来校准每个检测器。

2. 发明申请

US20060102845A1 Method and apparatus for timing calibration in a PET scanner 失效
公开(公告)号：US20060102845A1
公开(公告)日：2006-05-18
申请号：US10986792
申请日：2004-11-15
申请人： John Williams , Charles Stearns , David McDaniel , Alexander Ganin
发明人： John Williams , Charles Stearns , David McDaniel , Alexander Ganin
IPC分类号： G01T1/164
CPC分类号： G01T1/172 , G01T1/2985
摘要： The invention is directed to a method and apparatus for timing calibration in a PET scanner. According to one embodiment, the invention relates to a method for timing calibration in a PET scanner having a plurality of scintillator blocks. The method comprises: detecting, in a first scintillator block, a first radiation event, wherein the first scintillator block time-stamps the first radiation event; detecting, in a second scintillator block that is adjacent to the first scintillator block, a second radiation event that corresponds to the first radiation event, wherein the second scintillator block time-stamps the second radiation event; and determining a timing characteristic of the first scintillator block with respect to the second scintillator block based on a comparison between the time-stamps of the first radiation event and the second radiation event.

3. 发明申请

US20060145082A1 Method and system for positron emission tomography image reconstruction 有权
标题翻译：正电子发射断层扫描图像重建方法与系统
公开(公告)号：US20060145082A1
公开(公告)日：2006-07-06
申请号：US11026236
申请日：2004-12-30
申请人： Charles Stearns , David McDaniel , John Williams , Alexander Ganin , Ravindra Manjeshwar , Floribertus Philippus Heukensfeldt Jansen , Yiping Shao
发明人： Charles Stearns , David McDaniel , John Williams , Alexander Ganin , Ravindra Manjeshwar , Floribertus Philippus Heukensfeldt Jansen , Yiping Shao
IPC分类号： G01T1/164
CPC分类号： G01T1/2985
摘要： Methods and systems for controlling a positron emission tomography (PET) system are provided. The method includes receiving timing information from a PET system during an imaging scan using the PET system. The method further includes processing the received timing information and timing bias information relating to the PET system to control the PET system.
摘要翻译：提供了用于控制正电子发射断层摄影（PET）系统的方法和系统。该方法包括在使用PET系统的成像扫描期间从PET系统接收定时信息。该方法还包括处理接收到的定时信息和与PET系统有关的定时偏差信息以控制PET系统。

4. 发明申请

US20060091314A1 Methods and apparatus for real-time error correction 有权
标题翻译：用于实时纠错的方法和装置
公开(公告)号：US20060091314A1
公开(公告)日：2006-05-04
申请号：US10981915
申请日：2004-11-04
申请人： John Williams , David McDaniel
发明人： John Williams , David McDaniel
IPC分类号： G01T1/164
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/1611 , G01T1/171 , G01T1/172
摘要： Methods and apparatus for correcting for at least one of deadtime losses and random coincidences in a positron emission tomography (PET) medical imaging device having a plurality of detectors at successive locations circumferentially spaced about a viewing area, the method comprising, receiving signals indicative of positron-electron annihilation events occurring along a line of response between pairs of detectors for a plurality of predetermined time segments of data acquisition of the events, calculating a correction sinogram for each predetermined time segment from data acquired during each respective single time segment, calculating corrected counts in the correction sinogram for each time segment, calculating a time-weighted correction sinogram for each time segment, combining the time-weighted correction sinogram to generate an acquisition sinogram, and generating an image from the acquisition sinogram.
摘要翻译：用于校正正电子发射断层摄影（PET）医学成像装置中的死时间损失和随机重合中的至少一个的方法和装置，其具有在观察区域周围间隔开的连续位置处的多个检测器，所述方法包括：接收指示正电子的信号 - 电子束湮灭事件沿着多个检测器对之间的响应线发生，用于事件的数据采集的多个预定时间段，从在每个相应单个时间段期间获取的数据计算每个预定时间段的校正窦幅，计算校正计数在每个时间段的校正正弦图中，计算每个时间段的时间加权校正正弦曲线，组合时间加权校正窦幅图以产生采集正弦图，以及从采集中心图生成图像。

5. 发明授权

US09075151B2 Detector array and method of manufacturing the same 有权
标题翻译：检测器阵列及其制造方法
公开(公告)号：US09075151B2
公开(公告)日：2015-07-07
申请号：US13335285
申请日：2011-12-22
申请人： Timothy Patrick Rose , David McDaniel , Leonid Romanov
发明人： Timothy Patrick Rose , David McDaniel , Leonid Romanov
IPC分类号： G01T1/20 , G01T1/202
CPC分类号： G01T1/202 , G01T1/2018 , Y10T29/49
摘要： A detector unit for a detector array includes a photo sensor array, a light guide, and a plurality of scintillator elements formed unitarily with the light guide, the scintillator elements configured to emit absorbed energy in the form of light, the light guide being configured to transmit the light received from at least one of the scintillator elements to a photo sensor, the light guide and the plurality of scintillators being formed from the same material, an area covered by the photo sensors being smaller than an area covered by the scintillator elements and a number of photo sensors being less than a number of scintillator elements. A detector array and a method of manufacturing a detector array are also described herein.
摘要翻译：用于检测器阵列的检测器单元包括光传感器阵列，光导和与光导一体形成的多个闪烁器元件，所述闪烁器元件被配置为以光的形式发射吸收的能量，所述光导被配置为将从至少一个所述闪烁器元件接收的光传输到光传感器，所述光导和所述多个闪烁体由相同的材料形成，所述光传感器所覆盖的区域小于由所述闪烁器元件覆盖的区域，许多光传感器小于许多闪烁体元件。本文还描述了检测器阵列和制造检测器阵列的方法。

6. 发明申请

US20070191822A1 Method and apparatus for acne prevention 有权
标题翻译：预防痤疮的方法和装置
公开(公告)号：US20070191822A1
公开(公告)日：2007-08-16
申请号：US11783538
申请日：2007-04-10
申请人： David McDaniel
发明人： David McDaniel
IPC分类号： A61B18/18 , A61N5/06
CPC分类号： A61N5/0616 , A61B18/203 , A61B2017/00765 , A61B2017/22085 , A61B2018/00452 , A61B2018/00476 , A61B2018/1807 , A61K41/0057 , A61K41/0071 , A61N5/0617 , A61N5/062 , A61N2005/0651 , A61N2005/0652 , A61N2005/0659 , A61N2005/067
摘要： Disclosed is a system and method for treating and preventing skin disorders. More particularly, the disclosed invention is directed toward the prevention of acne and acne scarring by treating sebaceous oil glands and the surrounding tissue with an exogenous chromophore composition and then exposing the target tissue to visible, infrared, or ultraviolet light to inhibit the activity of the oil gland and eliminate acne bacteria. The method of the present invention may be further augmented by enhancing the penetration of the topical composition into the oil gland and surrounding tissue through the use of procedures including enzyme peeling, microderm abrasion, or ultrasound.
摘要翻译：公开了用于治疗和预防皮肤疾病的系统和方法。更具体地，所公开的发明涉及通过用外源发色团组合物治疗皮脂腺和周围组织来防止痤疮和痤疮瘢痕形成，然后将目标组织暴露于可见光，红外或紫外光以抑制油腺，消除痤疮细菌。本发明的方法可以通过使用包括酶剥离，微粒磨损或超声波在内的方法增强局部组合物渗透到油腺和周围组织中而进一步增强。

7. 发明申请

US20060066014A1 Feed apparatus and portable dust collector 失效
公开(公告)号：US20060066014A1
公开(公告)日：2006-03-30
申请号：US10952401
申请日：2004-09-28
申请人： David McDaniel
发明人： David McDaniel
IPC分类号： C21C7/00
CPC分类号： F27D1/1626 , C21C5/441
摘要： A feed apparatus feed apparatus for delivering particulate material to a foundry furnace having disposed therein a furnace form defining an annulus with the furnace exterior wall for receipt of the particulate material. The novel feed apparatus broadly includes a cover, having a top end, side wall, and a bottom end, the latter of which is adapted to fit on top of the furnace ring or melt deck floor; a rotatable tabletop that is adapted to fit on the top end of the cover while permitting air ingress into the cover and having at least one access port for delivering the particulate material into the interior of the cover; a form top that is adapted to fit within the cover on top of the furnace form to facilitate delivery of said particulate material into the annulus made by the furnace form and the furnace exterior wall; means for rotating the tabletop about the centerline of the cover; and means for centering the tabletop as it rotates about the centerline of the cover. In another aspect of the present invention there is provided a portable dust collector for filtering and removing of dust and particulate materials that are generated in industrial plants, such as coreless electric furnaces. The portable dust collector broadly includes a cover, having a top end, side wall, and a bottom end, the latter of which is adapted to fit on top of the furnace ring or melt deck floor; a rotatable tabletop that is adapted to fit on the top end of the cover while permitting air ingress into the cover and having at least one access port for delivering the particulate material into the interior of the cover; a form top that is adapted to fit within the cover on top of the furnace form to facilitate delivery of said particulate material into the annulus made by the furnace form and the furnace exterior wall; means for rotating the tabletop about the centerline of the cover; means for centering the tabletop as it rotates about the centerline of the cover; and means for filtering the dust and particulate materials that are generated within the cover during plant operations and collecting same for ultimate removal and disposition thereof.

8. 发明申请

US20050283211A1 Photomodulation methods and devices for regulating cell proliferation and gene expression 有权
标题翻译：用于调节细胞增殖和基因表达的光调制方法和装置
公开(公告)号：US20050283211A1
公开(公告)日：2005-12-22
申请号：US11116434
申请日：2005-04-28
申请人： David McDaniel
发明人： David McDaniel
IPC分类号： A61B18/18 , A61B18/20 , A61H33/00 , A61K8/00 , A61N5/06 , A61Q17/04 , A61Q19/08 , C12N20060101
CPC分类号： A61Q19/08 , A61B18/203 , A61B2018/00452 , A61B2018/0047 , A61K8/00 , A61K2800/81 , A61N5/0616 , A61N2005/0652 , A61N2005/0661 , A61Q17/04
摘要： Human and mammalian skin undergoes a variety of changes associated with chronological aging. Various environmental factors, disease states and genetic disorders may accelerate both the appearance of aging skin and also the structural and functional changes associated with aging skin. Ultraviolet radiation from the sun is one of the classic known and well-defined means of accelerating or worsening the aging of the skin and this is frequently termed photoaging. Other environmental factors, such as oxidative stress, free radicals, environmental toxins such as ozone and cultural customs or habits such as tobacco smoking are other known probe accelerators in photo aging skin. A wide variety of other factors known and unknown contribute to accelerated or premature aging of the skin. This invention discusses methods where electromagnetic radiation, in particular, light, can be used to photobiomodulate the activity of living cells to delay, diminish, retard or even reverse the structural and functional effects of aging of the skin and other living cells and tissues. In particular methods described for improving the appearance, structure, function of aging skin, including up and down regulating the genotypic markers for the phenotype of aging skin.
摘要翻译：人类和哺乳动物的皮肤经历与时间老化相关的各种变化。各种环境因素，疾病状态和遗传疾病都可能加速老化皮肤的出现，以及与老化皮肤相关的结构和功能变化。来自太阳的紫外线辐射是加速或恶化皮肤老化的经典已知和明确定义的手段之一，这通常被称为光老化。其他环境因素，如氧化应激，自由基，环境毒素如臭氧和文化习俗或习惯，如吸烟是其他已知的摄影老化皮肤的探针加速剂。已知和未知的各种其他因素有助于皮肤的加速或过早老化。本发明讨论了电磁辐射，特别是光线可用于光生物调节活细胞的活性以延缓，减少，延迟或甚至逆转皮肤和其它活细胞和组织老化的结构和功能效应的方法。具体描述用于改善皮肤老化的外观，结构，功能的方法，包括上调和下调老化皮肤表型的基因型标记。

9. 发明授权

US08467644B1 Light guide assembly for a radiation detector 有权
标题翻译：用于辐射探测器的导光组件
公开(公告)号：US08467644B1
公开(公告)日：2013-06-18
申请号：US13338704
申请日：2011-12-28
申请人： Chang Kim , David McDaniel , Gary McBroom
发明人： Chang Kim , David McDaniel , Gary McBroom
IPC分类号： G02B6/26 , G02B6/42 , G02B6/00
CPC分类号： G01T1/2018 , Y10T156/1089
摘要： A method of fabricating a light guide assembly includes the steps of providing an array of generally frustum-shaped light guides made of a light-transmissive material, providing an optical isolation frame of interconnected slats made of an opaque material, wherein the slats are arranged and profiled to correspondingly match the gaps between the light guides and the outer gap around the periphery of the light guide array, and bonding the light guide array and the optical isolation frame to each other.
摘要翻译：一种制造光导组件的方法包括以下步骤：提供由光透射材料制成的大致截头锥形光导阵列，提供由不透明材料制成的互连板条的光学隔离框架，其中板条被布置，并且成形为相应地匹配导光体周围的光导与外部间隙之间的间隙，并将光导阵列和光隔离框架彼此接合。

10. 发明申请

US20070041327A1 Multicast heartbeat signaling 审中-公开
标题翻译：组播心跳信令
公开(公告)号：US20070041327A1
公开(公告)日：2007-02-22
申请号：US11204964
申请日：2005-08-16
申请人： William Foster , Leo Nieuwesteeg , Flemming Andreasen , David McDaniel
发明人： William Foster , Leo Nieuwesteeg , Flemming Andreasen , David McDaniel
IPC分类号： G06F11/00 , H04J3/14
CPC分类号： H04L65/1043 , H04L12/18 , H04L67/14 , H04L67/145 , H04L69/40
摘要： A mechanism that provides for communication of heartbeat signals from servers (call agents) to clients (gateways) in a packet telephony network environment. Clients listen for receipt of multicast heartbeats from any of the servers that may be part of a multicast group. A client assigned to a particular server for control messaging, upon failure to receive a response to a message sent to the assigned server and failure to receive a heartbeat from the assigned server, may select a second server from among the servers and re-send the message to the second server. Without receipt of heartbeat signals, the client defaults to a normal retry behavior for re-sending the message first to the assigned server a number of times before attempting to re-send the message to the second server. With receipt of the heartbeat from the second server, the client adopts an aggressive retry behavior by re-sending the message to the assigned server a lesser number of retries before attempting to re-send the message to the second server. The clients use the multicast heartbeats as a hint, allowing them to switch to the more aggressive retry behavior and consequently reduce the time to re-associate with a new server and re-establish a new security association (if IPsec is used), resulting in a drastic reduction in service delay due to server failures.
摘要翻译：一种机制，用于在分组电话网络环境中提供从服务器（呼叫代理）到客户端（网关）的心跳信号的通信。客户端收听来自任何可能是多播组一部分的服务器的组播心跳信号。分配给特定服务器以用于控制消息收发的客户端，在未能接收到发送给所分配的服务器的消息的响应以及未能从所分配的服务器接收到心跳的响应时，可以从服务器中选择第二服务器并重新发送消息到第二台服务器。在没有收到心跳信号的情况下，客户端默认为正常的重试行为，以便在尝试将消息重新发送到第二个服务器之前先将消息首先发送到分配的服务器。在从第二台服务器接收到心跳信号之后，客户端在尝试将消息重新发送到第二个服务器之前，通过将消息重新发送到分配的服务器进行较少数量的重试，从而采取积极的重试行为。客户端使用组播心跳作为提示，允许他们切换到更积极的重试行为，从而减少与新服务器重新关联的时间，并重新建立新的安全关联（如果使用IPsec），导致由于服务器故障导致的服务延迟急剧减少。

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