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121. 发明授权

US07306598B2 Polymer matrix devices for treatment of vascular malformations 有权
标题翻译：用于治疗血管畸形的聚合物基质装置
公开(公告)号：US07306598B2
公开(公告)日：2007-12-11
申请号：US10456113
申请日：2003-06-05
申请人： Csaba Truckai , John H. Shadduck
发明人： Csaba Truckai , John H. Shadduck
IPC分类号： A61B18/18 , A61B5/04
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12118 , A61B17/12145 , A61B17/12168 , A61B17/12172 , A61B17/12181 , A61B2017/12068 , A61F2/07 , A61F2/848 , A61F2/90 , A61F2220/0016
摘要： A system for treating a wide-neck aneurysm comprising a mesh-like sleeve fabricated from a class of polymer filaments that carry conductive particles therein to provide the filaments with a specified resistivity. The releasable mesh-like sleeve is introduced to the site of a targeted vascular malformation by the working end of a catheter that carries an electrode arrangement at its distal terminus. The system further provides an electrical source and controller (i) that modulates power delivery to the polymer matrix which can then fuse the sleeve to the wall of a blood vessel to span across the vascular malformation.
摘要翻译：一种用于治疗宽颈动脉瘤的系统，包括由一类聚合物长丝制成的网状套筒，所述聚合物细丝在其中携带导电颗粒以提供具有指定电阻率的细丝。可释放的网状套筒通过导管的工作端引导到目标血管畸形部位，该导管在其远端具有电极装置。该系统还提供一种电源和控制器（i），其调节向聚合物基质的功率传递，然后可将该套管熔合到血管的壁以横跨血管畸形。

122. 发明申请

US20070233249A1 METHODS FOR TREATING BONE 审中-公开
标题翻译：治疗骨的方法
公开(公告)号：US20070233249A1
公开(公告)日：2007-10-04
申请号：US11672414
申请日：2007-02-07
申请人： John H. Shadduck
发明人： John H. Shadduck
IPC分类号： A61F2/44
CPC分类号： A61B17/7095 , A61B18/02 , A61B18/08 , A61B18/1206 , A61B2017/564
摘要： The present invention relates in certain embodiments to medical devices for treating vertebral compression fractures. In one embodiment, the invention relate to instruments and methods for introducing fill material into a vertebral body that slowly expands vertebral height without explosive balloon expansion as in kyphoplasty. The system provides a fill material that infills a vertebra without flowable bone cement as used in kyphoplasty and vertebroplasty procedures. Thus, the bone fill system prevents the possibility of extravasation of material into the spinal canal which occurs in a significant number of kyphoplasty and vertebroplasty procedures. An energy source can apply energy to a substantially rigid implant material in order to soften, melt, or fracture the implant material to infill a vertebral body.
摘要翻译：本发明在某些实施例中涉及用于治疗脊椎压缩性骨折的医疗装置。在一个实施方案中，本发明涉及用于将填充材料引入椎体中的器具和方法，所述椎体缓慢地扩张脊椎高度而没有爆炸性气囊膨胀，如在椎体后凸成形术中。系统提供填充椎体，不需要可流动的骨水泥，如用于椎体后凸成形术和椎体成形术。因此，骨填充系统防止在大量脊柱后凸成形术和椎体成形术程序中发生的材料外渗到椎管中的可能性。能量源可以将能量施加到基本上刚性的植入材料上，以便软化，熔化或折断植入材料以填充椎体。

123. 发明授权

US07186253B2 Electrosurgical jaw structure for controlled energy delivery 有权
标题翻译：用于受控能量输送的电外科钳口结构
公开(公告)号：US07186253B2
公开(公告)日：2007-03-06
申请号：US11118881
申请日：2005-04-29
申请人： Csaba Truckai , James Baker , Bruno Strul , John H. Shadduck
发明人： Csaba Truckai , James Baker , Bruno Strul , John H. Shadduck
IPC分类号： A61B18/14 , A61B18/12
CPC分类号： A61B18/1442 , A61B2018/00077 , A61B2018/00083 , A61B2018/00148 , A61B2018/0063 , A61B2018/00809
摘要： A working end of a surgical instrument that carries first and second jaws for delivering energy to tissue. In a preferred embodiment, at least one jaw of the working end defines a tissue-engagement plane that contacts the targeted tissue. The cross-section of the engagement plane reveals that it defines a surface conductive portion that overlies a variably resistive matrix of a temperature-sensitive resistive material or a pressure-sensitive resistive material. An interior of the jaw carries a conductive material or electrode that is coupled to an Rf source and controller. In an exemplary embodiment, the variably resistive matrix can comprise a positive temperature coefficient (PTC) material, such as a ceramic, that is engineered to exhibit a dramatically increasing resistance (i.e., several orders of magnitude) above a specific temperature of the material.
摘要翻译：手术器械的工作端，其携带用于将能量递送至组织的第一和第二钳口。在优选实施例中，工作端的至少一个钳口限定了接触目标组织的组织接合平面。接合平面的横截面显示它限定了覆盖在温度敏感电阻材料或压敏电阻材料的可变电阻矩阵上的表面导电部分。钳口的内部承载耦合到Rf源和控制器的导电材料或电极。在示例性实施例中，可变电阻矩阵可以包括正温度系数（PTC）材料，例如陶瓷，其被工程化以显示高于材料的特定温度的显着增加的电阻（即几个数量级）。

124. 发明授权

US07008419B2 Surgical instruments and techniques for treating gastro-esophageal reflux disease 失效
标题翻译：用于治疗胃食管反流病的手术器械和技术
公开(公告)号：US07008419B2
公开(公告)日：2006-03-07
申请号：US10780027
申请日：2004-02-17
申请人： John H. Shadduck
发明人： John H. Shadduck
IPC分类号： A61B18/18
CPC分类号： A61N1/326 , A61B18/1485 , A61B18/1492 , A61B90/39 , A61B2018/00047 , A61B2018/00285 , A61B2018/00482 , A61B2018/00494 , A61B2018/00553 , A61B2018/00678 , A61B2018/00726 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00875 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B2018/1861 , A61B2090/3782 , A61B2218/002
摘要： Instruments for thermally-mediated treatment of a patient's lower esophageal sphincter (LES) to induce an injury healing response to thereby populate the extracellular compartment of walls of the LES with collagen matrices to altere the biomechanics of the LES to provide an increased intra-esophageal pressure for preventing acid reflux. A preferred embodiment is a bougie-type device for trans-esophageal introduction that carries conductive electrodes for delivering Rf energy to walls of the LES (i) to induce the injury healing response or (ii) to “model” collagenous tissues of the LES by shrinking collagen fibers therein.
摘要翻译：用于热介导治疗患者下食管括约肌（LES）以诱导损伤愈合反应的仪器，从而用胶原基质填充LES的壁的细胞外隔室以提高LES的生物力学以提供增加的食管内压用于防止酸反流。优选的实施方案是用于经食道导入的双酚类装置，其携带用于将R f能量递送至LES（i）的壁的导电电极，以诱导损伤愈合反应或（ii）通过以下步骤“模拟”LES的胶原组织在其中收缩胶原纤维。

125. 发明授权

US06669694B2 Medical instruments and techniques for highly-localized thermally-mediated therapies 有权
标题翻译：用于高度局限性热介导治疗的医疗仪器和技术
公开(公告)号：US06669694B2
公开(公告)日：2003-12-30
申请号：US10017582
申请日：2001-12-07
申请人： John H. Shadduck
发明人： John H. Shadduck
IPC分类号： A61B1818
CPC分类号： A61B18/04 , A61B2017/00504 , A61B2018/00619 , A61B2018/0063 , A61B2018/048
摘要： This invention relates a novel surgical device scalable to small dimensions for thermally-mediated treatments or thermoplasties of targeted tissue volumes. An exemplary embodiment is adapted for shrinking, sealing or welding tissue. The instruments and techniques utilize a thermal energy delivery means, for example an electrical energy source, to instantly vaporize a biocompatible fluid media within an electrically insulated instrument body. The altered media is characterized by a (i) a high heat content, and (ii) a high exit velocity from the working end both of which characteristics are controlled to hydrate tissue and at the same time denature proteins to shrink, seal, weld or cause any other thermally-mediated treatment of an engaged tissue volume—while causing limited collateral thermal damage and while totally eliminating electrical current flow the engaged tissue volume. The system can further utilize a piezoelectric material that carries fluid channels to apply compressive forces to eject the gas media from the working end of allow a lesser electrical energy requirement to convert a liquid to a gas and to increase media exit pressure.
摘要翻译：本发明涉及一种可扩展到小尺寸的新型手术装置，用于热介导治疗或靶向组织体积的热塑性。示例性实施例适用于收缩，密封或焊接组织。仪器和技术利用热能递送装置，例如电能源，在电绝缘的仪器主体内立即蒸发生物相容的流体介质。改变的介质的特征在于（i）高的热量，和（ii）来自工作端的高出口速度，其特性被控制以水合组织，同时使蛋白质变性收缩，密封，焊接或引起任何其他热介导的接合组织体积的处理 - 同时引起有限的侧支热损伤并且同时完全消除接合的组织体积的电流。该系统可以进一步利用承载流体通道的压电材料来施加压缩力以从工作端喷射气体介质，从而允许将液体转化为气体的较小的电能需求并增加介质出口压力。

126. 发明授权

US06387103B2 Instruments and techniques for inducing neocollagenesis in skin treatments 有权
标题翻译：用于诱导皮肤治疗中的新胶原的仪器和技术
公开(公告)号：US06387103B2
公开(公告)日：2002-05-14
申请号：US09475479
申请日：1999-12-30
申请人： John H. Shadduck
发明人： John H. Shadduck
IPC分类号： A61M100
CPC分类号： A61B17/545
摘要： A system for atraumatic removal of skin surface layers in a treatment to induce neocollagenesis in the dermis to reduce wrinkles and alter the architecture of the dermal layers. A preferred embodiment of the inventive system comprises (i) a hand-held instrument with a resilient floating skin interface that carries microscopic diamond fragments for abrading the skin surface in a controlled manner, (ii) a fluid source for supplying sterile fluids to the skin interface for cleaning skin debris from the skin interface; and (iii) a negative pressure source for pulling fluid to the skin interface and thereafter aspirating fluid and skin debris from a treatment site. The skin interface is formed of a resilient floating member (e.g., silicone) that allows the working surface to flex and atraumatically engage the topography of the skin surface as it is translated across a treatment site. The system allows substantially deep surface layer removal without significant pain.
摘要翻译：用于在治疗中无创去除皮肤表面层的系统以在真皮中诱导新胶原形成以减少皱纹并改变真皮层的结构。本发明系统的优选实施例包括（i）具有弹性浮动皮肤界面的手持式仪器，其携带用于以受控方式研磨皮肤表面的微观金刚石碎片，（ii）用于向皮肤供应无菌流体的流体源用于从皮肤界面清洁皮肤碎屑的界面; 和（iii）用于将流体牵引到皮肤界面并且然后从治疗部位抽吸流体和皮肤碎屑的负压源。皮肤界面由弹性浮动构件（例如硅树脂）形成，其允许工作表面在穿过治疗部位被翻译时，使皮肤表面的形貌弯曲并且无损伤地接合皮肤表面的形貌。该系统允许基本上深的表面层去除而没有显着的疼痛。

127. 发明授权

US06210404B1 Microjoule electrical discharge catheter for thrombolysis in stroke patients 有权
标题翻译：用于中风患者溶栓的微焦耳放电导管
公开(公告)号：US06210404B1
公开(公告)日：2001-04-03
申请号：US09181906
申请日：1998-10-28
申请人： John H. Shadduck
发明人： John H. Shadduck
IPC分类号： A61B1804
CPC分类号： A61B18/1492 , A61B18/042 , A61B2018/0041 , A61B2018/1213 , A61B2218/002
摘要： A micro-catheter system utilizing a microjoule pulsed electrical discharge between first and second electrodes in a recessed lumen at the catheter's working end for creating a cavitating volume of electrolytic fluid composition including a pharmacologic agent. The expansion and collapse of media at a high repetition rate creates acoustic waves that propagate distally from the working end of the micro-catheter to disrupt thrombus. The expansion and collapse of such cavitation bubbles “jet” the pharmacologic agent at a controlled velocity into the acoustically-disrupted thrombus to further depolymerize the thrombus. The catheter system includes a computer-controller for independent modulation of (i) all aspects of pharmacologic agent delivery, and (ii) all parameters of electrical discharge to “tailor” the combined acoustic wave effects and pharmacologic agent effects to dissolve thrombus rapidly and efficiently.
摘要翻译：一种微导管系统，其利用在导管工作端处的凹腔中的第一和第二电极之间的微焦耳脉冲放电，以产生包含药剂的电解液组合物的空化体积。介质在高重复率下的膨胀和破裂产生从微导管的工作端向远端传播以破坏血栓的声波。这种气蚀气泡的膨胀和塌陷以可控制的速度将药理学“喷射”到声破裂的血栓中，以进一步解聚血栓。该导管系统包括一个计算机控制器，用于独立调制（i）药理学递送的所有方面，以及（ii）放电的所有参数以“调整”组合的声波效应和药理作用以迅速有效地溶解血栓。

128. 发明授权

US6099521A Semiconductor contact lens cooling system and technique for light-mediated eye therapies 失效
标题翻译：半导体隐形眼镜冷却系统和光介导眼科治疗技术
公开(公告)号：US6099521A
公开(公告)日：2000-08-08
申请号：US110065
申请日：1998-07-03
申请人： John H. Shadduck
发明人： John H. Shadduck
IPC分类号： A61B18/00 , A61F9/009 , A61F9/01 , A61B3/00
CPC分类号： A61F9/00825 , A61F9/00802 , A61F9/00821 , A61F9/009 , A61B2018/00011 , A61F2009/00844 , A61F2009/00872 , A61F2009/00882
摘要： An active form of heat sink contact lens device that utilizes a series of semiconductor Peltier paired elements operatively connected to a direct current power controller and power source for (i) pre-cooling the cornea before an optothermal treatment of the cornea, (ii) to cool the cornea rapidly following an optothermal treatment of the cornea, or (iii) to dynamically cool the anterior surface of the cornea during an optothermal treatment of the cornea based on temperature feedback from temperature sensors in the contact lens device. The sphero-concave lens with a medial portion of thermally conductive transparent material to allow the transmission of light beams which is formed to contact a patient's cornea. The perimeter portion of the lens also sphero-concave with a radius of curvature adapted to contact the sclera. In general, the semiconductor paired Peltier elements are carried in the perimeter portion of the contact lens device.
摘要翻译：一种主动形式的散热器隐形眼镜装置，其利用一系列半导体珀尔帖配对元件，其可操作地连接到直流电源控制器和电源，用于（i）在角膜的光热处理之前预冷却角膜，（ii）至在角膜的光热治疗后，快速冷却角膜，或（iii）基于接触镜装置中的温度传感器的温度反馈，在角膜的光热处理期间动态冷却角膜前表面。具有导热透明材料的中间部分的球状凹透镜，以允许透射形成为接触患者角膜的光束。透镜的周边部分也是具有适于接触巩膜的曲率半径的球面凹凸。通常，半导体成对的珀耳帖元件被携带在隐形眼镜装置的周边部分中。

129. 发明授权

US10835304B2 Medical ablation devices and methods 有权
公开(公告)号：US10835304B2
公开(公告)日：2020-11-17
申请号：US16841500
申请日：2020-04-06
申请人： John H. Shadduck
发明人： John H. Shadduck
IPC分类号： A61B18/04 , A61B18/00
CPC分类号： A61B18/04 , A61B2018/00577 , A61B2018/00589 , A61B2018/046
摘要： Ablation devices, more specifically needle injectors configured to deliver flowable thermal treatment media into an interface with tissue and that can provide a single dose of ablative energy.

130. 发明授权

US10518111B2 Supercavitating medical probe and method of use 有权
公开(公告)号：US10518111B2
公开(公告)日：2019-12-31
申请号：US14936512
申请日：2015-11-09
申请人： John H. Shadduck
发明人： John H. Shadduck
IPC分类号： A61N7/02 , A61B18/14 , A61B17/32 , A61B17/22 , A61B18/00 , A61B18/18 , A61F9/007
摘要： An electrosurgical working end that utilizes supercavitation phenomenon for controlled application of electrosurgical energy to tissue. In one preferred method of the invention, the system utilizes an electrosurgical surface that is rotatable in a liquid substance at very high surface velocities capable of localized lowering of the pressure of the substance below its saturated vapor pressure to cause supercavitation, and contemporaneously applying electrical energy from the electrosurgical surface across the cavity to ablate adjacent tissue. The system creates supercavitation with surface velocities of greater than about 70 m/sec in a liquid substance by means of high speed rotation and optionally ultrasound actuation.

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