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111. 发明申请

US20140314855A1 COATED MESOPOROUS NANOPARTICLES 审中-公开
标题翻译：包覆的多孔纳米粒子
公开(公告)号：US20140314855A1
公开(公告)日：2014-10-23
申请号：US14110839
申请日：2012-04-12
申请人： Paul Ducheyne , Sanjib Bhattacharyya
发明人： Paul Ducheyne , Sanjib Bhattacharyya
IPC分类号： A61K9/50
CPC分类号： A61K9/5031 , A61K9/5089 , A61K9/5115 , A61K9/5146 , A61K9/5192 , A61K47/60 , A61K47/6923 , A61K47/6929
摘要： Provided are methods for producing mesoporous nanoparticles that can, once loaded, retain small or large molecules (e.g., molecules having a molecular weight that is less or greater than about 900 Da) until release is desired, upon which time the mesoporous nanoparticles can release the loaded molecule in a controlled manner for a desired period of time, including an extended period of time. Also disclosed are methods for treating a subject comprising administering to the subject a mesoporous nanoparticle according to the present disclosure.
摘要翻译：提供了生产介孔纳米颗粒的方法，其可以一旦加载，保留小分子或大分子（例如分子量小于或大于约900Da的分子），直到需要释放，此时介孔纳米颗粒可释放以受控方式加载所需的时间段，包括延长的时间段。还公开了治疗受试者的方法，包括向受试者施用根据本公开的介孔纳米颗粒。

112. 发明申请

US20140294909A1 NANOCOMPOSITES OF GOLD AND POLYMERS 审中-公开
标题翻译：金和聚合物的纳米复合材料
公开(公告)号：US20140294909A1
公开(公告)日：2014-10-02
申请号：US14351443
申请日：2012-10-12
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： Jordan J. Green , Corey J. Bishop , Daniel Peng , Stephany Yi Tzeng
IPC分类号： A61K47/02 , A61K47/34 , A61K9/50 , A61K41/00
CPC分类号： A61K9/5115 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K41/0052 , A61K47/02 , A61K47/34 , A61K47/6923 , A61K48/0041 , A61K49/00 , C08G69/42 , C08G73/02 , C08G2220/00 , C08K3/08 , C08K3/22 , C08K2003/0806 , C08K2003/2265 , C08K2003/2289 , C08L79/02 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要： A layer-by-layer (LbL) system, which alternately ionically complexes anionic AuNPs to two unique cationic polymers (disulfide-reducible and hydrolytically degradable) and two anionic nucleic acids, is disclosed.
摘要翻译：公开了一种逐层（LbL）系统，其将阴离子AuNP与两种独特的阳离子聚合物（二硫化物可还原和可水解降解的）和两种阴离子核酸交替离子复合。

113. 发明申请

US20140271894A1 MATRIX-INCORPORATED FLUORESCENT POROUS SILICA PARTICLES FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物输送的基质合成荧光多孔二氧化硅颗粒
公开(公告)号：US20140271894A1
公开(公告)日：2014-09-18
申请号：US13803604
申请日：2013-03-14
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION
发明人： Dylan J. Boday , Jason T. Wertz
IPC分类号： A61K9/14
CPC分类号： A61K9/501 , A61K9/5026 , A61K9/5089 , A61K9/5115 , A61K9/5138 , A61K9/5192 , A61K47/6923 , A61K49/0093
摘要： A fluorescent porous silica particle for drug delivery includes a bridged silane fluorescent dye incorporated throughout the particle's matrix. Copolymerization of a bridged silane fluorescent dye (e.g., (R′O)3Si—R—Si(OR′)3, where R is a fluorescent organic bridging group, and where R′ is a methyl or ethyl group) and a tetralkoxysilane (e.g., Si(OR′)4, where R′ is a methyl or ethyl group) in the presence of a surfactant generates matrix-incorporated fluorescent porous silica particles of a predetermined size and shape. A capping layer is then bonded onto the surface of each particle and, subsequently, the surfactant within the pores of each particle is removed. The capping layer reversibly changes between closed and opened states responsive to a stimulus. A payload is then loaded within of the pores by applying the stimulus to open the capping layer. The payload is then entrapped within the pores by removing the stimulus to close the capping layer.
摘要翻译：用于药物递送的荧光多孔二氧化硅颗粒包括掺入整个颗粒的基质中的桥接硅烷荧光染料。桥联硅烷荧光染料（例如（R'O）3Si-R-Si（OR'）3）的共聚合，其中R是荧光有机桥连基团，其中R'是甲基或乙基）和四氮烷氧基硅烷例如在表面活性剂存在下的Si（OR'）4，其中R'是甲基或乙基）产生具有预定尺寸和形状的基质掺入的荧光多孔二氧化硅颗粒。然后将覆盖层结合到每个颗粒的表面上，随后除去每个颗粒的孔内的表面活性剂。覆盖层响应于刺激而在闭合和打开的状态之间可逆地改变。然后通过施加刺激来打开封盖层，将有效载荷装载在孔内。然后通过去除刺激以封闭封盖层，将有效载荷夹在孔内。

114. 发明申请

US20140271889A1 MULTIFUNCTIONAL METAL NANOPARTICLES HAVING A POLYDOPAMINE-BASED SURFACE AND METHODS OF MAKING AND USING THE SAME 有权
标题翻译：具有聚多异氰酸酯基表面的多官能金属纳米颗粒及其制备和使用方法
公开(公告)号：US20140271889A1
公开(公告)日：2014-09-18
申请号：US14294636
申请日：2014-06-03
申请人： Phillip B. Messersmith , Kvar C.L. Black, IV , Ji Yi , Jose G. Rivera
发明人： Phillip B. Messersmith , Kvar C.L. Black, IV , Ji Yi , Jose G. Rivera
IPC分类号： A61K9/51 , A61N5/06 , G01N33/58 , A61K41/00 , A61K39/395 , A61K39/40
CPC分类号： A61K41/0052 , A61K9/0092 , A61K9/1611 , A61K9/1641 , A61K9/1676 , A61K9/1682 , A61K9/5094 , A61K9/51 , A61K31/69 , A61K33/00 , A61K33/26 , A61K33/38 , A61K39/39558 , A61K39/40 , A61K41/0057 , A61K45/06 , A61K47/6923 , A61K49/1857 , A61K49/1875 , A61N5/062 , B82Y5/00 , B82Y15/00 , B82Y40/00 , C07K16/00 , C07K16/2863 , C07K16/30 , G01N21/4795 , G01N21/554 , G01N33/54346 , G01N33/553 , G01N33/587
摘要： The present invention provides nanoparticles including a metallic core having a length along each axis of from 1 to 100 nanometers and a coating disposed on at least part of the surface of the metallic core, wherein the coating comprises polydopamine, along with methods for making and using such nanoparticles. The metallic core may be gold, silver or iron oxide and the polydopamine coating may have other substances bound to it, such as silver, targeting ligands or antibodies, or other therapeutic or imaging contrast agents. The disclosed nanoparticles can be targeted to cells for treating cancer or bacterial infections, and for use in diagnostic imaging.
摘要翻译：本发明提供纳米颗粒，其包括金属芯，每个轴的长度为1至100纳米，涂层设置在金属芯的至少部分表面上，其中涂层包括聚多巴胺以及制备和使用方法这样的纳米颗粒。金属芯可以是金，银或氧化铁，并且聚多巴胺涂层可以具有与其结合的其它物质，例如银，靶向配体或抗体，或其它治疗或成像造影剂。所公开的纳米颗粒可以靶向用于治疗癌症或细菌感染的细胞，并用于诊断成像。

115. 发明申请

US20140249081A1 NANOPARTICLE PEPTIDE COMPOSITIONS 有权
标题翻译：纳米胶囊组合物
公开(公告)号：US20140249081A1
公开(公告)日：2014-09-04
申请号：US14174251
申请日：2014-02-06
申请人： Midatech Limited
发明人： Thomas Rademacher , Phillip Williams
IPC分类号： A61K9/14 , A61K45/06 , A61K38/22
CPC分类号： A61K9/14 , A61K9/51 , A61K9/5123 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K45/06 , A61K47/6923 , A61K47/6929 , B82Y5/00 , C07K5/0806 , C07K14/47 , C07K14/575
摘要： The present invention relates to amylin peptide-carrying nanoparticles, particularly for use in medicine, and includes methods for treatment of disorders, e.g., of blood glucose regulation. Nanoparticle composition comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said ligands comprise glutathione; and at least one amylin peptide that is non-covalently bound to the corona.
摘要翻译：本发明涉及具有胰岛淀粉样多肽的载体纳米颗粒，特别是用于医学中，并且包括用于治疗诸如血糖调节的病症的方法。纳米颗粒组合物包含纳米颗粒，其包含包含金属和/或半导体的芯; 以及包含共价连接到所述核的多个配体的电晕，其中所述配体包含谷胱甘肽; 和至少一种非共价结合于电晕的胰淀素肽。

116. 发明申请

US20140248360A1 NANOPARTICLE TUMOUR VACCINES 审中-公开
标题翻译：纳米颗粒肿瘤疫苗
公开(公告)号：US20140248360A1
公开(公告)日：2014-09-04
申请号：US14343435
申请日：2012-09-07
申请人： MIDATECH LIMITED , IMMUNOTOPE, INC.
发明人： Thomas Rademacher , Ramila Philip
IPC分类号： A61K9/14 , A61K39/00
CPC分类号： A61K9/141 , A61K39/0011 , A61K47/6923 , A61K47/6929
摘要： The present invention provides a vaccine for the prophylactic or therapeutic treatment of a tumour in a mammalian subject, as well as methods of using the vaccine, including in treatment of tumours and in generating a CTL response. The vaccine comprises a plurality of nanoparticles and a pharmaceutically acceptable carrier, salt or diluents. The nanoparticles comprise a core comprising a metal and/or a semiconductor atom; and a corona comprising a plurality of ligands covalently linked to the core, wherein at least a first ligand of said plurality comprises a carbohydrate moiety that is covalently linked to the core via a first linker, and wherein at least a second ligand of said plurality comprises an epitopic peptide that is covalently linked to the core via a second linker, said second linker comprising a peptide portion and a non-peptide portion, wherein said peptide portion comprises the sequence X1X2Z1, wherein X1 is an amino acid selected from A and G; X2 is an amino acid selected from A and G; and Z1 is an amino acid selected from Y and F, and wherein said epitopic peptide forms at least a portion of or is derived from a Tumour-Associated Antigen (TAA).
摘要翻译：本发明提供了用于哺乳动物受试者中的肿瘤的预防或治疗性治疗的疫苗，以及使用疫苗的方法，包括治疗肿瘤和产生CTL应答。疫苗包含多个纳米颗粒和药学上可接受的载体，盐或稀释剂。纳米颗粒包含包含金属和/或半导体原子的芯; 以及电晕，其包含共价连接到所述芯的多个配体，其中所述多个的至少第一配体包含经由第一接头共价连接到所述核的碳水化合物部分，并且其中所述多个的至少第二配体包含通过第二接头共价连接到核的表位肽，所述第二接头包含肽部分和非肽部分，其中所述肽部分包含序列X1X2Z1，其中X1是选自A和G的氨基酸; X2是选自A和G的氨基酸; 并且Z 1是选自Y和F的氨基酸，并且其中所述表位肽形成至少一部分或衍生自肿瘤相关抗原（TAA）的氨基酸。

117. 发明申请

US20140234220A1 METHOD AND COMPOSITION FOR DISPERSIONS OF GOLD NANOPARTICLES 审中-公开
标题翻译：黄金纳米粒子分布的方法和组成
公开(公告)号：US20140234220A1
公开(公告)日：2014-08-21
申请号：US14183229
申请日：2014-02-18
申请人： Dan V. Goia , John I. Njagi , Calin V. Pop
发明人： Dan V. Goia , John I. Njagi , Calin V. Pop
IPC分类号： A61K41/00 , A61K47/48
CPC分类号： A61K47/6923
摘要： The present disclosure relates to a method for making a gold nanoparticle dispersion. The method includes providing a first solution that has gold ions in a liquid medium, adding NTA molecules to the first solution to form a gold nanoparticle dispersion. When the NTA molecules are added to the first solution, the NTA molecules act as a reducing agent to reduce the gold ions to gold atoms, after which the gold atoms nucleate to form gold nanoparticles. The excess NTA molecules then attach to the surface of the gold nanoparticles to stabilize the dispersion. The present disclosure also relates to a dispersion composition that includes a liquid medium, gold nanoparticles dispersed throughout the liquid medium, and NTA molecules directly coating the gold nanoparticles.
摘要翻译：本公开涉及一种制备金纳米颗粒分散体的方法。该方法包括提供在液体介质中具有金离子的第一溶液，将NTA分子加入到第一溶液中以形成金纳米颗粒分散体。当NTA分子被添加到第一溶液中时，NTA分子用作还原剂以将金离子还原成金原子，之后金原子成核形成金纳米颗粒。然后过量的NTA分子附着到金纳米颗粒的表面以稳定分散体。本公开还涉及包含液体介质，分散在整个液体介质中的金纳米颗粒和直接涂覆金纳米颗粒的NTA分子的分散体组合物。

118. 发明授权

US08790934B2 Nanoparticles 有权
标题翻译：纳米颗粒
公开(公告)号：US08790934B2
公开(公告)日：2014-07-29
申请号：US13306924
申请日：2011-11-29
申请人： Soledad Penades , Javier Rojo , Manuel Martin-Lomas
发明人： Soledad Penades , Javier Rojo , Manuel Martin-Lomas
IPC分类号： G01N33/551 , G01N33/552 , G01N33/553 , G01N33/543
CPC分类号： G01N33/54346 , A61K9/5115 , A61K47/6923 , B82Y5/00 , B82Y10/00 , B82Y15/00 , G01N33/588 , G01N33/80 , Y10T436/24
摘要： Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or semiconductor atoms, which can be employed as a substrate for immobilising a plurality of ligands comprising carbohydrate groups. These “nanoparticles” can then be used to study carbohydrate mediated interactions, e.g. with other carbohydrates or proteins, and as therapeutics and diagnostic reagents.
摘要翻译：描述了研究和调节含碳水化合物的部分与其他物质的相互作用的材料和方法，特别是小颗粒，例如，金属或半导体原子的簇，其可以用作固定包含碳水化合物基团的多个配体的底物。然后可以使用这些“纳米颗粒”来研究碳水化合物介导的相互作用。与其他碳水化合物或蛋白质，以及作为治疗和诊断试剂。

119. 发明授权

US08785202B2 Colloidal metal compositions and methods 有权
标题翻译：胶体金属组成和方法
公开(公告)号：US08785202B2
公开(公告)日：2014-07-22
申请号：US12708326
申请日：2010-02-18
申请人： Lawrence Tamarkin , Giulio F. Paciotti
发明人： Lawrence Tamarkin , Giulio F. Paciotti
IPC分类号： A01N55/02 , A61K31/28 , A61K33/24 , G01N33/48 , G01N33/53
CPC分类号： C07K14/525 , A61K38/191 , A61K38/39 , A61K39/39 , A61K47/60 , A61K47/6923 , A61K49/0013 , A61K49/0017 , A61K49/0056 , A61K49/0065 , A61K51/1244 , A61K2039/55505 , A61K2039/55516 , A61K2039/55522 , C07K16/241
摘要： The present invention comprises compositions and methods for delivery systems of agents, including therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological factors. In general, these vector compositions comprise a colloidal metal, derivatized PEG (polyethylene glycol) and an agent. The invention also comprises methods and compositions for making such colloidal metal compositions and for treatment of cancer.
摘要翻译：本发明包括用于药物递送系统的组合物和方法，包括治疗化合物，药剂，药物，检测剂，核酸序列和生物因子。通常，这些载体组合物包含胶态金属，衍生化PEG（聚乙二醇）和试剂。本发明还包括制备这种胶体金属组合物和治疗癌症的方法和组合物。

120. 发明申请

US20140199340A1 TOLEROGENIC SYNTHETIC NANOCARRIERS FOR INDUCING REGULATORY B CELLS 有权
标题翻译：用于诱导调节性B细胞的富集合成纳米颗粒
公开(公告)号：US20140199340A1
公开(公告)日：2014-07-17
申请号：US14161660
申请日：2014-01-22
申请人： Selecta Biosciences, Inc.
发明人： Roberto A. Maldonado
IPC分类号： A61K39/00
CPC分类号： A61K39/385 , A61K9/127 , A61K9/14 , A61K9/51 , A61K9/5115 , A61K9/5146 , A61K9/5153 , A61K31/192 , A61K38/13 , A61K38/1816 , A61K38/38 , A61K39/00 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/36 , A61K47/50 , A61K47/52 , A61K47/544 , A61K47/593 , A61K47/643 , A61K47/69 , A61K47/6923 , A61K47/6929 , A61K47/6937 , A61K2039/5154 , A61K2039/55511 , A61K2039/55555 , A61K2039/577 , B82Y5/00 , B82Y40/00 , G01N33/505 , G01N33/56972 , G01N2333/7051 , G01N2333/70514 , G01N2333/70517 , Y02A50/401 , Y02A50/41 , A61K2300/00
摘要： Disclosed are synthetic nanocarrier methods, and related compositions, comprising B cell and/or MHC Class II-restricted epitopes and immunosuppressants in order to generate tolerogenic immune responses, such as the generation of antigen-specific regulatory B cells.
摘要翻译：公开了合成纳米载体方法和相关组合物，其包含B细胞和/或MHC II类限制性表位和免疫抑制剂，以产生耐受性免疫应答，例如产生抗原特异性调节性B细胞。

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