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1. 发明申请

US20150190476A1 NANOPARTICLE FILM DELIVERY SYSTEMS 审中-公开
标题翻译：纳米薄膜输送系统
公开(公告)号：US20150190476A1
公开(公告)日：2015-07-09
申请号：US14617413
申请日：2015-02-09
申请人： MonoSol Rx, LLC , Midatech Limited
发明人： Alexander M. Schobel , Garry L. Myers , Keith Joseph Kendall , Thomas Rademacher , Jan Mous , Justin N. W. Barry , Phillip Williams , Africa Garcia Barrientos
IPC分类号： A61K38/28 , A61K9/00 , A61K9/70 , A61K47/48 , A61K38/26
CPC分类号： A61K38/28 , A61K9/0056 , A61K9/006 , A61K9/2031 , A61K9/7007 , A61K38/00 , A61K38/26 , A61K47/549 , A61K47/6923 , A61K47/6941 , B82Y5/00 , Y10S977/773 , Y10S977/906
摘要： A therapeutic or bioeffecting film delivery system which includes nanoparticles having actives bound to or associated with the nanoparticles and which when administered allow the active to perform a therapeutic or bioeffecting function.
摘要翻译：一种治疗或生物影响的膜递送系统，其包括具有与纳米颗粒结合或与纳米颗粒相关联的活性物质的纳米颗粒，并且其在施用时允许活性物质进行治疗或生物影响功能。

2. 发明申请

US20130337005A1 NANOPARTICLES FOR PROVIDING IMMUNE RESPONSES AGAINST INFECTIOUS AGENTS 有权
公开(公告)号：US20130337005A1
公开(公告)日：2013-12-19
申请号：US13867238
申请日：2013-04-22
申请人： Midatech Limited
发明人： Thomas William Rademacher , Phillip Williams
IPC分类号： A61K47/48
CPC分类号： A61K47/48092 , A61K33/24 , A61K39/385 , A61K47/549 , A61K47/6415 , A61K47/646 , A61K47/6923 , A61K47/6929 , A61K2039/55555 , A61K2039/6031 , B82Y5/00 , Y02A50/412
摘要： Nanoparticles for providing immune responses for the treatment or prophylaxis of infection by infectious agents such as viruses, parasites, bacteria, prions and fungi are described which comprises a core including metal and/or semiconductor atoms, wherein the core is covalently linked to a plurality of ligands, the ligands including a carbohydrate residue capable of stimulating an innate immune response, a T cell helper peptide and a danger signal. This platform may then be adapted by including one or more further ligands capable of producing a specific response to a target infectious agent.

3. 发明申请

US20150099698A1 COMBINATION PEPTIDE-NANOPARTICLES AND DELIVERY SYSTEMS INCORPORATING SAME 有权
标题翻译：组合肽 - 纳米颗粒和输送系统
公开(公告)号：US20150099698A1
公开(公告)日：2015-04-09
申请号：US14048286
申请日：2013-10-08
申请人： Midatech Limited , MonoSol RX LLC
发明人： Phillip Williams , Thomas Rademacher , Alexander Mark Schobel , Eric Dadey
IPC分类号： A61K47/48 , A61K38/26 , A61J1/03 , A61K38/28
CPC分类号： A61J1/03 , A61K9/51 , A61K38/26 , A61K38/28 , A61K47/48092 , A61K47/48215 , A61K47/48861 , A61K47/48884 , A61K47/549 , A61K47/60 , A61K47/6923 , A61K47/6929 , Y10S977/773 , Y10S977/795 , Y10S977/838 , Y10S977/906 , Y10T428/2982 , A61K2300/00
摘要： Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein differing species of peptides are bound to the nanoparticles and incorporated into various dosage forms.
摘要翻译：纳米颗粒具有与芯共价连接的配体的核心和电晕，其中不同种类的肽与纳米颗粒结合并并入各种剂型中。

4. 发明申请

US20140341938A1 NANOPARTICLE-PEPTIDE COMPOSITIONS 有权
标题翻译：纳米颗粒组合物
公开(公告)号：US20140341938A1
公开(公告)日：2014-11-20
申请号：US14343083
申请日：2012-09-07
申请人： Midatech Limited
发明人： Thomas Rademacher , Phillip Williams
IPC分类号： C07K14/47 , C07K7/06 , C07K7/08 , C07K14/77
CPC分类号： C07K14/4748 , A61K38/38 , A61K39/0011 , A61K47/6923 , A61K47/6929 , A61K2039/55516 , A61K2039/572 , A61K2039/60 , A61K2039/627 , C07K7/06 , C07K7/08 , C07K14/77
摘要： The present invention provides nanoparticles and compositions comprising such nanoparticles, as well as methods for intracellular delivery of peptides, and methods of producing nanoparticles and related products. The nanoparticles comprise a core comprising a metal and/or a semiconductor atom; and a corona comprising a plurality of ligands covalently linked to the core, wherein at least a first ligand of said plurality comprises a carbohydrate moiety that is covalently linked to the core via a first linker, and wherein at least a second ligand of said plurality comprises a peptide of choice that is covalently linked to the core via a second linker. The second linker comprises a peptide portion and a non-peptide portion, wherein said peptide portion of said second linker comprises the sequence X1X2Z1, wherein: X1 is an amino acid selected from A and G; X2 is an amino acid selected from A and G; and Z1 is an amino acid selected from Y and F.
摘要翻译：本发明提供纳米颗粒和包含这种纳米颗粒的组合物，以及肽的细胞内递送方法，以及生产纳米颗粒及相关产品的方法。纳米颗粒包含包含金属和/或半导体原子的芯; 以及电晕，其包含共价连接到所述芯的多个配体，其中所述多个的至少第一配体包含经由第一接头共价连接到所述核的碳水化合物部分，并且其中所述多个的至少第二配体包含经由第二接头与核心共价连接的选择肽。第二接头包含肽部分和非肽部分，其中所述第二接头的所述肽部分包含序列X1X2Z1，其中：X1是选自A和G的氨基酸; X2是选自A和G的氨基酸; Z1是选自Y和F的氨基酸。

5. 发明申请

US20140249081A1 NANOPARTICLE PEPTIDE COMPOSITIONS 有权
标题翻译：纳米胶囊组合物
公开(公告)号：US20140249081A1
公开(公告)日：2014-09-04
申请号：US14174251
申请日：2014-02-06
申请人： Midatech Limited
发明人： Thomas Rademacher , Phillip Williams
IPC分类号： A61K9/14 , A61K45/06 , A61K38/22
CPC分类号： A61K9/14 , A61K9/51 , A61K9/5123 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K45/06 , A61K47/6923 , A61K47/6929 , B82Y5/00 , C07K5/0806 , C07K14/47 , C07K14/575
摘要： The present invention relates to amylin peptide-carrying nanoparticles, particularly for use in medicine, and includes methods for treatment of disorders, e.g., of blood glucose regulation. Nanoparticle composition comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said ligands comprise glutathione; and at least one amylin peptide that is non-covalently bound to the corona.
摘要翻译：本发明涉及具有胰岛淀粉样多肽的载体纳米颗粒，特别是用于医学中，并且包括用于治疗诸如血糖调节的病症的方法。纳米颗粒组合物包含纳米颗粒，其包含包含金属和/或半导体的芯; 以及包含共价连接到所述核的多个配体的电晕，其中所述配体包含谷胱甘肽; 和至少一种非共价结合于电晕的胰淀素肽。

6. 发明申请

US20170319505A1 SUSTAINED RELEASE ENCAPSULATED NANOPARTICLES 审中-公开
公开(公告)号：US20170319505A1
公开(公告)日：2017-11-09
申请号：US15525756
申请日：2015-11-11
申请人： Midatech Limited , Midatech Pharma (Wales) Limited
发明人： Phillip Williams , Rhian Groves , Daniel Palmer
IPC分类号： A61K9/51 , A61K31/00 , A61K9/16 , A61K47/69 , A61K47/34 , A61K9/00
CPC分类号： A61K9/5115 , A61K9/0019 , A61K9/1647 , A61K31/00 , A61K38/19 , A61K38/26 , A61K38/28 , A61K38/29 , A61K45/06 , A61K47/34 , A61K47/6923 , C01P2004/03 , C01P2004/61 , C01P2004/64
摘要： The present invention provides a microparticle comprising at least one biocompatible polymer, the microparticle encapsulating at least one nanoparticle, the nanoparticle comprising: (i) a core comprising a metal and/or a semiconductor; and (ii) a corona comprising a plurality of ligands covalently linked to the core, wherein said ligands comprise at least one carbohydrate and/or glutathione. The nanoparticle may additionally comprise a biologically active agent or detectable label covalently linked or non-covalently bound to said corona and/or said core. Also disclosed are pharmaceutical compositions comprising the microparticles, processes for their production and uses of the microparticles in methods of therapy.

7. 发明授权

US09474687B2 Combination peptide-nanoparticles and delivery systems incorporating same 有权
标题翻译：组合肽 - 纳米颗粒和包含其的递送系统
公开(公告)号：US09474687B2
公开(公告)日：2016-10-25
申请号：US14048286
申请日：2013-10-08
申请人： MonoSol RX LLC , Midatech Limited
发明人： Phillip Williams , Thomas Rademacher , Alexander Mark Schobel , Eric Dadey
IPC分类号： A61K9/51 , A61K47/48 , A61J1/03 , A61K38/28 , A61K38/26
CPC分类号： A61J1/03 , A61K9/51 , A61K38/26 , A61K38/28 , A61K47/48092 , A61K47/48215 , A61K47/48861 , A61K47/48884 , A61K47/549 , A61K47/60 , A61K47/6923 , A61K47/6929 , Y10S977/773 , Y10S977/795 , Y10S977/838 , Y10S977/906 , Y10T428/2982 , A61K2300/00
摘要： Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein differing species of peptides are bound to the nanoparticles and incorporated into various dosage forms.
摘要翻译：纳米颗粒具有与芯共价连接的配体的核心和电晕，其中不同种类的肽与纳米颗粒结合并并入各种剂型中。

8. 发明授权

US09352026B2 Nanoparticle-insulin and insulin analogue compositions 有权
标题翻译：纳米颗粒 - 胰岛素和胰岛素类似物组合物
公开(公告)号：US09352026B2
公开(公告)日：2016-05-31
申请号：US14608343
申请日：2015-01-29
申请人： Midatech Limited
发明人： Thomas Rademacher , Phillip Williams
IPC分类号： A61K9/14 , A61K38/28 , A61K47/26 , A61K47/48 , A61J1/00 , B65D25/20
CPC分类号： A61K38/28 , A61J1/00 , A61K9/143 , A61K9/146 , A61K47/26 , A61K47/48861 , A61K47/48884 , A61K47/6923 , A61K47/6929 , B65D25/205
摘要： The present invention relates to insulin- and insulin analog-carrying nanoparticles formulated together with or for use with free insulin or with an insulin analog, such as a rapidly-acting insulin analog. The compositions of the present invention find use in medicine, particularly in glycemic control, e.g. for controlling blood glucose levels in diabetic subjects. Nanoparticle compositions of the invention, formulated together with or for use with free insulin or with an insulin analog, comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprise at least one carbohydrate moiety; and at least one insulin peptide and/or insulin analog peptide that is non-covalently bound to the corona.
摘要翻译：本发明涉及与游离胰岛素或胰岛素类似物如快速作用的胰岛素类似物一起配制或用于胰岛素和胰岛素类似物的纳米颗粒。本发明的组合物可用于医药，特别是在血糖控制中。用于控制糖尿病患者的血糖水平。与游离胰岛素或胰岛素类似物一起配制或与胰岛素类似物一起使用的本发明的纳米颗粒组合物包含包含金属和/或半导体的芯的纳米颗粒; 和包含共价连接到所述核的多个配体的电晕，其中所述多个配体包含至少一个碳水化合物部分; 和至少一种与电晕非共价结合的胰岛素肽和/或胰岛素类似物肽。

9. 发明授权

US09114082B2 Nanoparticle peptide compositions 有权
标题翻译：纳米颗粒肽组合物
公开(公告)号：US09114082B2
公开(公告)日：2015-08-25
申请号：US14174251
申请日：2014-02-06
申请人： Midatech Limited
发明人： Thomas Rademacher , Phillip Williams
IPC分类号： A61K9/14 , A61K9/51 , C07K14/47 , C07K14/575 , A61K38/17 , B82Y5/00 , C07K5/083 , A61K38/00 , A61K47/48 , A61K38/22 , A61K45/06
CPC分类号： A61K9/14 , A61K9/51 , A61K9/5123 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K45/06 , A61K47/6923 , A61K47/6929 , B82Y5/00 , C07K5/0806 , C07K14/47 , C07K14/575
摘要： The present invention relates to amylin peptide-carrying nanoparticles, particularly for use in medicine, and includes methods for treatment of disorders, e.g., of blood glucose regulation. Nanoparticle composition comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said ligands comprise glutathione; and at least one amylin peptide that is non-covalently bound to the corona.
摘要翻译：本发明涉及具有胰岛淀粉样多肽的载体纳米颗粒，特别是用于医学中，并且包括用于治疗诸如血糖调节的病症的方法。纳米颗粒组合物包含纳米颗粒，其包含包含金属和/或半导体的芯; 以及包含共价连接到所述核的多个配体的电晕，其中所述配体包含谷胱甘肽; 和至少一种非共价结合于电晕的胰淀素肽。

10. 发明授权

US08895023B2 Nanoparticles for providing immune responses against infectious agents 有权
标题翻译：用于提供针对感染因子的免疫应答的纳米颗粒
公开(公告)号：US08895023B2
公开(公告)日：2014-11-25
申请号：US13867238
申请日：2013-04-22
申请人： Midatech Limited
发明人： Thomas William Rademacher , Phillip Williams
IPC分类号： A61K47/48 , B82Y5/00 , A61K39/385 , A61K33/24 , A61K39/00
CPC分类号： A61K47/48092 , A61K33/24 , A61K39/385 , A61K47/549 , A61K47/6415 , A61K47/646 , A61K47/6923 , A61K47/6929 , A61K2039/55555 , A61K2039/6031 , B82Y5/00 , Y02A50/412
摘要： Nanoparticles for providing immune responses for the treatment or prophylaxis of infection by infectious agents such as viruses, parasites, bacteria, prions and fungi are described which comprises a core including metal and/or semiconductor atoms, wherein the core is covalently linked to a plurality of ligands, the ligands including a carbohydrate residue capable of stimulating an innate immune response, a T cell helper peptide and a danger signal. This platform may then be adapted by including one or more further ligands capable of producing a specific response to a target infectious agent.
摘要翻译：描述了提供用于治疗或预防感染因子如病毒，寄生虫，细菌，朊病毒和真菌的感染的免疫应答的纳米颗粒，其包含包含金属和/或半导体原子的核心，其中所述核共价连接到多个配体，包括能够刺激先天免疫应答的碳水化合物残基的配体，T细胞辅助肽和危险信号。然后可以通过包括一种或多种能够产生针对目标感染因子的特异性应答的其它配体来适应该平台。

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