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101. 发明申请

US20080214470A1 Pin1-Modulating Compounds and Methods of Use Thereof 有权
标题翻译： Pin1调节化合物及其使用方法
公开(公告)号：US20080214470A1
公开(公告)日：2008-09-04
申请号：US11632588
申请日：2005-07-15
申请人： Kun Ping Lu , Robert K. Suto , Janusz M. Sowadski , Gunter S. Fischer , Joseph P. Noel , Mark Verdecia
发明人： Kun Ping Lu , Robert K. Suto , Janusz M. Sowadski , Gunter S. Fischer , Joseph P. Noel , Mark Verdecia
IPC分类号： A61K38/08 , C07K7/06 , A61P35/00 , C07K1/107 , C40B40/10
CPC分类号： C12Q1/533 , A61K38/00 , C07K7/06 , G01N33/573 , G01N2500/04
摘要： The invention is directed to peptide modulators of Pin1 and Pin1-related proteins and the use of such modulators for treatment of Pin1 associated states, e.g., for the treatment of cancer or neurodegenerative disease.
摘要翻译：本发明涉及Pin1和Pin1相关蛋白的肽调节剂以及这种调节剂用于治疗Pin1相关状态的用途，例如用于治疗癌症或神经变性疾病。

102. 发明授权

US07345021B1 Method for PR-39 peptide regulated stimulation of angiogenesis 失效
标题翻译： PR-39肽调节刺激血管生成的方法
公开(公告)号：US07345021B1
公开(公告)日：2008-03-18
申请号：US09426011
申请日：1999-10-25
申请人： Michael Simons , Youche Gao
发明人： Michael Simons , Youche Gao
IPC分类号： A61K38/00
CPC分类号： C07K14/8139 , A61K38/00
摘要： The present invention provides both a method and means for regulating angiogenesis within living cells, tissues, and organs in-situ. The regulation is performed using native PR-39 peptide or one of its shorter-length homolog, for interaction with such proteasomes as one present in the cytoplasm of viable cells. The result of PR-39 peptide interaction with proteasomes is a decrease in the intracellular degradation of active peptides such as HIF-1α and a consequential stimulation of angiogenesis in-situ.
摘要翻译：本发明提供了一种用于调节活细胞，组织和器官内原位血管生成的方法和手段。使用天然PR-39肽或其较短长度同源物之一进行调节，以与存在于活细胞的细胞质中的蛋白酶体相互作用。 PR-39肽与蛋白酶体相互作用的结果是活性肽如HIF-1α的细胞内降解和原位血管生成的相应刺激的降低。

103. 发明申请

US20080058276A1 ALZHEIMER'S DISEASE THERAPEUTICS BASED ON PIN-1 CATALYZED CONFORMATIONAL CHANGES IN PHOSPHORYLATED AMYLOID PRECURSOR PROTEIN 审中-公开
标题翻译： ALZHEIMER的疾病治疗基于PIN-1催化的合成氨基酸前体蛋白的一致性变化
公开(公告)号：US20080058276A1
公开(公告)日：2008-03-06
申请号：US11623672
申请日：2007-01-16
申请人： Kun LU , Linda NICHOLSON , Lucia PASTORINO , Xiao ZHOU , Soumya DE
发明人： Kun LU , Linda NICHOLSON , Lucia PASTORINO , Xiao ZHOU , Soumya DE
IPC分类号： A61K31/70 , A61P25/28 , C12N5/06 , C12Q1/02 , G01N33/00
CPC分类号： A61K31/70 , G01N33/6896 , G01N2800/2821
摘要： The present invention is directed to inhibiting amyloidogenic processing of amyloid precursor protein, and/or inhibiting production of amyloid beta peptides. These methods can involve accelerating cis/trans isomerization of amyloid precursor protein at a phosphorylated serine/threonine-proline motif and/or contacting a cell with a compound that mimics the cis conformation of a phosphorylated serine/threonine-proline motif of an amyloid precursor protein. The present invention also relates to treating and/or preventing in a subject a degenerative neurological disease characterized by amyloidogenic processing of amyloid precursor protein and/or overproduction of amyloid beta peptide. This method involves administering an agent that accelerates cis/trans isomerization of amyloid precursor protein at a phosphorylated serine/threonine-proline motif and/or inhibits production of amyloid β peptides. Methods of screening for therapeutic agents effective in treating and/or preventing such diseases, methods of screening for biological molecules involved in the amyloidogenic pathway, and compounds that mimic the cis conformation of a phosphorylated serine/threonine-proline motif of an amyloid precursor protein are also disclosed.
摘要翻译：本发明涉及抑制淀粉样蛋白前体蛋白的淀粉样蛋白形成加工和/或抑制淀粉样蛋白β肽的产生。这些方法可以涉及在磷酸化丝氨酸/苏氨酸 - 脯氨酸基序上加速淀粉样蛋白前体蛋白的顺式/反式异构化和/或使细胞与模拟淀粉样蛋白前体蛋白的磷酸化丝氨酸/苏氨酸 - 脯氨酸基序的顺式构象的化合物接触。本发明还涉及在受试者中治疗和/或预防退行性神经疾病，其特征在于淀粉样蛋白前体蛋白的淀粉样蛋白生成加工和/或淀粉样蛋白β肽的过量产生。该方法包括施用在磷酸化丝氨酸/苏氨酸 - 脯氨酸基序上加速淀粉样蛋白前体蛋白的顺式/反式异构化的试剂和/或抑制淀粉状蛋白β肽的产生。筛选有效治疗和/或预防此类疾病的治疗剂的方法，筛选参与淀粉样蛋白生成途径的生物分子的方法，以及模拟淀粉样蛋白前体蛋白的磷酸化丝氨酸/苏氨酸 - 脯氨酸基序的顺式构象的化合物是：也披露。

104. 发明授权

US07335362B2 Methods of treating pre-eclampsia or eclampsia 有权
标题翻译：治疗先兆子痫或子痫的方法
公开(公告)号：US07335362B2
公开(公告)日：2008-02-26
申请号：US10771518
申请日：2004-02-04
申请人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
发明人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
IPC分类号： A61K38/00 , A61K39/00 , G01N33/53 , C07K17/00
CPC分类号： A61K39/3955 , A61K31/522 , A61K38/1866 , A61K38/1891 , A61K45/06 , A61K2039/505 , C07K16/1217 , C07K16/18 , C07K16/2863 , C07K16/40 , C07K2317/76 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12Q1/485 , G01N33/689 , G01N33/6893 , G01N33/74 , G01N2500/00 , G01N2800/368
摘要： Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the binding of VEGF or PlGF to sFlt1- are also disclosed herein for the treatment of pre-eclampsia or eclampsia.
摘要翻译：本文公开了诊断先兆子痫和子痫的方法。本文还公开了使用增加VEGF或PlGF水平的化合物或降低sFlt-1水平的化合物治疗先兆子痫和子痫的方法。本文还公开了抑制VEGF或PlGF与sFlt-1结合的化合物用于治疗先兆子痫或子痫。

105. 发明申请

US20080008680A1 Antagonists of interleukin-15 有权
标题翻译：白细胞介素15的拮抗剂
公开(公告)号：US20080008680A1
公开(公告)日：2008-01-10
申请号：US11726086
申请日：2007-03-20
申请人： Terry Strom , Wlodzimierz Maslinski
发明人： Terry Strom , Wlodzimierz Maslinski
IPC分类号： A61K38/20 , A61P25/28 , A61P29/00 , C07H21/04 , C07K14/54 , C12N5/00 , G01N33/566 , G01N33/567
CPC分类号： G01N33/6869 , A61K38/00 , C07K14/5443 , C07K2319/00 , Y10S514/825
摘要： Disclosed herein are mutant IL-15 polypeptides and methods for using these polypeptides to modulate the immune response in a patient.
摘要翻译：本文公开了突变型IL-15多肽和使用这些多肽调节患者免疫应答的方法。

106. 发明申请

US20070298051A1 Adjuvants Of Immune Response 审中-公开
标题翻译：佐剂免疫反应
公开(公告)号：US20070298051A1
公开(公告)日：2007-12-27
申请号：US10580105
申请日：2004-11-19
申请人： Dan Barouch , Shawn Sumida , Norman Letvin
发明人： Dan Barouch , Shawn Sumida , Norman Letvin
IPC分类号： A61K48/00 , A61K31/7088 , A61K38/02 , A61P31/00 , A61P33/00 , A61P37/06 , A61P37/08 , A61P35/00 , A61P31/18 , A61K38/45 , A61K39/12
CPC分类号： A61K39/39 , A61K38/18 , A61K38/193 , A61K38/195 , A61K45/06 , A61K2039/53 , A61K2039/55522 , A61K2300/00
摘要： The present invention features methods to substantially increase the immunogenicity of a vaccine, preferably a DNA vaccine, and involves providing a mammal with a vaccine regimen, which includes an immunogen and Flt3L in combination with MIP-1α or MIP-3α. The methods of the present invention can be used for the prevention and treatment of various pathological states, including for example, cancer, microbial infections, autoimmune diseases, tissue rejection, and allergic reactions.
摘要翻译：本发明的特征在于显着增加疫苗，优选DNA疫苗的免疫原性的方法，并涉及为哺乳动物提供疫苗方案，其包括免疫原和Flt3L与MIP-1α或MIP-3α的组合。本发明的方法可用于预防和治疗各种病理状态，包括例如癌症，微生物感染，自身免疫性疾病，组织排斥和过敏反应。

107. 发明授权

US07288759B2 Tissue-like phantoms 失效
标题翻译：组织样幻影
公开(公告)号：US07288759B2
公开(公告)日：2007-10-30
申请号：US11222949
申请日：2005-09-09
申请人： John V. Frangioni , Alec M. De Grand
发明人： John V. Frangioni , Alec M. De Grand
IPC分类号： G01N23/00 , G01D18/00
CPC分类号： G01N23/223 , G01N2223/076
摘要： The invention is based, in part, on the discovery that by combining certain components one can generate a tissue-like phantom that mimics any desired tissue, is simple and inexpensive to prepare, and is stable over many weeks or months. In addition, new multi-modal imaging objects (e.g., beads) can be inserted into the phantoms to mimic tissue pathologies, such as cancer, or merely to serve as calibration standards. These objects can be imaged using one, two, or more (e.g., four) different imaging modalities (e.g., x-ray computed tomography (CT), positron emission tomography (PET), single photon emission computed tomography (SPECT), and near-infrared (NIR) fluorescence) simultaneously.
摘要翻译：本发明部分地基于通过组合某些组分的发现，可以产生模拟任何所需组织的组织样模型，其制备简单且便宜，并且在多个星期或数月内是稳定的。此外，可以将新的多模态成像对象（例如珠）插入到模体中以模拟诸如癌症的组织病理学，或者仅用作校准标准。这些物体可以使用一个，两个或更多（例如四个）不同的成像模式（例如，x射线计算机断层摄影（CT），正电子发射断层摄影（PET），单光子发射计算机断层摄影（SPECT）和近距离 - 红外（NIR）荧光）。

108. 发明申请

US20070132452A1 Arterial spin labeling with pulsed radio frequency sequences 有权
标题翻译：用脉冲射频序列进行动脉自旋标记
公开(公告)号：US20070132452A1
公开(公告)日：2007-06-14
申请号：US11591308
申请日：2006-11-01
申请人： David Alsop
发明人： David Alsop
IPC分类号： G01V3/00
CPC分类号： G01R33/56366 , G01R33/4833
摘要： In one aspect, a method for imaging fluid flow and/or perfusion using spin labeling is provided. The method comprises applying a first magnetic gradient sequence at least to a labeling region, applying a first pulsed radio frequency (RF) sequence to the labeling region to label the fluid, the first pulsed RF sequence comprising a first plurality of pulses wherein an amplitude envelope is non-zero, the first plurality of pulses each separated by a respective first plurality of intervals wherein the amplitude envelope is substantially zero, and acquiring at least one first signal emitted from an imaging region a predetermined delay after applying the first pulsed RF sequence.
摘要翻译：在一个方面，提供了一种使用自旋标记来成像流体流动和/或灌注的方法。该方法包括至少对标记区域施加第一磁梯度序列，向标记区域施加第一脉冲射频（RF）序列以标记流体，第一脉冲RF序列包括第一多个脉冲，其中幅度包络所述第一多个脉冲各自被相应的第一多个间隔隔开，其中所述振幅包络基本上为零，以及在施加所述第一脉冲RF序列之后获取从成像区域发射的预定延迟的至少一个第一信号。

109. 发明申请

US20070104707A1 Methods of diagnosing and treating complications of pregnancy 有权
标题翻译：诊断和治疗妊娠并发症的方法
公开(公告)号：US20070104707A1
公开(公告)日：2007-05-10
申请号：US11443920
申请日：2006-05-31
申请人： S. Karumanchi , Vikas Sukhatme , Mourad Toporsian , Michelle Letarte
发明人： S. Karumanchi , Vikas Sukhatme , Mourad Toporsian , Michelle Letarte
IPC分类号： A61K39/395 , A61K38/18
CPC分类号： A61K31/4439 , A61K31/455 , A61K31/513 , A61K31/522 , A61K38/13 , A61K38/1841 , A61K38/1866 , A61K38/1875 , A61K38/22 , G01N2800/368 , A61K2300/00
摘要： Disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using combinations of compounds that alter soluble endoglin and sF1t-1 expression levels or biological activity. Also disclosed are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using compounds that increase endothelial nitric oxide synthase levels or biological activity.
摘要翻译：本文公开了使用改变可溶内皮糖蛋白和sF 1 t-1表达水平或生物活性的化合物的组合来治疗妊娠相关的高血压病症例如先兆子痫和子痫的方法。还公开了使用增加内皮一氧化氮合酶水平或生物活性的化合物治疗怀孕相关的高血压病症如先兆子痫和子痫的方法。

110. 发明申请

US20060265769A1 Gab2 (p97) gene and methods of use thereof 审中-公开
标题翻译： Gab2（p97）基因及其使用方法
公开(公告)号：US20060265769A1
公开(公告)日：2006-11-23
申请号：US11300682
申请日：2005-12-13
申请人： Haihua Gu , Benjamin Neel , Jean-Pierre Kinet
发明人： Haihua Gu , Benjamin Neel , Jean-Pierre Kinet
IPC分类号： A01K67/027 , C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/74
CPC分类号： A01K67/0276 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/01 , A01K2267/0331 , C07K14/47 , C12N15/8509 , C12N2800/30 , C12N2830/006 , C12N2830/008 , C12N2830/85
摘要： This invention relates to the purification, cloning and characterization of a novel gene, Gab2. In response to extracellular stimuli (e.g., cyokines, growth factors, hormones and antigens), Gab2 binds several signal relay molecules, including the protein-tyrosine phosphatase SHP-2 and phosphatidylinositol-3-OH kinase (PI-3K), which results in the initiation of multiple signaling cascades. Gab2 nucleic acid molecules, peptides, vectors, host cells, probes, antibodies, knockout and transgenic animals are provided. The invention also relates to methods of diagnosis, prevention and treatment of Gab2-mediated conditions such as allergic responses, neoplastic disorders and immune disorders. The invention further relates to diagnostic kits for disorders associated with altered Gab2 expression.
摘要翻译：本发明涉及新基因Gab2的纯化，克隆和表征。对于细胞外刺激（例如细胞因子，生长因子，激素和抗原），Gab2结合几个信号中继分子，包括蛋白 - 酪氨酸磷酸酶SHP-2和磷脂酰肌醇-3-OH激酶（PI-3K），这导致启动多个信令级联。提供Gab2核酸分子，肽，载体，宿主细胞，探针，抗体，敲除和转基因动物。本发明还涉及诊断，预防和治疗Gab2介导的病症如过敏反应，肿瘤性疾病和免疫疾病的方法。本发明还涉及与改变的Gab2表达相关的病症的诊断试剂盒。

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