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1. 发明申请

US20070104707A1 Methods of diagnosing and treating complications of pregnancy 有权
标题翻译：诊断和治疗妊娠并发症的方法
公开(公告)号：US20070104707A1
公开(公告)日：2007-05-10
申请号：US11443920
申请日：2006-05-31
申请人： S. Karumanchi , Vikas Sukhatme , Mourad Toporsian , Michelle Letarte
发明人： S. Karumanchi , Vikas Sukhatme , Mourad Toporsian , Michelle Letarte
IPC分类号： A61K39/395 , A61K38/18
CPC分类号： A61K31/4439 , A61K31/455 , A61K31/513 , A61K31/522 , A61K38/13 , A61K38/1841 , A61K38/1866 , A61K38/1875 , A61K38/22 , G01N2800/368 , A61K2300/00
摘要： Disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using combinations of compounds that alter soluble endoglin and sF1t-1 expression levels or biological activity. Also disclosed are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using compounds that increase endothelial nitric oxide synthase levels or biological activity.
摘要翻译：本文公开了使用改变可溶内皮糖蛋白和sF 1 t-1表达水平或生物活性的化合物的组合来治疗妊娠相关的高血压病症例如先兆子痫和子痫的方法。还公开了使用增加内皮一氧化氮合酶水平或生物活性的化合物治疗怀孕相关的高血压病症如先兆子痫和子痫的方法。

2. 发明申请

US20090286271A1 Methods of Diagnosing and Treating Complications of Pregnancy 审中-公开
标题翻译：诊断和治疗妊娠并发症的方法
公开(公告)号：US20090286271A1
公开(公告)日：2009-11-19
申请号：US12227658
申请日：2007-05-31
申请人： Ananth S. Karumanchi , Vikas P. Sukhatme , Mourad Toporsian , Michelle V. Letarte
发明人： Ananth S. Karumanchi , Vikas P. Sukhatme , Mourad Toporsian , Michelle V. Letarte
IPC分类号： C12Q1/02 , G01N33/00
CPC分类号： G01N33/689 , A61K31/4439 , A61K31/455 , A61K31/513 , A61K31/522 , G01N33/74 , G01N2333/705 , G01N2800/368 , G01N2800/50
摘要： Disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using combinations of compounds that alter soluble endoglin, endothelial nitric oxide synthase, PGI2, TGF-β1, TGF-β3, activin A, BMP2, BMP7, and sFlt-1 expression levels or biological activity. Also disclosed are methods of diagnosing a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, that include the measurement of any one or more of the following: soluble endoglin, endothelial nitric oxide synthase, PGI2, TGF-β1, TGF-β3, activin A, BMP2, BMP7, and sFlt-1 expression levels or biological activity.
摘要翻译：本文公开了使用改变可溶内皮糖蛋白，内皮一氧化氮合酶，PGI2，TGF-β1，TGF-β3，激活素A，BMP2，BMP7的化合物的组合治疗怀孕相关的高血压病症如先兆子痫和子痫的方法，和sFlt-1表达水平或生物活性。还公开了诊断妊娠相关的高血压病症（例如先兆子痫和子痫）的方法，其包括测量以下任何一种或多种：可溶内皮糖蛋白，内皮一氧化氮合酶，PGI2，TGF-β1，TGF-β3 ，激活素A，BMP2，BMP7和sFlt-1表达水平或生物活性。

3. 发明授权

US07740849B2 Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders 有权
标题翻译：使用结合可溶内皮糖蛋白和SFLT-1的化合物治疗妊娠相关的高血压疾病
公开(公告)号：US07740849B2
公开(公告)日：2010-06-22
申请号：US11443920
申请日：2006-05-31
申请人： S. Ananth Karumanchi , Vikas P. Sukhatme , Mourad Toporsian , Michelle V. Letarte
发明人： S. Ananth Karumanchi , Vikas P. Sukhatme , Mourad Toporsian , Michelle V. Letarte
IPC分类号： A61K39/395
CPC分类号： A61K31/4439 , A61K31/455 , A61K31/513 , A61K31/522 , A61K38/13 , A61K38/1841 , A61K38/1866 , A61K38/1875 , A61K38/22 , G01N2800/368 , A61K2300/00
摘要： Disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using combinations of compounds that alter soluble endoglin and sFlt-1 expression levels or biological activity. Also disclosed are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using compounds that increase endothelial nitric oxide synthase levels or biological activity.
摘要翻译：本文公开了使用改变可溶内皮糖蛋白和sFlt-1表达水平或生物活性的化合物的组合来治疗怀孕相关的高血压病症（例如先兆子痫和子痫）的方法。还公开了使用增加内皮一氧化氮合酶水平或生物活性的化合物治疗怀孕相关的高血压病症如先兆子痫和子痫的方法。

4. 发明授权

US08795663B2 Soluble endoglin and uses thereof 有权
标题翻译：可溶性内皮糖蛋白及其用途
公开(公告)号：US08795663B2
公开(公告)日：2014-08-05
申请号：US13521849
申请日：2011-01-11
申请人： Mourad Toporsian
发明人： Mourad Toporsian
IPC分类号： C07K16/00 , C07K16/18 , A61K39/395
CPC分类号： C12N15/1136 , A61K38/00 , C07K14/70596 , C07K16/2896 , C07K2317/34 , C12N15/1138 , Y02A50/411
摘要： The invention provides isolated soluble endoglin polypeptides, nucleic acids encoding soluble endoglin polypeptides, antibodies that specifically bind soluble endoglin polypeptides, and kits containing these materials. The invention also provides methods for treating or decreasing the likelihood of developing a soluble endoglin-mediated disorder in a subject requiring the administration of an agent capable of reducing the expression or biological activity of a soluble endoglin polypeptide and methods for treating or decreasing the likelihood of developing a soluble endoglin-preventive disorder in a subject requiring the administration of a soluble endoglin polypeptide or a nucleic acid encoding the soluble endoglin polypeptide. The invention further provides methods for the diagnosis of a soluble endoglin-mediated disorder or a soluble endoglin-preventive disorder and methods for identifying a compound to treat a soluble endoglin-mediated or a soluble endoglin-preventive disorder.
摘要翻译：本发明提供分离的可溶内皮糖蛋白多肽，编码可溶内皮糖蛋白多肽的核酸，特异性结合可溶内皮糖蛋白多肽的抗体和含有这些材料的试剂盒。本发明还提供了治疗或降低在需要施用能够降低可溶内皮糖蛋白多肽的表达或生物学活性的试剂的受试者中发展可溶内皮糖蛋白介导的病症的可能性的方法和用于治疗或降低在需要施用可溶内皮糖蛋白多肽或编码可溶内皮糖蛋白多肽的核酸的受试者中开发可溶内皮糖蛋白预防性疾病。本发明还提供了用于诊断可溶内皮因素介导的病症或可溶内皮糖蛋白预防障碍的方法以及用于鉴定化合物以治疗可溶内皮糖蛋白介导的或可溶内皮抑素的预防障碍的方法。

5. 发明申请

US20130136745A1 SOLUBLE ENDOGLIN AND USES THEREOF 有权
标题翻译：可溶性内酰胺酶及其用途
公开(公告)号：US20130136745A1
公开(公告)日：2013-05-30
申请号：US13521849
申请日：2011-01-11
申请人： Mourad Toporsian
发明人： Mourad Toporsian
IPC分类号： C07K14/705 , C12N15/113 , G01N33/68 , C07K16/28
CPC分类号： C12N15/1136 , A61K38/00 , C07K14/70596 , C07K16/2896 , C07K2317/34 , C12N15/1138 , Y02A50/411
摘要： The invention provides isolated soluble endoglin polypeptides, nucleic acids encoding soluble endoglin polypeptides, antibodies that specifically bind soluble endoglin polypeptides, and kits containing these materials. The invention also provides methods for treating or decreasing the likelihood of developing a soluble endoglin-mediated disorder in a subject requiring the administration of an agent capable of reducing the expression or biological activity of a soluble endoglin polypeptide and methods for treating or decreasing the likelihood of developing a soluble endoglin-preventive disorder in a subject requiring the administration of a soluble endoglin polypeptide or a nucleic acid encoding the soluble endoglin polypeptide. The invention further provides methods for the diagnosis of a soluble endoglin-mediated disorder or a soluble endoglin-preventive disorder and methods for identifying a compound to treat a soluble endoglin-mediated or a soluble endoglin-preventive disorder.
摘要翻译：本发明提供分离的可溶内皮糖蛋白多肽，编码可溶内皮糖蛋白多肽的核酸，特异性结合可溶内皮糖蛋白多肽的抗体和含有这些材料的试剂盒。本发明还提供了治疗或降低在需要施用能够降低可溶内皮糖蛋白多肽的表达或生物学活性的试剂的受试者中发展可溶内皮糖蛋白介导的病症的可能性的方法和用于治疗或降低在需要施用可溶内皮糖蛋白多肽或编码可溶内皮糖蛋白多肽的核酸的受试者中开发可溶内皮糖蛋白预防性疾病。本发明还提供了用于诊断可溶内皮因素介导的病症或可溶内皮糖蛋白预防障碍的方法以及用于鉴定化合物以治疗可溶内皮糖蛋白介导的或可溶内皮抑素的预防障碍的方法。

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