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1. 发明授权

US07955805B2 Nucleic acids and polypeptides useful for diagnosing complications of pregnancy 有权
标题翻译：用于诊断怀孕并发症的核酸和多肽
公开(公告)号：US07955805B2
公开(公告)日：2011-06-07
申请号：US11300928
申请日：2005-12-15
申请人： S. Ananth Karumanchi , Vikas P. Sukhatme
发明人： S. Ananth Karumanchi , Vikas P. Sukhatme
IPC分类号： G01N33/53
CPC分类号： G01N33/689 , C12Q1/6883 , C12Q2600/158 , G01N33/6893 , G01N2800/321 , G01N2800/368
摘要： Disclosed herein are methods for diagnosing or treating pregnancy related hypertensive disorders that include the use of a polypeptide or a nucleic acid encoding a polypeptide selected from the following: follistatin related protein, interleukin 8, inhibin A, VEGF-C, angiogenin, beta fertilin, hypothetical protein, leukocyte associated Ig-like receptor secreted protein, erythroid differentiation protein, adipogenesis inhibitory factor, corticotropin releasing factor binding protein, alpha-1 anti-chymotrypsin, insulin-like growth factor binding protein-5, CD33L, cytokine receptor like factor 1, platelet derived endothelial growth factor, lysyl hydroxylase isoform 2, stanniocalcin precursor, secreted frizzled related protein, galectin-3, alpha defensin, ADAM-TS3, cholecystokinin precursor, interferon stimulated T-cell alpha chemoattractant precursor, azurocidin, sperminine oxidase, UDP glycosyltransferase 2 family polypeptide B28, neurotrophic tyrosine kinase receptor 2, neutral endopeptidase, CDC28 protein kinase regulatory subunit 2, beta glucosidase, lanosterol synthase, calcium/calmodulin-dependent serine protein kinase, estrogen receptor-alternatively spliced transcript H, chemokine (CX3C motif) receptor 1, tyrosinase-related protein 1, hydoxy-delta-5-steroid dehyrogenase, dihydropyramidinase-like-4, and cytochrome P450-family 11.
摘要翻译：本文公开了用于诊断或治疗怀孕相关性高血压病症的方法，其包括使用多肽或编码选自以下的多肽的核酸：卵泡抑素相关蛋白，白细胞介素8，抑制素A，VEGF-C，血管生成素，假性蛋白，白细胞相关的Ig样受体分泌蛋白，红细胞分化蛋白，脂肪形成抑制因子，促肾上腺皮质激素释放因子结合蛋白，α-1抗糜蛋白酶，胰岛素样生长因子结合蛋白-5，CD33L，细胞因子受体样因子1 ，血小板衍生的内皮生长因子，赖氨酰羟化酶同种型2，斯诺钙钙前体，分泌性卷曲相关蛋白，半乳凝素-3，α-防御素，ADAM-TS3，缩胆囊素前体，干扰素刺激的T细胞α化学引诱物前体，azurocidin，精氨酸氧化酶，UDP糖基转移酶 2家族多肽B28，神经营养性酪氨酸激酶受体2，中性endopept 雌激素受体 - 可变剪接的转录物H，趋化因子（CX3C基序）受体1，酪氨酸酶相关蛋白1，羟基-δ-蛋白激酶调控亚单位2，β-葡糖苷酶，羊毛甾醇合酶，钙/钙调蛋白依赖性丝氨酸蛋白激酶， 5-类固醇脱氢酶，二氢吡喃脒酶-4和细胞色素P450-家族11。

2. 发明申请

US20110014197A1 METHODS OF TREATING PRE-ECLAMPSIA OR ECLAMPSIA 审中-公开
标题翻译：治疗前列腺炎或ECLAMPSIA的方法
公开(公告)号：US20110014197A1
公开(公告)日：2011-01-20
申请号：US12892652
申请日：2010-09-28
申请人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
发明人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
IPC分类号： A61K39/395 , A61K38/18 , A61K33/20 , G01N33/573 , G01N33/68 , A61P15/00
CPC分类号： A61K39/3955 , A61K31/522 , A61K38/1866 , A61K38/1891 , A61K45/06 , A61K2039/505 , C07K16/1217 , C07K16/18 , C07K16/2863 , C07K16/40 , C07K2317/76 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12Q1/485 , G01N33/689 , G01N33/6893 , G01N33/74 , G01N2500/00 , G01N2800/368
摘要： Disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the binding of VEGF or PlGF to sFlt1—are also disclosed herein for the treatment of pre-eclampsia or eclampsia.
摘要翻译：本文公开了使用增加VEGF或PlGF水平的化合物或降低sFlt-1水平的化合物治疗先兆子痫和子痫的方法。抑制VEGF或PlGF与sFlt1结合的化合物也在本文中公开用于治疗先兆子痫或子痫。

3. 发明申请

US20090305963A1 Lipocalin 2 for the Treatment, Prevention, and Management of Cancer Metastasis, Angiogenesis, and Fibrosis 审中-公开
标题翻译： Lipocalin 2用于治疗，预防和控制癌症转移，血管生成和纤维化
公开(公告)号：US20090305963A1
公开(公告)日：2009-12-10
申请号：US11795392
申请日：2006-01-19
申请人： Vikas P. Sukhatme , S. Ananth Karumanchi , Pankaj Seth , Junichi Hanai , Tadanori Mammoto , Jonathan Barasch , Kiyoshi Mori
发明人： Vikas P. Sukhatme , S. Ananth Karumanchi , Pankaj Seth , Junichi Hanai , Tadanori Mammoto , Jonathan Barasch , Kiyoshi Mori
IPC分类号： A61K38/17 , A61P35/00 , C12Q1/68 , G01N33/574 , A61P7/04
CPC分类号： A61K38/1703 , A61K38/164 , A61K2300/00
摘要： The invention features methods and compositions for treating and preventing cancer metastasis, angiogenic disorders, and fibrotic disorders using lipocalin 2 compounds.
摘要翻译：本发明的特征在于使用脂质运载蛋白2化合物治疗和预防癌症转移，血管生成障碍和纤维化病症的方法和组合物。

4. 发明申请

US20090170767A1 Soluble Endoglin Compounds for the Treatment and Prevention of Cancer 审中-公开
标题翻译：可溶内皮糖蛋白化合物治疗和预防癌症
公开(公告)号：US20090170767A1
公开(公告)日：2009-07-02
申请号：US12227546
申请日：2007-05-31
申请人： S. Ananth Karumanchi , Vikas P. Sukhatme
发明人： S. Ananth Karumanchi , Vikas P. Sukhatme
IPC分类号： A61K38/16 , C12N5/06 , C07H21/04
CPC分类号： A61K31/439 , A61K31/455 , A61K31/513 , A61K31/522 , A61K38/179 , A61K45/06 , C07K14/70596 , A61K2300/00
摘要： Disclosed herein are soluble endoglin compounds and kits, pharmaceutical compositions, and articles of manufacture containing soluble endoglin compounds. Also disclosed herein are methods for treating an angiogenesis disorder, such as cancer, using soluble endoglin compounds, provided alone or in combination with a chemotherapeutic agent, an angiogenesis inhibitor, or an antiproliferative compound.
摘要翻译：本文公开了可溶内皮糖蛋白化合物和试剂盒，药物组合物和含有可溶内皮糖蛋白化合物的制品。本文还公开了使用可单独或与化疗剂，血管发生抑制剂或抗增殖化合物组合提供的可溶内皮糖蛋白化合物治疗血管生成障碍（例如癌症）的方法。

5. 发明授权

US07407659B2 Methods of diagnosing pre-eclampsia or eclampsia 有权
标题翻译：诊断先兆子痫或子痫的方法
公开(公告)号：US07407659B2
公开(公告)日：2008-08-05
申请号：US10624809
申请日：2003-07-21
申请人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
发明人： S. Ananth Karumanchi , Sharon Maynard , Vikas P. Sukhatme
IPC分类号： A61K38/00 , A61K39/00 , G01N33/53 , C07K17/00
CPC分类号： C07K16/1217 , A61K31/522 , A61K38/1866 , A61K38/1891 , A61K2039/505 , C07K16/2863 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12Q1/485 , G01N33/6893 , G01N33/74 , G01N2500/00 , G01N2800/368
摘要： Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the binding of VEGF or PlGF to sFlt1—are also disclosed herein for the treatment of pre-eclampsia or eclampsia.
摘要翻译：本文公开了诊断先兆子痫和子痫的方法。本文还公开了使用增加VEGF或PlGF水平的化合物或降低sFlt-1水平的化合物治疗先兆子痫和子痫的方法。抑制VEGF或PlGF与sFlt1结合的化合物也在本文中公开用于治疗先兆子痫或子痫。

6. 发明授权

US07344892B2 Screening for gestational disorders 有权
标题翻译：筛查妊娠期疾病
公开(公告)号：US07344892B2
公开(公告)日：2008-03-18
申请号：US10947791
申请日：2004-09-23
申请人： Ravi I. Thadhani , S. Ananth Karumanchi
发明人： Ravi I. Thadhani , S. Ananth Karumanchi
IPC分类号： G01N33/53 , G01N33/577
CPC分类号： G01N33/689 , G01N33/6893 , G01N2800/042 , G01N2800/321 , G01N2800/36 , G01N2800/368 , G01N2800/52 , G06F19/00 , Y10S436/804 , Y10S436/809
摘要： The invention relates to methods and compositions for identifying subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third trimester of pregnancy.
摘要翻译：本发明涉及用于识别具有或倾向于具有妊娠糖尿病，先兆子痫和妊娠高血压的受试者的方法和组合物。该方法适用于尿液和/或血液样品，可在妊娠前三个月进行。

7. 发明申请

US20050025762A1 Methods of diagnosing and treating pre-eclampsia or eclampsia 有权
标题翻译：诊断和治疗先兆子痫或子痫的方法
公开(公告)号：US20050025762A1
公开(公告)日：2005-02-03
申请号：US10771518
申请日：2004-02-04
申请人： S. Ananth Karumanchi , Sharon Maynard , Vikas Sukhatme
发明人： S. Ananth Karumanchi , Sharon Maynard , Vikas Sukhatme
IPC分类号： A61K31/522 , C07K16/12 , C07K16/28 , C12Q1/48 , G01N33/68 , G01N33/74 , A61K39/395 , A61K38/18
CPC分类号： A61K39/3955 , A61K31/522 , A61K38/1866 , A61K38/1891 , A61K45/06 , A61K2039/505 , C07K16/1217 , C07K16/18 , C07K16/2863 , C07K16/40 , C07K2317/76 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12Q1/485 , G01N33/689 , G01N33/6893 , G01N33/74 , G01N2500/00 , G01N2800/368
摘要： Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the binding of VEGF or PlGF to sFlt1- are also disclosed herein for the treatment of pre-eclampsia or eclampsia.
摘要翻译：本文公开了诊断先兆子痫和子痫的方法。本文还公开了使用增加VEGF或PlGF水平的化合物或降低sFlt-1水平的化合物治疗先兆子痫和子痫的方法。本文还公开了抑制VEGF或PlGF与sFlt-1结合的化合物用于治疗先兆子痫或子痫。

8. 发明申请

US20170242022A1 METHODS OF DIAGNOSING AND TREATING COMPLICATIONS OF PREGNANCY 审中-公开
公开(公告)号：US20170242022A1
公开(公告)日：2017-08-24
申请号：US15279102
申请日：2016-09-28
申请人： S. Ananth KARUMANCHI , Vikas P. SUKHATME , Mourad TOPORSIAN , Michelle V. LETARTE
发明人： S. Ananth KARUMANCHI , Vikas P. SUKHATME , Mourad TOPORSIAN , Michelle V. LETARTE
IPC分类号： G01N33/68 , G01N33/74
CPC分类号： G01N33/689 , A61K31/4439 , A61K31/455 , A61K31/513 , A61K31/522 , G01N33/74 , G01N2333/705 , G01N2800/368 , G01N2800/50
摘要： Disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using combinations of compounds that alter soluble endoglin, endothelial nitric oxide synthase, PGI2, TGF-β1, TGF-β3, activin A, BMP2, BMP7, and sFlt-1 expression levels or biological activity. Also disclosed are methods of diagnosing a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, that include the measurement of any one or more of the following: soluble endoglin, endothelial nitric oxide synthase, PGI2, TGF-β1, TGF-β3, activin A, BMP2, BMP7, and sFlt-1 expression levels or biological activity.

9. 发明授权

US09329190B2 Assays and methods of treatment relating to vitamin D insufficiency 有权
公开(公告)号：US09329190B2
公开(公告)日：2016-05-03
申请号：US13978193
申请日：2012-01-06
申请人： Ravi Thadhani , S. Ananth Karumanchi , Anders Hayden Berg , Ishir Bhan
发明人： Ravi Thadhani , S. Ananth Karumanchi , Anders Hayden Berg , Ishir Bhan
IPC分类号： G01N31/00 , G01N33/53 , G01N33/82
CPC分类号： G01N33/82 , A61K31/592 , A61K31/593 , C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , G01N2333/765
摘要： Described herein are assays directed to determining the level of bioavailable or free vitamin D in a blood sample in a subject. The values determined for bioavailable or free vitamin D indicate whether the subject suffers from insufficient levels of vitamin D. Also described herein are methods of treatment for vitamin D insufficiency.

10. 发明申请

US20140113885A1 ASSAYS AND METHODS OF TREATMENT RELATING TO VITAMIN D INSUFFICIENCY 有权
标题翻译：维生素D缺乏症的治疗方法和治疗方法
公开(公告)号：US20140113885A1
公开(公告)日：2014-04-24
申请号：US13978193
申请日：2012-01-06
申请人： Ravi Thadhani , S. Ananth Karumanchi , Anders Hayden Berg , Ishir Bhan
发明人： Ravi Thadhani , S. Ananth Karumanchi , Anders Hayden Berg , Ishir Bhan
IPC分类号： G01N33/82
CPC分类号： G01N33/82 , A61K31/592 , A61K31/593 , C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , G01N2333/765
摘要： Described herein are assays directed to determining the level of bioavailable or free vitamin D in a blood sample in a subject. The values determined for bioavailable or free vitamin D indicate whether the subject suffers from insufficient levels of vitamin D. Also described herein are methods of treatment for vitamin D insufficiency.
摘要翻译：本文描述了用于确定受试者血液样本中生物可利用或游离维生素D水平的测定。为生物利用度或游离维生素D确定的值表示受试者是否患有维生素D水平不足。本文还描述了治疗维生素D不足的方法。

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