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101. 发明申请

US20080003609A1 Method of detecting bladder urothelial carcinoma 审中-公开
标题翻译：检测膀胱尿路上皮癌的方法
公开(公告)号：US20080003609A1
公开(公告)日：2008-01-03
申请号：US11801676
申请日：2007-05-10
申请人： Bin Yang
发明人： Bin Yang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/16
摘要： A diagnostic method for bladder urethelial carcinoma includes obtaining an isolated nucleotide sample from a subject and detecting the promoter methylation of at least three tumor suppressor genes selected form group consisting of DAPK, RAR-beta, p14, p73, MGMT, APC, SOCS-1, BRCA-1, and FHIT.
摘要翻译：膀胱尿道上皮癌的诊断方法包括从受试者获得分离的核苷酸样品，并检测至少三种选自DAPK，RAR-β，p14，p73，MGMT，APC，SOCS-1的肿瘤抑制基因的启动子甲基化，BRCA-1和FHIT。

102. 发明授权

US10131889B1 Candida antarctica lipase B mutant, and methods for making and using the same 有权
公开(公告)号：US10131889B1
公开(公告)日：2018-11-20
申请号：US15810007
申请日：2017-11-11
申请人： Liming Liu , Bin Yang
发明人： Liming Liu , Bin Yang
IPC分类号： C12N9/20 , C12N15/74 , C12N15/00 , C12P9/00
摘要： The present invention relates to the field of bioengineering. It provides a Candida antarctica lipase B mutant and its application. The mutant enzyme overcomes the limit of the parent enzyme that can exhibit high enantioselectivity towards (R)-3-TBDMSO glutaric acid methyl monoester only at temperatures below 5° C. The mutant enzyme successfully increased R-ee value at 5-70° C. The mutant D223V/A281S exhibits high R-ee value (>99%), high conversion rate (80%), and high space-time yield (107.54 g L−1 d−1). The present invention lays a foundation for industrial production of (R)-3-TBDMSO glutaric acid methyl monoester using a biosynthesis approach and provide insights into conformational dynamics-based enzyme design.

103. 发明授权

US09182661B2 Screening method and apparatus for use in intaglio printing 有权
标题翻译：用于凹版印刷的筛选方法和装置
公开(公告)号：US09182661B2
公开(公告)日：2015-11-10
申请号：US13996967
申请日：2011-12-24
申请人： Haifeng Li , Bin Yang
发明人： Haifeng Li , Bin Yang
IPC分类号： H04N1/405 , G03F5/20
CPC分类号： G03F5/20 , H04N1/4055
摘要： The present application provides a screen method for intaglio printing, comprising: dividing multiple classes of regions according to a brightness range; and generating screen dots with various screen patterns for the grouped classes of regions. The present application also provides a screen device for intaglio printing, comprising: a dividing module configured to group multiple classes of regions according to the brightness range; and a generating module configured to generate screen dots with various screen patterns for the grouped classes of regions. Since multiple kinds of screen patterns are applied in the technical solutions in present application, the problem, i.e., water ripple will occur in the prior art, may be addressed, so as to improve the quality of printing.
摘要翻译：本申请提供了一种用于凹版印刷的屏幕方法，包括：根据亮度范围划分多个类别的区域; 并且为分组的区域类别生成具有各种屏幕图案的屏幕点。本申请还提供了一种用于凹版印刷的屏幕装置，包括：分割模块，被配置为根据亮度范围对多个类别的区域进行分组; 以及生成模块，被配置为生成用于所述分组的区域类别的各种屏幕图案的屏幕点。由于在本申请中的技术方案中应用了多种屏幕图案，所以可以解决现有技术中出现的水波纹问题，以提高打印质量。

104. 发明授权

US09134079B2 Flow control through plural, parallel connection channels to/from a manifold 有权
标题翻译：通过多个并联连接通道/从歧管进行流量控制
公开(公告)号：US09134079B2
公开(公告)日：2015-09-15
申请号：US12652027
申请日：2010-01-04
申请人： Anna Lee Tonkovich , Bin Yang , Steven T. Perry , Sean P. Fitzgerald , Ravi Arora , Robert Luzenski , Thomas D. Yuschak
发明人： Anna Lee Tonkovich , Bin Yang , Steven T. Perry , Sean P. Fitzgerald , Ravi Arora , Robert Luzenski , Thomas D. Yuschak
IPC分类号： B01J10/00 , F28F13/06 , B01J19/00 , B01L3/00
CPC分类号： F28F13/06 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00833 , B01J2219/00835 , B01J2219/0086 , B01J2219/00889 , B01J2219/00891 , B01J2219/00995 , B01L3/502746 , B01L2200/027 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B01L2400/086 , F28F2260/02 , Y10T137/0396
摘要： The invention provides apparatuses and techniques for controlling flow between a manifold and two or more connecting microchannels. Flow between plural connecting microchannels, that share a common manifold, can be made more uniform by the use of flow straighteners and distributors that equalize flow in connecting channels. Alternatively, flow can be made more uniform by sections of narrowed diameter within the channels. Methods of making apparatus and methods of conducting unit operations in connecting channels are also described.
摘要翻译：本发明提供用于控制歧管和两个或更多个连接微通道之间的流动的装置和技术。通过使用均衡连接通道中的流动的流平衡器和分配器，可以使共享共同歧管的多个连接微通道之间的流动更均匀。或者，可以通过通道内的变窄直径的部分使流动更均匀。还描述了在连接通道中进行单元操作的装置和方法的方法。

105. 发明授权

US08995023B2 Amplification modulation screening method and apparatus 有权
标题翻译：放大调制筛选方法及装置
公开(公告)号：US08995023B2
公开(公告)日：2015-03-31
申请号：US13996907
申请日：2011-12-23
申请人： Haifeng Li , Bin Yang
发明人： Haifeng Li , Bin Yang
IPC分类号： H04N1/405 , G09G3/20 , G06T11/40
CPC分类号： H04N1/4058 , G06T11/40 , G09G3/2011 , G09G2300/0426 , G09G2300/0443 , G09G2300/0452 , H04N1/4055
摘要： An amplitude modulation screening method is provided. The method comprises a step of utilizing regular hexagon screen dots to form a threshold matrix for amplitude screening. In embodiments of the present application, an amplitude modulation screening apparatus is also provided. The apparatus may comprise a matrix module configured to constitute a threshold matrix for amplitude screening using regular hexagon screen dots. Due to the threshold matrix formed with regular hexagon screen dots, the method and apparatus of the present application resolve the problem of the screen dots in the prior art, and improve the printing quality.
摘要翻译：提供了一种幅度调制屏蔽方法。该方法包括利用正六边形屏幕点形成用于振幅筛选的阈值矩阵的步骤。在本申请的实施例中，还提供了幅度调制筛选装置。该装置可以包括矩阵模块，该矩阵模块被配置为使用正六边形屏幕点构成用于振幅筛选的阈值矩阵。由于由正六边形屏幕点形成的阈值矩阵，本申请的方法和装置解决了现有技术中屏幕点的问题，并提高了打印质量。

106. 发明授权

US08987110B2 Semiconductor device fabrication method for improved isolation regions and defect-free active semiconductor material 有权
标题翻译：用于改进隔离区域和无缺陷活性半导体材料的半导体器件制造方法
公开(公告)号：US08987110B2
公开(公告)日：2015-03-24
申请号：US13467730
申请日：2012-05-09
申请人： Man Fai Ng , Bin Yang
发明人： Man Fai Ng , Bin Yang
IPC分类号： H01L21/762 , H01L21/84 , H01L21/8238
CPC分类号： H01L21/76224 , H01L21/76283 , H01L21/823807 , H01L21/823878 , H01L21/84
摘要： A fabrication method for a semiconductor device structure is provided. The device structure has a layer of silicon and a layer of silicon dioxide overlying the layer of silicon, and the method begins by forming an isolation recess by removing a portion of the silicon dioxide and a portion of the silicon. The isolation recess is filled with stress-inducing silicon nitride and, thereafter, the silicon dioxide is removed such that the stress-inducing silicon nitride protrudes above the silicon. Next, the exposed silicon is thermally oxidized to form silicon dioxide hardmask material overlying the silicon. Thereafter, a first portion of the silicon dioxide hardmask material is removed to reveal an accessible surface of the silicon, while leaving a second portion of the silicon dioxide hardmask material intact. Next, silicon germanium is epitaxially grown from the accessible surface of the silicon.
摘要翻译：提供了半导体器件结构的制造方法。器件结构具有硅层和覆盖硅层的二氧化硅层，并且该方法开始于通过去除一部分二氧化硅和一部分硅来形成隔离凹槽。隔离凹部填充有应力诱导性氮化硅，然后去除二氧化硅，使得应力诱导性氮化硅突出于硅上方。接下来，暴露的硅被热氧化以形成覆盖在硅上的二氧化硅硬掩模材料。此后，去除二氧化硅硬掩模材料的第一部分以露出硅的可接近表面，同时留下二氧化硅硬掩模材料的第二部分完好无损。接下来，从硅的可接近表面外延生长硅锗。

107. 发明授权

US08976383B2 Method and system for document printing management and control, and document source tracking 有权
标题翻译：文件打印管理和控制的方法和系统，以及文件来源跟踪
公开(公告)号：US08976383B2
公开(公告)日：2015-03-10
申请号：US13976335
申请日：2011-12-27
申请人： Wenfa Qi , Shuchang Han , Gaoyang Wang , Lidong Wang , Bin Yang
发明人： Wenfa Qi , Shuchang Han , Gaoyang Wang , Lidong Wang , Bin Yang
IPC分类号： G06F3/12 , G06K15/02 , H04L9/32 , H04N1/44 , H04L29/06 , H04L29/08 , G06K15/00
CPC分类号： G06F3/1238 , G06F3/1222 , G06F3/1288 , G06F3/1289 , G06K15/4095 , H04L63/102 , H04L63/20 , H04L67/125 , H04L67/34
摘要： Disclosed is a method and system for document printing management and control and source tracking. A printing management service program runs at a server end. A printing monitoring service program runs at a client end. The printing management service program saves client end information, monitors and manages a client end computer, sets a printing management policy, and delivers operation instructions to the client end. The printing monitoring service program collects the client end information, sends the client end information to the server end, and executes the operation instruction.
摘要翻译：公开了一种用于文件打印管理和控制和源跟踪的方法和系统。打印管理服务程序在服务器端运行。打印监控服务程序在客户端运行。打印管理服务程序保存客户端信息，监控和管理客户端计算机，设置打印管理策略，并向客户端传送操作指令。打印监控服务程序收集客户端信息，将客户端信息发送到服务器端，并执行操作指令。

108. 发明授权

US08847315B2 Complementary metal-oxide-semiconductor (CMOS) device and method 有权
标题翻译：互补金属氧化物半导体（CMOS）器件及方法
公开(公告)号：US08847315B2
公开(公告)日：2014-09-30
申请号：US13465064
申请日：2012-05-07
申请人： Bin Yang , Xia Li , Jun Yuan
发明人： Bin Yang , Xia Li , Jun Yuan
IPC分类号： H01L27/12 , H01L29/47 , H01L29/10 , H01L29/66 , H01L21/8238 , H01L21/84
CPC分类号： H01L21/823814 , H01L21/28026 , H01L21/823828 , H01L21/84 , H01L27/1203 , H01L27/1211 , H01L29/1054 , H01L29/165 , H01L29/42376 , H01L29/47 , H01L29/66545 , H01L29/66621 , H01L29/66628 , H01L29/66636 , H01L29/7834
摘要： A complementary metal-oxide-semiconductor (CMOS) device and methods of formation thereof are disclosed. In a particular embodiment, a CMOS device includes a silicon substrate, a dielectric insulator material on the silicon substrate, and an extension layer on the dielectric insulator material. The CMOS device further includes a gate in contact with a channel and in contact with an extension region. The CMOS device also includes a source in contact with the extension region and a drain in contact with the extension region. The extension region includes a first region in contact with the source and the gate and includes a second region in contact with the drain and the gate.
摘要翻译：公开了一种互补金属氧化物半导体（CMOS）器件及其形成方法。在特定实施例中，CMOS器件包括硅衬底，硅衬底上的介电绝缘体材料以及介电绝缘体材料上的延伸层。 CMOS器件还包括与沟道接触并与延伸区域接触的栅极。 CMOS器件还包括与延伸区域接触的源极和与延伸区域接触的漏极。延伸区域包括与源极和栅极接触的第一区域，并且包括与漏极和栅极接触的第二区域。

109. 发明申请

US20140186229A1 INTEGRATED MICROCHANNEL SYNTHESIS AND SEPARATION 有权
标题翻译：综合微通道合成与分离
公开(公告)号：US20140186229A1
公开(公告)日：2014-07-03
申请号：US13948967
申请日：2013-07-23
申请人： Anna Lee Y. Tonkovich , Robert D. Litt , Timothy M. Werner , Bin Yang
发明人： Anna Lee Y. Tonkovich , Robert D. Litt , Timothy M. Werner , Bin Yang
IPC分类号： B01J19/18
CPC分类号： B01J19/0093 , B01J19/1831 , B01J2219/00783 , B01J2219/00835 , B01J2219/00873 , B01J2219/00984 , C07C29/152 , C10G2/341 , C07C31/04
摘要： An integrated microchannel reactor and heat exchanger comprising: (a) a waveform sandwiched between opposing shim sheets and mounted to the shim sheets to form a series of microchannels, where each microchannel includes a pair of substantially straight side walls, and a top wall formed by at least one of the opposing shim sheets, and (b) a first set of microchannels in thermal communication with the waveform, where the waveform has an aspect ratio greater than two.
摘要翻译：一种集成微通道反应器和热交换器，包括：（a）夹在相对的垫片之间的波形并安装到垫片以形成一系列微通道，其中每个微通道包括一对基本上直的侧壁，以及由至少一个相对的垫片，和（b）与波形热连通的第一组微通道，其中波形的纵横比大于2。

110. 发明授权

US08765537B2 Metal gate fill by optimizing etch in sacrificial gate profile 有权
标题翻译：通过优化牺牲栅极剖面中的蚀刻来进行金属栅极填充
公开(公告)号：US08765537B2
公开(公告)日：2014-07-01
申请号：US13606035
申请日：2012-09-07
申请人： Man Fai Ng , Bin Yang
发明人： Man Fai Ng , Bin Yang
IPC分类号： H01L21/338
CPC分类号： H01L21/28114 , H01L29/42376 , H01L29/66545 , H01L29/6659 , H01L29/7833
摘要： A high-k metal gate electrode is formed with reduced gate voids. An embodiment includes forming a replaceable gate electrode, for example of amorphous silicon, having a top surface and a bottom surface, the top surface being larger than the bottom surface, removing the replaceable gate electrode, forming a cavity having a top opening larger than a bottom opening, and filling the cavity with metal. The larger top surface may be formed by etching the bottom portion of the amorphous silicon at greater temperature than the top portion, or by doping the top and bottom portions of the amorphous silicon differently such that the bottom has a greater lateral etch rate than the top.
摘要翻译：形成具有减小的栅极空隙的高k金属栅电极。一个实施例包括形成可替换的栅电极，例如具有顶表面和底表面的非晶硅，顶表面大于底表面，去除可更换的栅电极，形成具有大于底部开口，并用金属填充空腔。可以通过在比顶部更高的温度下蚀刻非晶硅的底部，或者通过不同地掺杂非晶硅的顶部和底部来形成较大的顶表面，使得底部具有比顶部更大的侧向蚀刻速率。

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