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101. 发明授权

US06906353B1 High speed implanted VCSEL 有权
标题翻译：高速植入VCSEL
公开(公告)号：US06906353B1
公开(公告)日：2005-06-14
申请号：US10715165
申请日：2003-11-17
申请人： Chan-Long Shieh , Hsing-Chung Lee
发明人： Chan-Long Shieh , Hsing-Chung Lee
IPC分类号： H01L33/00 , H01S3/08 , H01S5/183 , H01S5/20
CPC分类号： H01S5/18308 , H01S5/18341 , H01S5/18369 , H01S5/2063 , H01S5/3095 , H01S2301/166
摘要： A vertical cavity surface emitting laser includes a first mirror region forming a first distributed Bragg reflector, a first cladding region, an active region, a second cladding region including a high electrical resistance implanted region positioned to define a current path, a second mirror region, and a current spreading region. A first electrical contact is positioned on the current spreading region and a second electrical contact is positioned to conduct electrical current in circuit with the first electrical contact through the current path. The current spreading region and the second mirror region cooperate to produce substantially uniform current distribution in the current path. A third mirror region is positioned on the current spreading region. The second and third mirror regions cooperate to provide a complete distributed Bragg reflector.
摘要翻译：垂直腔表面发射激光器包括形成第一分布布拉格反射器的第一反射镜区域，第一包层区域，有源区域，包括定位成限定电流路径的高电阻注入区域的第二包层区域，第二镜像区域，和电流扩展区域。第一电触头位于电流扩展区上，并且第二电触点被定位成使电流通过电流路径与第一电触头相通。电流扩散区域和第二反射镜区域协作以在电流路径中产生基本均匀的电流分布。第三反射镜区域位于电流扩展区域上。第二和第三镜面区域配合以提供完整的布拉格反射器。

102. 发明申请

US20050031005A1 Low voltage multi-junction vertical cavity surface emitting laser 审中-公开
公开(公告)号：US20050031005A1
公开(公告)日：2005-02-10
申请号：US10939666
申请日：2004-09-13
申请人： Julian Cheng , Chan-Long Shieh , Guoli Liu , Medicharla Ramana Murty
发明人： Julian Cheng , Chan-Long Shieh , Guoli Liu , Medicharla Ramana Murty
IPC分类号： H01L21/00 , H01S3/08 , H01S3/14 , H01S5/00 , H01S5/02 , H01S5/183 , H01S5/323
CPC分类号： H01S5/18305 , H01S5/0216 , H01S5/0217 , H01S5/0427 , H01S5/18308 , H01S5/18316 , H01S5/18341 , H01S5/18369 , H01S5/3235 , H01S5/426
摘要： An optical device with a wavelength of operation, the device comprising a light emitting region which emits light at the wavelength of operation, the light emitting region including an active region and a contact region of a first conductivity type and a second conductivity type wherein the light emitting region is positioned within an optical gain cavity which includes a mirror and an opposed mirror and a substrate solder bonded using a bonding layer to at least one of the mirror and the opposed mirror.

103. 发明授权

US06361958B1 Biochannel assay for hybridization with biomaterial 有权
公开(公告)号：US06361958B1
公开(公告)日：2002-03-26
申请号：US09438600
申请日：1999-11-12
申请人： Chan-Long Shieh , Barbara Foley , Huinan Yu , Vi-En Choong
发明人： Chan-Long Shieh , Barbara Foley , Huinan Yu , Vi-En Choong
IPC分类号： G01N33543
CPC分类号： B01L3/5027 , B01J2219/00317 , B01J2219/00351 , B01J2219/00416 , B01J2219/00418 , B01J2219/00421 , B01J2219/00432 , B01J2219/0052 , B01J2219/00522 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L7/525 , B01L2300/0636 , B01L2300/0816 , B01L2300/087 , B01L2400/0415 , B01L2400/043 , B01L2400/049 , B82Y30/00 , C12Q1/6834 , C40B40/06 , C40B40/10 , C40B60/14 , Y10S366/02 , Y10S435/81 , C12Q2565/629
摘要： The invention relates to a microfluidic device with microchannels that have separated regions which have a member of a specific binding pair member such as DNA or RNA bound to porous polymer, beads or structures fabricated into the microchannel. The microchannels of the invention are fabricated from plastic and are operatively associated with a fluid propelling component and detector.

104. 发明授权

US6103467A Method and system for synthesizing oligonucleotides using nucleotide-specific dispensing bars 失效
标题翻译：使用核苷酸特异性分配棒合成寡核苷酸的方法和系统
公开(公告)号：US6103467A
公开(公告)日：2000-08-15
申请号：US901102
申请日：1997-07-28
申请人： Donald E Ackley , Chan-Long Shieh , Thomas B. Harvey, III
发明人： Donald E Ackley , Chan-Long Shieh , Thomas B. Harvey, III
IPC分类号： B01J19/00 , C08F2/00 , C40B40/06 , C40B60/14 , C40B70/00 , G01N35/10
CPC分类号： B01J19/0046 , B01J2219/00306 , B01J2219/00351 , B01J2219/00369 , B01J2219/00376 , B01J2219/00527 , B01J2219/00529 , B01J2219/0054 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00695 , B01J2219/00722 , C40B40/06 , C40B60/14 , C40B70/00 , G01N2035/1037
摘要： A plurality of oligonucleotides are synthesized at a plurality of locations on a substrate using a plurality of dispensing bars. Each of the plurality of dispensing bars has a respective plurality of dispensing heads arranged along a respective axis. Each of the plurality of dispensing bars is operative to selectively deposit a volume of a respective one of a plurality of nucleotide bases in any of a row of locations. A positioning mechanism positions the substrate with respect to the plurality of dispensing bars. A controller controls the plurality of dispensing bars and the positioning mechanism so that, at each of the plurality of locations, a respective sequence of nucleotide bases is deposited to form a respective oligonucleotide.
摘要翻译：使用多个分配棒在基板上的多个位置处合成多个寡核苷酸。多个分配棒中的每一个具有沿着相应轴线布置的相应的多个分配头。多个分配棒中的每一个可操作以选择性地将多个核苷酸碱基中的相应的一个核苷酸碱基的体积任意地沉积在一排位置中。定位机构使基板相对于多个分配杆定位。控制器控制多个分配棒和定位机构，使得在多个位置的每一个位置沉积相应的核苷酸碱基序列以形成相应的寡核苷酸。

105. 发明授权

US6090635A Method for forming a semiconductor device structure having a laser portion 有权
标题翻译：用于形成具有激光部分的半导体器件结构的方法
公开(公告)号：US6090635A
公开(公告)日：2000-07-18
申请号：US329133
申请日：1999-06-09
申请人： Mark Alan Rothman , Chan-Long Shieh , Craig Alfred Armiento , John Alvin Thompson , Alfred Joseph Negri
发明人： Mark Alan Rothman , Chan-Long Shieh , Craig Alfred Armiento , John Alvin Thompson , Alfred Joseph Negri
IPC分类号： G02B6/30 , G02B6/42 , H01L21/00
CPC分类号： G02B6/423 , G02B6/4249 , G02B6/30
摘要： A heterostructure device includes a ridge-waveguide laser monolithically integrated with a ridge-waveguide rear facet monitor (RFM). An integral V-groove etched directly into the device substrate enables passive alignment of an optical fiber to the active region of the laser. The layer and RFM facets were formed using an in-situ multistep reactive ion etch process.
摘要翻译：异质结构器件包括与脊 - 波导后小面监视器（RFM）单片集成的脊 - 波导激光器。直接蚀刻到器件衬底中的整体V型沟槽使得光纤能够被激活地对准激光器的有源区域。使用原位多步反应离子蚀刻工艺形成层和RFM面。

106. 发明授权

US6030781A Electric field amplified oligonucleotide ligase analysis 失效
标题翻译：电场扩增寡核苷酸连接酶分析
公开(公告)号：US6030781A
公开(公告)日：2000-02-29
申请号：US956674
申请日：1997-10-23
申请人： Chan-Long Shieh
发明人： Chan-Long Shieh
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6862 , C12Q2565/607
摘要： An electric field amplified oligonucleotide ligase analysis includes combining a plurality of oligonucleotide probes carried on a support at a binding site with a solution including a target molecule, a plurality of oligonucleotide segments including a marker and ligase. A first electric field surrounding the plurality of oligonucleotide probes is generated to attract the target molecule to a first of the plurality of oligonucleotide probes to which it hybridizes. A first of the plurality of oligonucleotide segments also hybridizes with the target molecule and covalently bonds to the first oligonucleotide probe due to the presence of ligase in the solution. The target molecule is separated by generating a second electric field surrounding the plurality of oligonucleotide probes. The generation of the electric fields are alternately repeated to amplify the hybridization signal.
摘要翻译：电场扩增寡核苷酸连接酶分析包括将携带在结合位点的载体上的多个寡核苷酸探针与包含靶分子，多个包含标记物和连接酶的寡核苷酸区段的溶液组合。产生围绕多个寡核苷酸探针的第一电场，以将靶分子吸引到与其杂交的多个寡核苷酸探针中的第一个。多个寡核苷酸片段中的第一个也与靶分子杂交，并且由于溶液中存在连接酶而与第一寡核苷酸探针共价结合。通过产生围绕多个寡核苷酸探针的第二电场来分离靶分子。交替重复电场的产生以放大杂交信号。

107. 发明授权

US5945286A Electrochemical-based molecular detection apparatus and method 失效
标题翻译：电化学分子检测装置及方法
公开(公告)号：US5945286A
公开(公告)日：1999-08-31
申请号：US956676
申请日：1997-10-23
申请人： Michael Krihak , Chan-Long Shieh
发明人： Michael Krihak , Chan-Long Shieh
IPC分类号： C12Q1/68
CPC分类号： B82Y30/00 , B82Y5/00 , C12Q1/6825 , B01J2219/00653
摘要： A molecular detection apparatus including an electrode, a peptide nucleic acid probe covalently bonded to the electrode and a protective layer covering portions of the electrode not having attached probes which prevents oxidation/reduction of intercalator molecules.
摘要翻译：一种分子检测装置，包括电极，共价键合到电极上的肽核酸探针和覆盖电极部分的保护层，该电极不具有防止嵌入剂分子氧化/还原的附着探针。

108. 发明授权

US5940683A LED display packaging with substrate removal and method of fabrication 失效
标题翻译： LED显示包装与基板去除及其制造方法
公开(公告)号：US5940683A
公开(公告)日：1999-08-17
申请号：US588470
申请日：1996-01-18
申请人： Paige M. Holm , Chan-Long Shieh , Curtis D. Moyer
发明人： Paige M. Holm , Chan-Long Shieh , Curtis D. Moyer
IPC分类号： H01L21/60 , G09F9/33 , H01L25/16 , H01L27/15 , H01L33/00 , H01L21/00
CPC分类号： H01L25/167 , G09F9/3026 , H01L25/162 , H01L27/156 , H01L2924/0002 , H01L33/0079
摘要： A light emitting diode display package and method of fabricating a light emitting diode (LED) display package including a LED array display chip, fabricated of an array of LEDs, formed on a substrate, having connection pads positioned about the perimeter of the LED array display chip, a separate silicon driver chip having connection pads routed to an uppermost surface, positioned to cooperatively engage those of the display chip when properly registered and interconnected using wafer level processing technology. The display chip being flip chip mounted to the driver chip and having a layer of interchip bonding dielectric positioned between the space defined by the display chip and the driver chip. The LED display and driver chip package subsequently having selectively removed the substrate onto which the LED array was initially formed, thereby exposing the connection pads of the display chip and a remaining indium-gallium-aluminum-phosphide (InGaAlP) epilayer. The light emitted from the LED display chip, being emitted through the remaining indium-gallium-aluminum-phosphide (InGaAlP) epilayer of the display chip.
摘要翻译：一种制造发光二极管（LED）显示封装的发光二极管显示封装和方法，所述发光二极管（LED）显示封装包括形成在基板上的由阵列LED制成的LED阵列显示芯片，所述LED阵列显示芯片具有围绕所述LED阵列显示器周边定位的连接焊盘芯片，具有连接到最上表面的连接焊盘的单独的硅驱动器芯片，定位成当使用晶片级处理技术正确地注册和互连时协作地接合显示芯片的那些。显示芯片被倒装芯片安装到驱动器芯片上，并且具有位于由显示芯片和驱动器芯片限定的空间之间的芯片间接合电介质层。 LED显示器和驱动器芯片封装随后选择性地去除了最初形成LED阵列的衬底，从而暴露显示芯片的连接焊盘和剩余的铟 - 镓 - 铝 - 磷化物（InGaAlP）外延层。从LED显示芯片发出的光通过显示芯片的剩余的铟镓铝磷化物（InGaAlP）外延层发射。

109. 发明授权

US5719033A Thin film transistor bio/chemical sensor 失效
标题翻译：薄膜晶体管生物/化学传感器
公开(公告)号：US5719033A
公开(公告)日：1998-02-17
申请号：US496269
申请日：1995-06-28
申请人： Donald E. Ackley , Chan-Long Shieh
发明人： Donald E. Ackley , Chan-Long Shieh
IPC分类号： G01N27/414 , G01N33/53 , G01N33/537 , G01N33/543
CPC分类号： G01N27/414 , Y10S436/806
摘要： A chemical sensor includes a thin film transistor with a gate positioned on one side. An insulating layer is positioned on the opposite side and an indicator film is positioned on the insulating layer in generally opposed relationship to the gate. Induced charge in the indicator film caused by a biological or chemical species changes the channel current in the transistor. A potential on the gate is then used to null out the resulting change in channel current. The potential used to null out the current change is an extremely sensitive measure of the induced charge.
摘要翻译：化学传感器包括具有位于一侧的栅极的薄膜晶体管。绝缘层位于相对侧，并且指示膜位于与栅极大致相对关系的绝缘层上。由生物或化学物质引起的指示剂膜中的诱导电荷改变晶体管中的沟道电流。然后，门上的电位用于清除所导致的通道电流变化。用于消除当前变化的电位是感应电荷的极其敏感的测量。

110. 发明授权

US5671303A Molecular detection apparatus and method using optical waveguide detection 失效
标题翻译：使用光波导检测的分子检测装置及方法
公开(公告)号：US5671303A
公开(公告)日：1997-09-23
申请号：US634103
申请日：1996-04-17
申请人： Chan-Long Shieh , Donald E. Ackley , George N. Maracas , Thomas B. Harvey, III
发明人： Chan-Long Shieh , Donald E. Ackley , George N. Maracas , Thomas B. Harvey, III
IPC分类号： G01N21/64 , G01N21/77 , G02B6/00 , G02B6/10 , G01N21/41
CPC分类号： G01N21/6454 , G01N21/7703 , G02B6/10
摘要： A target molecule at a binding site is detected using an optical waveguide having a surface proximate to the binding site, and a waveguide detector coupled to the optical waveguide. An incident light beam is applied to the binding site along an axis transverse to the surface of the optical waveguide. The incident light beam impinges an optical indicator associated with the target molecule to form secondary light which is coupled into the optical waveguide. The secondary light is detected by the waveguide detector to thereby detect the target molecule.
摘要翻译：使用具有接近结合位点的表面的光波导和耦合到光波导的波导检测器来检测结合位点处的靶分子。沿着横向于光波导表面的轴将入射光束施加到结合位点。入射光束照射与靶分子相关联的光学指示器，以形成耦合到光波导中的次级光。二次光被波导检测器检测，从而检测目标分子。

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