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91. 发明申请

US20030040466A1 Ligand sensor devices and uses thereof 有权
标题翻译：配体传感器装置及其用途
公开(公告)号：US20030040466A1
公开(公告)日：2003-02-27
申请号：US10068570
申请日：2002-02-06
发明人： Vitaly Vodyanoy , Alexandre M. Samoylov , Tatiana I. Samoylova , Suram T. Pathirana
IPC分类号： A61K038/16 , G01N033/53 , C12M001/34
CPC分类号： C40B30/04 , C12N15/1037 , C40B40/02 , G01N29/022 , G01N33/54353 , G01N33/54373 , G01N33/5438 , G01N33/54393 , G01N33/545 , G01N33/6842 , G01N33/6845 , G01N2291/014 , G01N2291/02466 , G01N2291/02475 , G01N2291/0256 , G01N2291/0426
摘要： Methods and compositions for evaluating the affinity of one or more ligands of interest are provided. In particular, a ligand sensor device (LSD) comprising a sensor coupled to a peptide of interest is provided. Assays using the LSD allow detection of ligand-peptide interactions directly in tissue samples and thus provide an in vitro assay to characterize peptide ligands. The LSD and assays find particular use in characterizing cell-specific peptides isolated from in vivo screening in animals to determine their suitability for use in human therapy.
摘要翻译：提供了用于评估一种或多种感兴趣配体的亲和力的方法和组合物。特别地，提供了包含耦合到感兴趣的肽的传感器的配体传感器装置（LSD）。使用LSD的测定允许在组织样品中直接检测配体 - 肽相互作用，从而提供体外测定以表征肽配体。 LSD和测定法特别用于表征从动物体内筛选中分离的细胞特异性肽，以确定其在人类治疗中的适用性。

92. 发明申请

US20030004426A1 Method and apparatus for detecting environmental smoke exposure 失效
标题翻译：检测环境烟雾暴露的方法和装置
公开(公告)号：US20030004426A1
公开(公告)日：2003-01-02
申请号：US10153096
申请日：2002-05-22
发明人： Richard J. Melker , Mark Gold
IPC分类号： A61B005/08
CPC分类号： G01N29/4427 , G01N29/022 , G01N29/069 , G01N33/497 , G01N2291/014 , G01N2291/0217 , G01N2291/02408 , G01N2291/0256 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427
摘要： The present invention includes a method and apparatus for detecting exposure to environmental tobacco smoke by analyzing a sample of breath using electronic sensor technology, including surface acoustic-wave gas sensor technology. The method determines the presence and concentration of substance(s) (or a class of substances) indicative of environmental smoke exposure. Diagnostic software is used to identify substances where a stored library of signatures is compared to the signature obtained from the system. Signal processing and neural networks are preferably utilized in the analysis.
摘要翻译：本发明包括通过使用包括表面声波气体传感器技术的电子传感器技术分析呼吸样本来检测对环境烟草烟雾的暴露的方法和装置。该方法确定指示环境烟雾暴露的物质（或一类物质）的存在和浓度。诊断软件用于识别存储的签名库与从系统获取的签名进行比较的物质。在分析中优选使用信号处理和神经网络。

93. 发明申请

US20020197390A1 Use of an array of polymeric sensors of varying thickness for detecting analytes in fluids 有权
公开(公告)号：US20020197390A1
公开(公告)日：2002-12-26
申请号：US09910242
申请日：2001-07-20
发明人： Nathan S. Lewis , Erik J. Severin , Michael Freund , Adam J. Matzger
IPC分类号： B05D001/02
CPC分类号： G01N33/0031 , G01N15/0826 , G01N27/126 , G01N29/022 , G01N29/449 , G01N2291/0217 , G01N2291/0256 , G01N2291/02863 , G01N2291/0423 , G01N2291/0426
摘要： Chemical sensors for detecting the activity of a molecule or analyte of interest is provided. The chemical sensors comprise and array or plurality of sensors that are capable of interacting with a molecule of interest, wherein the interaction provides a response fingerprint. The fingerprint can be associated with a library of similar molecules of interest to determine the molecule's activity and diffusion coefficient.

94. 发明授权

US06422061B1 Apparatus, systems and methods for detecting and transmitting sensory data over a computer network 失效
公开(公告)号：US06422061B1
公开(公告)日：2002-07-23
申请号：US09518179
申请日：2000-03-02
申请人： Steven A. Sunshine , Gregory Steinthal , Christopher K. Boehr , Robert K. Nakayama
发明人： Steven A. Sunshine , Gregory Steinthal , Christopher K. Boehr , Robert K. Nakayama
IPC分类号： G01N3100
CPC分类号： G01N33/0031 , G01N29/022 , G01N33/0009 , G01N2291/0217 , G01N2291/0256 , G01N2291/0423 , G01N2291/0426 , G01N2291/106 , G06F19/00
摘要： A vapor sensing device that is sufficiently small and lightweight to be handheld, and also modular so as to allow the device to be conveniently adapted for use in sensing the presence and concentration of a wide variety of specified vapors. The device provides these benefits using a sensor module that incorporates a sample chamber and a plurality of sensors located on a chip releasably carried within or adjacent to the sample chamber. Optionally, the sensor module can be configured to be releasably plugged into a receptacle formed in the device. Vapors are directed to pass through the sample chamber, whereupon the sensors provide a distinct combination of electrical signals in response to each. The sensors of the sensor module can take the form of chemically sensitive resistors having resistances that vary according to the identity and concentration of an adjacent vapor. These chemically sensitive resistors can each be connected in series with a reference resistor, between a reference voltage and ground, such that an analog signal is established for each chemically sensitive resistor. The resulting analog signals are supplied to an analog-to-digital converter, to produce corresponding digital signals. These digital signals are appropriately analyzed for vapor identification. The device can then subsequently transmit the digital signals over a computer network, such as the Internet, for analysis at a remote location.

95. 发明申请

US20020018210A1 Optical method for the characterization of laterally-patterned samples in integrated circuits 有权
标题翻译：用于表征集成电路中横向图案化样品的光学方法
公开(公告)号：US20020018210A1
公开(公告)日：2002-02-14
申请号：US09969336
申请日：2001-10-01
申请人： Brown University Research Foundation
发明人： Humphrey J. Maris
IPC分类号： G01N021/00
CPC分类号： G01N29/0681 , G01B11/02 , G01B11/0658 , G01B11/0666 , G01B11/24 , G01N21/1702 , G01N21/1717 , G01N21/211 , G01N21/4788 , G01N21/9501 , G01N21/956 , G01N29/2418 , G01N2021/1706 , G01N2291/02827 , G01N2291/02881 , G01N2291/0426 , G01N2291/0427
摘要： Disclosed is a method for characterizing a sample having a structure disposed on or within the sample, comprising the steps of applying a first pulse of light to a surface of the sample for creating a propagating strain pulse in the sample, applying a second pulse of light to the surface so that the second pulse of light interacts with the propagating strain pulse in the sample, sensing from a reflection of the second pulse a change in optical response of the sample, and relating a time of occurrence of the change in optical response to at least one dimension of the structure.
摘要翻译：公开了一种用于表征具有设置在样品上或样品内的结构的样品的方法，包括以下步骤：将第一脉冲光施加到样品的表面，以在样品中产生传播的应变脉冲，施加第二脉冲的光使得第二脉冲光与样品中的传播应变脉冲相互作用，从第二脉冲的反射中检测样品的光学响应的变化，并将光学响应的变化的发生时间与结构的至少一个维度。

96. 发明申请

US20010045416A1 Quality control plasma monitor for laser shock processing 失效
标题翻译：激光冲击加工质量控制等离子体显示器
公开(公告)号：US20010045416A1
公开(公告)日：2001-11-29
申请号：US09896267
申请日：2001-06-29
申请人： LSP TECHNOLOGIES, INC.
发明人： David W. Sokol , Craig T. Walters , Harold M. Epstein , Allan H. Clauer , Jeffrey L. Dulaney , Mark O'Loughlin
IPC分类号： B23K026/00 , B23K026/04
CPC分类号： C21D10/005 , G01N23/20 , G01N29/14 , G01N29/2418 , G01N2291/0237 , G01N2291/0251 , G01N2291/0426
摘要： A method and apparatus for quality control of laser shock processing. The method includes measuring emissions and characteristics of a workpiece when subjected to a pulse of coherent energy from a laser. These empirically measured emissions and characteristics of the workpiece are correlated to theoretical shock pressure, residual stress profile, or fatigue life of the workpiece. The apparatus may include a radiometer or acoustic detection device for measuring these characteristics.
摘要翻译：一种用于激光冲击加工质量控制的方法和装置。该方法包括当经受来自激光器的相干能量的脉冲时测量工件的发射和特性。这些经验测量的工件的排放和特性与工件的理论冲击压力，残余应力分布或疲劳寿命相关。该装置可以包括用于测量这些特性的辐射计或声学检测装置。

97. 发明授权

US06271921B1 Optical stress generator and detector 有权
公开(公告)号：US06271921B1
公开(公告)日：2001-08-07
申请号：US09511719
申请日：2000-02-23
申请人： Humphrey J. Maris , Robert J Stoner
发明人： Humphrey J. Maris , Robert J Stoner
IPC分类号： G01B1106
CPC分类号： G01N21/1702 , G01N29/0681 , G01N29/2418 , G01N2291/02827 , G01N2291/02881 , G01N2291/0426 , G01N2291/0427 , Y10S977/834 , Y10S977/90 , Y10S977/901 , Y10S977/955 , Y10S977/956
摘要： Disclosed is a system for the characterization of thin films and interfaces between thin films through measurements of their mechanical and thermal properties. In the system light is absorbed in a thin film or in a structure made up of several thin films, and the change in optical transmission or reflection is measured and analyzed. The change in reflection or transmission is used to give information about the ultrasonic waves that are produced in the structure. The information that is obtained from the use of the measurement methods and apparatus of this invention can include: (a) a determination of the thickness of thin films with a speed and accuracy that is improved compared to earlier methods; (b) a determination of the thermal, elastic, and optical properties of thin films; (c) a determination of the stress in thin films; and (d) a characterization of the properties of interfaces, including the presence of roughness and defects.

98. 发明授权

US06237397B1 Chemical sensor and coating for same 失效
标题翻译：化学传感器和涂层相同
公开(公告)号：US06237397B1
公开(公告)日：2001-05-29
申请号：US09413628
申请日：1999-10-06
申请人： Ruth Shinar , Guojun Liu , Marc D. Porter
发明人： Ruth Shinar , Guojun Liu , Marc D. Porter
IPC分类号： G01N2902
CPC分类号： G01N29/022 , G01N2291/014 , G01N2291/0256 , G01N2291/02863 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427
摘要： An acoustic wave based-chemical sensor containing a crystal substrate and a coating of small particulate matter is disclosed. The small particulate matter can be graphite particles. Transducers are connected to the crystal substrate to generate an alternating potential across the crystal substrate, which in turn causes the crystal to resonate due to the converse piezoelectric effect. The coating absorbs the analyte, thus changing the mass of the sensor, and accordingly changing its resonant frequency. The transducers detect this change in resonant frequency to indicate that the analyte is present. The use of small particulate matter results in a coating having a large surface area which facilitates mass uptake of large amounts of VOCs, improved acoustic properties even with relatively thick coatings, and a high operational temperature range.
摘要翻译：公开了一种包含晶体衬底和小颗粒物质涂层的基于声波的化学传感器。小颗粒物可以是石墨颗粒。传感器连接到晶体衬底以在晶体衬底之间产生交替电位，这又导致晶体由于相反的压电效应而谐振。涂层吸收分析物，从而改变传感器的质量，从而改变其共振频率。传感器检测谐振频率的这种变化，以表明分析物存在。使用小的颗粒物质可形成具有大表面积的涂层，其有利于大量挥发性有机物的吸收，甚至在相对较厚的涂层和较高的操作温度范围内也改善了声学性能。

99. 发明授权

US06196059B1 Piezoelectric resonator, process for the fabrication thereof including its use as a sensor element for the determination of the concentration of a substance contained in a liquid and/or for the determination of the physical properties of the liquid 失效
标题翻译：压电谐振器，其制造方法包括其用作用于确定液体中所含物质的浓度的传感器元件和/或用于确定液体的物理性质
公开(公告)号：US06196059B1
公开(公告)日：2001-03-06
申请号：US09132617
申请日：1998-08-11
申请人： Conrad Kösslinger , Erich Uttenthaler , Andreas Nitsch , Thomas Härle
发明人： Conrad Kösslinger , Erich Uttenthaler , Andreas Nitsch , Thomas Härle
IPC分类号： G01N2700
CPC分类号： H03H9/19 , B06B1/0692 , B06B2201/71 , G01H13/00 , G01N29/022 , G01N29/036 , G01N29/222 , G01N2291/015 , G01N2291/0222 , G01N2291/0256 , G01N2291/02809 , G01N2291/0426 , H03H3/02
摘要： Disclosed is a piezoelectric resonator, a process for the fabrication thereof and its use as a sensor element, which implemented in a through-flow cell, is integratable in a measurement system for the determination of the concentration of a substance contained in a liquid and/or for the determination of the physical properties of the liquid. The piezoelectric resonator is designed plane and is provided on its surface with electric contact areas for an electrode and a counter electrode, which is connectable to a signal source as well as to a measurement device. For measuring, the piezoelectric resonator is brought into contact with the to-be-examined liquid on one side, with the resonator responding to the accumulation of the mass of the to-be-detected substance or to a change in the physical properties of the liquid by changing its resonance frequency and/or oscillation amplitude. The present invention is distinguished by the fact that the piezoelectric resonator is provided with contact electrode areas which is contactable from one single side of the resonator. The resonator is the heart piece of a sensor element, which is integrated in a through-flow cell. The through-flow cell us insertable module-like in a measurement arrangement for determining the concentration of a substance contained in a liquid and/or determining the physical properties of the liquid.
摘要翻译：公开了一种压电谐振器，其制造方法及其作为传感器元件的用途，其在通流池中实现，可在测量系统中积分，用于确定液体中所含物质的浓度和/ 或用于确定液体的物理性质。压电谐振器是设计平面的，并且在其表面上设置有用于电极和对电极的电接触区域，其可连接到信号源以及测量装置。为了测量，压电谐振器在一侧与待检查液体接触，谐振器响应待检测物质的质量的积累或对物质的变化通过改变其共振频率和/或振荡幅度来限制液体。本发明的特征在于压电谐振器设置有可从谐振器的一个单侧接触的接触电极区域。谐振器是传感器元件的心脏片，其集成在通流池中。在用于确定液体中所含物质的浓度和/或确定液体的物理性质的测量装置中，可插入模块状的通流池。

100. 发明授权

US6134944A System and method for preconcentrating, identifying, and quantifying chemical and biological substances 失效
标题翻译：预浓缩，鉴定和定量化学和生物物质的系统和方法
公开(公告)号：US6134944A
公开(公告)日：2000-10-24
申请号：US302047
申请日：1999-04-29
申请人： Conrad M. Yu , Jackson C. Koo
发明人： Conrad M. Yu , Jackson C. Koo
IPC分类号： G01N1/40 , G01N29/02 , G01N30/12 , G01N29/18 , G01N31/06
CPC分类号： G01N29/022 , G01N30/12 , G01N1/40 , G01N2030/121 , G01N2291/02466 , G01N2291/0256 , G01N2291/0423 , G01N2291/0426
摘要： A system and method for preconcentrating, identifying, and quantifying chemical and biological substances is disclosed. An input valve directs a first volume of a sample gas to a surface acoustic wave (SAW) device. The SAW device preconcentrates and detects a mass of a substance within the sample gas. An output valve receives a second volume of the sample gas containing the preconcentrated substance from the SAW device and directs the second volume to a gas chromatograph (GC). The GC identifies the preconcentrated substance within the sample gas. A shunt valve exhausts a volume of the sample gas equal to the first volume minus the second volume away from the SAW device and the GC. The method of the present invention includes the steps of opening an input valve for passing a first volume of a sample gas to a SAW device; preconcentrating and detecting a mass of a substance within the sample gas using the SAW device; opening an output valve for passing a second volume of the sample gas containing the preconcentrated substance to a gas chromatograph (GC); and then identifying the preconcentrated substance within the sample gas using the GC.
摘要翻译：公开了一种用于预浓缩，鉴定和定量化学和生物物质的系统和方法。输入阀将第一体积的样品气体引导到表面声波（SAW）装置。 SAW器件预浓缩并检测样品气体中物质的质量。输出阀从SAW装置接收含有预浓缩物质的样品气体的第二体积，并将第二体积引导至气相色谱仪（GC）。 GC识别样品气体中的预浓缩物质。分流阀排出等于第一容积的样品气体的体积减去远离SAW器件和GC的第二体积。本发明的方法包括以下步骤：打开用于将第一体积样品气体传递到SAW器件的输入阀; 使用SAW器件预浓缩和检测样品气体内的物质的质量; 打开输出阀，用于将含有预浓缩物质的第二体积的样品气体通入气相色谱仪（GC）; 然后使用GC鉴定样品气体中的预浓缩物质。

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