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91. 发明申请

US20130013083A1 Tissue-Engineered Constructs 审中-公开
标题翻译：组织工程建设
公开(公告)号：US20130013083A1
公开(公告)日：2013-01-10
申请号：US13542098
申请日：2012-07-05
申请人： Juliana L. BLUM , Shannon L.M. DAHL , Laura E. NIKLASON , Justin T. STRADER , William E. TENTE , Heather L. PRITCHARD , Joseph J. LUNDQUIST
发明人： Juliana L. BLUM , Shannon L.M. DAHL , Laura E. NIKLASON , Justin T. STRADER , William E. TENTE , Heather L. PRITCHARD , Joseph J. LUNDQUIST
IPC分类号： A61F2/04
CPC分类号： A61F2/04 , A61F2/06 , A61L27/36 , A61L27/3633 , A61L27/3679 , A61L27/3683 , A61L27/507 , A61L27/60 , A61L2430/22
摘要： Constructs including a tubular biodegradable polyglycolic acid scaffold may be coated with extracellular matrix proteins and are substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, an arterial graft, a venous graft, a duct graft, a skin graft, or a urinary graft or conduit.
摘要翻译：包括管状可生物降解聚乙醇酸支架的构建体可以被细胞外基质蛋白包被并且基本上是无细胞的。构建体可以用作动静脉移植物，冠状动脉移植物，动脉移植物，静脉移植物，导管移植物，皮肤移植物或尿移植物或导管。

92. 发明申请

US20120330413A1 Biomedical Valve Devices, Support Frames for Use in Such Devices, and Related Methods 有权
标题翻译：生物医学阀门装置，用于这种装置的支撑框架及相关方法
公开(公告)号：US20120330413A1
公开(公告)日：2012-12-27
申请号：US13602514
申请日：2012-09-04
申请人： Dusan Pavcnik
发明人： Dusan Pavcnik
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2220/0075 , A61L27/3625 , A61L27/507
摘要： Biomedical valve devices, support frames for use in such devices, methods of making such devices, and methods of treating animals, including humans, for valve-related conditions are described. The biomedical valve devices can includes a native tissue valve attached to a support frame or a tissue attached to a support frame in a manner to form a valve. The tissue valve or tissue can be autogenous to the animal being treated.
摘要翻译：描述了用于阀相关状况的生物医学阀装置，用于这种装置的支撑框架，制造这种装置的方法以及治疗包括人类在内的动物的方法。生物医学阀装置可以包括以形成阀的方式附接到支撑框架或附接到支撑框架的组织的天然组织瓣膜。组织瓣膜或组织可以与待治疗的动物自发生长。

93. 发明申请

US20120323315A1 DURABLE MULTI-LAYER HIGH STRENGTH POLYMER COMPOSITE SUITABLE FOR IMPLANT AND ARTICLES PRODUCED THEREFROM 有权
标题翻译：耐久多层高强度聚合物复合材料适用于生产的植物和植物
公开(公告)号：US20120323315A1
公开(公告)日：2012-12-20
申请号：US13485823
申请日：2012-05-31
申请人： William C. Bruchman , Cody L. Hartman
发明人： William C. Bruchman , Cody L. Hartman
IPC分类号： A61F2/24 , C08L27/18 , B05D3/00 , B32B37/26 , B05D7/24
CPC分类号： A61F2/2403 , A61F2/24 , A61F2/2415 , A61F2210/0076 , A61F2230/00 , A61F2240/001 , A61F2240/005 , A61L27/34 , A61L27/48 , A61L27/507 , A61L27/56 , A61L2420/04 , A61L2420/08 , A61L2430/20 , Y10T29/49412 , C08L27/18
摘要： A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. The composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as heart pacing lead or heart valve leaflet. The composite material includes at least one porous expanded fluoropolymer layer and an elastomer substantially filling substantially all of the pores of the porous expanded fluoropolymer.
摘要翻译：公开了一种适用于各种植入构型的薄的，生物相容的，高强度的复合材料。复合材料在高周期弯曲应用中保持灵活性，使其特别适用于高柔性植入物，如心脏起搏引线或心脏瓣膜小叶。复合材料包括至少一个多孔膨胀氟聚合物层和基本上填充多孔膨胀氟聚合物的基本上所有孔的弹性体。

94. 发明授权

US08197553B2 Composite scaffolds and methods using same for generating complex tissue grafts 有权
标题翻译：复合支架和使用它们的方法产生复杂的组织移植物
公开(公告)号：US08197553B2
公开(公告)日：2012-06-12
申请号：US12285107
申请日：2008-09-29
申请人： Dan Gazit , Abraham J. Domb , Gadi Turgeman , Gadi Pelled , Tony Azzam
发明人： Dan Gazit , Abraham J. Domb , Gadi Turgeman , Gadi Pelled , Tony Azzam
IPC分类号： A61F2/02
CPC分类号： A61L27/3604 , A61L27/18 , A61L27/20 , A61L27/22 , A61L27/3625 , A61L27/38 , A61L27/3839 , A61L27/3886 , A61L27/3891 , A61L27/3895 , A61L27/40 , A61L27/48 , A61L27/507 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2300/604 , A61L2430/36 , C12M25/14 , C12N5/0068 , C12N5/0662 , C12N2501/155 , C12N2502/28 , C12N2510/00 , C12N2533/40 , C12N2533/54 , C12N2533/70 , C12N2533/72 , C08L67/04 , C08L71/02
摘要： A composite scaffold for engineering a heterogeneous tissue is provided. The composite scaffold includes: (a) a first scaffold being capable of supporting formation of a first tissue type thereupon; and (b) a second scaffold being capable of supporting formation of a second tissue type thereupon; wherein the first scaffold and the second scaffold are arranged with respect to each other such that when the first scaffold supports the first tissue type and the second scaffold supports the second tissue type, a distance between any cell of the second tissue type and the first tissue type does not exceed 200 μm.
摘要翻译：提供了一种用于工程异质组织的复合支架。所述复合支架包括：（a）第一支架能够支撑其上形成第一组织类型; 和（b）第二支架能够支持其上形成第二组织类型; 其中所述第一支架和所述第二支架相对于彼此布置，使得当所述第一支架支撑所述第一组织类型并且所述第二支架支撑所述第二组织型时，所述第二组织类型的任何细胞与所述第一组织之间的距离类型不超过200μm。

95. 发明授权

US08192348B2 Engineered blood vessels 有权
标题翻译：工程血管
公开(公告)号：US08192348B2
公开(公告)日：2012-06-05
申请号：US10562955
申请日：2004-07-01
申请人： Robert T. Tranquillo , Jeffrey Ross , Morayma Reyes
发明人： Robert T. Tranquillo , Jeffrey Ross , Morayma Reyes
IPC分类号： A61F2/04
CPC分类号： A61L27/507 , A61L27/3808 , A61L27/3826 , A61L27/383 , A61L27/3843 , A61L27/3891 , C12N5/0691 , C12N2500/25 , C12N2501/11 , C12N2501/135 , C12N2501/15 , C12N2501/165 , C12N2501/39 , C12N2506/02 , C12N2506/03 , C12N2506/11 , C12N2506/1353 , C12N2533/30 , C12N2533/54 , C12N2533/56
摘要： The present invention relates to engineered blood vessels and methods of making such vessels using matrices comprising endothelial and smooth muscle cells, or cells capable of differentiating into endothelial and smooth muscle cell lineages (e.g., stem cells, or the progenitors thereof).
摘要翻译：本发明涉及工程化血管和使用包含内皮和平滑肌细胞或能够分化成内皮和平滑肌细胞谱系的细胞（例如，干细胞或其祖细胞）的基质制备这种血管的方法。

96. 发明申请

US20120136427A1 IMPLANTABLE MEDICAL DEVICES HAVING CONTROLLED SURFACE PROPERTIES FOR IMPROVED HEALING RESPONSE 有权
标题翻译：具有控制表面特性的可植入医疗器械，用于改善治疗反应
公开(公告)号：US20120136427A1
公开(公告)日：2012-05-31
申请号：US13168844
申请日：2011-06-24
申请人： Julio C. Palmaz , Eugene A. Sprague
发明人： Julio C. Palmaz , Eugene A. Sprague
IPC分类号： A61F2/82
CPC分类号： A61F2/07 , A61F2/0077 , A61F2/82 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/0086 , A61F2002/072 , A61F2002/91541 , A61F2002/9155 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61L27/04 , A61L27/3679 , A61L27/507 , A61L31/022 , Y10T29/49936
摘要： An implantable medical device that is fabricated from materials that present a blood or body fluid or tissue contact surface that has controlled heterogeneities in material constitution. An endoluminal stent-graft and web-stent that is made of a monolithic material formed into differentiated regions defining structural members and web regions extending across interstitial spaces between the structural members. The endoluminal stent-graft is characterized by having controlled heterogeneities at a the blood flow surface of the stent.
摘要翻译：一种植入式医疗装置，其由呈现血液或体液或组织接触表面的材料制成，其具有控制的材料构成的异质性。由整体材料制成的腔内支架移植物和网状支架，其形成限定结构构件的分化区域和跨过结构构件之间的间隙空间延伸的腹膜区域。腔内支架移植物的特征在于在支架的血流表面具有受控的异质性。

97. 发明申请

US20120041539A1 PROTEIN BIOMATERIAL AND BIOCOACERVATE VESSEL GRAFT SYSTEMS AND METHODS OF MAKING AND USING THEREOF 有权
标题翻译：蛋白质生物材料和生物矿物油料系统及其制备和使用方法
公开(公告)号：US20120041539A1
公开(公告)日：2012-02-16
申请号：US13131083
申请日：2009-11-17
申请人： David B Masters
发明人： David B Masters
IPC分类号： A61F2/06 , C09J189/00
CPC分类号： A61L31/16 , A61L24/0015 , A61L24/043 , A61L24/108 , A61L27/26 , A61L27/507 , A61L27/54 , A61L31/041 , A61L31/047 , A61L2300/802 , C08L89/06
摘要： The present invention relates to protein biocoacervates and biomaterials vessel graft systems used in cardiovascular applications and other medical applications, the components utilized in the vessel graft systems and the methods of making and using such systems. More specifically the present invention relates to protein biocoacervates and biomaterials vessel graft systems used in various medical applications and/or the devices used in such vessel graft systems including, but not limited to, vessel grafts as drug delivery devices for the controlled release of pharmacologically active agents, tubular grafts, vascular grafts, protein biomaterial sutures and biomeshes, protein biomaterial adhesives and glues, and other biocompatible biocoacervate or biomaterial devices used in the vessel graft systems of the present invention.
摘要翻译：本发明涉及用于心血管应用和其它医疗应用的蛋白质生物凝聚物和生物材料血管移植物系统，用于血管移植系统的组分以及制备和使用这些系统的方法。更具体地，本发明涉及用于各种医疗应用中的蛋白质生物凝聚物和生物材料血管移植物系统和/或在这种血管移植系统中使用的装置，包括但不限于作为用于控制释放药理学活性的药物递送装置的血管移植物药剂，管状移植物，血管移植物，蛋白质生物材料缝线和生物体组织，蛋白质生物材料粘合剂和胶水，以及用于本发明的血管移植系统中的其它生物相容性生物封隔物或生物材料装置。

98. 发明申请

US20120027807A1 TISSUE ENGINEERED MYOCARDIUM AND METHODS OF PRODUCTION AND USES THEREOF 审中-公开
标题翻译：组织工程心肌梗塞及其生产方法及其用途
公开(公告)号：US20120027807A1
公开(公告)日：2012-02-02
申请号：US13121279
申请日：2009-10-09
申请人： Kenneth R. Chien , Ibrahim J. Domian , Murali Chiravuri , Peter Van Der Meer , Kevin Kit Parker , Adam W. Feinberg
发明人： Kenneth R. Chien , Ibrahim J. Domian , Murali Chiravuri , Peter Van Der Meer , Kevin Kit Parker , Adam W. Feinberg
IPC分类号： A61K35/34 , A61K9/00 , C12Q1/02 , A61P9/00 , C12N5/0775 , C12N5/10
CPC分类号： A61L27/3804 , A61L27/507 , A61L27/54 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2300/432
摘要： The present invention generally relates to a population of committed ventricular progenitor (CVP) cells and their use to generate a tissue engineered myocardium, in particular two dimensional tissue engineered myocardium which is comparable to functional ventricular heart muscle. One embodiment of present invention provides a composition and methods for the production of a tissue engineered myocardium which has functional properties of cardiac muscle, such as contractibility (e.g. contraction force) and numerous properties of mature fully functional ventricular heart muscle tissue. In particular, in one embodiment, a composition comprising the tissue engineered myocardium comprises committed ventricular progenitor (CVP) cells seeded on a free-standing biopolymer structure to form functional ventricular myocardium tissue.
摘要翻译：本发明一般涉及致心肌祖细胞（CVP）细胞群及其用于产生组织工程化心肌的用途，特别是与功能性心室肌肉相当的二维组织工程化心肌。本发明的一个实施方案提供了用于生产具有心肌功能特性的组织工程化心肌的组合物和方法，例如收缩性（例如收缩力）和成熟的完全功能性心室肌肉组织的许多性质。特别地，在一个实施方案中，包含组织改造心肌的组合物包括接种在独立的生物聚合物结构上以承载心室祖细胞（CVP）细胞以形成功能性心室心肌组织。

99. 发明申请

US20120009677A1 METHOD FOR PRODUCING A BIO-ARTIFICIAL TRANSPLANT 审中-公开
标题翻译：用于生产人造革的方法
公开(公告)号：US20120009677A1
公开(公告)日：2012-01-12
申请号：US13181945
申请日：2011-07-13
申请人： Augustinus Bader
发明人： Augustinus Bader
IPC分类号： C12N5/0786
CPC分类号： A61L27/3886 , A61L27/3604 , A61L27/3687 , A61L27/3804 , A61L27/3826 , A61L27/383 , A61L27/507
摘要： The invention relates to a method for producing a bio-artificial transplant from biological tissue provided for transplantation, which has cells that are compatible with the recipient applied thereto. According to the invention, a controlled tissue generation is carried out in-vitro, during which selected cells that are capable of remodelling the carrier structures are added to native tissue that is maintained in a culture and the culture is continued until a new tissue which has been substantially transformed is obtained, said tissue containing the added recipient-compatible cells.
摘要翻译：本发明涉及一种用于生物人造移植物从生物组织中提取的用于移植的方法，该方法具有与应用于其的受体相容的细胞。根据本发明，在体外进行受控组织产生，在此期间将能够重塑载体结构的所选择的细胞加入保持在培养物中的天然组织，并持续培养直到具有获得基本上转化的，所述组织含有添加的受体相容细胞。

100. 发明授权

US08075940B2 Bioactive material coating method and tube 有权
标题翻译：生物活性材料涂层方法和管
公开(公告)号：US08075940B2
公开(公告)日：2011-12-13
申请号：US12866235
申请日：2009-01-19
申请人： Dae-Joong Kim , In-Su Baek , Jong-Sang Park , Hye-Yeong Nam , Chengzhe Bai
发明人： Dae-Joong Kim , In-Su Baek , Jong-Sang Park , Hye-Yeong Nam , Chengzhe Bai
IPC分类号： A61L33/00
CPC分类号： A61L27/507 , A61L27/16 , A61L27/54 , A61L27/56 , A61L2300/416 , A61L2420/02 , A61M1/3655 , C08L27/18
摘要： A method for coating bioactive material and a structured coated with a bioactive material are disclosed. The bioactive material coating method includes: flowing a coating solution, produced as a bioactive material is dissolved in a mixed solvent, inside a structure having a lumen; and coating the bioactive material on at least one of inner and outer surfaces of the structure, with different concentrations. The mixed solvent is mixed with two or more solvents having different features. The occurrence of the strangulation of blood vessels and inflammation can be reduced. An increase in the size of the myofibroblast is not suppressed. The coating solution is produced as a medication is dissolved in a mixed solvent, where the mixed solvent is produced as a polar solvent and a nonpolar solvent are mixed with each other at a certain ratio.
摘要翻译：公开了一种用于涂覆生物活性材料和涂覆有生物活性材料的结构的方法。生物活性物质涂布方法包括：将作为生物活性物质生产的涂布溶液溶解在具有内腔的结构内的混合溶剂中; 以及在所述结构的内表面和外表面中的至少一个上以不同的浓度涂覆所述生物活性材料。将混合溶剂与具有不同特征的两种或更多种溶剂混合。可以减少血管和炎症的窒息的发生。肌成纤维细胞的大小的增加不被抑制。将药物溶解在混合溶剂中时，制成涂布溶液，混合溶剂是作为极性溶剂制备混合溶剂，非极性溶剂以一定比例混合。

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