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91. 发明授权

US07083634B2 Stabilized polyester/cyanoacrylate tissue adhesive formulation 失效
公开(公告)号：US07083634B2
公开(公告)日：2006-08-01
申请号：US10300076
申请日：2002-11-20
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61B17/08
CPC分类号： A61L24/001 , A61B17/00491 , A61B17/11 , A61L24/043 , A61L24/06 , C08L35/04
摘要： The present invention is directed to adhesive/hemostatic formulations of 2-alkoxyalkyl cyanoacrylate, an absorbable liquid or solid polymeric modifier, and a general stabilizer against premature anionic polymerization of cyanoacrylates. The present adhesive formulations are useful as tissue adhesives/sealants, hemostatic agents, or as a means of patching and anastomotic coupling of damaged organs.

92. 发明申请

US20050287071A1 Formulation for a cement preparation as bone substitute 审中-公开
标题翻译：作为骨替代物的水泥制剂的制剂
公开(公告)号：US20050287071A1
公开(公告)日：2005-12-29
申请号：US11141769
申请日：2005-05-31
申请人： Robert Wenz
发明人： Robert Wenz
IPC分类号： A61K33/42 , A61K49/04 , A61L24/00 , A61L24/02 , A61L27/12 , A61L27/50
CPC分类号： A61L24/02 , A61K33/42 , A61K49/0409 , A61L24/001 , A61L27/12 , A61L27/50 , A61L2430/02 , A61K2300/00
摘要： A bone cement comprises a powdery component including calcium phosphate and an aqueous liquid component. A radiopaque material is added to at least one of the powder and liquid components, and the components may be combined into a pasty substance for application to bone.
摘要翻译：骨水泥包括包含磷酸钙和水性液体组分的粉末组分。将不透射线材料加入到粉末和液体组分中的至少一种上，并且组分可以组合成用于施用于骨的糊状物质。

93. 发明申请

US20050281797A1 Lung volume reduction using glue compositions 有权
标题翻译：使用胶水组合物减轻肺体积
公开(公告)号：US20050281797A1
公开(公告)日：2005-12-22
申请号：US11008093
申请日：2004-12-08
申请人： Glen Gong , Ronald Dieck
发明人： Glen Gong , Ronald Dieck
IPC分类号： A61K31/704 , A61K31/7072 , A61K33/24 , A61K35/74 , A61K38/16 , A61K38/18 , A61K38/45 , A61K38/54 , A61K45/06
CPC分类号： A61K45/06 , A61K31/704 , A61K31/7072 , A61K35/74 , A61K38/166 , A61K38/18 , A61K38/38 , A61K38/39 , A61K38/45 , A61K38/57 , A61L24/001 , A61L24/0015 , A61L24/06 , A61L24/106 , A61L2430/36 , A61K2300/00 , C08L33/08 , C08L33/10 , C08L35/04
摘要： The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an adhering moiety coupled to one or more other moieties including, for example, a cross-linkable moiety and/or one other adhering moiety. The methods and compositions of the invention find use, for example, in treating pulmonary conditions, such as emphysema.
摘要翻译：本发明涉及用于密封损伤的肺组织的局部区域以减少整体肺容积的方法和组合物。粘合剂组合物提供了胶粘剂，其特征在于连接至一个或多个其它部分的粘合部分，包括例如可交联部分和/或一个其它粘合部分。本发明的方法和组合物可用于例如治疗肺部疾病如肺气肿。

94. 发明申请

US20050268820A1 Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface 审中-公开
标题翻译：表面具有磷酸钙晶须的磷酸四钙（TTCP）
公开(公告)号：US20050268820A1
公开(公告)日：2005-12-08
申请号：US11131891
申请日：2005-05-18
申请人： Jiin-Huey Lin , Chien-Ping Ju , Wen-Cheng Chen
发明人： Jiin-Huey Lin , Chien-Ping Ju , Wen-Cheng Chen
IPC分类号： A61C5/00 , A61K33/42 , A61L24/00 , A61L24/02 , A61L27/12 , A61L27/50 , C04B12/02 , C04B28/34 , C04B35/00 , C30B7/00 , C30B29/14 , C30B29/62
CPC分类号： A61L24/001 , A61L24/02 , A61L27/12 , A61L27/50 , C04B12/02 , C04B12/025 , C04B28/344 , C04B28/346 , C04B2111/00086 , C04B2111/00206 , C04B2111/0025 , C04B2111/00836 , C30B7/00 , C30B29/14 , C30B29/62 , Y10T428/2991 , Y10T428/2993 , C04B22/126 , C04B22/064 , C04B20/008 , C04B40/0082 , C04B40/0259 , C04B14/383
摘要： A tetracalcium phosphate (TTCP) particle for use in preparing a fast-setting, bioresorbable calcium phosphate cement is disclosed. The TTCP particle has a basic calcium phosphate whiskers or fine crystals on a surface thereof, the basic calcium phosphate whiskers or fine crystals having a Ca/P molar ratio greater than 1.33, and having a length up to about 5000 nm and a width up to about 500 nm.
摘要翻译：公开了一种用于制备快速凝固的生物可再吸收的磷酸钙水泥的四磷酸钙（TTCP）颗粒。 TTCP颗粒在其表面上具有碱性磷酸钙晶须或细晶体，碱式磷酸钙晶须或Ca / P摩尔比大于1.33的细晶体，并且具有高达约5000nm的长度和宽度直到约500nm。

95. 发明申请

US20050268819A1 Injectable calcium phosphate cements and the preparation and use thereof 失效
公开(公告)号：US20050268819A1
公开(公告)日：2005-12-08
申请号：US11129227
申请日：2005-05-13
申请人： Jiin-Huey Lin , Chien-Ping Ju , Wen-Cheng Chen
发明人： Jiin-Huey Lin , Chien-Ping Ju , Wen-Cheng Chen
IPC分类号： A61C5/00 , A61C5/06 , A61K6/033 , A61K33/42 , A61L24/00 , A61L24/02 , A61L27/12 , A61L27/50 , C04B12/02 , C04B14/36 , C04B28/34
CPC分类号： A61L24/02 , A61C5/62 , A61K6/0008 , A61K6/0067 , A61K6/033 , A61K6/0643 , A61K33/42 , A61L24/001 , A61L27/12 , A61L27/50 , C04B12/02 , C04B12/025 , C04B14/366 , C04B28/34 , C04B28/344 , C04B28/346 , C04B2111/00836 , Y10T428/2991 , Y10T428/2993 , C04B20/008 , C04B40/0272 , C04B40/0218 , C04B40/0263 , C04B20/1014 , C04B22/064 , C04B22/126 , C04B20/023 , C04B20/107 , A61K6/087 , C08L89/00
摘要： A calcium phosphate cement suitable for use in dental and bone prosthesis is disclosed, which include calcium phosphate particles having a diameter of 0.05 to 100 microns, wherein said calcium phosphate particles on their surfaces have whiskers or fine crystals having a width ranging from 1 to 100 nm and a length ranging from 1 to 1000 nm.

96. 发明申请

US20050245966A1 Controlled viscosity tissue adhesive 审中-公开
标题翻译：受控粘度组织粘合剂
公开(公告)号：US20050245966A1
公开(公告)日：2005-11-03
申请号：US10968464
申请日：2004-10-19
申请人： Julius Hammerslag , James Quinn
发明人： Julius Hammerslag , James Quinn
IPC分类号： A61L15/16 , A61L24/00 , A61L24/06
CPC分类号： A61L24/001 , A61L24/06 , C08L35/04
摘要： Disclosed are methods and compositions for closing and sealing a wound, laceration, incision, or other percutaneous opening using an adhesive. In one preferred embodiment, the sides of the percutaneous opening are brought together in apposition and the adhesive is applied topically over the apposed opening and the skin adjacent thereto. Adhesives used in the methods of the preferred embodiments exhibit sufficient viscosity to substantially prevent flow of the adhesive into the percutaneous opening. Adhesives may also be used in surgical applications, as a covering for a trauma to the outer surface of the skin, or as a secondary means of closure in combination with other means of closure, including staples and sutures. In a preferred embodiment, the adhesive is a adhesive comprising cyanoacrylate monomer, cyanoacrylate polymer, and a plasticizer.
摘要翻译：公开了用于使用粘合剂封闭和密封伤口，裂伤，切口或其它经皮开口的方法和组合物。在一个优选实施例中，将经皮开口的两侧并排放置在一起，并将粘合剂局部地施加在安置的开口和与其相邻的皮肤上。在优选实施方案中使用的粘合剂表现出足够的粘度以基本上防止粘合剂流入经皮开口。粘合剂也可以用于外科应用中，作为用于皮肤外表面的创伤的覆盖物，或作为与其他封闭装置（包括缝钉和缝合线）相结合的次级封闭装置。在优选的实施方案中，粘合剂是包含氰基丙烯酸酯单体，氰基丙烯酸酯聚合物和增塑剂的粘合剂。

97. 发明申请

US20050175709A1 Therapeutic microparticles 审中-公开
标题翻译：治疗性微粒
公开(公告)号：US20050175709A1
公开(公告)日：2005-08-11
申请号：US11008820
申请日：2004-12-09
申请人： Ace Baty , Robert Cleek , Daniel Davidson , Melissa Matzen , Michael Vonesh , Joshua Williams
发明人： Ace Baty , Robert Cleek , Daniel Davidson , Melissa Matzen , Michael Vonesh , Joshua Williams
IPC分类号： A61B17/12 , A61B17/42 , A61F2/02 , A61K9/14 , A61K47/48 , A61L24/00 , A61L24/04
CPC分类号： A61L24/0042 , A61B17/12022 , A61B17/12109 , A61B17/12186 , A61B2017/1205 , A61B2017/4216 , A61L24/001 , A61L24/046 , A61L2430/36 , C08L69/00
摘要： Biodegradable, compression resistant microparticles adapted for injection through a catheter system, such as is useful for selective embolization procedures. The microparticles can optimally be neutrally buoyant relative to a target bodily fluid. Various active agents may be included in the microparticles, such an anesthetic which can reduce pain during an embolization procedure. The invention further comprises methods and equipment for testing and delivering compression resistant microparticles.
摘要翻译：适于通过导管系统注射的可生物降解，抗压缩的微粒，例如可用于选择性栓塞程序。微粒可以相对于目标体液最佳地为中性浮力。可以在微粒中包括各种活性剂，这种麻醉剂可以在栓塞过程中减轻疼痛。本发明还包括用于测试和递送抗压缩微粒的方法和设备。

98. 发明申请

US20050090714A1 Gynecologic embolotherapy methods 审中-公开
标题翻译：妇科肿瘤治疗方法
公开(公告)号：US20050090714A1
公开(公告)日：2005-04-28
申请号：US10846313
申请日：2004-05-13
申请人： Richard Greff
发明人： Richard Greff
IPC分类号： A61B17/12 , A61B17/00 , A61B17/42 , A61L24/00 , A61L24/06 , A61M25/00 , A61B1/307
CPC分类号： A61B17/42 , A61B17/00491 , A61B17/12022 , A61B17/12109 , A61B17/12186 , A61B17/1219 , A61B2017/4216 , A61L24/001 , A61L24/02 , A61L24/06 , A61L31/18 , A61L2430/36 , A61M31/005 , C08L29/04
摘要： This invention is directed to novel methods for gynecologic embolotherapy. The methods directly access the blood vessels to be embolized transcervically rather than arterially. The methods provide precise directed delivery of embolizing compositions, and are particularly suited for treating uterine fibroids. Kits containing one or more devices for transcervical injection and an embolizing composition are also provided. In a preferred embodiment, fluid embolizing compositions are used. In a more preferred embodiment, these fluid embolic compositions comprise a biocompatible polymer, a biocompatible solvent and a biocompatible water insoluble contrast agent. In a most preferred embodiment, the contrast agent is characterized by having an average particle size of about 10 μm or less.
摘要翻译：本发明涉及妇科膀胱治疗的新方法。该方法直接进入血管以栓塞栓塞，而不是动脉栓塞。所述方法提供栓塞组合物的精确定向递送，并且特别适用于治疗子宫肌瘤。还提供了包含用于子宫颈内注射的一种或多种装置和栓塞组合物的试剂盒。在优选的实施方案中，使用流体栓塞组合物。在更优选的实施方案中，这些流体栓塞组合物包含生物相容性聚合物，生物相容性溶剂和生物相容性水不溶性造影剂。在最优选的实施方案中，造影剂的特征在于平均粒度为约10μm或更小。

99. 发明授权

US06875427B1 Light energized tissue adhesive 有权
标题翻译：光通电组织粘合剂
公开(公告)号：US06875427B1
公开(公告)日：2005-04-05
申请号：US09973332
申请日：2001-10-09
申请人： Dale P. DeVore , Braden P. DeVore , Barbara A. Soltz , Robert Soltz , Michael A. Soltz
发明人： Dale P. DeVore , Braden P. DeVore , Barbara A. Soltz , Robert Soltz , Michael A. Soltz
IPC分类号： A61K38/00 , A61K38/39 , A61L24/00 , A61L24/10 , A61L31/04 , A61L31/14
CPC分类号： A61L31/044 , A61K38/39 , A61L24/001 , A61L24/102 , A61L31/14
摘要： Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 800 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films, which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space.
摘要翻译：根据本发明，提供组织粘合剂组合物和相关联的激光曝光系统用于粘合或密封生物组织。组合物由化学衍生的可溶性胶原组成，其被配制成浓度范围为300mg / ml（30％）至800mg / ml（80％））的胶原蛋白。特别地，例如，I型胶原首先通过从牛或猪皮提取而纯化而制备。然后将胶原蛋白制剂用巯基试剂进行化学衍生化，以提高内聚强度，并与二级衍生剂（如羧基）一起提高焊料对组织的粘合强度。然后将组合物形成粘稠溶液，凝胶或固体膜，当暴露于由红外激光产生的能量时，例如经历热诱导相变。固体或半固体蛋白质组合物变得粘稠，使得高浓度蛋白质能够渗透经处理的生物组织的间隙或填充组织中的空隙。随着热能释放到周围环境中，蛋白质组合物再次变得固体或半固体，粘附到处理过的组织或组织空间。

100. 发明申请

US20050038471A1 Photochemical tissue bonding 有权
标题翻译：光化学组织粘结
公开(公告)号：US20050038471A1
公开(公告)日：2005-02-17
申请号：US10732032
申请日：2003-12-09
申请人： Barbara Chan , Timothy Johnson , Irene Kochevar , Mark Randolph , Robert Redmond , Jonathan Winograd
发明人： Barbara Chan , Timothy Johnson , Irene Kochevar , Mark Randolph , Robert Redmond , Jonathan Winograd
IPC分类号： A61B17/00 , A61F9/008 , A61L24/00 , A61B18/18
CPC分类号： A61B17/11 , A61B2017/00508 , A61B2017/00517 , A61F9/0079 , A61F9/0081 , A61F9/00821 , A61F2009/00842 , A61F2009/00853 , A61F2009/00872 , A61F2009/00887 , A61L24/001 , A61L2430/32 , A61N5/062
摘要： Photochemical tissue boding methods for bonding neural tissues include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair, neural repair, blood vessel repair and corneal repair.
摘要翻译：用于粘合神经组织的光化学组织编织方法包括将光敏剂施用于组织和/或组织移植物，随后用电磁能照射以产生组织密封。该方法可用于组织粘连，例如伤口闭合，组织移植，皮肤移植，肌肉骨骼组织修复，韧带或肌腱修复，神经修复，血管修复和角膜修复。

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