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1. 发明授权

US06780840B1 Method for making a light energized tissue adhesive 有权
标题翻译：制造光通电组织粘合剂的方法
公开(公告)号：US06780840B1
公开(公告)日：2004-08-24
申请号：US09973263
申请日：2001-10-09
申请人： Dale P. DeVore , Braden P. DeVore , Barbara A. Soltz , Robert Soltz , Michael A. Soltz
发明人： Dale P. DeVore , Braden P. DeVore , Barbara A. Soltz , Robert Soltz , Michael A. Soltz
IPC分类号： A61K3800
CPC分类号： A61B18/22 , A61B17/00491 , A61B2017/0007 , A61B2017/00084 , A61B2017/005 , A61B2017/00508 , A61B2017/00517 , A61L24/102
摘要： Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 800 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films, which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space.
摘要翻译：根据本发明，提供组织粘合剂组合物和相关联的激光曝光系统用于粘合或密封生物组织。组合物由化学衍生的可溶性胶原组成，其被配制成浓度范围为300mg / ml（30％）至800mg / ml（80％））的胶原蛋白。特别地，例如，首先通过从牛或猪皮提取而制备I型胶原并纯化。然后将胶原蛋白制剂用巯基试剂进行化学衍生，以提高内聚强度，并与二级衍生剂（如羧基）一起提高焊料对组织的粘合强度。然后将组合物形成粘稠溶液，凝胶或固体膜，当暴露于由红外激光产生的能量时，例如经历热诱导相变。固体或半固体蛋白质组合物变得粘稠，使得高浓度蛋白质能够渗透经处理的生物组织的间隙或填充组织中的空隙。随着热能释放到周围环境中，蛋白质组合物再次变得固体或半固体，粘附到处理过的组织或组织空间。

2. 发明授权

US06875427B1 Light energized tissue adhesive 有权
标题翻译：光通电组织粘合剂
公开(公告)号：US06875427B1
公开(公告)日：2005-04-05
申请号：US09973332
申请日：2001-10-09
申请人： Dale P. DeVore , Braden P. DeVore , Barbara A. Soltz , Robert Soltz , Michael A. Soltz
发明人： Dale P. DeVore , Braden P. DeVore , Barbara A. Soltz , Robert Soltz , Michael A. Soltz
IPC分类号： A61K38/00 , A61K38/39 , A61L24/00 , A61L24/10 , A61L31/04 , A61L31/14
CPC分类号： A61L31/044 , A61K38/39 , A61L24/001 , A61L24/102 , A61L31/14
摘要： Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 800 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films, which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space.
摘要翻译：根据本发明，提供组织粘合剂组合物和相关联的激光曝光系统用于粘合或密封生物组织。组合物由化学衍生的可溶性胶原组成，其被配制成浓度范围为300mg / ml（30％）至800mg / ml（80％））的胶原蛋白。特别地，例如，I型胶原首先通过从牛或猪皮提取而纯化而制备。然后将胶原蛋白制剂用巯基试剂进行化学衍生化，以提高内聚强度，并与二级衍生剂（如羧基）一起提高焊料对组织的粘合强度。然后将组合物形成粘稠溶液，凝胶或固体膜，当暴露于由红外激光产生的能量时，例如经历热诱导相变。固体或半固体蛋白质组合物变得粘稠，使得高浓度蛋白质能够渗透经处理的生物组织的间隙或填充组织中的空隙。随着热能释放到周围环境中，蛋白质组合物再次变得固体或半固体，粘附到处理过的组织或组织空间。

3. 发明授权

US06773699B1 Light energized tissue adhesive conformal patch 有权
标题翻译：光通电组织粘贴贴片
公开(公告)号：US06773699B1
公开(公告)日：2004-08-10
申请号：US09973385
申请日：2001-10-09
申请人： Barbara A. Soltz , Dale P. DeVore , Braden P. DeVore , Robert Soltz , Michael A. Soltz
发明人： Barbara A. Soltz , Dale P. DeVore , Braden P. DeVore , Robert Soltz , Michael A. Soltz
IPC分类号： A61K3800
CPC分类号： A61B18/22 , A61B17/00491 , A61B2017/0007 , A61B2017/00084 , A61B2017/005 , A61B2017/00508 , A61B2017/00517 , A61L31/044
摘要： Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 80 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films which are used to encapsulate structural components such as a cojoinal network or mesh. The resultant patch which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space and are reinforced by the embedded cojoinal network or mesh.
摘要翻译：根据本发明，提供组织粘合剂组合物和相关联的激光曝光系统用于粘合或密封生物组织。组合物由化学衍生的可溶性胶原组成，其被配制成浓度范围为300mg / ml（30％）至80mg / ml（80％））的胶原蛋白。特别地，例如，I型胶原首先通过从牛或猪皮提取而纯化而制备。然后将胶原蛋白制剂用巯基试剂进行化学衍生化，以提高内聚强度，并与二级衍生剂（如羧基）一起提高焊料对组织的粘合强度。然后将组合物形成粘稠溶液，凝胶或固体膜，其用于包封结构组分如共同网络或网状物。例如，当暴露于由红外激光器产生的能量时，产生的贴片经历热诱导相变。固体或半固体蛋白质组合物变得粘稠，使得高浓度蛋白质能够渗透经处理的生物组织的间隙或填充组织中的空隙。随着热能释放到周围环境中，蛋白质组合物再次变成固体或半固体，粘附到经处理的组织或组织空间，并通过嵌入的共同网络或网来加强。

4. 发明授权

US06939364B1 Composite tissue adhesive 有权
标题翻译：复合组织粘合剂
公开(公告)号：US06939364B1
公开(公告)日：2005-09-06
申请号：US09973335
申请日：2001-10-09
申请人： Barbara A. Soltz , Dale P. DeVore , Braden P. DeVore , Robert Soltz , Michael A. Soltz
发明人： Barbara A. Soltz , Dale P. DeVore , Braden P. DeVore , Robert Soltz , Michael A. Soltz
IPC分类号： A61B17/00 , A61B17/03 , A61B18/22
CPC分类号： A61B18/22 , A61B17/00491 , A61B2017/0007 , A61B2017/00084 , A61B2017/005 , A61B2017/00508 , A61B2017/00517
摘要： Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 800 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films, which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space.
摘要翻译：根据本发明，提供组织粘合剂组合物和相关联的激光曝光系统用于粘合或密封生物组织。组合物由化学衍生的可溶性胶原组成，其被配制成浓度范围为300mg / ml（30％）至800mg / ml（80％））的胶原蛋白。特别地，例如，I型胶原首先通过从牛或猪皮提取而纯化而制备。然后将胶原蛋白制剂用巯基试剂进行化学衍生化，以提高内聚强度，并与二级衍生剂（如羧基）一起提高焊料对组织的粘合强度。然后将组合物形成粘稠溶液，凝胶或固体膜，当暴露于由红外激光产生的能量时，例如经历热诱导相变。固体或半固体蛋白质组合物变得粘稠，使得高浓度蛋白质能够渗透经处理的生物组织的间隙或填充组织中的空隙。随着热能释放到周围环境中，蛋白质组合物再次变得固体或半固体，粘附到处理过的组织或组织空间。

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