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91. 发明授权

US6045565A Percutaneous myocardial revascularization growth factor mediums and method 失效
标题翻译：经皮心肌血运重建生长因子介质及方法
公开(公告)号：US6045565A
公开(公告)日：2000-04-04
申请号：US184220
申请日：1998-11-02
申请人： Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang , Timothy J. Mickley
发明人： Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang , Timothy J. Mickley
IPC分类号： A61B17/32 , A61B17/00 , A61B17/22 , A61B17/34 , A61B19/00 , A61F2/02 , A61M25/00
CPC分类号： A61B17/32002 , A61B17/3468 , A61B17/3478 , A61F2/2493 , A61B17/320758 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/320084 , A61B2018/00208 , A61B2018/00392 , A61B2018/1425 , A61B2018/1861 , A61B90/39 , A61M2025/0089
摘要： Devices and methods for increasing blood perfusion within the myocardium of the heart by wounding the myocardium and applying growth factors to promote vascularization. One method includes driving spikes into the myocardium from within the heart, with the spikes being formed of biodegradable material, containing releasable growth factors, and having lumens and side holes. An alternative method utilizes non-biodegradable spikes with lumens and side holes. Another method promotes vascularization by injecting angiogenic material into holes bored into the myocardium, leaving a patent hole. Another method includes injecting angiogenic material into the myocardium without boring, leaving no patent hole. The angiogenic material can be carried in a biodegradable adhesive. Revascularization of the myocardium is promoted in one method by externally wounding the heart and applying a patch including growth factors.
摘要翻译：通过伤害心肌并应用生长因子促进血管形成来增加心脏心肌内的血液灌注的装置和方法。一种方法包括从心脏内将尖峰驱动到心肌中，其中尖峰由可生物降解的材料形成，包含可释放的生长因子，并且具有腔和侧孔。一种替代方法是利用不可生物降解的钉与流明和侧孔。另一种方法通过将血管生成材料注入穿入心肌的孔中来促进血管形成，留下专利孔。另一种方法包括将血管生成物质注入到心肌中而无需镗孔，没有留下专利孔。血管生成物质可以携带在可生物降解的粘合剂中。通过外部伤心并施用包括生长因子的贴片在一种方法中促进心肌的血运重建。

92. 发明授权

US6035856A Percutaneous bypass with branching vessel 失效
公开(公告)号：US6035856A
公开(公告)日：2000-03-14
申请号：US813040
申请日：1997-03-06
申请人： Daniel M. LaFontaine , Roger N. Hastings , Charles L. Euteneuer , Lixiao Wang
发明人： Daniel M. LaFontaine , Roger N. Hastings , Charles L. Euteneuer , Lixiao Wang
IPC分类号： A61B17/00 , A61B17/064 , A61B17/11 , A61B18/14 , A61B19/00 , A61F2/06 , A61F2/82 , A61F2/90 , A61M25/00
CPC分类号： A61F2/958 , A61B18/1492 , A61F2/064 , A61F2/954 , A61B17/064 , A61B2017/00243 , A61B2017/00252 , A61B2017/1135 , A61B2018/00214 , A61B2018/00386 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/90 , A61F2002/065 , A61F2002/828 , A61M25/0082 , Y10S623/901
摘要： In order to bypass a restriction in a parent vessel, a first site in a branch vessel branching from the aorta is accessed intraluminally. An occlusion is formed at the first site, and the aperture is formed in the branching vessel, intraluminally, proximal of the first site. An aperture is formed in the parent vessel distal of the restriction, and a lumen is formed which communicates between the branching vessel proximal of the occlusion, and the parent vessel distal of the restriction.

93. 发明授权

US5873811A Composition containing a radioactive component for treatment of vessel wall 失效
标题翻译：含有用于治疗血管壁的放射性成分的组合物
公开(公告)号：US5873811A
公开(公告)日：1999-02-23
申请号：US782542
申请日：1997-01-10
申请人： Lixiao Wang , Roger N. Hastings
发明人： Lixiao Wang , Roger N. Hastings
IPC分类号： A61B17/22 , A61F2/00 , A61F2/82 , A61K38/17 , A61K51/00 , A61K51/12 , A61M29/02 , A61M36/04 , A61N5/10 , A61P9/08
CPC分类号： A61F2/82 , A61K51/1279 , A61K51/1282 , A61M25/104 , A61N5/1002 , A61B2017/22002 , A61F2002/30448 , A61F2220/005 , A61M2025/105 , A61M29/02
摘要： A method and composition for inhibiting restenosis. The composition includes an adhesive or polymeric material having a radioactive component dispersed therethrough. A biologically compatible adhesive including a radioactive material is applied to a vessel region where inhibition of restenosis is desired in a preferred method. In one composition, the radioactive material is admixed with the adhesive. In another composition, the radioactive material is chemically bonded to a polymeric adhesive. The adhesive is preferably cured in place. The radioactive material has a preferred half life of less than six months. In one method, the application of adhesive is followed by stent placement, leaving radioactive adhesive extending beyond both stent ends. The application can include forcing adhesive from a double walled balloon having a porous outer wall.
摘要翻译：用于抑制再狭窄的方法和组合物。该组合物包括具有分散在其中的放射性组分的粘合剂或聚合材料。将包含放射性物质的生物相容性粘合剂施用于在优选方法中需要抑制再狭窄的血管区域。在一种组合物中，放射性物质与粘合剂混合。在另一种组合物中，放射性物质化学键合到聚合物粘合剂上。粘合剂优选在适当的地方固化。放射性物质的半衰期优选少于6个月。在一种方法中，粘合剂的应用之后是支架放置，留下放射性粘合剂延伸超过两个支架末端。该应用可以包括从具有多孔外壁的双壁球囊迫使粘合剂。

94. 发明授权

US5769883A Biodegradable drug delivery vascular stent 失效
公开(公告)号：US5769883A
公开(公告)日：1998-06-23
申请号：US561374
申请日：1995-11-21
申请人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
发明人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
IPC分类号： A61F2/00 , A61F2/02 , A61F2/82 , A61F2/88 , A61L31/14 , A61L31/16 , A61F2/06 , A61F2/04
CPC分类号： A61F2/82 , A61F2/88 , A61L31/041 , A61L31/044 , A61L31/047 , A61L31/148 , A61L31/16 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61F2250/0068 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2300/622 , Y10S623/901
摘要： A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.

95. 发明授权

US5716410A Temporary stent and method of use 失效
标题翻译：临床支架及使用方法
公开(公告)号：US5716410A
公开(公告)日：1998-02-10
申请号：US577089
申请日：1995-12-22
申请人： Lixiao Wang , Roger Hastings , Paul Buscemi , Sew-Wah Tay
发明人： Lixiao Wang , Roger Hastings , Paul Buscemi , Sew-Wah Tay
IPC分类号： A61F2/00 , A61F2/06 , A61F2/84 , A61F2/88 , A61M25/10 , A61F2/04 , A61M25/00
CPC分类号： A61M25/1027 , A61F2/88 , A61F2/958 , A61F2210/0033 , A61F2230/0017 , A61M2025/0058 , A61M2025/1004
摘要： A temporary stent comprises a coil of tubular thermoplastic material and a heating element inside the tubular material, or a film with a metal film resistive heating element coated thereon. A method of temporarily supporting the wall of a vessel comprises the steps of inserting a thermoplastic body having a first outer dimension less than the inside dimension of the vessel into the vessel to the desired support position; heating the thermoplastic above its softening transition temperature and expanding it to a second outer dimension larger than its first outer dimension; cooling the thermoplastic body to below its softening transition temperature while at its second outer dimension; allowing the cooled thermoplastic body to temporarily support the vessel; heating the thermoplastic above its softening transition temperature to soften the thermoplastic; and removing the softened thermoplastic body from the vessel.
摘要翻译：临时支架包括管状热塑性材料的线圈和管状材料内的加热元件，或者涂覆有金属膜电阻加热元件的膜。临时支撑容器壁的方法包括以下步骤：将具有小于容器的内部尺寸的第一外部尺寸的热塑性主体插入容器中至所需的支撑位置; 将热塑性塑料高于其软化转变温度并将其膨胀至大于其第一外部尺寸的第二外部尺寸; 在其第二外部尺寸下将热塑性体冷却至其软化转变温度以下; 允许冷却的热塑性体暂时支撑容器; 将热塑性塑料加热到其软化转变温度以软化热塑性塑料; 以及从容器中去除软化的热塑性体。

96. 发明授权

US5714110A Process improvements for preparing catheter balloons 失效
标题翻译：制备导管球囊的工艺改进
公开(公告)号：US5714110A
公开(公告)日：1998-02-03
申请号：US650222
申请日：1996-05-20
申请人： Lixiao Wang , Paul James Miller , Daniel J. Horn , Deborah A. Frank
发明人： Lixiao Wang , Paul James Miller , Daniel J. Horn , Deborah A. Frank
IPC分类号： A61F2/958 , A61M25/00 , A61M25/16 , A61M29/02 , B29C35/04 , B29C49/04 , B29C49/18 , B29C49/78 , B29C49/08
CPC分类号： A61M25/1029 , A61M25/0045 , A61M25/1002 , A61M25/104 , B29C49/18 , B29C49/783 , A61M2025/1075 , A61M2025/1088 , B29C2049/0089 , B29C35/041 , B29C49/04 , B29K2067/00 , B29K2105/258 , B29K2905/12 , B29L2031/7542 , Y10T428/1331 , Y10T428/1352 , Y10T428/139
摘要： A method for forming a balloon for a dilatation catheter may utilize the steps of extruding a tubing preform of a polyester resin and then blowing the tubing into an oriented balloon, wherein the tubing preform is dried prior to blowing into the balloon form. Other process steps by which balloon cone and waist thicknesses may be reduced involve varying the axial tension and blowing pressure at several stages as a mold containing the balloon preform is dipped into a heating medium. Specifically, tubing of a thermoplastic material is placed in a mold and blown by pressurizing and tensioning the tubing and gradually dipping the mold into a heated heat transfer media so as to sequentially blow a first waist, a body and a second waist portion. The tubing is subjected to a relatively lower pressure while the body portion is blown than while the first and second waist portions are blown.
摘要翻译：用于形成用于扩张导管的球囊的方法可以采用以下步骤：挤出聚酯树脂的管坯预成型件，然后将管道吹入定向气囊中，其中将管坯预先吹入气囊形式之前进行干燥。球囊和腰部厚度可能减小的其他工艺步骤包括在将包含球囊预制件的模具浸入加热介质中时，在几个阶段改变轴向张力和吹塑压力。具体地说，将热塑性材料的管材放置在模具中，并通过加压和张紧管子并将模具逐渐浸入加热的传热介质中，以便顺序地吹动第一腰部，身体和第二腰部部分而吹塑。当吹塑本体部分时，管道相对于第一和第二腰部部分被吹送而受到相对较低的压力。

97. 发明授权

US5500013A Biodegradable drug delivery vascular stent 失效
公开(公告)号：US5500013A
公开(公告)日：1996-03-19
申请号：US372822
申请日：1995-01-13
申请人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
发明人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
IPC分类号： A61F2/00 , A61F2/02 , A61F2/82 , A61F2/88 , A61L31/14 , A61L31/16 , A61F2/06
CPC分类号： A61F2/82 , A61F2/88 , A61L31/041 , A61L31/044 , A61L31/047 , A61L31/148 , A61L31/16 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61F2250/0068 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2300/622 , Y10S623/901
摘要： A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.

98. 发明授权

US5496276A Catheter balloon with retraction coating 失效
公开(公告)号：US5496276A
公开(公告)日：1996-03-05
申请号：US447220
申请日：1995-05-22
申请人： Lixiao Wang , Linda J. Vickerman
发明人： Lixiao Wang , Linda J. Vickerman
IPC分类号： A61F2/958 , A61M25/00 , A61M29/02 , B29C35/04 , B29C49/04 , A61M29/00
CPC分类号： A61M25/0045 , A61M25/1002 , A61M25/1038 , A61M25/104 , A61M2025/1031 , A61M2025/1075 , A61M2025/1088 , B29C2049/0089 , B29C35/041 , B29C49/04 , B29K2067/00 , B29K2105/258 , B29L2031/7542
摘要： An inflatable balloon (14) for a catheter (10) includes a coating (15) which causes the balloon to prefer a predetermined, low profile configuration, such as a trifold configuration (40), when deflated. The balloon has a wall (13) which has an exterior polymeric coating (15). The coating (15) is set while the balloon is in the predetermined low-profile deflated configuration so that after inflation, the coating acts to urge the balloon to return to the low profile configuration as the balloon is deflated.

99. 发明授权

US5464450A Biodegradable drug delivery vascular stent 失效
标题翻译：生物降解药物输送血管支架
公开(公告)号：US5464450A
公开(公告)日：1995-11-07
申请号：US215206
申请日：1994-03-21
申请人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
发明人： Paul J. Buscemi , Elizabeth A. Stejskal , Donald F. Palme, II , Lixiao Wang
IPC分类号： A61F2/00 , A61F2/02 , A61F2/82 , A61F2/88 , A61L31/14 , A61L31/16 , A61F2/06 , A61F2/04 , A61M29/02
CPC分类号： A61F2/82 , A61F2/88 , A61L31/148 , A61L31/16 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61L2300/604
摘要： A stent made of biodegradable material includes a drug that is released at a rate controlled by the rate of degradation of the biodegradable material. The stent includes a main body of a generally tubular shape. The main body may further include a plurality of apertures extending therethrough and a slot defined by opposing edges which permits insertion and positioning of the stent.
摘要翻译：由可生物降解材料制成的支架包括以可生物降解材料的降解速率控制的速率释放的药物。支架包括大体管状的主体。主体还可以包括延伸穿过其中的多个孔和由允许插入和定位支架的相对边缘限定的狭槽。

100. 发明授权

US5403340A Shrinking balloon catheter having nonlinear compliance curve 失效
标题翻译：收缩球囊导管具有非线性顺应性曲线
公开(公告)号：US5403340A
公开(公告)日：1995-04-04
申请号：US245372
申请日：1994-05-18
申请人： Lixiao Wang , The Thomas T. Tran
发明人： Lixiao Wang , The Thomas T. Tran
IPC分类号： A61M25/00 , A61M29/02 , A61M29/00 , A61M31/00
CPC分类号： A61M25/1029 , A61M25/104 , B29L2022/022 , B29L2031/7542 , Y10S264/909
摘要： A balloon catheter, having a non-linear compliance curve, made up of a single layered balloon, that was molded from a polymeric material to have a specific nominal diameter and then shrunk to a diameter that is less than the specific nominal diameter. When the shrunk balloon is expanded it has the characteristics of a compliant balloon until its diameter has been expanded to its original specific nominal diameter after which it follows the non compliant compliance curve that it would have had it not been shrunk.
摘要翻译：具有非线性顺应性曲线的球囊导管由单层气囊构成，其由聚合物材料模制成具有特定公称直径，然后收缩至小于特定公称直径的直径。当缩小的气球膨胀时，它具有适应气囊的特征，直到其直径已经扩展到其原始的特定公称直径，然后遵循不符合的顺应曲线，它将不会收缩。

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