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91. 发明授权

US07742173B2 Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample 有权
标题翻译：样品的偏振敏感光学频域成像的方法，布置和系统
公开(公告)号：US07742173B2
公开(公告)日：2010-06-22
申请号：US11697012
申请日：2007-04-05
申请人： Seok-Hyun Yun , Johannes F. De Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Seok-Hyun Yun , Johannes F. De Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , G01B9/02002 , G01B9/02004 , G01B9/02011 , G01B9/02091 , G01B2290/70
摘要： Arrangements and methods are provided for obtaining data associated with a sample. For example, at least one first electro-magnetic radiation can be provided to a sample and at least one second electro-magnetic radiation can be provided to a reference (e.g., a non-reflective reference). A frequency of such radiation(s) can repetitively vary over time with a first characteristic period. In addition, a polarization state of the first electro-magnetic radiation, the second electro-magnetic radiation, a third electro-magnetic radiation (associated with the first radiation) or a fourth electro-magnetic radiation (associated with the second radiation) can repetitively vary over time with a second characteristic period which is shorter than the first period. The data for imaging at least one portion of the sample can be provided as a function of the polarization state. In addition or alternatively, the third and fourth electro-magnetic radiations can be combined so as to determine an axial reflectance profile of at least one portion of the sample.
摘要翻译：提供了用于获取与样本相关的数据的安排和方法。例如，可以向样品提供至少一个第一电磁辐射，并且可以向参考（例如，非反射参考）提供至少一个第二电磁辐射。这种辐射的频率可以在第一特征周期内随时间重复地变化。此外，第一电磁辐射，第二电磁辐射，第三电磁辐射（与第一辐射相关联）或第四电磁辐射（与第二辐射相关联）的极化状态可以重复地随着时间而变化，其具有比第一周期短的第二特征周期。用于成像至少一部分样品的数据可以作为偏振态的函数提供。另外或替代地，可以组合第三和第四电磁辐射，以便确定样品的至少一部分的轴向反射率分布。

92. 发明申请

US20100094576A1 APPARATUS AND METHOD FOR RANGING AND NOISE REDUCTION OF LOW COHERENCE INTERFEROMETRY LCI AND OPTICAL COHERENCE TOMOGRAPHY OCT SIGNALS BY PARALLEL DETECTION OF SPECTRAL BANDS 有权
标题翻译：通过平行检测光谱仪的低相干干涉LCI和光学相干TOMOGRAPHY OCT信号的范围和噪声降低的装置和方法
公开(公告)号：US20100094576A1
公开(公告)日：2010-04-15
申请号：US12570443
申请日：2009-09-30
申请人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02 , G06F19/00
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。信号保持不变。喷射噪声的降低增加了系统的动态范围和灵敏度。

93. 发明授权

US07538859B2 Methods and systems for monitoring and obtaining information of at least one portion of a sample using conformal laser therapy procedures, and providing electromagnetic radiation thereto 有权
标题翻译：用于使用保形激光治疗程序监测和获得样品的至少一部分的信息并向其提供电磁辐射的方法和系统
公开(公告)号：US07538859B2
公开(公告)日：2009-05-26
申请号：US11670058
申请日：2007-02-01
申请人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc
发明人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc
IPC分类号： G01L1/24
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/6852 , A61B18/24 , A61B2017/00057 , A61B2017/22051 , A61B2018/207 , A61B2090/306 , A61B2090/3614
摘要： In one exemplary embodiment of the present invention, method and system can be provided for obtaining information associated with at least one portion of a sample. For example, a temperature change can be caused in the portion of the sample. At least one first electro-magnetic radiation can be forwarded to a section near or in the portion of the sample. A deformation of the section can be identified at a plurality of depths as a function of (i) a phase of at least one second electro-magnetic radiation provided from the section, and/or (ii) a rate of change of the phase and/or an amplitude of the second electro-magnetic radiation. In another exemplary embodiment of the present invention, method and system can be provided for controlling a temperature distribution in a sample. For example, an electro-magnetic radiation can be provided to the section in the sample at a particular wavelength. The temperature distribution can be controlled by modifying the particular wavelength of the electro-magnetic radiation when the electro-magnetic radiation is provided to the section.
摘要翻译：在本发明的一个示例性实施例中，可以提供方法和系统来获得与样本的至少一部分相关联的信息。例如，可以在样品的部分中引起温度变化。至少一个第一电磁辐射可以转发到样品附近或部分的部分。可以在多个深度处识别该部分的变形作为（i）从该部分提供的至少一个第二电磁辐射的相位和/或（ii）相的变化率和 /或第二电磁辐射的振幅。在本发明的另一示例性实施例中，可以提供方法和系统来控制样品中的温度分布。例如，可以以特定波长向样品中的部分提供电磁辐射。当电磁辐射提供给该部分时，可以通过修改电磁辐射的特定波长来控制温度分布。

94. 发明申请

US20070236700A1 METHODS, ARRANGEMENTS AND SYSTEMS FOR POLARIZATION-SENSITIVE OPTICAL FREQUENCY DOMAIN IMAGING OF A SAMPLE 有权
标题翻译：方法，用于样品的偏振光敏频域成像的安排和系统
公开(公告)号：US20070236700A1
公开(公告)日：2007-10-11
申请号：US11697012
申请日：2007-04-05
申请人： Seok-Hyun Yun , Johannes F. De Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Seok-Hyun Yun , Johannes F. De Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , G01B9/02002 , G01B9/02004 , G01B9/02011 , G01B9/02091 , G01B2290/70
摘要： Arrangements and methods are provided for obtaining data associated with a sample. For example, at least one first electro-magnetic radiation can be provided to a sample and at least one second electro-magnetic radiation can be provided to a reference (e.g., a non-reflective reference). A frequency of such radiation(s) can repetitively vary over time with a first characteristic period. In addition, a polarization state of the first electro-magnetic radiation, the second electro-magnetic radiation, a third electro-magnetic radiation (associated with the first radiation) or a fourth electro-magnetic radiation (associated with the second radiation) can repetitively vary over time with a second characteristic period which is shorter than the first period. The data for imaging at least one portion of the sample can be provided as a function of the polarization state. In addition or alternatively, the third and fourth electro-magnetic radiations can be combined so as to determine an axial reflectance profile of at least one portion of the sample.
摘要翻译：提供了用于获取与样本相关的数据的安排和方法。例如，可以向样品提供至少一个第一电磁辐射，并且可以向参考（例如，非反射参考）提供至少一个第二电磁辐射。这种辐射的频率可以在第一特征周期内随时间重复地变化。此外，第一电磁辐射，第二电磁辐射，第三电磁辐射（与第一辐射相关联）或第四电磁辐射（与第二辐射相关联）的偏振状态可以重复地随着时间而变化，其具有比第一周期短的第二特征周期。用于成像至少一部分样品的数据可以作为偏振态的函数提供。另外或替代地，可以组合第三和第四电磁辐射，以便确定样品的至少一部分的轴向反射率分布。

95. 发明授权

US5836872A Digital optical visualization, enhancement, quantification, and classification of surface and subsurface features of body surfaces 失效
标题翻译：数字光学可视化，增强，量化，以及身体表面和地下特征的分类
公开(公告)号：US5836872A
公开(公告)日：1998-11-17
申请号：US509039
申请日：1990-04-13
申请人： Robert O. Kenet , Barney J. Kenet , Guillermo J. Tearney
发明人： Robert O. Kenet , Barney J. Kenet , Guillermo J. Tearney
IPC分类号： A61B5/103 , A61B18/20 , A61B19/00 , G06T5/00 , A61B5/00
CPC分类号： G06T7/0012 , A61B5/0059 , A61B5/0064 , A61B5/444 , G06K9/20 , G06T5/50 , G06T7/0081 , A61B18/20 , A61B18/203 , A61B2018/00452 , A61B2018/00476 , A61B2018/00904 , A61B2090/373 , A61B5/0062 , A61B5/0068 , A61B5/7264 , A61B5/745 , G06T2207/10048 , G06T2207/20012 , G06T2207/20021 , G06T2207/20148 , G06T2207/30041 , G06T2207/30088 , G06T2207/30096 , G06T2207/30101
摘要： A method for monitoring a region of a body surface includes recording at a first time a first multispectral digital image of the surface including the region, recording at a subsequent time a subsequent multispectral digital image of the surface including the region, and comparing the first and the subsequent images. Also, such a method in which the first and subsequent images are high magnification images, and further including recording low magnification images that include the high magnification images. Also, a method for forming a diagnostically useful classification of pigmented skin lesions includes using such a method to construct a database containing quantitatively extracted selected features from images recorded from a plurality of skin lesions, and correlating the features from each such lesion in the database with the medical history of the skin lesion from which the image was recorded. Also, a method for diagnosis of a premelanomatous or early melanomatous condition includes using the method for characterizing a surface region including the lesion and comparing the features of the lesion so obtained with the features in a database obtained from a number of skin lesions including lesions known to be premelanomatous or early melanomatous, or classifying the features of the lesion according to the diagnostically useful classification of pigmented skin lesions.
摘要翻译：一种用于监测身体表面的区域的方法包括：在第一时间记录包括该区域的表面的第一多光谱数字图像，在随后的时间记录包括该区域的表面的后续多光谱数字图像，以及将第一和第随后的图像。此外，这样的方法，其中第一和后续图像是高倍率图像，并且还包括记录包括高倍放大图像的低倍率图像。此外，用于形成有色皮肤损伤的诊断上有用的分类的方法包括使用这样的方法来构建包含从多个皮肤损伤记录的图像中定量提取的所选特征的数据库，并将数据库中每个这样的损伤的特征与数据库中的特征相关联，记录图像的皮肤病变的病史。此外，用于诊断早产性黑色素瘤或早期黑色素瘤病症的方法包括使用用于表征包括病变的表面区域的方法，并将如此获得的病变的特征与数据库中的特征进行比较，所述数据库从多个皮肤损伤获得，包括已知的病变根据染色皮肤损伤的诊断上有用的分类，进行早发性或早期黑色素瘤，或分类病变的特征。

96. 发明授权

US09646377B2 Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof 有权
公开(公告)号：US09646377B2
公开(公告)日：2017-05-09
申请号：US14243508
申请日：2014-04-02
申请人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc , Norman S. Nishioka
发明人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc , Norman S. Nishioka
IPC分类号： A61B5/00 , G06T7/00
CPC分类号： A61B5/0084 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/6852 , A61B5/7271 , G06T7/0012 , G06T2207/10056 , G06T2207/10101
摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

97. 发明授权

US09351642B2 Non-contact optical system, computer-accessible medium and method for measurement at least one mechanical property of tissue using coherent speckle technique(s) 有权
标题翻译：非接触式光学系统，计算机可访问介质和使用相干散斑技术测量组织的至少一种机械特性的方法
公开(公告)号：US09351642B2
公开(公告)日：2016-05-31
申请号：US13256175
申请日：2010-03-12
申请人： Seemantini K. Nadkarni , Guillermo J. Tearney
发明人： Seemantini K. Nadkarni , Guillermo J. Tearney
IPC分类号： A61B6/00 , A61B5/00 , A61B5/02
CPC分类号： A61B5/0059 , A61B5/0062 , A61B5/02007
摘要： Exemplary embodiments of apparatus and method for determining at least one material property of an anatomical structure can be provided. According to one exemplary embodiment, it is possible to apply at least one first coherent radiation to at least one portion of the anatomical structure, and receive at least one second coherent radiation from such portion(s). The first and second coherent radiations can be associated with one another. In addition, it is possible to determine the material property based on the second coherent radiation(s). Such determination can be performed without (i) any portion of an apparatus performing the procedure causing an induction of at least one mechanical deformation on or in the anatomical structure, and/or (ii) any mechanical deformation on or in the anatomical structure.
摘要翻译：可以提供用于确定解剖结构的至少一种材料性质的装置和方法的示例性实施例。根据一个示例性实施例，可以将至少一个第一相干辐射施加到解剖结构的至少一个部分，并且从这些部分接收至少一个第二相干辐射。第一和第二相干辐射可以彼此相关联。此外，可以基于第二相干辐射来确定材料特性。可以执行这种确定，而不需要（i）执行该过程的装置的任何部分，导致解剖结构上或解剖结构中的至少一个机械变形，和/或（ii）解剖结构上或解剖结构中的任何机械变形。

98. 发明授权

US08965487B2 Process, system and software arrangement for measuring a mechanical strain and elastic properties of a sample 有权
标题翻译：用于测量样品的机械应变和弹性性能的工艺，系统和软件布置
公开(公告)号：US08965487B2
公开(公告)日：2015-02-24
申请号：US11211482
申请日：2005-08-24
申请人： Brett Eugene Bouma , Raymond C. Chan , Guillermo J. Tearney
发明人： Brett Eugene Bouma , Raymond C. Chan , Guillermo J. Tearney
IPC分类号： A61B5/02 , A61B5/00
CPC分类号： A61B5/0066 , A61B5/0059 , A61B5/02007
摘要： A system, process and software arrangement are provided to determining data associated with at least one structural change of tissue. In particular, a first optical coherence tomography (“OCT”) signal which contains first information regarding the tissue at a first stress level, and a second OCT signal which contains second information regarding the tissue at a second stress level are received. The first and second information are compared to produce comparison information. The data associated with the at least one structural change is determined as a function of the comparison information and further information associated with (i) at least one known characteristics of the tissue and/or (ii) characteristics of an OCT system. Further, at least one optical coherence tomography (“OCT”) signal which contains information regarding the tissue can be received, and the modulus of the tissue may be determined as a function of the received at least one OCT signal.
摘要翻译：提供系统，过程和软件布置以确定与组织的至少一个结构变化相关联的数据。特别地，接收包含关于第一应力水平的组织的第一信息的第一光学相干断层摄影（“OCT”）信号和包含关于第二应力水平的组织的第二信息的第二OCT信号。比较第一和第二信息以产生比较信息。与至少一个结构变化相关联的数据被确定为比较信息和与（i）组织的至少一个已知特征和/或（ii）OCT系统的特征相关联的进一步信息的函数。此外，可以接收包含关于组织的信息的至少一个光学相干断层摄影（“OCT”）信号，并且可以根据所接收的至少一个OCT信号来确定组织的模量。

99. 发明授权

US08922781B2 Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample 有权
标题翻译：用于通过同时照射和检测样品上的多个点来执行光学成像的装置，装置，内窥镜，导管和方法
公开(公告)号：US08922781B2
公开(公告)日：2014-12-30
申请号：US11288994
申请日：2005-11-29
申请人： Guillermo J. Tearney , Johannes F. de Boer , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Johannes F. de Boer , Brett Eugene Bouma
IPC分类号： G01B9/02 , G02B21/00 , A61B5/00 , G02B23/24 , G02B23/26
CPC分类号： G02B23/2469 , A61B5/0066 , A61B5/0073 , A61B5/6852 , G01B9/02001 , G01B9/02091 , G02B21/0032 , G02B21/0056 , G02B23/2453 , G02B23/26
摘要： Devices, arrangements, endoscopes, catheters and methods adapted to propagate at least one electro-magnetic radiation are provided. In particular, a waveguide apparatus specifically configured may be utilized to split the electro-magnetic radiation into a plurality of beams that are intended to illuminate a biological sample, and impart a unique associated characteristic unto each of the beams. The beams may be intended to illuminate a biological sample at distinct locations, and impart a unique associated characteristic unto each of the beams. In addition, a control apparatus may be provided which is configured to control at least one of the fibers and which can be input to the fibers so as to modify the unique associated characteristics of the beams being propagated along the fibers, and thereby modify the characteristics of the distinct locations on the sample.
摘要翻译：提供了适于传播至少一个电磁辐射的装置，布置，内窥镜，导管和方法。特别地，可以使用专门配置的波导装置将电磁辐射分割成旨在照射生物样品的多个光束，并且向每个光束赋予独特的相关特征。光束可以用于在不同的位置照射生物样品，并且赋予每个光束唯一的相关特征。此外，可以提供控制装置，其被配置为控制光纤中的至少一个并且可以输入到光纤，以便改变沿着光纤传播的光束的独特相关特性，从而改变特性的样品上不同的位置。

100. 发明申请

US20140221747A1 APPARATUS, SYSTEMS AND METHODS WHICH INCLUDE AND/OR UTILIZE FLEXIBLE FORWARD SCANNING CATHETER 审中-公开
标题翻译：包括和/或利用灵活的前向扫描导管的装置，系统和方法
公开(公告)号：US20140221747A1
公开(公告)日：2014-08-07
申请号：US14170833
申请日：2014-02-03
申请人： Guillermo J. Tearney , William C. Warger, II , Robert Carruth , Lara Wurster , Michalina Gora
发明人： Guillermo J. Tearney , William C. Warger, II , Robert Carruth , Lara Wurster , Michalina Gora
IPC分类号： A61B1/00 , A61B1/04 , A61B1/07
CPC分类号： A61B1/00172 , A61B1/04 , A61B1/07
摘要： These and other objects of the present disclosure can be achieved by provision of an apparatus for illuminating a structure(s), which can include a first arrangement and a second arrangement which can each be configured to rotate and deflect a radiation(s) transmitted therethrough at an angle with respect to an axis of rotation thereof. There can be a plurality of rotating third arrangements, where at least one can be connected to the first arrangement, and at least another one can be connected to the second arrangement. A fourth arrangement can be connected to the third arrangements, and can he configured to rotate the third arrangements. One of the rotating third arrangements can be flexible, can have a length that is greater than ten times a diameter of the first arrangement or the second arrangement, can he surrounded by a housing, and/or can contain an optical waveguide arrangement extending therethrough.
摘要翻译：本公开的这些和其它目的可以通过提供用于照亮结构的装置来实现，该结构可以包括第一布置和第二布置，其可以被配置成旋转和偏转穿过其中的辐射相对于其旋转轴线成一定角度。可以有多个旋转的第三布置，其中至少一个可以连接到第一布置，并且至少另一个可以连接到第二布置。可以将第四布置连接到第三布置，并且可以将其配置为旋转第三布置。旋转的第三布置中的一个可以是柔性的，可以具有大于第一布置或第二布置的直径的十倍的长度，可以被壳体包围和/或可以包含延伸穿过其中的光波导装置。

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