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1. 发明申请

US20140221747A1 APPARATUS, SYSTEMS AND METHODS WHICH INCLUDE AND/OR UTILIZE FLEXIBLE FORWARD SCANNING CATHETER 审中-公开
标题翻译：包括和/或利用灵活的前向扫描导管的装置，系统和方法
公开(公告)号：US20140221747A1
公开(公告)日：2014-08-07
申请号：US14170833
申请日：2014-02-03
申请人： Guillermo J. Tearney , William C. Warger, II , Robert Carruth , Lara Wurster , Michalina Gora
发明人： Guillermo J. Tearney , William C. Warger, II , Robert Carruth , Lara Wurster , Michalina Gora
IPC分类号： A61B1/00 , A61B1/04 , A61B1/07
CPC分类号： A61B1/00172 , A61B1/04 , A61B1/07
摘要： These and other objects of the present disclosure can be achieved by provision of an apparatus for illuminating a structure(s), which can include a first arrangement and a second arrangement which can each be configured to rotate and deflect a radiation(s) transmitted therethrough at an angle with respect to an axis of rotation thereof. There can be a plurality of rotating third arrangements, where at least one can be connected to the first arrangement, and at least another one can be connected to the second arrangement. A fourth arrangement can be connected to the third arrangements, and can he configured to rotate the third arrangements. One of the rotating third arrangements can be flexible, can have a length that is greater than ten times a diameter of the first arrangement or the second arrangement, can he surrounded by a housing, and/or can contain an optical waveguide arrangement extending therethrough.
摘要翻译：本公开的这些和其它目的可以通过提供用于照亮结构的装置来实现，该结构可以包括第一布置和第二布置，其可以被配置成旋转和偏转穿过其中的辐射相对于其旋转轴线成一定角度。可以有多个旋转的第三布置，其中至少一个可以连接到第一布置，并且至少另一个可以连接到第二布置。可以将第四布置连接到第三布置，并且可以将其配置为旋转第三布置。旋转的第三布置中的一个可以是柔性的，可以具有大于第一布置或第二布置的直径的十倍的长度，可以被壳体包围和/或可以包含延伸穿过其中的光波导装置。

2. 发明申请

US20120022338A1 APPARATUS, SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM FOR ANALYZING INFORMATION REGARDING CARDIOVASCULAR DISEASES AND FUNCTIONS 审中-公开
标题翻译：装置，系统，方法和计算机可访问的媒体，用于分析有关心血管疾病和功能的信息
公开(公告)号：US20120022338A1
公开(公告)日：2012-01-26
申请号：US13118109
申请日：2011-05-27
申请人： Balachundhar Subramaniam , William C. Warger, II , Brett Simon , Guillermo J. Tearney , Li Li
发明人： Balachundhar Subramaniam , William C. Warger, II , Brett Simon , Guillermo J. Tearney , Li Li
IPC分类号： A61B5/00 , A61B8/00 , A61B6/00 , A61B5/05
CPC分类号： A61B5/0095 , A61B5/0044 , A61B5/0066 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0086 , A61B5/02007 , A61B5/0205 , A61B5/0261 , A61B5/07 , A61B5/073 , A61B5/14535 , A61B5/14551 , A61B5/412 , A61B8/12
摘要： According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for determining information regarding a tissue or an object at or within the tissue. For example, with at least one first arrangement which is situated inside a particular organ of the body, it is possible to generate at least one electromagnetic radiation in the tissue, wherein the tissue is different from and outside of the particular organ. The particular signals that are responsive to the at least one electromagnetic radiation can be detected (e.g., possibly with at least one second arrangement), at least one characteristic of the tissue and/or information regarding the object at or in the tissue can be determined (e.g., with the second arrangement(s)). Alternatively or in addition, the tissue can be different from and outside of the particular organ, and the first arrangement(s) can be situated inside a particular organ of the body. To that end, the can include (i) the heart, (ii) major vessels attached to the heart, (iii) coronary artery, and/or (iv) blood therein.
摘要翻译：根据本公开的示例性实施例，可以提供装置和方法来确定关于组织或组织内或组织内的物体的信息。例如，利用位于身体的特定器官内的至少一个第一布置，可以在组织中产生至少一个电磁辐射，其中组织与特定器官不同和在外。可以检测响应于至少一个电磁辐射的特定信号（例如，可能具有至少一个第二布置），可以确定组织的至少一个特性和/或关于组织上或组织中的物体的信息（例如，第二种配置）。或者或另外，组织可以不同于特定器官和外部，并且第一布置可以位于身体的特定器官内部。为此，可以包括（i）心脏，（ii）附着于心脏的主要血管，（iii）冠状动脉和/或（iv）血液中的血液。

3. 发明授权

US09510758B2 Apparatus, systems and methods for measuring blood pressure within at least one vessel 有权
标题翻译：用于测量至少一个血管内的血压的装置，系统和方法
公开(公告)号：US09510758B2
公开(公告)日：2016-12-06
申请号：US13283143
申请日：2011-10-27
申请人： William C. Warger, II , Simon C. Schlachter , Joseph Gardecki , Brett Eugene Bouma , Guillermo J. Tearney
发明人： William C. Warger, II , Simon C. Schlachter , Joseph Gardecki , Brett Eugene Bouma , Guillermo J. Tearney
IPC分类号： A61B6/00 , A61B5/021 , A61B5/00 , A61B5/1455 , A61B5/0205 , A61B3/14 , A61B5/02 , A61B5/12 , A61B5/20
CPC分类号： A61B5/021 , A61B3/14 , A61B5/0066 , A61B5/02007 , A61B5/02055 , A61B5/12 , A61B5/14558 , A61B5/202 , A61B5/4064 , A61B5/407 , A61B5/42 , A61B2576/00
摘要： Exemplary apparatus and method for obtaining information for at least one structure can be provided. For example, it is possible to forward at least one first electro-magnetic radiation to the at least one structure which is external from the apparatus. At least one second electro magnetic radiation provided from the at least one structure (which is based on the first electro-magnetic radiation(s)) can be detected. It is also possible to determine at least one characteristic of the structure(s) based on the second electro-magnetic radiation(s), and obtain data relating to a pressure of at least one portion of the structure(s) based on the characteristic(s).
摘要翻译：可以提供用于获得至少一个结构的信息的示例性装置和方法。例如，可以将至少一个第一电磁辐射转发到从装置外部的至少一个结构。可以检测从至少一个结构（其基于第一电磁辐射）提供的至少一个第二电磁辐射。也可以基于第二电磁辐射来确定结构的至少一个特性，并且基于特性获得与结构的至少一部分的压力有关的数据（s）。

4. 发明申请

US20120108956A1 APPARATUS, SYSTEMS AND METHODS FOR MEASURING BLOOD PRESSURE WITHIN AT LEAST ONE VESSEL 有权
标题翻译：装置，系统和方法，用于在最小的一条船上测量血压
公开(公告)号：US20120108956A1
公开(公告)日：2012-05-03
申请号：US13283143
申请日：2011-10-27
申请人： William C. Warger, II , Simon C. Schlachter , Joseph Gardecki , Brett Eugene Bouma , Guillermo J. Tearney
发明人： William C. Warger, II , Simon C. Schlachter , Joseph Gardecki , Brett Eugene Bouma , Guillermo J. Tearney
IPC分类号： A61B6/00
CPC分类号： A61B5/021 , A61B3/14 , A61B5/0066 , A61B5/02007 , A61B5/02055 , A61B5/12 , A61B5/14558 , A61B5/202 , A61B5/4064 , A61B5/407 , A61B5/42 , A61B2576/00
摘要： Exemplary apparatus and method for obtaining information for at least one structure can be provided. For example, it is possible to forward at least one first electro-magnetic radiation to the at least one structure which is external from the apparatus. At least one second electro magnetic radiation provided from the at least one structure (which is based on the first electro-magnetic radiation(s)) can be detected. It is also possible to determine at least one characteristic of the structure(s) based on the second electro-magnetic radiation(s), and obtain data relating to a pressure of at least one portion of the structure(s) based on the characteristic(s).
摘要翻译：可以提供用于获得至少一个结构的信息的示例性装置和方法。例如，可以将至少一个第一电磁辐射转发到从装置外部的至少一个结构。可以检测从至少一个结构（其基于第一电磁辐射）提供的至少一个第二电磁辐射。也可以基于第二电磁辐射来确定结构的至少一个特性，并且基于特性获得与结构的至少一部分的压力有关的数据（s）。

5. 发明授权

US08428331B2 Phase subtraction cell counting method 有权
标题翻译：相减细胞计数法
公开(公告)号：US08428331B2
公开(公告)日：2013-04-23
申请号：US11890801
申请日：2007-08-07
申请人： Charles A. DiMarzio , William C. Warger, II
发明人： Charles A. DiMarzio , William C. Warger, II
IPC分类号： G06K9/00
CPC分类号： G02B21/0004 , G02B21/18
摘要： A method and device are provided for counting cells in a sample of living tissue, such as an embryo. The method involves obtaining a microscopic image of the unstained tissue that reveals cell boundaries, such as a differential interference contrast (DIC) image, and an optical quadrature microscopy (OQM) image which is used to prepare an image of optical path length deviation (OPD) across the cell cluster. The boundaries of individual cells in the cell cluster are modeled as ellipses and used, together with the maximum optical path length deviation of a cell, to calculate ellipsoidal model cells that are subtracted from the OPD image. The process is repeated until the OPD image is depleted of phase signal attributable to cells of the cell cluster, and the cell count is obtained from the number of cells subtracted. The method is capable of accurately and non-invasively counting the number of cells in a living embryo at the 2-30 cell stage, and can be employed to assess the developmental stage and health of human embryos for fertility treatments.
摘要翻译：提供了一种用于计数诸如胚胎的生物体组织样品中的细胞的方法和装置。该方法包括获得显示细胞边界的未染色组织的微观图像，例如差分干涉对比（DIC）图像和用于准备光程长度偏差图像（OPD）的光学正交显微镜（OQM）图像）。细胞簇中的单个细胞的边界被建模为椭圆并与细胞的最大光程长度偏差一起使用，以计算从OPD图像中减去的椭圆体模型细胞。重复该过程直到OPD图像耗尽归因于细胞簇的细胞的相位信号，并且从减去的细胞数获得细胞计数。该方法能准确，非侵入性地计数2-30细胞期活细胞中的细胞数，可用于评估人胚胎发育阶段和健康状况，用于生殖治疗。

6. 发明授权

US07471450B2 Confocal reflectance microscope system with dual rotating wedge scanner assembly 失效
标题翻译：共焦反射显微镜系统与双旋转楔形扫描仪组装
公开(公告)号：US07471450B2
公开(公告)日：2008-12-30
申请号：US11244814
申请日：2005-10-06
申请人： Charles M. DiMarzio , William C. Warger, II
发明人： Charles M. DiMarzio , William C. Warger, II
IPC分类号： G02B21/06 , G02B21/00
CPC分类号： G02B21/0032 , G02B21/0036 , G02B21/0052
摘要： A confocal reflectance microscope system incorporates a dual-wedge laser scanner assembly. The scanner assembly incorporates a pair of rotatably mounted prisms, each prism having an angle selected to deviate a light beam from a light source by a desired angle. Each prism is mounted for rotation at a desired speed of rotation and in a desired direction to scan the light beam over the target. An image is built up from successive reflected signals returned from the target.
摘要翻译：共焦反射显微镜系统包含双楔形激光扫描仪组件。扫描器组件包括一对可旋转地安装的棱镜，每个棱镜具有选择的角度，以使来自光源的光束偏离所需的角度。每个棱镜安装成以期望的旋转速度旋转并且在期望的方向上旋转以扫描目标上的光束。从目标返回的连续反射信号构建图像。

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