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1. 发明授权

US10534129B2 System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque 有权
公开(公告)号：US10534129B2
公开(公告)日：2020-01-14
申请号：US12058279
申请日：2008-03-28
申请人： Guillermo J. Tearney , Seemantini K. Nadkarni , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Seemantini K. Nadkarni , Brett Eugene Bouma
IPC分类号： G02B6/04 , G02B6/06 , A61B1/00 , A61B5/00 , G02B6/32
摘要： Apparatus and method according to an exemplary embodiment of the present invention can be provided for analyzing tissue. For example, the apparatus can include at least one first arrangement configured to illuminate at least one anatomical structure with at least one of at least one electro-magnetic radiation. The apparatus can also include at least one second arrangement that may include at least two wave-guiding arrangements associated with one another that are configured to receive a further electro-magnetic radiation reflected from the tissue and transmit at least one speckle pattern associated with the further electro-magnetic radiation. The wave-guiding arrangements may be structured so as to reduce crosstalk therebetween.

2. 发明授权

US09351642B2 Non-contact optical system, computer-accessible medium and method for measurement at least one mechanical property of tissue using coherent speckle technique(s) 有权
标题翻译：非接触式光学系统，计算机可访问介质和使用相干散斑技术测量组织的至少一种机械特性的方法
公开(公告)号：US09351642B2
公开(公告)日：2016-05-31
申请号：US13256175
申请日：2010-03-12
申请人： Seemantini K. Nadkarni , Guillermo J. Tearney
发明人： Seemantini K. Nadkarni , Guillermo J. Tearney
IPC分类号： A61B6/00 , A61B5/00 , A61B5/02
CPC分类号： A61B5/0059 , A61B5/0062 , A61B5/02007
摘要： Exemplary embodiments of apparatus and method for determining at least one material property of an anatomical structure can be provided. According to one exemplary embodiment, it is possible to apply at least one first coherent radiation to at least one portion of the anatomical structure, and receive at least one second coherent radiation from such portion(s). The first and second coherent radiations can be associated with one another. In addition, it is possible to determine the material property based on the second coherent radiation(s). Such determination can be performed without (i) any portion of an apparatus performing the procedure causing an induction of at least one mechanical deformation on or in the anatomical structure, and/or (ii) any mechanical deformation on or in the anatomical structure.
摘要翻译：可以提供用于确定解剖结构的至少一种材料性质的装置和方法的示例性实施例。根据一个示例性实施例，可以将至少一个第一相干辐射施加到解剖结构的至少一个部分，并且从这些部分接收至少一个第二相干辐射。第一和第二相干辐射可以彼此相关联。此外，可以基于第二相干辐射来确定材料特性。可以执行这种确定，而不需要（i）执行该过程的装置的任何部分，导致解剖结构上或解剖结构中的至少一个机械变形，和/或（ii）解剖结构上或解剖结构中的任何机械变形。

3. 发明申请

US20070208400A1 SYSTEM AND METHOD FOR PROVIDING CELL SPECIFIC LASER THERAPY OF ATHEROSCLEROTIC PLAQUES BY TARGETING LIGHT ABSORBERS IN MACROPHAGES 审中-公开
标题翻译：系统和方法，通过瞄准光吸收器在大脑中提供细胞特异性激光治疗
公开(公告)号：US20070208400A1
公开(公告)日：2007-09-06
申请号：US11680962
申请日：2007-03-01
申请人： Seemantini K. Nadkarni , Guillermo J. Tearney , Brett Eugene Bouma , Benjamin J. Vakoc , Richard Rox Anderson
发明人： Seemantini K. Nadkarni , Guillermo J. Tearney , Brett Eugene Bouma , Benjamin J. Vakoc , Richard Rox Anderson
IPC分类号： A61F2/00 , A61N5/06
CPC分类号： A61B18/245 , A61N5/0601 , A61N5/062
摘要： An apparatus and method according to the present invention can be provided, e.g., for a cell specific laser therapy of atherosclerotic plaques, particularly to systems and methods for targeting endogenous light absorbers present within plaque macrophages and exogenous nanoparticle targeting. In one exemplary embodiment, an electro-magnetic radiation can be forwarded to an anatomical structure. The electromagnetic radiation may have at least one property configured to (a) modify at least one characteristic of at least one first cell, and (b) minimize any modification of and/or modify at least one characteristic of at least second cell. The first and second cells may be different from one another, the characteristics of the first and second cells can be different from one another, and the first cell and/or the second cell may have at least one macrophage feature, and the characteristic of the at least one first cell and/or the at least one second cell can be temperature. According to still another exemplary embodiment, a location associated with the first cell and the second cell can be determined. For example, the electromagnetic radiation can be forwarded in a vicinity of the location.
摘要翻译：可以提供根据本发明的装置和方法，例如用于动脉粥样硬化斑块的细胞特异性激光治疗，特别是用于靶向存在于斑块巨噬细胞内和内源性纳米颗粒靶向内源性光吸收剂的系统和方法。在一个示例性实施例中，电磁辐射可以被转发到解剖结构。电磁辐射可以具有至少一个特性，其被配置为（a）修改至少一个第一小区的至少一个特征，以及（b）使对至少第二小区的至少一个特征的任何修改和/或修改最小化。第一和第二细胞可以彼此不同，第一和第二细胞的特征可以彼此不同，并且第一细胞和/或第二细胞可以具有至少一种巨噬细胞特征，并且至少一个第一细胞和/或至少一个第二细胞可以是温度。根据另一示例性实施例，可以确定与第一小区和第二小区相关联的位置。例如，电磁辐射可以在该位置附近转发。

4. 发明授权

US08772039B2 Optical thromboelastography system and method for evaluation of blood coagulation metrics 有权
标题翻译：光学血栓弹性成像系统及血液凝固指标评估方法
公开(公告)号：US08772039B2
公开(公告)日：2014-07-08
申请号：US13467626
申请日：2012-05-09
申请人： Seemantini K. Nadkarni
发明人： Seemantini K. Nadkarni
IPC分类号： G01N33/86 , G01N33/48 , G01N21/49
CPC分类号： G01N33/4905 , A61B5/14546
摘要： Device, method, and computer program product for determining a material parameter of a blood coagulation cascade based on parameters of light diffused at a biofluid sample. In one example, the biofluid sample includes a blood sample. Laser light scattered by the sample is collected by the optical system in reflection and/or transmission mode. An image of the sample in so collected light is formed, and data representing fluctuations of laser speckle intensity with is processed to derive numerical descriptors associated with blood coagulation and fibrinolysis. In a specific case, such numerical descriptors are derived based on temporal dynamic of a viscoelastic characteristic of the blood sample.
摘要翻译：基于在生物流体样品上扩散的光的参数来确定凝血级联的材料参数的装置，方法和计算机程序产品。在一个实例中，生物流体样品包括血液样品。由样品散射的激光由反射和/或透射模式的光学系统收集。形成如此收集的光中的样品的图像，并且处理表示激光散斑强度波动的数据，以得到与血液凝固和纤维蛋白溶解相关的数值描述符。在具体情况下，这样的数值描述符是基于血样的粘弹性特征的时间动态得出的。

5. 发明授权

US09664606B2 Compensation for causes of temporal fluctuations of backscattered speckle patterns in laser speckle rheology of biological fluids 有权
公开(公告)号：US09664606B2
公开(公告)日：2017-05-30
申请号：US14428506
申请日：2013-09-16
申请人： Zeinab Hajjarian , Seemantini K. Nadkarni
发明人： Zeinab Hajjarian , Seemantini K. Nadkarni
IPC分类号： G01N21/00 , G01N11/02 , G01N21/41 , G01N21/47 , G01N21/59 , G01N33/487
CPC分类号： G01N11/02 , G01N21/41 , G01N21/47 , G01N21/4795 , G01N21/59 , G01N33/487 , G01N2021/4769 , G01N2021/479 , G01N2021/4792 , G01N2021/4797
摘要： An algorithm for determining viscoelastic modulus of an optically scattering biofluid that takes into account variable scattering and/or absorption characteristics of the biofluid. A correction to mean square displacement value charactetizing the Brownian motion of light scatterers is introduced based on a polarization-sensitive Monte-Carlo ray-tracing taking into account optical properties of the biofluid determined with the use of laser speckle rheology measurements. In contradistinction with a diffusion model, the correction-implemented determination of the viscoelastic modulus applies to a biofluid with substantially any concentration of light-scattering particles.

6. 发明授权

US09618319B2 Laser speckle microrheometer for measuring mechanical properties of biological tissue 有权
公开(公告)号：US09618319B2
公开(公告)日：2017-04-11
申请号：US13985945
申请日：2012-02-20
申请人： Seemantini K. Nadkarni
发明人： Seemantini K. Nadkarni
IPC分类号： G01B9/02 , G01N21/47 , A61B5/00
CPC分类号： G01B9/02 , A61B5/0059 , A61B5/0066 , G01N21/4795 , G01N2203/0089 , G01N2203/0094
摘要： Volumetric distribution of a micromechanical parameter of a biological tissue, such as viscoelastic parameter or tissue stiffness, is determined, with microscopic resolution, from optical data representing light scattered by sequential layers of the tissue and, optionally, displayed to visualization. A particular layer of the tissue is defined through coherence-gating of light received at the optical detector. Coherence-gating is achieved with the use of an interferometer the sample arm of which contains the tissue, illuminated with defocused light, and an optical length of a reference arm of which is repeatedly adjusted, within a coherence length of used light, to ensure that each of the sequential optical interferograms represents light scattered only by a particular tissue layer a position of which is re-defined through the tissue via such adjustment.

7. 发明申请

US20120301967A1 OPTICAL THROMBOELASTOGRAPHY SYSTEM AND METHOD FOR EVALUATION OF BLOOD COAGULATION METRICS 有权
标题翻译：光学凝血图谱系统及评估血液凝聚指标的方法
公开(公告)号：US20120301967A1
公开(公告)日：2012-11-29
申请号：US13467626
申请日：2012-05-09
申请人： Seemantini K. Nadkarni
发明人： Seemantini K. Nadkarni
IPC分类号： G01N21/49
CPC分类号： G01N33/4905 , A61B5/14546
摘要： Device, method, and computer program product for determining a material parameter of a blood coagulation cascade based on parameters of light diffused at a biofluid sample. In one example, the biofluid sample includes a blood sample. Laser light scattered by the sample is collected by the optical system in reflection and/or transmission mode. An image of the sample in so collected light is formed, and data representing fluctuations of laser speckle intensity with is processed to derive numerical descriptors associated with blood coagulation and fibrinolysis. In a specific case, such numerical descriptors are derived based on temporal dynamic of a viscoelastic characteristic of the blood sample.
摘要翻译：基于在生物流体样品上扩散的光的参数来确定凝血级联的材料参数的装置，方法和计算机程序产品。在一个实例中，生物流体样品包括血液样品。由样品散射的激光由反射和/或透射模式的光学系统收集。形成如此收集的光中的样品的图像，并且处理表示激光散斑强度波动的数据，以得到与血液凝固和纤维蛋白溶解相关的数值描述符。在具体情况下，这样的数值描述符是基于血样的粘弹性特征的时间动态得出的。

8. 发明授权

US11172888B2 Optical blood-coagulation sensor 有权
公开(公告)号：US11172888B2
公开(公告)日：2021-11-16
申请号：US14653434
申请日：2013-12-19
申请人： Seemantini K. Nadkarni
发明人： Seemantini K. Nadkarni
IPC分类号： A61B5/00 , G01N33/49 , G01N21/47 , A61B5/02 , A61B5/15 , G01N21/51
摘要： Hand-held optical thromboelastographic sensor and method of using the same for simultaneous assessment of multiple parameters of blood coagulation at a point-of-care. The sensor includes an optical system registering laser speckle intensity associated with a stationary blood sample and data-processing circuitry programmed to derive the multiple parameters from speckle intensity. The circuitry may be part of a mobile device configured to operate without communication with a central server and/or data storage.

9. 发明申请

US20150276571A1 COMPENSATION FOR CAUSES OF TEMPORAL FLUCTUATIONS OF BACKSCATTERED SPECKLE PATTERNS IN LASER SPECKLE RHEOLOGY OF BIOLOGICAL FLUIDS 有权
标题翻译：补偿生物流体激光光谱学背景色谱图中时间波动的原因
公开(公告)号：US20150276571A1
公开(公告)日：2015-10-01
申请号：US14428506
申请日：2013-09-16
申请人： Zeinab HAJJARIAN , Seemantini K. NADKARNI
发明人： Zeinab Hajjarian , Seemantini K. Nadkarni
IPC分类号： G01N11/02 , G01N21/47 , G01N21/59 , G01N33/487
CPC分类号： G01N11/02 , G01N21/41 , G01N21/47 , G01N21/4795 , G01N21/59 , G01N33/487 , G01N2021/4769 , G01N2021/479 , G01N2021/4792 , G01N2021/4797
摘要： An algorithm for determining viscoelastic modulus of an optically scattering biofluid that takes into account variable scattering and/or absorption characteristics of the biofluid. A correction to mean square displacement value characterizing the Brownian motion of light scatterers is introduced based on a polarization-sensitive Monte-Carlo ray-tracing taking into account optical properties of the biofluid determined with the use of laser speckle rheology measurements. In contradistinction with a diffusion model, the correction-implemented determination of the viscoelastic modulus applies to a biofluid with substantially any concentration of light-scattering particles.
摘要翻译：考虑到生物流体的可变散射和/或吸收特性的光散射生物流体的粘弹性模量的算法。考虑到使用激光散斑流变学测量确定的生物流体的光学特性，基于偏振敏感的蒙特卡罗光线跟踪引入了表征光散射体的布朗运动的平均位移值的校正。与扩散模型相反，校正实现的粘弹性模量的确定适用于具有基本上任何浓度的光散射颗粒的生物流体。

10. 发明申请

US20140036272A1 LASER SPECKLE MICRORHEOMETER FOR MEASURING MECHANICAL PROPERTIES OF BIOLOGICAL TISSUE 有权
标题翻译：用于测量生物组织机械特性的激光光谱仪
公开(公告)号：US20140036272A1
公开(公告)日：2014-02-06
申请号：US13985945
申请日：2012-02-20
申请人： Seemantini K. Nadkarni
发明人： Seemantini K. Nadkarni
IPC分类号： G01B9/02
CPC分类号： G01B9/02 , A61B5/0059 , A61B5/0066 , G01N21/4795 , G01N2203/0089 , G01N2203/0094
摘要： Volumetric distribution of a micromechanical parameter of a biological tissue, such as viscoelastic parameter or tissue stiffness, is determined, with microscopic resolution, from optical data representing light scattered by sequential layers of the tissue and, optionally, displayed to visualization. A particular layer of the tissue is defined through coherence-gating of light received at the optical detector. Coherence-gating is achieved with the use of an interferometer the sample arm of which contains the tissue, illuminated with defocused light, and an optical length of a reference arm of which is repeatedly adjusted, within a coherence length of used light, to ensure that each of the sequential optical interferograms represents light scattered only by a particular tissue layer a position of which is re-defined through the tissue via such adjustment.
摘要翻译：通过微观分辨率，从表示由组织的顺序层散射的光的光学数据确定生物组织的微机械参数的体积分布，例如粘弹性参数或组织刚度，并且可选地显示为可视化。通过在光学检测器处接收的光的相干选择来限定组织的特定层。使用干涉仪实现相干门控，该干涉仪的样品臂包含组织，用散焦光照亮，并且在所使用的光的相干长度内重复调节参考臂的光学长度，以确保每个顺序光学干涉图表示仅由特定组织层散射的光，其特征在于通过这种调整通过组织重新定义该组织层。

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