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1. 发明授权

US07903257B2 Apparatus and method for ranging and noise reduction of low coherence interferometry (LCI) and optical coherence tomography (OCT) signals by parallel detection of spectral bands 有权
标题翻译：用于通过光谱带的并行检测的低相干干涉测量（LCI）和光学相干断层扫描（OCT）信号的测距和降噪的装置和方法
公开(公告)号：US07903257B2
公开(公告)日：2011-03-08
申请号：US11954794
申请日：2007-12-12
申请人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B11/02 , G01B9/02 , G01J3/45
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。信号保持不变。喷射噪声的降低增加了系统的动态范围和灵敏度。

2. 发明授权

US09060689B2 Apparatus, method and system for performing phase-resolved optical frequency domain imaging 有权
标题翻译：用于执行相位分辨光学频域成像的装置，方法和系统
公开(公告)号：US09060689B2
公开(公告)日：2015-06-23
申请号：US11445990
申请日：2006-06-01
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Johannes F. De Boer , Benjamin J. Vakoc , Seok-Hyun Yun
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Johannes F. De Boer , Benjamin J. Vakoc , Seok-Hyun Yun
IPC分类号： G01N21/55 , A61B5/00 , G01N21/45 , G01N21/47 , G01N21/49 , G01B9/02
CPC分类号： A61B5/0073 , A61B5/0066 , A61B2560/0223 , G01B9/02091 , G01N21/45 , G01N21/4795 , G01N21/49
摘要： Apparatus, system and method are provided which utilize signals received from a reference and a sample. In particular, a radiation is provided which includes at least one first electro-magnetic radiation directed to the sample and at least one second electro-magnetic radiation directed to the reference. A frequency of the radiation varies over time. An interference can be detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. It is possible to obtain a particular signal associated with at least one phase of at least one frequency component of the interference, and compare the particular signal to at least one particular information. Further, it is possible to receive at least one portion of the radiation and provide a further radiation, such that the particular signal can be calibrated based on the further signal.
摘要翻译：提供了使用从参考和样本接收的信号的装置，系统和方法。特别地，提供了一种辐射，其包括指向样品的至少一个第一电磁辐射和指向该参考的至少一个第二电磁辐射。辐射的频率随时间而变化。可以在与第一辐射相关联的至少一个第三辐射与与第二辐射相关联的至少一个第四辐射之间检测干扰。可以获得与干扰的至少一个频率分量的至少一个相位相关联的特定信号，并将特定信号与至少一个特定信息进行比较。此外，可以接收辐射的至少一部分并提供另外的辐射，使得可以基于另外的信号来校准特定信号。

3. 发明授权

US08416818B2 Process and apparatus for a wavelength tuning source 有权
公开(公告)号：US08416818B2
公开(公告)日：2013-04-09
申请号：US13160335
申请日：2011-06-14
申请人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
发明人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
IPC分类号： H01S3/10
CPC分类号： G01J3/10 , A61B5/0059 , A61B5/0066 , G01B9/02004 , G01B9/02091 , G01J3/12 , G01J9/0215 , G01N21/4795 , G02B27/48 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S5/141 , H01S5/146 , H01S5/4087
摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.

4. 发明授权

US07742173B2 Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample 有权
标题翻译：样品的偏振敏感光学频域成像的方法，布置和系统
公开(公告)号：US07742173B2
公开(公告)日：2010-06-22
申请号：US11697012
申请日：2007-04-05
申请人： Seok-Hyun Yun , Johannes F. De Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Seok-Hyun Yun , Johannes F. De Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , G01B9/02002 , G01B9/02004 , G01B9/02011 , G01B9/02091 , G01B2290/70
摘要： Arrangements and methods are provided for obtaining data associated with a sample. For example, at least one first electro-magnetic radiation can be provided to a sample and at least one second electro-magnetic radiation can be provided to a reference (e.g., a non-reflective reference). A frequency of such radiation(s) can repetitively vary over time with a first characteristic period. In addition, a polarization state of the first electro-magnetic radiation, the second electro-magnetic radiation, a third electro-magnetic radiation (associated with the first radiation) or a fourth electro-magnetic radiation (associated with the second radiation) can repetitively vary over time with a second characteristic period which is shorter than the first period. The data for imaging at least one portion of the sample can be provided as a function of the polarization state. In addition or alternatively, the third and fourth electro-magnetic radiations can be combined so as to determine an axial reflectance profile of at least one portion of the sample.
摘要翻译：提供了用于获取与样本相关的数据的安排和方法。例如，可以向样品提供至少一个第一电磁辐射，并且可以向参考（例如，非反射参考）提供至少一个第二电磁辐射。这种辐射的频率可以在第一特征周期内随时间重复地变化。此外，第一电磁辐射，第二电磁辐射，第三电磁辐射（与第一辐射相关联）或第四电磁辐射（与第二辐射相关联）的极化状态可以重复地随着时间而变化，其具有比第一周期短的第二特征周期。用于成像至少一部分样品的数据可以作为偏振态的函数提供。另外或替代地，可以组合第三和第四电磁辐射，以便确定样品的至少一部分的轴向反射率分布。

5. 发明申请

US20100094576A1 APPARATUS AND METHOD FOR RANGING AND NOISE REDUCTION OF LOW COHERENCE INTERFEROMETRY LCI AND OPTICAL COHERENCE TOMOGRAPHY OCT SIGNALS BY PARALLEL DETECTION OF SPECTRAL BANDS 有权
标题翻译：通过平行检测光谱仪的低相干干涉LCI和光学相干TOMOGRAPHY OCT信号的范围和噪声降低的装置和方法
公开(公告)号：US20100094576A1
公开(公告)日：2010-04-15
申请号：US12570443
申请日：2009-09-30
申请人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02 , G06F19/00
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。信号保持不变。喷射噪声的降低增加了系统的动态范围和灵敏度。

6. 发明申请

US20070236700A1 METHODS, ARRANGEMENTS AND SYSTEMS FOR POLARIZATION-SENSITIVE OPTICAL FREQUENCY DOMAIN IMAGING OF A SAMPLE 有权
标题翻译：方法，用于样品的偏振光敏频域成像的安排和系统
公开(公告)号：US20070236700A1
公开(公告)日：2007-10-11
申请号：US11697012
申请日：2007-04-05
申请人： Seok-Hyun Yun , Johannes F. De Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Seok-Hyun Yun , Johannes F. De Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , G01B9/02002 , G01B9/02004 , G01B9/02011 , G01B9/02091 , G01B2290/70
摘要： Arrangements and methods are provided for obtaining data associated with a sample. For example, at least one first electro-magnetic radiation can be provided to a sample and at least one second electro-magnetic radiation can be provided to a reference (e.g., a non-reflective reference). A frequency of such radiation(s) can repetitively vary over time with a first characteristic period. In addition, a polarization state of the first electro-magnetic radiation, the second electro-magnetic radiation, a third electro-magnetic radiation (associated with the first radiation) or a fourth electro-magnetic radiation (associated with the second radiation) can repetitively vary over time with a second characteristic period which is shorter than the first period. The data for imaging at least one portion of the sample can be provided as a function of the polarization state. In addition or alternatively, the third and fourth electro-magnetic radiations can be combined so as to determine an axial reflectance profile of at least one portion of the sample.
摘要翻译：提供了用于获取与样本相关的数据的安排和方法。例如，可以向样品提供至少一个第一电磁辐射，并且可以向参考（例如，非反射参考）提供至少一个第二电磁辐射。这种辐射的频率可以在第一特征周期内随时间重复地变化。此外，第一电磁辐射，第二电磁辐射，第三电磁辐射（与第一辐射相关联）或第四电磁辐射（与第二辐射相关联）的偏振状态可以重复地随着时间而变化，其具有比第一周期短的第二特征周期。用于成像至少一部分样品的数据可以作为偏振态的函数提供。另外或替代地，可以组合第三和第四电磁辐射，以便确定样品的至少一部分的轴向反射率分布。

7. 发明授权

US08922781B2 Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample 有权
标题翻译：用于通过同时照射和检测样品上的多个点来执行光学成像的装置，装置，内窥镜，导管和方法
公开(公告)号：US08922781B2
公开(公告)日：2014-12-30
申请号：US11288994
申请日：2005-11-29
申请人： Guillermo J. Tearney , Johannes F. de Boer , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Johannes F. de Boer , Brett Eugene Bouma
IPC分类号： G01B9/02 , G02B21/00 , A61B5/00 , G02B23/24 , G02B23/26
CPC分类号： G02B23/2469 , A61B5/0066 , A61B5/0073 , A61B5/6852 , G01B9/02001 , G01B9/02091 , G02B21/0032 , G02B21/0056 , G02B23/2453 , G02B23/26
摘要： Devices, arrangements, endoscopes, catheters and methods adapted to propagate at least one electro-magnetic radiation are provided. In particular, a waveguide apparatus specifically configured may be utilized to split the electro-magnetic radiation into a plurality of beams that are intended to illuminate a biological sample, and impart a unique associated characteristic unto each of the beams. The beams may be intended to illuminate a biological sample at distinct locations, and impart a unique associated characteristic unto each of the beams. In addition, a control apparatus may be provided which is configured to control at least one of the fibers and which can be input to the fibers so as to modify the unique associated characteristics of the beams being propagated along the fibers, and thereby modify the characteristics of the distinct locations on the sample.
摘要翻译：提供了适于传播至少一个电磁辐射的装置，布置，内窥镜，导管和方法。特别地，可以使用专门配置的波导装置将电磁辐射分割成旨在照射生物样品的多个光束，并且向每个光束赋予独特的相关特征。光束可以用于在不同的位置照射生物样品，并且赋予每个光束唯一的相关特征。此外，可以提供控制装置，其被配置为控制光纤中的至少一个并且可以输入到光纤，以便改变沿着光纤传播的光束的独特相关特性，从而改变特性的样品上不同的位置。

8. 发明申请

US20120002686A1 PROCESS AND APPARATUS FOR A WAVELENGTH TUNING SOURCE 有权
标题翻译：波长调谐源的过程和装置
公开(公告)号：US20120002686A1
公开(公告)日：2012-01-05
申请号：US13160335
申请日：2011-06-14
申请人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
发明人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
IPC分类号： H01S3/10
CPC分类号： G01J3/10 , A61B5/0059 , A61B5/0066 , G01B9/02004 , G01B9/02091 , G01J3/12 , G01J9/0215 , G01N21/4795 , G02B27/48 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S5/141 , H01S5/146 , H01S5/4087
摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.
摘要翻译：可以提供用于过滤电磁辐射的装置和源装置，其可以包括被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件的至少一个光谱分离装置。装置和源装置还可以具有至少一个连续旋转的光学布置，其被配置为接收与一个或多个部件相关联的至少一个信号。此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

9. 发明授权

US07864822B2 Process and apparatus for a wavelength tuning source 有权
标题翻译：用于波长调谐源的过程和装置
公开(公告)号：US07864822B2
公开(公告)日：2011-01-04
申请号：US12369556
申请日：2009-02-11
申请人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
发明人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
IPC分类号： H01S3/10
CPC分类号： G01J3/10 , A61B5/0059 , A61B5/0066 , G01B9/02004 , G01B9/02091 , G01J3/12 , G01J9/0215 , G01N21/4795 , G02B27/48 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S5/141 , H01S5/146 , H01S5/4087
摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.
摘要翻译：可以提供用于过滤电磁辐射的装置和源装置，其可以包括被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件的至少一个光谱分离装置。装置和源装置还可以具有至少一个连续旋转的光学布置，其被配置为接收与一个或多个部件相关联的至少一个信号。此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

10. 发明授权

US07797119B2 Apparatus and method for rangings and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands 有权
标题翻译：用于低相干干涉测量LCI和光学相干断层扫描的脉冲和降噪的装置和方法通过光谱带的并行检测
公开(公告)号：US07797119B2
公开(公告)日：2010-09-14
申请号：US11956129
申请日：2007-12-13
申请人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01R35/00
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。信号保持不变。喷射噪声的降低增加了系统的动态范围和灵敏度。

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