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91. 发明授权

US5514360A Negative thermal expansion materials 失效
标题翻译：负热膨胀材料
公开(公告)号：US5514360A
公开(公告)日：1996-05-07
申请号：US397695
申请日：1995-03-01
申请人： Arthur W. Sleight , Mary A. Thundathil , John S. O. Evans
发明人： Arthur W. Sleight , Mary A. Thundathil , John S. O. Evans
IPC分类号： C01G41/00 , C01G25/02 , C01G27/02
CPC分类号： C01G41/00
摘要： A method for making tungstate compounds according to the formula XW.sub.2 O.sub.8, wherein X is selected from the group consisting of zirconium, hafnium, and combinations thereof, is described. Also described are compositions that include the tungstate compounds, and a method for reducing the positive thermal expansion of a material using such tungstate compounds. Substantially single phase compounds can be made by practicing the method, which method also reduces the synthesis time relative to known methods, and expands the reactants that can be used for the synthesis over the methods reported previously. The tungstate compounds generally can be made by forming a solution, particularly an aqueous solution, comprising a W.sup.6+ compound and a second metal compound wherein the metal is selected from the group consisting of Zr.sup.4+, Hf.sup.4+ and combinations thereof. The solvent is removed from the solution by any known method to leave the solutes as a solid product. The solid product is then heated to a temperature of greater than about 600.degree. C., preferably at least about 1165.degree. C., more preferably from about 1165.degree. C. to about 1250.degree. C., and even more preferably to about 1200.degree. C. The heated product is then cooled to ambient temperature, generally relatively rapidly, to produce substantially single phase tungstate compounds.
摘要翻译：描述了制备根据式XW2O8的钨酸盐化合物的方法，其中X选自锆，铪及其组合。还描述了包括钨酸盐化合物的组合物，以及使用这种钨酸盐化合物减少材料的正热膨胀的方法。基本上单相化合物可以通过实施该方法制备，该方法相对于已知方法也降低了合成时间，并且扩展了可以用于合成的反应物，这些反应物先前报道的方法。钨酸盐化合物通常可以通过形成包含W6 +化合物和第二金属化合物的溶液，特别是水溶液来制备，其中金属选自Zr4 +，Hf4 +及其组合。通过任何已知的方法将溶剂从溶液中除去，以使溶质作为固体产物。然后将固体产物加热至大于约600℃，优选至少约1165℃，更优选约1165℃至约1250℃，甚至更优选至约1200℃的温度。然后将加热的产物通常相对快速地冷却至环境温度，以产生基本上单相的钨酸盐化合物。

92. 发明授权

US5470724A Boomerang DNA amplification 失效
标题翻译： Boomerang DNA扩增
公开(公告)号：US5470724A
公开(公告)日：1995-11-28
申请号：US184941
申请日：1994-01-19
申请人： Kevin G. Ahern
发明人： Kevin G. Ahern
IPC分类号： C07K14/415 , C12N15/10 , C12Q1/68 , C12P19/34
CPC分类号： C12N15/10 , C07K14/415 , C12Q1/6853
摘要： Methods for amplifying DNA sequences of interest are disclosed. The methods can be performed using only one primer and are also useful in cloning protocols and for sequencing large DNAs. The methods comprise cleaving a sample DNA using an agent, such as a restriction endonuclease, that produces discrete DNA fragments; ligating the fragments to "adapter" polynucleotides having a ligatable end and first and second self-complementary sequences separated by a spacer sequence, thereby forming ligated duplexes; denaturing the ligated duplexes to form templates; annealing molecules of an oligonucleotide primer to the templates, the primers being homologous to a primer target site associated with the sequence of interest; extending the primers using a DNA polymerizing agent to form duplex products; and denaturing the duplex products. Subsequent multiple cycles of annealing primers, extending the primers, and denaturing duplex products are usually performed so as to achieve the desired degree of amplification. Sequencing of large DNAs is performed using multiple rounds of DNA amplification, each round employing a primer homologous with a primer target site in the sequence of interest previously amplified. Cloning is facilitated by including a replication origin and selectable marker in the adapters.
摘要翻译：公开了扩增感兴趣的DNA序列的方法。该方法只能使用一个引物进行，也可用于克隆方案和测序大型DNA。所述方法包括使用产生离散DNA片段的试剂例如限制性内切核酸酶切割样品DNA; 将片段连接到具有可连接末端的“衔接子”多核苷酸和由间隔序列分隔的第一和第二自身互补序列，从而形成连接的双链体; 使连接的双链体变性以形成模板; 将寡核苷酸引物的退火分子与模板反应，引物与与感兴趣的序列相关的引物靶位点同源; 使用DNA聚合剂扩展引物以形成双链体产物; 并使双相产物变性。通常进行随后的退火引物，延伸引物和变性双链体的多个循环，以达到所需的扩增程度。使用多轮DNA扩增进行大DNA的测序，每轮使用与引物靶位点同源的引物，其预先扩增的感兴趣序列。通过在适配器中包含复制起点和可选标记来促进克隆。

93. 发明授权

US5212904A Fertilizing apparatus 失效
标题翻译：施肥设备
公开(公告)号：US5212904A
公开(公告)日：1993-05-25
申请号：US748854
申请日：1991-08-23
申请人： James L. Green , Bruce A. Briggs , Doris L. Briggs
发明人： James L. Green , Bruce A. Briggs , Doris L. Briggs
IPC分类号： A01G9/02 , A01G9/10 , A01G27/04 , A01G29/00
CPC分类号： A01G29/00
摘要： The fertilizing apparatus comprises a diffusion member having a porous member associated with it to retain fertilizer inside a compartment defined by the diffusion member. The diffusion member provides a diffusion pathway that is protected from gravitational water flow and rapid temperature fluctuation. The compartment is filled with fertilizer and inserted into growth media adjacent a plant's root system so that the diffusion pathway is substantially occupied by the plant growth media. A plurality of diffusion members, each member having a different length, may be used to establish diffusion times for specific fertilizer formulations. The fertilizing apparatus can be adapted for use with a closed, insulated pallet system for producing container-grown plants.
摘要翻译：施肥装置包括具有与其相关联的多孔构件的扩散构件，以将肥料保持在由扩散构件限定的隔室内。扩散构件提供了防止重力水流动和快速温度波动的扩散路径。隔室充满肥料，并插入到植物根系附近的生长培养基中，使得扩散途径基本上被植物生长培养基占据。可以使用多个扩散构件，每个构件具有不同的长度，以建立特定肥料制剂的扩散时间。施肥设备可以适用于封闭的绝缘托盘系统，用于生产容器生长的植物。

94. 发明授权

US5202891A Nonlinear optical material 失效
标题翻译：非线性光学材料
公开(公告)号：US5202891A
公开(公告)日：1993-04-13
申请号：US813211
申请日：1991-12-23
申请人： Arthur W. Sleight , Jinfan Huang
发明人： Arthur W. Sleight , Jinfan Huang
IPC分类号： G02F1/355
CPC分类号： G02F1/3551
摘要： Nonlinear optical materials having the general formula Ca.sub.1.40-X M.sub.X V.sub.0.98.+-.0.05 O.sub.4.00.+-.0.08 wherein X is 0.07 to 0.43 and M is selected from the group consisting of Bi, La, Ce, Y, Pm, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Sc, and mixtures thereof are described. Compositions satisfying this formula belong to the space group R3c wherein a=b=10.8.+-.0.1 .ANG., and c=38.0.+-.0.3 .ANG.. These NLO compositions are capable of doubling the frequency of light at about 0.1 to about 3.3 times the efficiency of KH.sub.2 PO.sub.4 (KDP). No damage to the NLO material is observed when they are exposed to high-power lasers.
摘要翻译：具有通式Ca1.40-XMXV0.98 +/- 0.05O4.00 +/- 0.08的非线性光学材料，其中X为0.07至0.43，M选自Bi，La，Ce，Y，Pm， Pr，Nd，Sm，Eu，Gd，Tb，Dy，Ho，Er，Tm，Yb，Lu，Sc及其混合物。满足该式的组合物属于空间群R3c，其中a = b = 10.8 +/- 0.1 ANGSTROM，c = 38.0 +/- 0.3 ANGSTROM。这些NLO组合物能够将光的频率加倍至KH2PO4（KDP）效率的约0.1至约3.3倍。当暴露于高功率激光器时，不会观察到NLO材料的损坏。

95. 发明授权

US5149992A MOS folded source-coupled logic 失效
标题翻译： MOS折叠源耦合逻辑
公开(公告)号：US5149992A
公开(公告)日：1992-09-22
申请号：US693532
申请日：1991-04-30
申请人： David J. Allstot , Sayfe Kiasei
发明人： David J. Allstot , Sayfe Kiasei
IPC分类号： H01L27/02 , H03K19/094
CPC分类号： H03K19/09432 , H01L27/0203
摘要： In integrated circuitry having both analog and digital circuits fabricated on the same substrate, switching transients produced by the digital circuitry can propagate through the substrate and induce deleterious effects in the associated analog circuitry. Such switching transients are greatly minimized by a CMOS source-coupled current-steering differential logic topology. In the preferred embodiment, gain and level shifting functions are merged, and connections to the power bus are made through constant current sources.
摘要翻译：在具有在相同衬底上制造的模拟和数字电路的集成电路中，由数字电路产生的开关瞬变可以传播通过衬底并且在相关联的模拟电路中引起有害影响。这种开关瞬变通过CMOS源极耦合的电流导向差分逻辑拓扑被大大地最小化。在优选实施例中，增益和电平移位功能被合并，并且通过恒定电流源与电力总线的连接。

96. 发明授权

US5039792A Allatostatins which inhibit insect juvenile hormone biosynthesis 失效
标题翻译：抑制昆虫幼体激素生物合成的抑制素
公开(公告)号：US5039792A
公开(公告)日：1991-08-13
申请号：US452163
申请日：1989-12-18
申请人： Rene Feyereisen , Grahame E. Pratt , Dan E. Farnsworth , Ned R. Siegel , Kam F. Fok
发明人： Rene Feyereisen , Grahame E. Pratt , Dan E. Farnsworth , Ned R. Siegel , Kam F. Fok
IPC分类号： C07K7/08
CPC分类号： C07K7/08 , Y10S530/858
摘要： An eighteen amino acid neuropeptide isolated from brain complexes of adult female cockroach, Diploptera punctata, is identified as an allatostatin because it inhibits the biosynthesis of juvenile growth hormone in cockroach corpora allata. Primary structure of the isolated allatostatin is Al a-Tyr-Ser-Tyr-Val-Ser-Glu-Tyr-Lys-Arg-Leu-Pro-Val-Tyr-Asn-Phe-Gly-Leu-NH.sub.2. A synthetic peptide of this sequence and three synthetic peptides with truncated sequences conserving the amidated carboxyl portion of the native sequence have allatostatin activity. Certain derivatives of the peptides also have allatostatin activity including compounds having the sequence: X-Val-Tyr-Asn-Phe-Gly-Leu-NH.sub.2, in which X is Leu-Arg, Leu-Pro, Arg-Leu-Pro-, Ala-Tyr-Ser-Tyr-Val-Ser-Glu-Tyr-Lys-Arg-Leu-Pro, acetyl-Ala-Tyr-Ser-Tyr-Val-Ser-Glu-Tyr-Lys-Arg-Leu-Pro, or acetyl-Arg-Leu-Pro. These peptides have the potential for regulating the growth of certain insects, and may be useful in the area of insect control.
摘要翻译：从成年雌性蟑螂（Diploptera punctata）的脑复合物中分离出的十八个氨基酸神经肽被鉴定为全收养素抑制因子，因为它抑制蟑螂中的幼体生长激素的生物合成。分离的全收养素的一级结构是Al a-Tyr-Ser-Tyr-Val-Ser-Glu-Tyr-Lys-Arg-Leu-Pro-Val-Tyr-Asn-Phe-Gly-Leu-NH 2。该序列的合成肽和保留天然序列的酰胺化羧基部分的具有截短序列的三个合成肽具有保护素的活性。肽的某些衍生物还具有全胃肠抑素活性，包括具有以下序列的化合物：X-Val-Tyr-Asn-Phe-Gly-Leu-NH 2，其中X为Leu-Arg，Leu-Pro，Arg-Leu-Pro- Ala-Tyr-Ser-Tyr-Val-Ser-Glu-Tyr-Lys-Arg-Leu-Pro，乙酰基-Ila-Tyr-Ser-Tyr-Val-Ser-Glu-Tyr-Lys-Arg-Leu-Pro，或乙酰基-Arg-Leu-Pro。这些肽具有调节某些昆虫生长的潜力，并且可能在昆虫控制领域是有用的。

97. 发明授权

US5034194A Windowless flow cell and mixing chamber 失效
标题翻译：无窗流通池和混合室
公开(公告)号：US5034194A
公开(公告)日：1991-07-23
申请号：US152012
申请日：1988-02-03
申请人： Robert J. Miller , James D. Ingle
发明人： Robert J. Miller , James D. Ingle
IPC分类号： G01N21/05 , G01N30/34 , G01N30/74 , G01N35/00 , G01N35/08
CPC分类号： G01N21/05 , G01N2021/0346 , G01N2030/347 , G01N2035/00514 , G01N35/085 , Y10S436/909
摘要： A windowless flow cell for detecting substances in a flowing fluid stream by chemiluminescence, fluorescence or absorption in flow injection analysis schemes, liquid chromatographs, or gas chromatographs is described. Furthermore, the mixing characteristics of the invention suggest its use as a micro-volume mixing chamber for a variety of experiments.A windowless flow cell comprising an upper body plate, upper wire spacer, mid-body plate, lower body spacer plate, and lower body plate interconnected by anchor bolts is described. Cell wires are attached to the upper body plate and the lower body plate. A primary reagent port through the upper body plate, with secondary reagent port and tertiary reagent port through the mid-body plate provide the fluids to be mixed. A thin film of the mixture of fluids to be examined flows down the cell wires through the examining chamber and through the drop detector and overflow detector prior to exiting the drain port by way of a low vacuum source.A micro-volume mixing chamber comprising a plexiglass mainframe with viewing windows of an examining chamber into which a plurality of reagent ports flow to form a fluid film on cell wires is described. The examining chamber also comprises gas inlet ports for control of pressure and of the type of gas environment.
摘要翻译：描述了用于通过流动注射分析方案中的化学发光，荧光或吸收来检测流动流体物流中的物质的无窗流动池，液相色谱仪或气相色谱仪。此外，本发明的混合特性表明其用作用于各种实验的微体积混合室。描述了一种无窗流动池，其包括通过地脚螺栓相互连接的上主体板，上部线间隔件，中部本体板，下部主体间隔板和下部主体板。电池线连接到上主体板和下主体板上。通过上体板的主试剂口，通过中体板的第二试剂口和第三试剂口提供要混合的流体。待检查的流体混合物的薄膜在通过低真空源离开排水口之前通过检查室和通过液滴检测器和溢流检测器流下。描述了一种微体积混合室，其包括具有检查室的观察窗的有机玻璃主机，多个试剂端口在其中流动以在单元电线上形成流体膜。检查室还包括用于控制压力和气体环境类型的气体入口。

98. 发明授权

US4820692A Methylthioribose analogs, their preparation and use as medicinal agents and biocides 失效
标题翻译：甲基二糖类似物，其制备和用作药剂和杀生物剂
公开(公告)号：US4820692A
公开(公告)日：1989-04-11
申请号：US1778
申请日：1987-01-09
申请人： Michael K. Riscoe , John H. Fitchen , Adolph J. Ferro
发明人： Michael K. Riscoe , John H. Fitchen , Adolph J. Ferro
IPC分类号： C07H5/02 , C07H15/14 , C07H19/06 , A61K31/70 , C07H15/00 , C07H15/04 , C12P13/12
CPC分类号： C07H5/02 , C07H15/14 , C07H19/06
摘要： Compounds of the formula: ##STR1## wherein R is H, Cl, F, Br, I or R.sub.1 S--, in which R.sub.1 is C.sub.1 -C.sub.10 linear or branched chain alkyl or halogenated linear or branched chain alkyl, andwherein R.sub.2, R.sub.3 and R.sub.4 are the same or different and each is H-- or --OH,with the proviso that at least one of R.sub.2, R.sub.3 and R.sub.4 is hydroxy and the further proviso that when R.sub.2, R.sub.3 and R.sub.4 are all OH, R.sub.1 is other than methyl, are useful in inhibiting the growth of MTR kinase-dependent microorganisms and parasitic protazoans. The compounds wherein R is R.sub.1 S are novel, except those wherein R.sub.1 is methyl or isobutyl when R.sub.2, R.sub.3 and R.sub.4 are all OH.
摘要翻译：其中R为H，Cl，F，Br，I或R1S + 13的化合物，其中R 1为C 1 -C 10直链或支链烷基或卤代直链或支链烷基，其中R2，R3 R 4和R 4相同或不同，各自为H或-OH，条件是R 2，R 3和R 4中的至少一个为羟基，另外条件是当R 2，R 3和R 4全部为OH时，R 1为甲基，可用于抑制MTR激酶依赖性微生物和寄生性原生动物的生长。其中R为R 1S的化合物是新的，除了当R 2，R 3和R 4全部为OH时，R 1为甲基或异丁基的那些化合物。

99. 发明授权

US4581359A Pharmacological treatments with N-7-substituted derivatives of theophylline 失效
标题翻译：用茶碱的N-7-取代衍生物进行药理学处理
公开(公告)号：US4581359A
公开(公告)日：1986-04-08
申请号：US602665
申请日：1984-04-23
申请人： James W. Ayres
发明人： James W. Ayres
IPC分类号： A61K31/52
CPC分类号： A61K31/52 , Y10S514/826
摘要： Methods for the management of bronchopulmonary insufficiency and other conditions are disclosed. The methods involve administration of an N-7-substituted derivative of theophylline selected from the group consisting of dyphylline, etophylline, proxyphylline and mixtures thereof. The derivative can be administered intravenously, intramuscularly, or in the lungs, concurrently with some form of theophylline or administered alone to a patient whose body has a known or an unknown theophylline content. Theophylline and the derivative can be administered in the same dosage form or in separate dosage forms. They can have the same route of administration or different routes of administration; for example, theophylline can be given orally, while the derivative is given as a zero-order intravenous infusion. A high total plasma concentration of methyl xanthine is achieved safely by using a combination of theophylline and one or more of the derivatives. Rapid injection of a loading dose of the derivative is also disclosed.
摘要翻译：公开了治疗支气管肺功能不全等条件的方法。所述方法包括施用选自由二苯胺，乙酸盐，丙酸盐及其混合物组成的组的茶碱的N-7-取代衍生物。该衍生物可以与某些形式的茶碱一起静脉内，肌肉内或肺内给药，或单独施用于其身体具有已知或未知的茶碱含量的患者。茶碱和衍生物可以以相同的剂型或分开的剂型给药。它们可以具有相同的给药途径或不同的给药途径; 例如，茶碱可以口服给药，而衍生物作为零级静脉输注给药。通过使用茶碱和一种或多种衍生物的组合，可以安全地实现甲基黄嘌呤的高总血浆浓度。还公开了快速注射载体剂量的衍生物。

100. 发明公开

US20240380408A9 SCALING-FRIENDLY, ANALOG CORRELATORS USING CHARGE-BASED MARGIN PROPAGATION 审中-公开
公开(公告)号：US20240380408A9
公开(公告)日：2024-11-14
申请号：US18485939
申请日：2023-10-12
申请人： Washington University , Oregon State University
发明人： Aravind Nagulu , Shantanu Chakrabartty , Arun Natarajan
IPC分类号： H03M1/12
CPC分类号： H03M1/124
摘要： A non-multiply-accumulate (non-MAC) charge-based analog correlator system including a sampler circuit block, an operand generation circuit block, and a margin propagation (MP) correlation computation circuit block is disclosed. The sampler circuit block is configured to sample a plurality of input analog signals. The operand generation circuit block is configured to generate operands based on the sampled plurality of input analog signals, and the margin propagation (MP) correlation computation circuit block is configured to generate correlated output signals based on the operands and using calculations in a charge domain.

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