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1. 发明授权

US07578951B2 Method of making microcapsules utilizing a fluid ejector 有权
标题翻译：利用流体喷射器制造微胶囊的方法
公开(公告)号：US07578951B2
公开(公告)日：2009-08-25
申请号：US10765402
申请日：2004-01-27
申请人： John Stephen Dunfield , James W. Ayres
发明人： John Stephen Dunfield , James W. Ayres
IPC分类号： B01J13/02 , B01J13/04 , A61K9/50 , B41J2/04
CPC分类号： B01J13/04 , B01J13/10 , B01J13/16 , Y10T428/2984
摘要： A method of making microcapsules including activating a fluid ejector at a frequency greater than 10 kilohertz where each activation of the fluid ejector generates essentially a drop, and the fluid ejector is fluidically coupled to a first fluid including a core component. The method further includes ejecting the drop of the first fluid into a second fluid, the drop having a volume. In addition, the method includes generating a microcapsule, that includes the core component, in the second fluid for each drop of the first fluid ejected.
摘要翻译：一种制造微胶囊的方法，包括以大于10千赫兹的频率活化流体喷射器，其中流体喷射器的每次激活基本上产生一滴，并且流体喷射器流体耦合到包括核心部件的第一流体。该方法还包括将第一流体的液滴喷射到第二流体中，该液滴具有一个体积。此外，该方法包括在喷射的第一流体的每一滴的第二流体中产生包括核心部件的微胶囊。

2. 发明授权

US06720005B1 Coated, platform-generating tablet 失效
公开(公告)号：US06720005B1
公开(公告)日：2004-04-13
申请号：US09887318
申请日：2001-06-21
申请人： James W. Ayres
发明人： James W. Ayres
IPC分类号： A61K936
CPC分类号： A61K9/2846 , A61K9/2059 , A61K9/2072 , A61K9/2866
摘要： An expanding tablet is described comprising a drug release controlling membrane material. After swallowing, the tablet hydrates and expands such that the membrane ruptures to directly expose some surfaces of the core tablet to hydrating and eroding liquids, thus generating in situ a tablet which is platform supported on non-exposed surfaces, and which releases active ingredient in approximately zero order fashion. More particularly, the dosage form is adapted for controlled release of various pharmaceuticals. A working embodiment of the tablet was a spray-coated tablet comprising a core having greater than 25% of an expandable material which expands upon exposure to an aqueous environment and at least one active ingredient, e.g., glipizide, and an outer rupturable coating surrounding the core comprising a rate release modifying membrane and a water-soluble modifier. A method for administering an active ingredient also is described. The method comprises (1) providing a tablet according to the invention, and (2) administering the tablet to a patient.

3. 发明授权

US4783253A Process for separating radioactive and hazardous metal contaminants from soils 失效
标题翻译：将放射性和有害金属污染物与土壤分离的过程
公开(公告)号：US4783253A
公开(公告)日：1988-11-08
申请号：US853995
申请日：1986-04-21
申请人： James W. Ayres , Alfred W. Western
发明人： James W. Ayres , Alfred W. Western
IPC分类号： B07C5/346 , B09C1/02 , B07C5/34 , B03B5/16
CPC分类号： B07C5/346 , B09C1/02
摘要： A process for treating radioactive contaminated soils to remove radioactive metal oxide contaminants therefrom comprises creating a suspension of particles of the soil in a column of water, alternately forcing fresh water in the column upwardly to force ligher soil particles upwardly in the column and allowing heavier particles to gravitationally settle in the bottom of the water column. The heavy particles comprising radioactive metal oxides are collected and handled for radioactive waste material storage. The aqueous slurry of lighter soil particles is directed to a separator for removing substantial amounts of water after which the particles are directed to a conveyor and spread out to a substantially uniform thickness and detected for any radioactivity. Portions of material in which radioactive particles are detected ar diverted and the uncontaminated soil material is recovered.
摘要翻译：用于处理放射性污染土壤以除去其中的放射性金属氧化物污染物的方法包括在水柱中产生土壤颗粒的悬浮液，交替地迫使柱中的淡水向上施力以迫使土壤颗粒在柱中向上并允许较重的颗粒重力沉降在水柱的底部。收集并处理包含放射性金属氧化物的重粒子用于放射性废物储存。较轻土壤颗粒的含水浆液被引导到用于除去大量水的分离器，之后将颗粒引导到输送机上并展开至基本上均匀的厚度并且检测任何放射性。检测到放射性粒子的部分材料被转移，未被污染的土壤物质被回收。

4. 发明授权

US4237888A Two-membrane medicated device for rate-controlled administration of prostaglandins 失效
标题翻译：用于速率控制前列腺素给药的双膜药物装置
公开(公告)号：US4237888A
公开(公告)日：1980-12-09
申请号：US23126
申请日：1979-03-23
申请人： Theodore J. Roseman , Osmer C. Carpenter , Richard W. Baker , James W. Ayres
发明人： Theodore J. Roseman , Osmer C. Carpenter , Richard W. Baker , James W. Ayres
IPC分类号： A61F13/20 , A61K9/00 , A61K31/557
CPC分类号： A61F13/28 , A61F13/2051 , A61F13/2068 , A61F13/2074 , A61K31/557 , A61K9/0036 , A61F13/2011 , A61F2013/8414
摘要： The present specification describes a medicated device adapted for a single, acute, and rate-controlled rectal or vaginal administration to a mammal of a lipophilic prostaglandin. The device accomplishes drug administration at an essentially time-independent rate of dosage. Further, the device advantageously results in the substantial exhaustion of the prostaglandin from the device at the conclusion of the single, acute use. The device comprises three elements:(A) an inert resilient support means contoured for easy vaginal or rectal insertion;(B) a first flexible polymer film layer affixed to the support means and containing the prostaglandin dispersed therethrough, this first polymer film not being rate limiting as to the release of drug from the device; and(C) a second polymer film, laminated onto the first polymer film and providing a release rate therefrom of prostaglandin, which is rate limiting both as to the release of prostaglandin from the device and absorption rate by the rectal or vaginal tissues.
摘要翻译：本说明书描述适用于对亲脂性前列腺素的哺乳动物的单次，急性和速率控制的直肠或阴道给药的药物装置。该装置以基本上时间独立的剂量速率实现药物给药。此外，该装置有利地导致在单次急性使用结束时来自装置的前列腺素的显着耗尽。该装置包括三个元件：（A）易于阴道或直肠插入的惰性弹性支撑装置; （B）固定在支撑装置上并含有分散在其中的前列腺素的第一柔性聚合物膜层，该第一聚合物膜不限制药物从装置中的释放; 和（C）第二聚合物膜，层压在第一聚合物膜上并提供前列腺素的释放速率，前列腺素的释放速率限于前列腺素从装置中的释放和由直肠或阴道组织吸收的速率。

5. 发明授权

US5260061A Propionibacteria metabolites inhibit spoilage yeast in foods 失效
标题翻译：丙酸杆菌代谢物抑制食物中的腐败酵母
公开(公告)号：US5260061A
公开(公告)日：1993-11-09
申请号：US852292
申请日：1992-03-16
申请人： James W. Ayres , William E. Sandine , George H. Weber
发明人： James W. Ayres , William E. Sandine , George H. Weber
IPC分类号： A23C9/12 , A23C9/127 , A23C19/06 , A23C19/10 , A23L2/44 , A23L3/3508 , A23L3/3526 , A23L3/3571 , A61K38/00 , C12G3/02 , C12H1/00 , A23C3/08 , A23C13/16 , A23C19/11 , A23L3/00
CPC分类号： A23C19/062 , A23C19/10 , A23C9/1203 , A23C9/127 , A23L2/44 , A23L3/3508 , A23L3/3526 , A23L3/3571 , C12G3/02 , C12H1/006 , A23Y2300/00 , A61K38/00 , Y10S435/822
摘要： A metabolite material of propionibacteria is added to a food product to inhibit the growth of yeast. The metabolite material is produced by growing propionibacteria cells in a liquid growth medium to produce a mixture containing the metabolite material. The mixture can be concentrated and added to a food product as a concentrated liquid or powder. The metabolite material added to a food product may contain viable cells of propionibacteria.

6. 发明授权

US4983406A Preservation of feed 失效
标题翻译：保存饲料
公开(公告)号：US4983406A
公开(公告)日：1991-01-08
申请号：US343948
申请日：1989-04-25
申请人： James W. Ayres , William E. Sandine , Richard B. Parker
发明人： James W. Ayres , William E. Sandine , Richard B. Parker
IPC分类号： A23K3/03
CPC分类号： A23K30/18 , A23K30/15 , Y10S426/807
摘要： This invention relates to the preservation of high moisture animal feeds which utilize a fermentation (either natural or induced) to improve the quality of the animal food. More specifically, this invention utilizes dimethyl fumarate (DMF) in plant feeds in combination with fermentation microorganisms to produce an animal feed which is high in nutrient value and low in spoilage microorganisms.
摘要翻译：本发明涉及使用发酵（天然或诱导的）来提高动物食品质量的高水分动物饲料的保存。更具体地说，本发明利用发酵微生物与植物饲料中的富马酸二甲酯（DMF）相结合产生营养价值高且腐败微生物低的动物饲料。

7. 再颁专利

USRE32079E Method and starter compositions for the growth of acid producing bacteria and bacterial compositions produced thereby 失效
标题翻译：用于生产酸产生菌的方法和起始组合物以及由此产生的细菌组合物
公开(公告)号：USRE32079E
公开(公告)日：1986-02-04
申请号：US519391
申请日：1983-08-01
申请人： William E. Sandine , James W. Ayres
发明人： William E. Sandine , James W. Ayres
IPC分类号： A23C19/032 , C12N1/00 , C12N1/04 , C12N1/20 , C12N1/38
CPC分类号： C12N1/04 , A23C19/0323 , C12N1/00 , C12N1/20 , C12N1/38
摘要： A method for growing acid producing bacteria in the presence of an essentially water insoluble or a temporarily water insolubilized and thus initially solid form of a neutralizing agent in a growth medium is described. The water insoluble or insolubilized neutralizing agent is a base, basic salt or mixture thereof adapted to provide a controlled reaction with the acid produced by the bacteria without substantially raising the pH of the growth medium. Preferably the neutralizing agent is in a water insoluble form. Bulk starter compositions for growing the bacteria including the insoluble or the insolubilized neutralizing agent are also described. Further, bacterial compositions with enchanced storability and viability because of the insoluble or the insolubilized neutralizing agent are described. The method and bulk starter compositions are particularly adapted to growing lactic acid producing bacteria which are then used in making food and beverage products for animals and humans.

8. 发明授权

US4308867A Two-member medicated device for rate-controlled administration of lipophilic pharmaceuticals 失效
标题翻译：用于脂质药物速率控制的双组分药物装置
公开(公告)号：US4308867A
公开(公告)日：1982-01-05
申请号：US23125
申请日：1979-03-23
申请人： Theodore J. Roseman , Osmer S. Carpenter , Richard W. Baker , James W. Ayres
发明人： Theodore J. Roseman , Osmer S. Carpenter , Richard W. Baker , James W. Ayres
IPC分类号： A61K9/48 , A61F13/20 , A61K9/00 , A61K31/557 , A61M7/00
CPC分类号： A61F13/28 , A61F13/2051 , A61F13/2068 , A61F13/2074 , A61K31/557 , A61K9/0036 , A61F13/2011 , Y10S604/904
摘要： The present specification describes a medicated device adapted for a single and rate-controlled rectal or vaginal administration to a mammal of a systemically active pharmaceutical (SAP). The device accomplishes drug administration at an essentially time-independent rate of dosage. Further, the device advantageously results in the substantial exhaustion of the SAP from the device at the conclusion of the single, acute use. The device comprises three elements:(A) an inert resilient support means contoured for easy vaginal or rectal insertion;(B) a first flexible polymer film layer affixed to the support means and containing the SAP dispersed therethrough, this first polymer film not being rate limiting as to the release of drug from the device; and(C) a second polymer film, laminated onto the first polymer film and providing a release rate therefrom of prostaglandin, which is rate limiting both as to the release of prostaglandin from the device and absorption rate by the rectal or vaginal tissues.
摘要翻译：本说明书描述了一种适用于单一和速率控制的直肠或阴道给药的药物装置，其用于系统活性药物（SAP）的哺乳动物。该装置以基本上时间独立的剂量速率实现药物给药。此外，该装置有利地导致在单次急性使用结束时SAP从装置中显着耗尽。该装置包括三个元件：（A）易于阴道或直肠插入的惰性弹性支撑装置; （B）第一柔性聚合物膜层，其固定在支撑装置上并含有分散在其中的SAP，该第一聚合物膜不能限制药物从装置中的释放; 和（C）第二聚合物膜，层压在第一聚合物膜上并提供前列腺素的释放速率，前列腺素的释放速率限于前列腺素从装置中的释放和由直肠或阴道组织吸收的速率。

9. 发明授权

US5707652A Methods of treating circadian rhythm phase disorders 失效
标题翻译：治疗昼夜节律期疾病的方法
公开(公告)号：US5707652A
公开(公告)日：1998-01-13
申请号：US480558
申请日：1995-06-07
申请人： Alfred J. Lewy , Robert L. Sack , Keith A. Parrott , James W. Ayres
发明人： Alfred J. Lewy , Robert L. Sack , Keith A. Parrott , James W. Ayres
IPC分类号： A61K9/22 , A61K9/52 , A61K31/40 , A61K31/4045 , A61K45/06 , A61K9/26 , A61K9/54
CPC分类号： A61K9/5047 , A61K31/40 , A61K31/4045 , A61K45/06 , A61K9/5078 , A61K9/5084
摘要： Methods for treating circadian rhythm disorders and sleep disorders are described. The method involves oral administration of a sustained release composition of melatonin to produce a normal melatonin pattern when the normal pattern has been disrupted or is missing.
摘要翻译：描述了治疗昼夜节律障碍和睡眠障碍的方法。该方法包括口服施用褪黑激素的持续释放组合物，以在正常模式被破坏或缺失时产生正常的褪黑激素模式。

10. 发明授权

US4581359A Pharmacological treatments with N-7-substituted derivatives of theophylline 失效
标题翻译：用茶碱的N-7-取代衍生物进行药理学处理
公开(公告)号：US4581359A
公开(公告)日：1986-04-08
申请号：US602665
申请日：1984-04-23
申请人： James W. Ayres
发明人： James W. Ayres
IPC分类号： A61K31/52
CPC分类号： A61K31/52 , Y10S514/826
摘要： Methods for the management of bronchopulmonary insufficiency and other conditions are disclosed. The methods involve administration of an N-7-substituted derivative of theophylline selected from the group consisting of dyphylline, etophylline, proxyphylline and mixtures thereof. The derivative can be administered intravenously, intramuscularly, or in the lungs, concurrently with some form of theophylline or administered alone to a patient whose body has a known or an unknown theophylline content. Theophylline and the derivative can be administered in the same dosage form or in separate dosage forms. They can have the same route of administration or different routes of administration; for example, theophylline can be given orally, while the derivative is given as a zero-order intravenous infusion. A high total plasma concentration of methyl xanthine is achieved safely by using a combination of theophylline and one or more of the derivatives. Rapid injection of a loading dose of the derivative is also disclosed.
摘要翻译：公开了治疗支气管肺功能不全等条件的方法。所述方法包括施用选自由二苯胺，乙酸盐，丙酸盐及其混合物组成的组的茶碱的N-7-取代衍生物。该衍生物可以与某些形式的茶碱一起静脉内，肌肉内或肺内给药，或单独施用于其身体具有已知或未知的茶碱含量的患者。茶碱和衍生物可以以相同的剂型或分开的剂型给药。它们可以具有相同的给药途径或不同的给药途径; 例如，茶碱可以口服给药，而衍生物作为零级静脉输注给药。通过使用茶碱和一种或多种衍生物的组合，可以安全地实现甲基黄嘌呤的高总血浆浓度。还公开了快速注射载体剂量的衍生物。

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