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1. 发明授权

US07578951B2 Method of making microcapsules utilizing a fluid ejector 有权
标题翻译：利用流体喷射器制造微胶囊的方法
公开(公告)号：US07578951B2
公开(公告)日：2009-08-25
申请号：US10765402
申请日：2004-01-27
申请人： John Stephen Dunfield , James W. Ayres
发明人： John Stephen Dunfield , James W. Ayres
IPC分类号： B01J13/02 , B01J13/04 , A61K9/50 , B41J2/04
CPC分类号： B01J13/04 , B01J13/10 , B01J13/16 , Y10T428/2984
摘要： A method of making microcapsules including activating a fluid ejector at a frequency greater than 10 kilohertz where each activation of the fluid ejector generates essentially a drop, and the fluid ejector is fluidically coupled to a first fluid including a core component. The method further includes ejecting the drop of the first fluid into a second fluid, the drop having a volume. In addition, the method includes generating a microcapsule, that includes the core component, in the second fluid for each drop of the first fluid ejected.
摘要翻译：一种制造微胶囊的方法，包括以大于10千赫兹的频率活化流体喷射器，其中流体喷射器的每次激活基本上产生一滴，并且流体喷射器流体耦合到包括核心部件的第一流体。该方法还包括将第一流体的液滴喷射到第二流体中，该液滴具有一个体积。此外，该方法包括在喷射的第一流体的每一滴的第二流体中产生包括核心部件的微胶囊。

2. 发明授权

US06720005B1 Coated, platform-generating tablet 失效
公开(公告)号：US06720005B1
公开(公告)日：2004-04-13
申请号：US09887318
申请日：2001-06-21
申请人： James W. Ayres
发明人： James W. Ayres
IPC分类号： A61K936
CPC分类号： A61K9/2846 , A61K9/2059 , A61K9/2072 , A61K9/2866
摘要： An expanding tablet is described comprising a drug release controlling membrane material. After swallowing, the tablet hydrates and expands such that the membrane ruptures to directly expose some surfaces of the core tablet to hydrating and eroding liquids, thus generating in situ a tablet which is platform supported on non-exposed surfaces, and which releases active ingredient in approximately zero order fashion. More particularly, the dosage form is adapted for controlled release of various pharmaceuticals. A working embodiment of the tablet was a spray-coated tablet comprising a core having greater than 25% of an expandable material which expands upon exposure to an aqueous environment and at least one active ingredient, e.g., glipizide, and an outer rupturable coating surrounding the core comprising a rate release modifying membrane and a water-soluble modifier. A method for administering an active ingredient also is described. The method comprises (1) providing a tablet according to the invention, and (2) administering the tablet to a patient.

3. 发明授权

US4783253A Process for separating radioactive and hazardous metal contaminants from soils 失效
标题翻译：将放射性和有害金属污染物与土壤分离的过程
公开(公告)号：US4783253A
公开(公告)日：1988-11-08
申请号：US853995
申请日：1986-04-21
申请人： James W. Ayres , Alfred W. Western
发明人： James W. Ayres , Alfred W. Western
IPC分类号： B07C5/346 , B09C1/02 , B07C5/34 , B03B5/16
CPC分类号： B07C5/346 , B09C1/02
摘要： A process for treating radioactive contaminated soils to remove radioactive metal oxide contaminants therefrom comprises creating a suspension of particles of the soil in a column of water, alternately forcing fresh water in the column upwardly to force ligher soil particles upwardly in the column and allowing heavier particles to gravitationally settle in the bottom of the water column. The heavy particles comprising radioactive metal oxides are collected and handled for radioactive waste material storage. The aqueous slurry of lighter soil particles is directed to a separator for removing substantial amounts of water after which the particles are directed to a conveyor and spread out to a substantially uniform thickness and detected for any radioactivity. Portions of material in which radioactive particles are detected ar diverted and the uncontaminated soil material is recovered.
摘要翻译：用于处理放射性污染土壤以除去其中的放射性金属氧化物污染物的方法包括在水柱中产生土壤颗粒的悬浮液，交替地迫使柱中的淡水向上施力以迫使土壤颗粒在柱中向上并允许较重的颗粒重力沉降在水柱的底部。收集并处理包含放射性金属氧化物的重粒子用于放射性废物储存。较轻土壤颗粒的含水浆液被引导到用于除去大量水的分离器，之后将颗粒引导到输送机上并展开至基本上均匀的厚度并且检测任何放射性。检测到放射性粒子的部分材料被转移，未被污染的土壤物质被回收。

4. 发明授权

US4237888A Two-membrane medicated device for rate-controlled administration of prostaglandins 失效
标题翻译：用于速率控制前列腺素给药的双膜药物装置
公开(公告)号：US4237888A
公开(公告)日：1980-12-09
申请号：US23126
申请日：1979-03-23
申请人： Theodore J. Roseman , Osmer C. Carpenter , Richard W. Baker , James W. Ayres
发明人： Theodore J. Roseman , Osmer C. Carpenter , Richard W. Baker , James W. Ayres
IPC分类号： A61F13/20 , A61K9/00 , A61K31/557
CPC分类号： A61F13/28 , A61F13/2051 , A61F13/2068 , A61F13/2074 , A61K31/557 , A61K9/0036 , A61F13/2011 , A61F2013/8414
摘要： The present specification describes a medicated device adapted for a single, acute, and rate-controlled rectal or vaginal administration to a mammal of a lipophilic prostaglandin. The device accomplishes drug administration at an essentially time-independent rate of dosage. Further, the device advantageously results in the substantial exhaustion of the prostaglandin from the device at the conclusion of the single, acute use. The device comprises three elements:(A) an inert resilient support means contoured for easy vaginal or rectal insertion;(B) a first flexible polymer film layer affixed to the support means and containing the prostaglandin dispersed therethrough, this first polymer film not being rate limiting as to the release of drug from the device; and(C) a second polymer film, laminated onto the first polymer film and providing a release rate therefrom of prostaglandin, which is rate limiting both as to the release of prostaglandin from the device and absorption rate by the rectal or vaginal tissues.
摘要翻译：本说明书描述适用于对亲脂性前列腺素的哺乳动物的单次，急性和速率控制的直肠或阴道给药的药物装置。该装置以基本上时间独立的剂量速率实现药物给药。此外，该装置有利地导致在单次急性使用结束时来自装置的前列腺素的显着耗尽。该装置包括三个元件：（A）易于阴道或直肠插入的惰性弹性支撑装置; （B）固定在支撑装置上并含有分散在其中的前列腺素的第一柔性聚合物膜层，该第一聚合物膜不限制药物从装置中的释放; 和（C）第二聚合物膜，层压在第一聚合物膜上并提供前列腺素的释放速率，前列腺素的释放速率限于前列腺素从装置中的释放和由直肠或阴道组织吸收的速率。

5. 发明授权

US5260061A Propionibacteria metabolites inhibit spoilage yeast in foods 失效
标题翻译：丙酸杆菌代谢物抑制食物中的腐败酵母
公开(公告)号：US5260061A
公开(公告)日：1993-11-09
申请号：US852292
申请日：1992-03-16
申请人： James W. Ayres , William E. Sandine , George H. Weber
发明人： James W. Ayres , William E. Sandine , George H. Weber
IPC分类号： A23C9/12 , A23C9/127 , A23C19/06 , A23C19/10 , A23L2/44 , A23L3/3508 , A23L3/3526 , A23L3/3571 , A61K38/00 , C12G3/02 , C12H1/00 , A23C3/08 , A23C13/16 , A23C19/11 , A23L3/00
CPC分类号： A23C19/062 , A23C19/10 , A23C9/1203 , A23C9/127 , A23L2/44 , A23L3/3508 , A23L3/3526 , A23L3/3571 , C12G3/02 , C12H1/006 , A23Y2300/00 , A61K38/00 , Y10S435/822
摘要： A metabolite material of propionibacteria is added to a food product to inhibit the growth of yeast. The metabolite material is produced by growing propionibacteria cells in a liquid growth medium to produce a mixture containing the metabolite material. The mixture can be concentrated and added to a food product as a concentrated liquid or powder. The metabolite material added to a food product may contain viable cells of propionibacteria.

6. 发明授权

US4983406A Preservation of feed 失效
标题翻译：保存饲料
公开(公告)号：US4983406A
公开(公告)日：1991-01-08
申请号：US343948
申请日：1989-04-25
申请人： James W. Ayres , William E. Sandine , Richard B. Parker
发明人： James W. Ayres , William E. Sandine , Richard B. Parker
IPC分类号： A23K3/03
CPC分类号： A23K30/18 , A23K30/15 , Y10S426/807
摘要： This invention relates to the preservation of high moisture animal feeds which utilize a fermentation (either natural or induced) to improve the quality of the animal food. More specifically, this invention utilizes dimethyl fumarate (DMF) in plant feeds in combination with fermentation microorganisms to produce an animal feed which is high in nutrient value and low in spoilage microorganisms.
摘要翻译：本发明涉及使用发酵（天然或诱导的）来提高动物食品质量的高水分动物饲料的保存。更具体地说，本发明利用发酵微生物与植物饲料中的富马酸二甲酯（DMF）相结合产生营养价值高且腐败微生物低的动物饲料。

7. 再颁专利

USRE32079E Method and starter compositions for the growth of acid producing bacteria and bacterial compositions produced thereby 失效
标题翻译：用于生产酸产生菌的方法和起始组合物以及由此产生的细菌组合物
公开(公告)号：USRE32079E
公开(公告)日：1986-02-04
申请号：US519391
申请日：1983-08-01
申请人： William E. Sandine , James W. Ayres
发明人： William E. Sandine , James W. Ayres
IPC分类号： A23C19/032 , C12N1/00 , C12N1/04 , C12N1/20 , C12N1/38
CPC分类号： C12N1/04 , A23C19/0323 , C12N1/00 , C12N1/20 , C12N1/38
摘要： A method for growing acid producing bacteria in the presence of an essentially water insoluble or a temporarily water insolubilized and thus initially solid form of a neutralizing agent in a growth medium is described. The water insoluble or insolubilized neutralizing agent is a base, basic salt or mixture thereof adapted to provide a controlled reaction with the acid produced by the bacteria without substantially raising the pH of the growth medium. Preferably the neutralizing agent is in a water insoluble form. Bulk starter compositions for growing the bacteria including the insoluble or the insolubilized neutralizing agent are also described. Further, bacterial compositions with enchanced storability and viability because of the insoluble or the insolubilized neutralizing agent are described. The method and bulk starter compositions are particularly adapted to growing lactic acid producing bacteria which are then used in making food and beverage products for animals and humans.

8. 发明授权

US4308867A Two-member medicated device for rate-controlled administration of lipophilic pharmaceuticals 失效
标题翻译：用于脂质药物速率控制的双组分药物装置
公开(公告)号：US4308867A
公开(公告)日：1982-01-05
申请号：US23125
申请日：1979-03-23
申请人： Theodore J. Roseman , Osmer S. Carpenter , Richard W. Baker , James W. Ayres
发明人： Theodore J. Roseman , Osmer S. Carpenter , Richard W. Baker , James W. Ayres
IPC分类号： A61K9/48 , A61F13/20 , A61K9/00 , A61K31/557 , A61M7/00
CPC分类号： A61F13/28 , A61F13/2051 , A61F13/2068 , A61F13/2074 , A61K31/557 , A61K9/0036 , A61F13/2011 , Y10S604/904
摘要： The present specification describes a medicated device adapted for a single and rate-controlled rectal or vaginal administration to a mammal of a systemically active pharmaceutical (SAP). The device accomplishes drug administration at an essentially time-independent rate of dosage. Further, the device advantageously results in the substantial exhaustion of the SAP from the device at the conclusion of the single, acute use. The device comprises three elements:(A) an inert resilient support means contoured for easy vaginal or rectal insertion;(B) a first flexible polymer film layer affixed to the support means and containing the SAP dispersed therethrough, this first polymer film not being rate limiting as to the release of drug from the device; and(C) a second polymer film, laminated onto the first polymer film and providing a release rate therefrom of prostaglandin, which is rate limiting both as to the release of prostaglandin from the device and absorption rate by the rectal or vaginal tissues.
摘要翻译：本说明书描述了一种适用于单一和速率控制的直肠或阴道给药的药物装置，其用于系统活性药物（SAP）的哺乳动物。该装置以基本上时间独立的剂量速率实现药物给药。此外，该装置有利地导致在单次急性使用结束时SAP从装置中显着耗尽。该装置包括三个元件：（A）易于阴道或直肠插入的惰性弹性支撑装置; （B）第一柔性聚合物膜层，其固定在支撑装置上并含有分散在其中的SAP，该第一聚合物膜不能限制药物从装置中的释放; 和（C）第二聚合物膜，层压在第一聚合物膜上并提供前列腺素的释放速率，前列腺素的释放速率限于前列腺素从装置中的释放和由直肠或阴道组织吸收的速率。

9. 发明申请

US20090317458A1 Fluid-jet pens configured for making modulated release bioactive agents 有权
标题翻译：配置用于制备调制释放生物活性剂的流体喷枪
公开(公告)号：US20090317458A1
公开(公告)日：2009-12-24
申请号：US12551134
申请日：2009-08-31
申请人： JOHN STEPHEN DUNFIELD , JAMES W. AYRES
发明人： JOHN STEPHEN DUNFIELD , JAMES W. AYRES
IPC分类号： A61K9/127
CPC分类号： A61K9/10 , A61K9/1075 , A61K9/113 , A61K9/1277
摘要： The present invention is drawn to methods of preparing a bioactive agent-containing emulsion for delivery to a biological system. This method can comprise the step of jetting a bioactive agent and a first fluid medium from a fluid-jet pen into a second fluid medium to form a bioactive agent-containing emulsion, wherein the second fluid comprises a continuous phase of the emulsion. Alternatively, a method of preparing a bioactive agent-containing liposome can comprise jetting a lipid-containing composition and a bioactive agent from a fluid-jet pen into a medium to form a bioactive agent-containing liposome carried by the medium. The present invention is also drawn to fluid-jet pens and systems configured for making liposome- and emulsion-containing biological agents.
摘要翻译：本发明涉及制备用于递送至生物系统的含生物活性剂的乳液的方法。该方法可以包括将生物活性剂和第一流体介质从流体喷射笔喷射到第二流体介质中以形成含生物活性剂的乳液的步骤，其中第二流体包含乳液的连续相。或者，制备含生物活性剂的脂质体的方法可以包括将来自流体喷射笔的含脂质组合物和生物活性剂喷射到培养基中以形成由培养基携带的含生物活性剂的脂质体。本发明还涉及配置用于制备含脂质体和乳液的生物制剂的流体喷射笔和系统。

10. 发明授权

US06733784B1 Coated, platform-generating tablet 失效
标题翻译：涂层平台生产平板电脑
公开(公告)号：US06733784B1
公开(公告)日：2004-05-11
申请号：US10334835
申请日：2002-12-31
申请人： James W. Ayres
发明人： James W. Ayres
IPC分类号： A61K928
CPC分类号： A61K9/2846 , A61K9/2059 , A61K9/2072 , A61K9/2866
摘要： An expanding tablet is described comprising a drug release controlling membrane material. After swallowing, the tablet hydrates and expands such that the membrane ruptures to directly expose some surfaces of the core tablet to hydrating and eroding liquids, thus generating in situ a tablet which is platform supported on non-exposed surfaces, and which releases active ingredient in approximately zero order fashion. More particularly, the dosage form is adapted for controlled release of various pharmaceuticals. A working embodiment of the tablet was a spray-coated tablet comprising a core having greater than 25% of an expandable material which expands upon exposure to an aqueous environment and at least one active ingredient, e.g., glipizide, and an outer rupturable coating surrounding the core comprising a rate release modifying membrane and a water-soluble modifier. A method for administering an active ingredient also is described. The method comprises (1) providing a tablet according to the invention, and (2) administering the tablet to a patient.
摘要翻译：描述了包含药物释放控制膜材料的膨胀片剂。吞咽后，片剂水合并膨胀，使得膜破裂以直接暴露芯片的一些表面以水合和侵蚀液体，从而原位产生平板支撑在非暴露表面上的片剂，并释放活性成分大概零级时尚。更具体地，剂型适于各种药物的控制释放。片剂的一个实施方案是喷涂片剂，其包含具有大于25％的可膨胀材料的核心，所述可膨胀材料在暴露于水性环境中时膨胀，并且至少一种活性成分例如格列吡嗪和外部可破裂涂层芯包含速率释放修饰膜和水溶性改性剂。还描述了施用活性成分的方法。该方法包括（1）提供根据本发明的片剂，和（2）将片剂给予患者。

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