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1. 发明授权

US4820692A Methylthioribose analogs, their preparation and use as medicinal agents and biocides 失效
标题翻译：甲基二糖类似物，其制备和用作药剂和杀生物剂
公开(公告)号：US4820692A
公开(公告)日：1989-04-11
申请号：US1778
申请日：1987-01-09
申请人： Michael K. Riscoe , John H. Fitchen , Adolph J. Ferro
发明人： Michael K. Riscoe , John H. Fitchen , Adolph J. Ferro
IPC分类号： C07H5/02 , C07H15/14 , C07H19/06 , A61K31/70 , C07H15/00 , C07H15/04 , C12P13/12
CPC分类号： C07H5/02 , C07H15/14 , C07H19/06
摘要： Compounds of the formula: ##STR1## wherein R is H, Cl, F, Br, I or R.sub.1 S--, in which R.sub.1 is C.sub.1 -C.sub.10 linear or branched chain alkyl or halogenated linear or branched chain alkyl, andwherein R.sub.2, R.sub.3 and R.sub.4 are the same or different and each is H-- or --OH,with the proviso that at least one of R.sub.2, R.sub.3 and R.sub.4 is hydroxy and the further proviso that when R.sub.2, R.sub.3 and R.sub.4 are all OH, R.sub.1 is other than methyl, are useful in inhibiting the growth of MTR kinase-dependent microorganisms and parasitic protazoans. The compounds wherein R is R.sub.1 S are novel, except those wherein R.sub.1 is methyl or isobutyl when R.sub.2, R.sub.3 and R.sub.4 are all OH.
摘要翻译：其中R为H，Cl，F，Br，I或R1S + 13的化合物，其中R 1为C 1 -C 10直链或支链烷基或卤代直链或支链烷基，其中R2，R3 R 4和R 4相同或不同，各自为H或-OH，条件是R 2，R 3和R 4中的至少一个为羟基，另外条件是当R 2，R 3和R 4全部为OH时，R 1为甲基，可用于抑制MTR激酶依赖性微生物和寄生性原生动物的生长。其中R为R 1S的化合物是新的，除了当R 2，R 3和R 4全部为OH时，R 1为甲基或异丁基的那些化合物。

2. 发明授权

US5416250A Genetic control of ethylene biosynthesis in plants using S-adenosylmethionine hydrolase 失效
标题翻译：使用S-腺苷甲硫氨酸水解酶对植物进行乙烯生物合成的遗传控制
公开(公告)号：US5416250A
公开(公告)日：1995-05-16
申请号：US255833
申请日：1994-06-08
申请人： Adolph J. Ferro , Richard K. Bestwick , Lyle R. Brown
发明人： Adolph J. Ferro , Richard K. Bestwick , Lyle R. Brown
IPC分类号： C12N9/14 , C12N15/82 , A01H4/00
CPC分类号： C12N15/8222 , C12N15/8235 , C12N15/8249 , C12N9/14
摘要： A method for control of ethylene biosynthesis in plants comprising a vector containing a selective gene under plant promoter control, and a DNA insert comprising codons for a functional heterologous polypeptide having AdoMetase activity and flanked by a plant promoter on one side and a polyA signal sequence on the other side; and,transforming a plant host with said vector wherein the plant host transformed thereby is capable of expressing the heterologous polypeptide having AdoMetase activity under the control of said control region. The presence of the AdoMetase gene and the expression of AdoMetase in transgenic plants lowers AdoMet levels and generates an inhibitor of ACC synthase causing a corresponding decrease in ethylene biosynthesis and precursor availability. The current construction of transgenic plants containing a copy(s) of the T3 AdoMetase gene allow for construction of plants that will control ethylene biosynthesis under restricted conditions resulting in fruits, vegetables, and flowers which have been modified internally to improve shelf life and preservation qualities.
摘要翻译：一种用于在植物中控制乙烯生物合成的方法，其包含在植物启动子控制下含有选择性基因的载体，以及DNA插入片段，其包含具有AdoMetase活性的功能性异源多肽的密码子，并且侧面有一侧的植物启动子和polyA信号序列另一边; 并且用所述载体转化植物宿主，其中由此转化的植物宿主能够在所述对照区域的控制下表达具有AdoMetase活性的异源多肽。 AdoMetase基因的存在和AdoMetase在转基因植物中的表达降低了AdoMet水平，并产生了ACC合成酶的抑制剂，导致乙烯生物合成和前体可用性的相应降低。目前，含有T3 AdoMetase基因拷贝的转基因植物的构建允许在限制条件下控制乙烯生物合成的植物的构建，从而在内部进行改良以改善保质期和保存性质的水果，蔬菜和鲜花。

3. 发明授权

US5589623A Genetic control of ethylene biosynthesis in plants 失效
标题翻译：植物中乙烯生物合成的遗传控制
公开(公告)号：US5589623A
公开(公告)日：1996-12-31
申请号：US360974
申请日：1994-12-20
申请人： Adolph J. Ferro , Richard K. Bestwick , Lyle R. Brown
发明人： Adolph J. Ferro , Richard K. Bestwick , Lyle R. Brown
IPC分类号： C12N9/14 , C12N15/82 , A01H4/00
CPC分类号： C12N15/8222 , C12N15/8235 , C12N15/8249 , C12N9/14
摘要： A method for control of ethylene biosynthesis in plants comprising a vector containing a selective gene under plant promoter control, and a DNA insert comprising codons for a functional heterologous polypeptide having AdoMetase activity and flanked by a plant promoter on one side and a polyA signal sequence on the other side; and, transforming a plant host with said vector wherein the plant host transformed thereby is capable of expressing the heterologous polypeptide having AdoMetase activity under the control of said control region. The presence of the AdoMetase gene and the expression of AdoMetase in transgenic plants lowers AdoMet levels and generates an inhibitor of ACC synthase causing a corresponding decrease in ethylene biosynthesis and precursor availability. The current construction of transgenic plants containing a copy(s) of the T3 AdoMetase gene allow for construction of plants that will control ethylene biosynthesis under restricted conditions resulting in fruits, vegetables, and flowers which have been modified internally to improve shelf life and preservation qualities.
摘要翻译：一种用于在植物中控制乙烯生物合成的方法，其包含在植物启动子控制下含有选择性基因的载体，以及DNA插入片段，其包含具有AdoMetase活性的功能性异源多肽的密码子，并且侧面有一侧的植物启动子和polyA信号序列另一边; 并且用所述载体转化植物宿主，其中由此转化的植物宿主能够在所述对照区域的控制下表达具有AdoMetase活性的异源多肽。 AdoMetase基因的存在和AdoMetase在转基因植物中的表达降低了AdoMet水平，并产生了ACC合成酶的抑制剂，导致乙烯生物合成和前体可用性的相应降低。目前，含有T3 AdoMetase基因拷贝的转基因植物的构建允许在限制条件下控制乙烯生物合成的植物的构建，从而在内部进行改良以改善保质期和保存性质的水果，蔬菜和鲜花。

4. 发明授权

US5750864A Regulated expression of heterologous genes in plants 失效
标题翻译：调节异源基因在植物中的表达
公开(公告)号：US5750864A
公开(公告)日：1998-05-12
申请号：US261677
申请日：1994-06-17
申请人： Richard Keith Bestwick , Adolph J. Ferro
发明人： Richard Keith Bestwick , Adolph J. Ferro
IPC分类号： C07K14/415 , C12N9/14 , C12N15/55 , C12N15/82 , A01H5/08 , A01G7/00
CPC分类号： C07K14/415 , C12N15/8235 , C12N15/8249 , C12N9/14
摘要： The use of AdoMetase to reduce ethylene biosynthesis in plants is facilitated by the exploitation of the tissue and stage specific properties of the E4 promoter from tomato. The E4 promoter, isolated from tomato or other plants by methods described herein, provides a useful regulatable promoter for the expression of a variety of heterologous genes, including the AdoMetase gene.
摘要翻译：通过利用组织和来自番茄的E4启动子的特异性特性促进了使用AdoMetase来减少植物中的乙烯生物合成。通过本文所述的方法从番茄或其他植物中分离的E4启动子提供了用于表达多种异源基因（包括AdoMetase基因）的有用的可调控启动子。

5. 发明授权

US5366954A Floral preservative comprising 5-deoxy-5-ethylthio-D-ribose and method of use 失效
标题翻译：包含5-脱氧-5-乙硫基-D-核糖的防腐剂及其使用方法
公开(公告)号：US5366954A
公开(公告)日：1994-11-22
申请号：US944916
申请日：1992-09-15
申请人： Richard K. Bestwick , Vijaya K. Mokkapati , Adolph J. Ferro
发明人： Richard K. Bestwick , Vijaya K. Mokkapati , Adolph J. Ferro
IPC分类号： A01N3/02 , C07H15/14
CPC分类号： C07H15/14 , A01N3/02
摘要： The present invention includes a method of extending bloom life of a cut flower. In the method, a storage solution containing 5-deoxy-5-ethylthio-D-ribose (ETR) is provided, and the stem of the cut flower is bathed in the solution. ETR is safe for human use, and is effective at relatively low concentrations. A method for synthesizing 5-deoxy-5-alkylthioribose compounds is also disclosed.
摘要翻译：本发明包括延长切花寿命的方法。在该方法中，提供含有5-脱氧-5-乙硫基-D-核糖（ETR）的储存溶液，将切花的茎沐浴在溶液中。 ETR对于人类使用是安全的，并且在相对低的浓度下是有效的。还公开了合成5-脱氧-5-烷基硫代糖类化合物的方法。

6. 发明授权

US5859330A Regulated expression of heterologous genes in plants and transgenic fruit with a modified ripening phenotype 失效
标题翻译：调节异源基因在植物和转基因水果中的表达，具有修饰的成熟表型
公开(公告)号：US5859330A
公开(公告)日：1999-01-12
申请号：US331355
申请日：1994-10-27
申请人： Richard Keith Bestwick , Adolph J. Ferro
发明人： Richard Keith Bestwick , Adolph J. Ferro
IPC分类号： C07K14/415 , C12N9/14 , C12N15/82 , A01H5/00 , A01H5/08
CPC分类号： C07K14/415 , C12N15/8216 , C12N15/8222 , C12N15/8235 , C12N15/8249 , C12N9/14
摘要： The present invention relates to chimeric genes having (i) a DNA sequence encoding a product that is effective to reduce ethylene biosynthesis in fruit from the plant, and (ii) a promoter whose expression is induced during fruit ripening or by ethylene synthesis by the fruit, where the DNA sequence is heterologous to the promoter and the DNA sequence is operably linked to the promoter to enable expression of the product. The invention describes vectors and transgenic plants, vegetables, flowers and fruits carrying the chimeric gene, as well as methods related thereto.
摘要翻译：本发明涉及嵌合基因，其具有（i）编码有效减少来自植物的果实中的乙烯生物合成的产物的DNA序列，和（ii）在果实成熟期间诱导其表达或通过水果的乙烯合成的启动子，其中DNA序列与启动子是异源的，并且DNA序列可操作地连接到启动子以使得能够表达产物。本发明描述了携带嵌合基因的载体和转基因植物，蔬菜，花和果实以及与之相关的方法。

7. 发明授权

US5750870A Plant genetic transformation methods and transgenic plants 失效
标题翻译：植物遗传转化方法和转基因植物
公开(公告)号：US5750870A
公开(公告)日：1998-05-12
申请号：US384556
申请日：1995-02-03
申请人： Helena V. Mathews , Richard Keith Bestwick , Adolph J. Ferro
发明人： Helena V. Mathews , Richard Keith Bestwick , Adolph J. Ferro
IPC分类号： A01H4/00 , C12N9/02 , C12N9/14 , C12N15/82 , A01H5/00 , A01H5/08
CPC分类号： C12N9/0071 , A01H4/001 , A01H4/008 , C12N15/8205 , C12N15/8209 , C12N15/8249 , C12N9/14 , C12Y114/17004
摘要： An efficient transformation system for plants has been developed that yields high transformation efficiencies and pure transgenic plants. Genomic integration of transgenes was confirmed by genomic DNA hybridization analysis. Pure transgenic plants have been successfully established in soil.
摘要翻译：已经开发了一种有效的植物转化系统，其产生高转化效率和纯转基因植物。通过基因组DNA杂交分析证实转基因的基因组整合。在土壤中成功建立了纯转基因植物。

8. 发明授权

US5723746A Reduced ethylene synthesis and delayed fruit ripening in transgenic tomatoes expressing S-adenosylmethionine hydrolase 失效
标题翻译：表达S-腺苷甲硫氨酸水解酶的转基因番茄中乙烯合成减少和果实成熟延迟
公开(公告)号：US5723746A
公开(公告)日：1998-03-03
申请号：US46583
申请日：1993-04-09
申请人： Richard Keith Bestwick , Adolph J. Ferro
发明人： Richard Keith Bestwick , Adolph J. Ferro
IPC分类号： A01H5/00 , C12N5/10 , C12N9/14 , C12N15/09 , C12N15/55 , C12N15/82 , A01H4/00 , A01H5/08 , C12N5/14
CPC分类号： C12N15/8222 , C12N15/8235 , C12N15/8249 , C12N9/14
摘要： The use of AdoMetase to reduce ethylene biosynthesis in plants is facilitated by the exploitation of the tissue and stage specific properties of the E8 promoter from tomato. Expression of AdoMetase is shown to be limited to the ripening tomato fruit. The functional properties of several regions of the E8 promoter are also described. The E8 promoter, and variants described herein, provides a useful regulatable promoter for the expression of other genes as well as the AdoMetase gene.
摘要翻译：通过利用组织和来自番茄的E8启动子的特异性来促进使用AdoMetase来减少植物中的乙烯生物合成。显示AdoMetase的表达限于成熟番茄果实。还描述了E8启动子的几个区域的功能特性。本文所述的E8启动子和变体提供了用于表达其他基因以及AdoMetase基因的有用的可调控启动子。

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