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1. 发明授权

US07323211B2 Bone-adherent implant with shock-absorbing property and manufacturing method thereof 失效
标题翻译：具有减震性的骨粘连植入物及其制造方法
公开(公告)号：US07323211B2
公开(公告)日：2008-01-29
申请号：US10844734
申请日：2004-05-13
申请人： Suong-Hyu Hyon , Kazuaki Matsumura , Sadami Tsutsumi
发明人： Suong-Hyu Hyon , Kazuaki Matsumura , Sadami Tsutsumi
IPC分类号： B05D1/36
CPC分类号： A61L27/34 , A61L27/50 , Y10T428/31692 , Y10T428/31855
摘要： It is to provide an implant with shock-absorbing property that is able to be strongly secured in a living body as well as a manufacturing method of such implant.The implant comprising: a substrate; a first film on the substrate, which is comprised of a polymer and has a functional group that enables adsorption of calcium ions; and a second film formed on the first film and being comprised of calcium phosphate. The manufacturing method of the implant comprising: forming said first film on a substrate; and subsequently, dipping the substrate in a calcium ion solution and in a phosphate ion solution alternately as to form the second film.
摘要翻译：本发明提供能够牢固地固定在生物体中的具有减震性的植入物以及这种植入物的制造方法。植入物包括：基底; 在基材上的第一膜，其由聚合物组成并具有能够吸附钙离子的官能团; 以及形成在第一膜上并由磷酸钙构成的第二膜。所述植入物的制造方法包括：在基底上形成所述第一膜; 然后交替地将基板浸入钙离子溶液和磷酸盐离子溶液中以形成第二膜。

2. 发明授权

US07683106B2 Primer for dental materials and pulp capping agent for dentin regeneration 有权
标题翻译：用于牙科材料的底漆和牙本质再生的纸浆封端剂
公开(公告)号：US07683106B2
公开(公告)日：2010-03-23
申请号：US10548374
申请日：2004-03-05
申请人： Masahiro Yoshiyama , Yoshihiro Nishitani , Sadami Tsutsumi , Suong-Hyu Hyon
发明人： Masahiro Yoshiyama , Yoshihiro Nishitani , Sadami Tsutsumi , Suong-Hyu Hyon
IPC分类号： A61K6/08 , C08K3/38
CPC分类号： C09J129/04 , A61K6/0029 , A61L24/102 , C08L31/04
摘要： A dental material primer and a dentin-regenerating pulp-capping agent which exhibit an excellent dentin-regenerating action, are disclosed. The dental material primer includes a hydrolyzed ethylene-vinyl acetate copolymer in which collagen is immobilized and the dentin-regenerating pulp-capping agent includes a hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized, and a binder.
摘要翻译：公开了牙科材料底漆和表现出优异牙本质再生作用的牙本质再生浆果覆盖剂。牙科材料底漆包括其中固定有胶原的水解乙烯 - 乙酸乙烯酯共聚物，牙本质再生的纸浆覆盖剂包括其中固定有胶原的水解乙烯 - 乙酸乙烯酯共聚物和粘合剂。

3. 发明申请

US20060252846A1 Primer for dental materials and pulp capping agent for dentin regeneration 有权
标题翻译：用于牙科材料的底漆和牙本质再生的纸浆封端剂
公开(公告)号：US20060252846A1
公开(公告)日：2006-11-09
申请号：US10548374
申请日：2004-03-05
申请人： Masahiro Yoshiyama , Yoshihiro Nishitani , Sadami Tsutsumi , Suong-Hyu Hyon
发明人： Masahiro Yoshiyama , Yoshihiro Nishitani , Sadami Tsutsumi , Suong-Hyu Hyon
IPC分类号： A61K6/00
CPC分类号： C09J129/04 , A61K6/0029 , A61L24/102 , C08L31/04
摘要： The present invention provides a dental material primer and a dentin-regenerating pulp-capping agent which exhibit excellent a dentin-regenerating action. The present invention relates to the dental material primer comprising a hydrolyzed ethylene-vinyl acetate copolymer in which collagen is immobilized and the dentin-regenerating pulp-capping agent comprising a hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized, and a binder.
摘要翻译：本发明提供一种表现出优异牙本质再生作用的牙科材料底漆和牙本质再生浆果覆盖剂。本发明涉及包含水解乙烯 - 乙酸乙烯酯共聚物的牙科材料底漆，其中胶原被固定，并且含有胶原蛋白被固定的水解乙烯 - 乙酸乙烯酯共聚物的牙本质再生纸浆覆盖剂和粘合剂。

4. 发明申请

US20070259327A1 Cryopreservation medium and cryopreservation method for tissues and cells 审中-公开
标题翻译：冷冻保存培养基和组织和细胞的低温保存方法
公开(公告)号：US20070259327A1
公开(公告)日：2007-11-08
申请号：US11418421
申请日：2006-05-03
申请人： Yasuhiro Iwanaga , Kazuaki Matsumura , Jong-Yoon Kim , Hajime Sugai , Suong-Hyu Hyon
发明人： Yasuhiro Iwanaga , Kazuaki Matsumura , Jong-Yoon Kim , Hajime Sugai , Suong-Hyu Hyon
IPC分类号： C12N5/08 , A01N1/02
CPC分类号： A01N1/02 , A01N1/0221
摘要： A cryopreservation medium and a cryopreservation method which make it possible to cryopreserve tissues and cells with high viability are provided. A cryopreservation medium contains polyphenol at a concentration of from 30 to 120 ppm. In an embodiment, a cryopreservation method for tissues and cells comprises: incubating tissues or cells for 2 hours in culture medium supplemented with polyphenol at concentrations of from 30 to 120 ppm; suspending tissues or cells in a cryopreservation medium; freezing the suspension of the tissues or cells in the cryopreservation medium; and storing the frozen suspension of tissues or cells in the cryopreservation medium.
摘要翻译：提供了一种冷冻保存培养基和一种低温保存方法，其可以以高活力冷冻保存组织和细胞。冷冻保存培养基含有浓度为30至120ppm的多酚。在一个实施方案中，用于组织和细胞的冷冻保存方法包括：在补充有30至120ppm浓度的多酚的培养基中孵育组织或细胞2小时; 将组织或细胞悬浮在冷冻保存培养基中; 冻结冷冻保存培养基中组织或细胞的悬浮液; 并将冷冻的组织或细胞悬浮液储存在冷冻保存培养基中。

5. 发明申请

US20070259329A1 Anergy-inducing cellular composition 审中-公开
标题翻译：抗生素诱导细胞组成
公开(公告)号：US20070259329A1
公开(公告)日：2007-11-08
申请号：US11418422
申请日：2006-05-03
申请人： Jong-Yoon Kim , Kazuaki Matsumura , Yasuhiro Iwanaga , Hajime Sugai , Suong-Hyu Hyon
发明人： Jong-Yoon Kim , Kazuaki Matsumura , Yasuhiro Iwanaga , Hajime Sugai , Suong-Hyu Hyon
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0226
摘要： The invention is directed to an anergy-inducing cellular composition comprising: cells having antigenic determinants on the cell surface and an anergy-inducing compound [e.g., (−)-epigallocatechin-3-o-gallate (EGCG)] attached by its chemical affinity to the antigenic determinants. In one embodiment, the anergy-inducing compound blocks co-stimulatory molecules among the antigenic determinants of the cells, which upon encountering with T-cell renders the latter anergic, that is, unresponsive toward alloantigens. In another embodiment, EGCG is of high purity for its efficient attachment to the antigenic determinants. The anergy-inducing cellular composition is prepared by immersing the cells in a culture media solution (RPMI 1640) containing 50-500 ppm EGCG at low physiological temperatures for one to two hours to minimize the cells' mortality. A specific use of the resulting anergic cellular composition is suggested, which is the attenuation of two undesirable acute allogenic responses resulting from major histocompatibility disparity, namely, transplant rejection and GVHD.
摘要翻译：本发明涉及一种免疫诱导细胞组合物，其包含：在细胞表面具有抗原决定簇的细胞和通过其化学亲合力附着的无能力诱导化合物[例如（ - ） - 表没食子儿茶素-3-邻氯乙酸酯（EGCG）] 对抗原决定簇。在一个实施方案中，所述无反应诱导化合物阻断所述细胞的抗原决定簇之间的共刺激分子，其在与T细胞相遇时使得后者不敏感，即对同种异体抗原无反应。在另一个实施方案中，EGCG与抗原决定簇的有效连接具有高纯度。通过将细胞浸入含有50-500ppm EGCG的培养基溶液（RPMI 1640）中在低生理温度下浸泡1至2小时来制备无能诱导细胞组合物，以使细胞的死亡率最小化。提出了所得到的无菌细胞组合物的具体用途，其是由主要组织相容性差异（即移植排斥和GVHD）引起的两种不希望的急性同种异体反应的减弱。

6. 发明申请

US20110172315A1 COMPOSITION FOR CRYOPRESERVATION OF CELLS AND TISSUES 审中-公开
标题翻译：用于细胞和组织的组织的组合物
公开(公告)号：US20110172315A1
公开(公告)日：2011-07-14
申请号：US13001237
申请日：2009-06-26
申请人： Kazuaki Matsumura , Hajime Sugai , Suong-Hyu Hyon
发明人： Kazuaki Matsumura , Hajime Sugai , Suong-Hyu Hyon
IPC分类号： A01N25/00 , C12N5/071 , A01P15/00 , C09K15/20 , C09K15/18 , A23L1/305 , H01M2/14 , B05D5/00
CPC分类号： A01N1/0221 , A23L3/375 , A23V2002/00 , A61K9/19 , A61K47/34 , C12N5/0602
摘要： A composition for cryopreservation of cells and tissues of human and other animals in a safe manner without using toxic substances such as DMSO, as well as for freeze preserving or freeze-drying of foods and pharmaceuticals. In examples, ε-poly-L-lysine is reacted with succinic anhydride so that 60% or more of amino groups are blocked; and, thus obtained polymer compound is added to Dulbecco-modified eagle MEM culture medium (DMEM) on market sale to form a cryopreservation liquid. In examples for foods or pharmaceuticals, the ε-poly-L-lysine derivative was added by 0.5-10 wt % to curb freeze concentration.
摘要翻译：用于以不安全的方式冷冻保存人和其他动物的细胞和组织的组合物，而不使用有毒物质如DMSO，以及用于食品和药物的冷冻保存或冷冻干燥。在实施例中，将聚-L-赖氨酸与琥珀酸酐反应，使得60％以上的氨基被封闭; 并将所获得的高分子化合物在市售上添加到Dulbecco改良的Eagle MEM培养基（DMEM）中以形成冷冻保存液。在食品或药物的实例中，加入0.5〜10重量％的α-聚-L-赖氨酸衍生物来抑制冷冻浓度。

7. 发明授权

US5100669A Polylactic acid type microspheres containing physiologically active substance and process for preparing the same 失效
标题翻译：含有生理活性物质的聚乳酸型微生物及其制备方法
公开(公告)号：US5100669A
公开(公告)日：1992-03-31
申请号：US315167
申请日：1989-02-24
申请人： Suong-Hyu Hyon , Yoshita Ikada
发明人： Suong-Hyu Hyon , Yoshita Ikada
IPC分类号： A61K9/58 , A61K9/16 , A61K9/51 , A61K9/52 , A61K47/00 , A61K47/34
CPC分类号： A61K9/5153 , A61K9/1647 , Y10S514/963 , Y10S977/773 , Y10S977/915 , Y10T428/2989
摘要： Microspheres comprising polylactic acid and a water soluble physiologically active substance and having a mean particle size of from about 0.01 .mu.m to 300 .mu.m, which show not more than 30% of an eluted amount of said physiologically active substance based on the content of said physiologically active substance in the polylactic acid type microspheres after 24 hours in in vitro elution test in phosphate buffer of pH 7.4 at 37.degree. C., and a process for preparing the same. The polylactic acid type microspheres of this invention is advantageous in that the active substance can be uniformly incorporated into the microspheres without loss of the activity, can gradually release the active substance for a long time of period of more than one week.

8. 发明授权

US4966924A Soft contact lens and method of manufacturing the same 失效
标题翻译：软隐形眼镜及其制造方法
公开(公告)号：US4966924A
公开(公告)日：1990-10-30
申请号：US351348
申请日：1989-05-15
申请人： Suong-Hyu Hyon , Yoshito Ikada
发明人： Suong-Hyu Hyon , Yoshito Ikada
IPC分类号： B29C39/02 , B29C39/38 , B29D11/00 , B29K29/00 , B29L11/00 , G02B1/04 , G02C7/04
CPC分类号： G02C7/04 , B29D11/00076 , G02B1/043
摘要： A soft contact lens of PVA having a tensile strength of not less than 10 kg/cm.sup.2, a water content ranging from 40 to 95% by weight, a visible light transparency of not less than 90%, and an oxygen permeability of not less than 30.times.10.sup.-11 cm.sup.3 .multidot.(STP).multidot.cm/cm.sup.2 .multidot.sec.multidot.mmHg. This soft contact lens can be prepared by forming a solution of PVA in a mixed solvent of water and an organic solvent, pouring the PVA solution in a mold having a shape of contact lens, and crystallizing at a temperature of not more than ordinary temperature. The soft contact lens has a high mechanical strength, high water content, high transparency and high oxygen permeability.

9. 发明授权

US4765937A Method of preparing high strength and modulus poly(vinyl alcohol) fibers 失效
标题翻译：制备高强度和模量的聚（乙烯醇）纤维的方法
公开(公告)号：US4765937A
公开(公告)日：1988-08-23
申请号：US28943
申请日：1987-03-23
申请人： Suong-Hyu Hyon , Yoshito Ikada
发明人： Suong-Hyu Hyon , Yoshito Ikada
IPC分类号： D01D5/00 , D01F6/14
CPC分类号： D01F6/14 , D07B2501/2061
摘要： High strength and modulus fibers are prepared from a poly(vinyl alcohol) solution in a mixed solvent consisting of water and water-miscible organic solvent. Upon extruding the poly(vinyl alcohol) solution into a coagulation bath, gel fibers are formed as a consequence of favorable gel structure with homogeneous net-works. Drawing the gel fibers to an exceedingly high degree leads to formation of poly(vinyl alcohol) fibers which have a superhigh tensile strength and a superhigh modulus.
摘要翻译：由聚（乙烯醇）溶液在由水和水混溶性有机溶剂组成的混合溶剂中制备高强度和模量的纤维。在将聚（乙烯醇）溶液挤出到凝固浴中时，由于具有均匀网状物的良好凝胶结构，形成凝胶纤维。将凝胶纤维拉伸到非常高的程度导致形成具有超高拉伸强度和超高模量的聚（乙烯醇）纤维。

10. 发明授权

US4727030A Preparation of porous polyvinyl alcohol gel containing an immobilized enzyme 失效
标题翻译：制备含有固定化酶的多孔聚乙烯醇凝胶
公开(公告)号：US4727030A
公开(公告)日：1988-02-23
申请号：US791274
申请日：1985-10-25
申请人： Fumihiro Ishimura , Koji Murata , Suong-Hyu Hyon , Yoshito Ikada
发明人： Fumihiro Ishimura , Koji Murata , Suong-Hyu Hyon , Yoshito Ikada
IPC分类号： C12N11/08 , C12N11/04 , C12N11/02 , C12N11/14
CPC分类号： C12N11/04
摘要： A porous gel containing an immobilized enzyme is prepared by mixing an aqueous solution of polyvinyl alcohol having a saponification degree of not lower than 95 mol% and an average polymerization degree of not lower than 1,000, with an enzyme or enzyme-producing cell, and activated carbon powder, pouring the mixture into a container of any desired form, gelating and molding the mixture by dehydrating it up to a dehydration ratio of not lower than 50%, immersing the resulting molding in water, and drying the immersed molding. Preferably, dehydrating is by leaving the mixture to stand at room temperature or a temperature of from 30.degree. C. to 40.degree. C. The enzyme or enzyme-producing cell may be mixed with or adsorbed on an inorganic or organic carrier. The dried molding may be granulated.
摘要翻译：通过将皂化度不低于95摩尔％且平均聚合度不低于1,000的聚乙烯醇水溶液与酶或酶产生细胞混合并制备含有固定化酶的多孔凝胶，并将其活化碳粉，将混合物倒入任何所需形式的容器中，通过将其脱水至脱水率不低于50％，将混合物凝胶化和模塑，将所得模制品浸入水中，并干燥浸渍的模制品。优选地，脱水是通过在室温或30℃至40℃的温度下使混合物静置。酶或酶产生细胞可以与无机或有机载体混合或吸附在无机或有机载体上。干燥的成型品可以造粒。

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