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1. 发明授权

US07790109B2 Micro-fluid reaction vessel, method for manufacturing the same, and micro-fluid reaction method using the vessel 有权
标题翻译：微流体反应容器，其制造方法和使用该容器的微流体反应方法
公开(公告)号：US07790109B2
公开(公告)日：2010-09-07
申请号：US11625877
申请日：2007-01-23
申请人： Su-hyeon Kim , Jin-tae Kim , Kak Namkoong , In-ho Lee , Chin-sung Park , Young-sun Lee
发明人： Su-hyeon Kim , Jin-tae Kim , Kak Namkoong , In-ho Lee , Chin-sung Park , Young-sun Lee
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , B01J10/00 , B01J10/02 , B01J12/00 , B01J12/02 , F15C1/04 , F15C3/00 , F15C1/06
CPC分类号： B01L3/502738 , B01L7/52 , B01L2200/0689 , B01L2300/0816 , B01L2300/0825 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , B29C33/3857 , B29C33/60 , Y10T137/218 , Y10T137/2202 , Y10T137/2224
摘要： A micro-fluid reaction vessel includes an upper plate formed of an elastomer, a lower plate adhered to the upper plate, a micro-chamber and a micro-channel formed on an inner surface of the upper plate facing the lower plate and an inlet hole and an outlet hole formed in the upper plate and through which a fluid flows into or out of, respectively. The micro-channel is constructed to be closed by pressure applied to the upper plate and elastically restored when the pressure is not applied. A micro fluid reaction method uses the micro fluid reaction vessel and a method of manufacturing forms the microfluid reaction vessel.
摘要翻译：微流体反应容器包括由弹性体形成的上板，粘附到上板的下板，形成在面向下板的上板的内表面上的微室和微通道，以及入口孔以及形成在上板中并且流体分别流入或流出的出口孔。微通道被构造为通过施加到上板的压力而关闭，并且当不施加压力时弹性恢复。微流体反应方法使用微流体反应容器和制造方法形成微流体反应容器。

2. 发明授权

US07838300B2 Method of reducing temperature difference between a pair of substrates 有权
标题翻译：降低一对基板之间的温度差的方法
公开(公告)号：US07838300B2
公开(公告)日：2010-11-23
申请号：US11689640
申请日：2007-03-22
申请人： Kak Namkoong , Su-hyeon Kim , Jin-tae Kim , Chin-sung Park , Young-sun Lee
发明人： Kak Namkoong , Su-hyeon Kim , Jin-tae Kim , Chin-sung Park , Young-sun Lee
IPC分类号： G01N25/20 , B01L3/02
CPC分类号： B81B3/0081 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00873 , B01L3/5027 , B01L7/5255 , B01L2200/14 , B01L2200/147 , B01L2300/1805 , B01L2300/1827 , B81B2201/051 , F28F21/02 , F28F2013/006
摘要： A method of reducing a temperature difference between a high-temperature and a low-temperature substrate includes interposing a heat transfer facilitating layer which has a higher thermal conductivity than air and can hold particles between the substrates, and maintaining close contact between the high-temperature substrate, the heat transfer facilitating layer, and the low-temperature substrate, wherein formation of an air layer can be at least substantially prevented between the high-temperature substrate and the heat transfer facilitating layer, and between the low-temperature substrate and the heat transfer facilitating layer.
摘要翻译：降低高温和低温基板之间的温度差的方法包括：介于热传导率高于空气的传热促进层，并且可以在基板之间保持颗粒，并且保持高温基板，传热促进层和低温基板，其中至少可以在高温基板和传热促进层之间以及在低温基板和热量之间基本上防止空气层的形成转移促进层。

3. 发明授权

US08771610B2 Method of reducing temperature difference between a pair of substrates and fluid reaction device using the same 失效
标题翻译：降低一对基板与使用其的液体反应装置之间的温度差的方法
公开(公告)号：US08771610B2
公开(公告)日：2014-07-08
申请号：US12904557
申请日：2010-10-14
申请人： Kak Namkoong , Su-hyeon Kim , Jin-tae Kim , Chin-sung Park , Young-sun Lee
发明人： Kak Namkoong , Su-hyeon Kim , Jin-tae Kim , Chin-sung Park , Young-sun Lee
IPC分类号： B01L3/00
CPC分类号： B81B3/0081 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00873 , B01L3/5027 , B01L7/5255 , B01L2200/14 , B01L2200/147 , B01L2300/1805 , B01L2300/1827 , B81B2201/051 , F28F21/02 , F28F2013/006
摘要： A fluid reaction device includes a microfluidic reaction chip which accommodates a fluid, a heater, and a heat transfer facilitating layer which is interposed between the microfluidic reaction chip and the heater, the heat transfer facilitating layer has a higher thermal conductivity than air and can hold particles, wherein formation of an air layer can be prevented.
摘要翻译：流体反应装置包括容纳流体的微流体反应芯片，加热器和介于微流体反应芯片和加热器之间的传热促进层，传热促进层具有比空气更高的导热性并且可以保持颗粒，其中可以防止空气层的形成。

4. 发明申请

US20080053647A1 METHOD OF REDUCING TEMPERATURE DIFFERENCE BETWEEN A PAIR OF SUBSTRATES AND FLUID REACTION DEVICE USING THE SAME 有权
标题翻译：降低基板对流与使用其的流体反应装置之间的温度差异的方法
公开(公告)号：US20080053647A1
公开(公告)日：2008-03-06
申请号：US11689640
申请日：2007-03-22
申请人： Kak Namkoong , Su-hyeon Kim , Jin-tae Kim , Chin-sung Park , Young-sun Lee
发明人： Kak Namkoong , Su-hyeon Kim , Jin-tae Kim , Chin-sung Park , Young-sun Lee
IPC分类号： F28F7/00
CPC分类号： B81B3/0081 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00873 , B01L3/5027 , B01L7/5255 , B01L2200/14 , B01L2200/147 , B01L2300/1805 , B01L2300/1827 , B81B2201/051 , F28F21/02 , F28F2013/006
摘要： A method of reducing a temperature difference between a high-temperature and a low-temperature substrate includes interposing a heat transfer facilitating layer which has a higher thermal conductivity than air and can hold particles between the substrates, and maintaining close contact between the high-temperature substrate, the heat transfer facilitating layer, and the low-temperature substrate, wherein formation of an air layer can be at least substantially prevented between the high-temperature substrate and the heat transfer facilitating layer, and between the low-temperature substrate and the heat transfer facilitating layer. A fluid reaction device includes a microfluidic reaction chip which accommodates a fluid, a heater, and a heat transfer facilitating layer which is interposed between the microfluidic reaction chip and the heater, the heat transfer facilitating layer has a higher thermal conductivity than air and can hold particles, wherein formation of an air layer can be prevented.
摘要翻译：降低高温和低温基板之间的温度差的方法包括：介于热传导率高于空气的传热促进层，并且可以在基板之间保持颗粒，并且保持高温基板，传热促进层和低温基板，其中至少可以在高温基板和传热促进层之间以及在低温基板和热量之间基本上防止空气层的形成转移促进层。流体反应装置包括容纳流体的微流体反应芯片，加热器和介于微流体反应芯片和加热器之间的传热促进层，传热促进层具有比空气更高的导热性并且可以保持颗粒，其中可以防止空气层的形成。

5. 发明授权

US07767439B2 Real-time PCR monitoring apparatus and method 有权
标题翻译：实时PCR监测装置及方法
公开(公告)号：US07767439B2
公开(公告)日：2010-08-03
申请号：US10890350
申请日：2004-07-13
申请人： Kwang-wook Oh , Jin-tae Kim , Kak Namkoong , Chin-sung Park
发明人： Kwang-wook Oh , Jin-tae Kim , Kak Namkoong , Chin-sung Park
IPC分类号： C12M1/34 , C12M3/00 , C12Q1/68 , G01N21/25
CPC分类号： G01N21/645 , B01L3/50851 , B01L7/52 , B01L2300/0627 , B01L2300/18 , G01N21/0332
摘要： A real time polymerase chain reaction (“PCR”) monitoring apparatus includes, a microchip-type PCR tube that has a PCR solution-containing PCR chamber, a micro-heater, a detection unit detecting a PCR product signal based on the PCR solution, a plurality of modules, each of which includes the abovementioned elements in addition to a cooling fan and a control unit controlling the micro-heater and the cooling fan to adjust the temperature of the PCR chamber, a base instrument that comprises a power supply unit connected to the modules and a data communication unit connected to the control unit of each of the modules, and a display unit displaying data from the data communication unit, wherein the control unit of each of the modules independently controls at least one of both the detection unit and the temperature of the PCR chamber of the PCR tube in each of the modules.
摘要翻译：实时聚合酶链式反应（“PCR”）监测装置包括：具有含PCR溶液的PCR室的微芯片型PCR管，微加热器，基于PCR溶液检测PCR产物信号的检测单元，多个模块，每个模块除了冷却风扇之外还包括上述元件，以及控制单元，其控制微加热器和冷却风扇来调节PCR室的温度;基础仪器，包括连接的电源单元连接到每个模块的控制单元的数据通信单元和从数据通信单元显示数据的显示单元，其中每个模块的控制单元独立地控制检测单元中的至少一个以及每个模块中PCR管的PCR室的温度。

6. 发明授权

US07754452B2 Polymerase chain reaction module, and multiple polymerase chain reaction system including the module 有权
标题翻译：聚合酶链反应模块，以及多个聚合酶链反应系统，包括该模块
公开(公告)号：US07754452B2
公开(公告)日：2010-07-13
申请号：US11377793
申请日：2006-03-16
申请人： Jin-tae Kim , Kak Namkoong , Kwang-wook Oh , Chin-sung Park , Yu-jin Seo
发明人： Jin-tae Kim , Kak Namkoong , Kwang-wook Oh , Chin-sung Park , Yu-jin Seo
IPC分类号： C12P19/34 , C12M1/36 , G01N15/06
CPC分类号： B01L7/52 , B01L3/5027 , B01L9/52 , B01L2300/0822 , B01L2300/1827 , B01L2300/1844 , C12Q1/686
摘要： Provided are a polymerase chain reaction (PCR) module and a PCR system including the same. The PCR module includes: a detachable PCR chip including a PCR chamber unit in which a PCR solution is accommodated; a heater unit for heating the PCR solution in the PCR chip with a preset temperature; a detecting unit for detecting a PCR signal of the PCR solution; a PCR chip installation unit for mounting/detaching the PCR chip using a one-touch method, in which the heater unit is adhered to the PCR chip with a predetermined pressure when mounting the PCR chip and the heater unit is separated from the PCR chip when detaching the PCR chip; and a housing covering at least the heater unit and the detecting unit so that they are not exposed to the outside.
摘要翻译：提供了聚合酶链反应（PCR）模块和包括其的PCR系统。所述PCR模块包括：可拆卸PCR芯片，其包括其中容纳PCR溶液的PCR室单元; 用于以预设温度加热PCR芯片中的PCR溶液的加热器单元; 用于检测PCR溶液的PCR信号的检测单元; 用于使用一触式方法安装/分离PCR芯片的PCR芯片安装单元，其中当将PCR芯片和加热器单元安装在PCR芯片上时，将加热器单元以预定的压力粘附到PCR芯片上，与PCR芯片分离，分离PCR芯片; 以及至少覆盖加热器单元和检测单元的壳体，使得它们不暴露于外部。

7. 发明申请

US20060140051A1 Microfluidic device including microchannel on which plurality of electromagnets are disposed, and methods of mixing sample and lysing cells using the microfluidic device 审中-公开
标题翻译：微流体装置包括其上设置有多个电磁体的微通道，以及使用微流体装置混合样品和裂解细胞的方法
公开(公告)号：US20060140051A1
公开(公告)日：2006-06-29
申请号：US11285924
申请日：2005-11-22
申请人： Jin-tae Kim , Kwang-wook Oh , Yoon-kyoung Cho , Sang-hyun Peak , Sook-young Kim , Chin-sung Park , Kak Namkoong
发明人： Jin-tae Kim , Kwang-wook Oh , Yoon-kyoung Cho , Sang-hyun Peak , Sook-young Kim , Chin-sung Park , Kak Namkoong
IPC分类号： B01F13/08
CPC分类号： C12N1/066 , B01F13/0059 , B01F13/0809
摘要： Provided is a microfluidic device including at least one inlet, at least one outlet, and a microchannel connecting the inlet and the outlet. The microfluidic device includes two or more electromagnets disposed on sidewalls of the microchannel and oriented in a predetermined direction with respect to the direction in which the microchannel extends.
摘要翻译：提供了一种微流体装置，其包括连接入口和出口的至少一个入口，至少一个出口和微通道。微流体装置包括设置在微通道的侧壁上并相对于微通道延伸的方向在预定方向上定向的两个或多个电磁体。

8. 发明授权

US07799557B2 Polymerase chain reaction (PCR) module and multiple PCR system using the same 有权
标题翻译：聚合酶链反应（PCR）模块和多重PCR系统使用相同
公开(公告)号：US07799557B2
公开(公告)日：2010-09-21
申请号：US11080705
申请日：2005-03-15
申请人： Kwang-wook Oh , Jin-tae Kim , Kak Namkoong , Chin-sung Park , Yoon-kyoung Cho
发明人： Kwang-wook Oh , Jin-tae Kim , Kak Namkoong , Chin-sung Park , Yoon-kyoung Cho
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N21/6486 , B01L3/50851 , B01L7/52 , B01L2300/0627 , B01L2300/18 , G01N21/0332
摘要： Provided are a DNA PCR module and a multiple PCR system using the same. More particularly, provided are a DNA PCR module with a combined PCR thermal cycler and PCR product detector, and a multiple PCR system using the same.
摘要翻译：提供了DNA PCR模块和使用其的多重PCR系统。更具体地，提供了具有组合的PCR热循环仪和PCR产物检测器的DNA PCR模块，以及使用其的多重PCR系统。

9. 发明申请

US20060078931A1 Microchip unit, and method of conducting biochemical reaction using the microchip unit 审中-公开
标题翻译： Microchip单元和使用微芯片单元进行生化反应的方法
公开(公告)号：US20060078931A1
公开(公告)日：2006-04-13
申请号：US11245348
申请日：2005-10-06
申请人： Kwang-wook Oh , Yu-jin Seo , Gyeong-sik Ok , Jin-tae Kim , Kak Namkoong , Chin-sung Park
发明人： Kwang-wook Oh , Yu-jin Seo , Gyeong-sik Ok , Jin-tae Kim , Kak Namkoong , Chin-sung Park
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2300/0816 , B01L2400/065
摘要： Provided is a microchip unit, including a microchip on which a plurality of micro-channels are formed, a housing disposed below the microchip to fix the microchip; and at least two injecting and sealing elements having through-holes corresponding to inlets of the microchip. The injecting and sealing elements are vertically fixed on the top of the housing and slide in a horizontal direction from a first location to a second location and vice versa. The through-holes are aligned with inlets of the microchip so that a reaction solution can be injected through the through-holes when the injecting and sealing elements are placed at the first location. The inlets of the microchip are sealed by elastic members formed on bottom surfaces of the injecting and sealing elements when the injecting and sealing elements are placed at the second location.
摘要翻译：提供一种微芯片单元，其包括形成有多个微通道的微芯片，设置在微芯片下面以固定微芯片的壳体; 以及至少两个具有对应于微芯片的入口的通孔的注入和密封元件。注射和密封元件垂直地固定在壳体的顶部上，并且在从第一位置到第二位置的水平方向上滑动，反之亦然。通孔与微芯片的入口对准，使得当注射和密封元件放置在第一位置时，反应溶液可以通过通孔注入。当注射和密封元件放置在第二位置时，微芯片的入口由形成在注射和密封元件的底表面上的弹性构件密封。

10. 发明授权

US08697433B2 Polymerase chain reaction (PCR) module and multiple PCR system using the same 失效
标题翻译：聚合酶链反应（PCR）模块和多重PCR系统使用相同
公开(公告)号：US08697433B2
公开(公告)日：2014-04-15
申请号：US12843552
申请日：2010-07-26
申请人： Kwang-wook Oh , Jin-tae Kim , Kak Namkoong , Chin-sung Park , Yoon-kyoung Cho
发明人： Kwang-wook Oh , Jin-tae Kim , Kak Namkoong , Chin-sung Park , Yoon-kyoung Cho
IPC分类号： C12M1/00 , C12M1/36 , C12M1/38 , C12M1/34 , C12M3/00
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/50851 , B01L2300/0627 , B01L2300/18
摘要： Provided are a PCR module and a multiple PCR system using the same. More particularly, provided are a PCR module with a combined PCR thermal cycler and PCR product detector, and a multiple PCR system using the same.
摘要翻译：提供了PCR模块和使用该PCR模块的多重PCR系统。更具体地，提供了具有组合的PCR热循环仪和PCR产物检测器的PCR模块，以及使用其的多重PCR系统。

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