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1. 发明授权

US06251601B1 Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays 有权
标题翻译：使用核酸微阵列同时测量基因表达和基因组异常
公开(公告)号：US06251601B1
公开(公告)日：2001-06-26
申请号：US09243067
申请日：1999-02-02
申请人： Yijia Bao , Diping Che , Wan-Liang Li , Uwe Richard Müller , Steven A. Seelig , Jufang Shi
发明人： Yijia Bao , Diping Che , Wan-Liang Li , Uwe Richard Müller , Steven A. Seelig , Jufang Shi
IPC分类号： C12Q168
CPC分类号： C12Q1/6837 , B01J2219/00529 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , C40B40/06
摘要： The invention comprises a multi-color, comparative hybridization assay method using an array of nucleic acid target elements attached to a solid support for the simultaneous detection of both gene expression and chromosomal abnormalities in a tissue sample. The method of the invention employs a comparative hybridization of a tissue mRNA or cDNA sample labeled in a first fluorescent color, a tissue chromosomal DNA sample labeled in a second fluorescent color, and at least one reference nucleic acid labeled in a third fluorescent color, to the array. The fluorescent color presence and intensity at each of at least two target elements are detected and the fluorescent ratios (i) of the first and third colors and (ii) the second and third colors determined. Gene expression and chromosomal abnormalities are thus simultaneously detected.
摘要翻译：本发明包括使用连接到固体支持物上的核酸靶元件阵列同时检测组织样品中基因表达和染色体异常两者的多色比较杂交测定方法。本发明的方法采用将标记有第一荧光色的组织mRNA或cDNA样品，以第二荧光颜色标记的组织染色体DNA样品和至少一种以第三荧光颜色标记的参考核酸的比较杂交，阵列。检测至少两个目标元素中的每一个的荧光颜色存在和强度，并确定第一和第三颜色的荧光比（i）和（ii）第二和第三颜色的荧光比（i）。因此同时检测基因表达和染色体异常。

2. 发明授权

US06516728B1 Continuously width-adjustable trolley travelling winch 有权
标题翻译：连续宽度可调的手推车旅行绞车
公开(公告)号：US06516728B1
公开(公告)日：2003-02-11
申请号：US09230270
申请日：1999-01-20
申请人： Richard Müller , Johann Lung , Manfred Finzel
发明人： Richard Müller , Johann Lung , Manfred Finzel
IPC分类号： E61B300
CPC分类号： B66C11/06 , B61B13/04 , B66C9/06
摘要： In a travelling trolley assembly, the two side frame bars (6, 7) which extend on either side of the running rail (2) are connected to one another via two connecting columns (8). The connecting columns (8) are smooth and cylindrical on the outside are fitted into receiving or sliding-guidance devices which are formed in the side frame bars (6, 7) below the running rail (2). In order to adjust the distance between the two side frame bars (6, 7) and to fix the distance which has been set, receiving devices, through which a threaded rod (46) which is parallel to the connecting column (8) passes, are situated in the vicinity of the connecting columns (8). The distance is adjusted and fixed with the aid of screw threads (94, 95), preferably lock nuts, which rest on the connecting rod (46). This type of fixing arrangement does not damage the shape of the guide columns (8), so that dismantling is easy to carry out at any time.
摘要翻译：在行进小车组件中，在跑道（2）的任一侧上延伸的两个侧框杆（6,7）通过两个连接柱（8）相互连接。连接柱（8）是平滑的，外侧的圆柱体装配在形成在运行轨道（2）下方的侧框架杆（6,7）中的接收或滑动引导装置中。为了调节两侧框架杆（6,7）之间的距离并固定已设定的距离，与连接柱（8）平行的螺纹杆（46）穿过的接收装置，位于连接柱（8）附近。借助于安装在连接杆（46）上的螺纹（94,95），优选地锁定螺母来调节和固定距离。这种类型的固定装置不会损坏导向柱（8）的形状，从而易于在任何时间执行拆卸。

3. 发明授权

US06455260B1 Biological assays for analyte detection 有权
公开(公告)号：US06455260B1
公开(公告)日：2002-09-24
申请号：US09978365
申请日：2001-10-16
申请人： Uwe Richard Müller , Diping Che , Yijia Bao
发明人： Uwe Richard Müller , Diping Che , Yijia Bao
IPC分类号： C12Q168
CPC分类号： G01N33/552 , C12Q1/6834
摘要： Fluorescence-based assay methods for detecting biological analytes in a sample. The fluorescence background in these methods is significantly lower than in conventional assay methods. Also provided are methods of attaching nucleic acids to a metallic or metalloid surface.

4. 发明授权

US06497400B2 Cable control with a simplified assembly 有权
标题翻译：电缆控制与组装简化
公开(公告)号：US06497400B2
公开(公告)日：2002-12-24
申请号：US09242505
申请日：1999-02-16
申请人： Reiner Bühlmayer , Helmut Noller , Richard Müller , Anita Schmiedt , Manfred Finzel
发明人： Reiner Bühlmayer , Helmut Noller , Richard Müller , Anita Schmiedt , Manfred Finzel
IPC分类号： B66D114
CPC分类号： B66C11/06 , B66D1/28 , B66D1/30
摘要： In a rope hoist (9), the output shaft (37) of the gearing (19) is provided in one piece with an end plate (57). This end plate (57) is designed in such a way that it can be inserted into a locating seat (66) of the tubular rope drum (17). The end plate (57) is screwed in the rope drum (17) by means of radial fitting screws (72). There is also a recess (67) at the other end of the rope drum (17), and a similar end plate (75) can be fastened in this recess (67) in the same manner. This other end plate carries a bearing journal (76). On account of this arrangement, the manufacture of the rope drum (17) and the entire assembly are simplified, complicated shaft joints between the output shaft (37) and the rope drum (17) being dispensed with on account of the mounting of the rope drum (17) by means of the output shaft (37) of the gearing (19). In addition, the rope hoist (9) may be split up into comparatively small subassemblies for dispatch.
摘要翻译：在钢丝绳葫芦（9）中，传动装置（19）的输出轴（37）与端板（57）一体地设置。该端板（57）被设计成使其能够插入到管状绳卷筒（17）的定位座（66）中。端板（57）通过径向配合螺钉（72）拧入绳索滚筒（17）中。在绳筒（17）的另一端还有一个凹槽（67），同样的方式可以在该凹槽（67）上固定一个相似的端板（75）。该另一个端板承载轴颈（76）。由于这种布置，绳索滚筒（17）和整个组件的制造被简化，由于绳索的安装，输出轴（37）和绳索滚筒（17）之间的复杂的轴接头被省去滚筒（17）借助于齿轮（19）的输出轴（37）。此外，绳索葫芦（9）可以分成较小的子组件进行调度。

5. 发明授权

US06905823B2 Cellular arrays and methods of detecting and using genetic disorder markers 有权
标题翻译：细胞阵列和检测和使用遗传疾病标记物的方法
公开(公告)号：US06905823B2
公开(公告)日：2005-06-14
申请号：US09971742
申请日：2001-10-04
申请人： Olli-P Kallioniemi , Uwe Richard Müller , Guido Sauter , Juha Kononen , Maarit Barlund
发明人： Olli-P Kallioniemi , Uwe Richard Müller , Guido Sauter , Juha Kononen , Maarit Barlund
IPC分类号： C12N15/09 , B01L3/00 , C12M1/00 , G01N1/08 , G01N1/28 , G01N1/31 , G01N1/36 , G01N33/50 , G01N33/543 , G02B21/34 , C12Q1/68 , C12N15/00 , C12N15/63 , C12N1/20 , C07H21/04
CPC分类号： C12Q1/6886 , B01J2219/00659 , B01J2219/00702 , B01J2219/00743 , B01L3/5085 , C12Q1/6809 , C12Q1/6837 , C12Q1/6841 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156 , G01N1/08 , G01N1/2813 , G01N1/312 , G01N33/5005 , G01N33/54306 , G01N2001/282 , G01N2001/288 , G01N2001/368 , G02B21/34 , C12Q2543/10 , C12Q2539/103 , C12Q2537/157 , C12Q2565/501
摘要： A method is disclosed for rapid molecular profiling of tissue or other cellular specimens by placing a donor specimen in an assigned location in a recipient array, providing copies of the array, and performing a different biological analysis of each copy. The results of the different biological analyses are compared to determine if there are correlations between the results of the different biological analyses at each assigned location. In some embodiments, the specimens may be tissue specimens from different tumors, which are subjected to multiple parallel molecular (including genetic and immunological) analyses. The results of the parallel analyses are then used to detect common molecular characteristics of the genetic disorder type, which can subsequently be used in the diagnosis or treatment of the disease. The biological characteristics of the tissue can be correlated with clinical or other information, to detect characteristics associated with the tissue, such as susceptibility or resistance to particular types of drug treatment. Other examples of suitable tissues which can be placed in the matrix include tissue from transgenic or model organisms, or cellular suspensions (such as cytological preparations or specimens of liquid malignancies or cell lines).
摘要翻译：公开了一种用于通过将供体样本放置在受体阵列中的分配位置以提供阵列的拷贝以及对每个拷贝执行不同生物学分析的组织或其它细胞标本的快速分子分析的方法。比较不同生物分析的结果，以确定每个分配位置的不同生物分析结果之间是否存在相关性。在一些实施方案中，样品可以是来自不同肿瘤的组织标本，其经受多重平行分子（包括遗传和免疫）分析。然后并行分析的结果用于检测遗传病症类型的常见分子特征，随后可用于诊断或治疗疾病。组织的生物学特征可以与临床或其他信息相关联，以检测与组织相关的特征，例如对特定类型的药物治疗的易感性或抗性。可以放置在基质中的合适组织的其他实例包括来自转基因或模型生物体的细胞或细胞悬浮液（例如细胞学制剂或液体恶性肿瘤或细胞系的标本）。

6. 发明授权

US06306589B1 Biological assays for analyte detection 失效
标题翻译：分析物检测的生物测定
公开(公告)号：US06306589B1
公开(公告)日：2001-10-23
申请号：US09085625
申请日：1998-05-27
申请人： Uwe Richard Müller , Diping Che , Yijia Bao
发明人： Uwe Richard Müller , Diping Che , Yijia Bao
IPC分类号： C12Q168
CPC分类号： G01N33/552 , C12Q1/6834
摘要： Fluorescence-based assay methods for detecting biological analytes in a sample. The fluorescence background in these methods is significantly lower than in conventional assay methods. Also provided are methods of attaching nucleic acids to a metallic or metalloid surface.
摘要翻译：用于检测样品中生物分析物的基于荧光的测定方法。这些方法中的荧光背景显着低于常规测定方法。还提供了将核酸连接到金属或准金属表面的方法。

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