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1. 发明授权

US06251601B1 Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays 有权
标题翻译：使用核酸微阵列同时测量基因表达和基因组异常
公开(公告)号：US06251601B1
公开(公告)日：2001-06-26
申请号：US09243067
申请日：1999-02-02
申请人： Yijia Bao , Diping Che , Wan-Liang Li , Uwe Richard Müller , Steven A. Seelig , Jufang Shi
发明人： Yijia Bao , Diping Che , Wan-Liang Li , Uwe Richard Müller , Steven A. Seelig , Jufang Shi
IPC分类号： C12Q168
CPC分类号： C12Q1/6837 , B01J2219/00529 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , C40B40/06
摘要： The invention comprises a multi-color, comparative hybridization assay method using an array of nucleic acid target elements attached to a solid support for the simultaneous detection of both gene expression and chromosomal abnormalities in a tissue sample. The method of the invention employs a comparative hybridization of a tissue mRNA or cDNA sample labeled in a first fluorescent color, a tissue chromosomal DNA sample labeled in a second fluorescent color, and at least one reference nucleic acid labeled in a third fluorescent color, to the array. The fluorescent color presence and intensity at each of at least two target elements are detected and the fluorescent ratios (i) of the first and third colors and (ii) the second and third colors determined. Gene expression and chromosomal abnormalities are thus simultaneously detected.
摘要翻译：本发明包括使用连接到固体支持物上的核酸靶元件阵列同时检测组织样品中基因表达和染色体异常两者的多色比较杂交测定方法。本发明的方法采用将标记有第一荧光色的组织mRNA或cDNA样品，以第二荧光颜色标记的组织染色体DNA样品和至少一种以第三荧光颜色标记的参考核酸的比较杂交，阵列。检测至少两个目标元素中的每一个的荧光颜色存在和强度，并确定第一和第三颜色的荧光比（i）和（ii）第二和第三颜色的荧光比（i）。因此同时检测基因表达和染色体异常。

2. 发明授权

US06306589B1 Biological assays for analyte detection 失效
标题翻译：分析物检测的生物测定
公开(公告)号：US06306589B1
公开(公告)日：2001-10-23
申请号：US09085625
申请日：1998-05-27
申请人： Uwe Richard Müller , Diping Che , Yijia Bao
发明人： Uwe Richard Müller , Diping Che , Yijia Bao
IPC分类号： C12Q168
CPC分类号： G01N33/552 , C12Q1/6834
摘要： Fluorescence-based assay methods for detecting biological analytes in a sample. The fluorescence background in these methods is significantly lower than in conventional assay methods. Also provided are methods of attaching nucleic acids to a metallic or metalloid surface.
摘要翻译：用于检测样品中生物分析物的基于荧光的测定方法。这些方法中的荧光背景显着低于常规测定方法。还提供了将核酸连接到金属或准金属表面的方法。

3. 发明授权

US06455260B1 Biological assays for analyte detection 有权
公开(公告)号：US06455260B1
公开(公告)日：2002-09-24
申请号：US09978365
申请日：2001-10-16
申请人： Uwe Richard Müller , Diping Che , Yijia Bao
发明人： Uwe Richard Müller , Diping Che , Yijia Bao
IPC分类号： C12Q168
CPC分类号： G01N33/552 , C12Q1/6834
摘要： Fluorescence-based assay methods for detecting biological analytes in a sample. The fluorescence background in these methods is significantly lower than in conventional assay methods. Also provided are methods of attaching nucleic acids to a metallic or metalloid surface.

4. 发明申请

US20110204212A1 CONFOCAL IMAGING METHODS AND APPARATUS 有权
标题翻译：协同成像方法和装置
公开(公告)号：US20110204212A1
公开(公告)日：2011-08-25
申请号：US13099062
申请日：2011-05-02
申请人： Wenyi Feng , Theofilos Kotseroglou , Mark Wang , Alexander Triener , Diping Che , Robert Kain
发明人： Wenyi Feng , Theofilos Kotseroglou , Mark Wang , Alexander Triener , Diping Che , Robert Kain
IPC分类号： G01J1/58 , G01J1/42
CPC分类号： G01N21/6456 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2021/6421 , G02B21/0032 , G02B21/004
摘要： The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
摘要翻译：本发明提供了用于以快速扫描速率获得样品的高分辨率图像的成像装置和方法。具有比垂直尺寸长的水平尺寸的矩形检测器阵列可以与定位成将样本的一部分的矩形图像引导到矩形检测器阵列的成像光学元件一起使用。扫描装置可以被配置成以扫描轴尺寸扫描样本，其中矩形检测器阵列的垂直尺寸和图像的两个矩形尺寸中的较短的尺寸在扫描轴尺寸上，并且其中垂直尺寸因为矩形检测器阵列足够短以在单个轴上实现共焦。

5. 发明申请

US20120168644A1 CONFOCAL IMAGING METHODS AND APPARATUS 有权
标题翻译：协同成像方法和装置
公开(公告)号：US20120168644A1
公开(公告)日：2012-07-05
申请号：US13417474
申请日：2012-03-12
申请人： Wenyi Feng , Theofilos Kotseroglou , Mark Wang , Alexander Triener , Diping Che , Robert Kain
发明人： Wenyi Feng , Theofilos Kotseroglou , Mark Wang , Alexander Triener , Diping Che , Robert Kain
IPC分类号： G01N21/64
CPC分类号： G01N21/6456 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2021/6421 , G02B21/0032 , G02B21/004
摘要： The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
摘要翻译：本发明提供了用于以快速扫描速率获得样品的高分辨率图像的成像装置和方法。具有比垂直尺寸长的水平尺寸的矩形检测器阵列可以与定位成将样本的一部分的矩形图像引导到矩形检测器阵列的成像光学元件一起使用。扫描装置可以被配置成以扫描轴尺寸扫描样本，其中矩形检测器阵列的垂直尺寸和图像的两个矩形尺寸中的较短的尺寸在扫描轴尺寸上，并且其中垂直尺寸因为矩形检测器阵列足够短以在单个轴上实现共焦。

6. 发明授权

US07329860B2 Confocal imaging methods and apparatus 有权
标题翻译：共焦成像方法和仪器
公开(公告)号：US07329860B2
公开(公告)日：2008-02-12
申请号：US11286309
申请日：2005-11-23
申请人： Wenyi Feng , Theofilos Kotseroglou , Mark Wang , Alexander Triener , Diping Che , Robert Kain
发明人： Wenyi Feng , Theofilos Kotseroglou , Mark Wang , Alexander Triener , Diping Che , Robert Kain
IPC分类号： H01L27/00
CPC分类号： G01N21/6456 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2021/6421 , G02B21/0032 , G02B21/004
摘要： The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
摘要翻译：本发明提供了用于以快速扫描速率获得样品的高分辨率图像的成像装置和方法。具有比垂直尺寸长的水平尺寸的矩形检测器阵列可以与定位成将样本的一部分的矩形图像引导到矩形检测器阵列的成像光学元件一起使用。扫描装置可以被配置成以扫描轴尺寸扫描样本，其中矩形检测器阵列的垂直尺寸和图像的两个矩形尺寸中的较短的尺寸在扫描轴尺寸上，并且其中垂直尺寸因为矩形检测器阵列足够短以在单个轴上实现共焦。

7. 发明授权

US08158926B2 Confocal imaging methods and apparatus 有权
标题翻译：共焦成像方法和仪器
公开(公告)号：US08158926B2
公开(公告)日：2012-04-17
申请号：US13099062
申请日：2011-05-02
申请人： Wenyi Feng , Theofilos Kotseroglou , Mark Wang , Alexander Triener , Diping Che , Robert Kain
发明人： Wenyi Feng , Theofilos Kotseroglou , Mark Wang , Alexander Triener , Diping Che , Robert Kain
IPC分类号： H01L27/00
CPC分类号： G01N21/6456 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2021/6421 , G02B21/0032 , G02B21/004
摘要： The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
摘要翻译：本发明提供了用于以快速扫描速率获得样品的高分辨率图像的成像装置和方法。具有比垂直尺寸长的水平尺寸的矩形检测器阵列可以与定位成将样本的一部分的矩形图像引导到矩形检测器阵列的成像光学元件一起使用。扫描装置可以被配置成以扫描轴尺寸扫描样本，其中矩形检测器阵列的垂直尺寸和图像的两个矩形尺寸中的较短的尺寸在扫描轴尺寸上，并且其中垂直尺寸因为矩形检测器阵列足够短以在单个轴上实现共焦。

8. 发明授权

US07960685B2 Confocal imaging methods and apparatus 有权
标题翻译：共焦成像方法和仪器
公开(公告)号：US07960685B2
公开(公告)日：2011-06-14
申请号：US12537100
申请日：2009-08-06
申请人： Wenyi Feng , Theofilos Kotseroglou , Mark Wang , Alexander Triener , Diping Che , Robert Kain
发明人： Wenyi Feng , Theofilos Kotseroglou , Mark Wang , Alexander Triener , Diping Che , Robert Kain
IPC分类号： H01L27/00
CPC分类号： G01N21/6456 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2021/6421 , G02B21/0032 , G02B21/004
摘要： The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
摘要翻译：本发明提供了用于以快速扫描速率获得样品的高分辨率图像的成像装置和方法。具有比垂直尺寸长的水平尺寸的矩形检测器阵列可以与定位成将样本的一部分的矩形图像引导到矩形检测器阵列的成像光学元件一起使用。扫描装置可以被配置成以扫描轴尺寸扫描样本，其中矩形检测器阵列的垂直尺寸和图像的两个矩形尺寸中的较短的尺寸在扫描轴尺寸上，并且其中垂直尺寸因为矩形检测器阵列足够短以在单个轴上实现共焦。

9. 发明授权

US07589315B2 Confocal imaging methods and apparatus 有权
标题翻译：共焦成像方法和仪器
公开(公告)号：US07589315B2
公开(公告)日：2009-09-15
申请号：US11871085
申请日：2007-10-11
申请人： Wenyi Feng , Theofilos Kotseroglou , Mark Wang , Alexander Triener , Diping Che , Robert Kain
发明人： Wenyi Feng , Theofilos Kotseroglou , Mark Wang , Alexander Triener , Diping Che , Robert Kain
IPC分类号： H01L27/00
CPC分类号： G01N21/6456 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2021/6421 , G02B21/0032 , G02B21/004
摘要： The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
摘要翻译：本发明提供了用于以快速扫描速率获得样品的高分辨率图像的成像装置和方法。具有比垂直尺寸长的水平尺寸的矩形检测器阵列可以与定位成将样本的一部分的矩形图像引导到矩形检测器阵列的成像光学元件一起使用。扫描装置可以被配置成以扫描轴尺寸扫描样本，其中矩形检测器阵列的垂直尺寸和图像的两个矩形尺寸中的较短的尺寸在扫描轴尺寸上，并且其中垂直尺寸因为矩形检测器阵列足够短以在单个轴上实现共焦。

10. 发明授权

US6140653A Large-field fluorescence imaging apparatus 失效
标题翻译：大场荧光成像装置
公开(公告)号：US6140653A
公开(公告)日：2000-10-31
申请号：US49748
申请日：1998-03-27
申请人： Diping Che
发明人： Diping Che
IPC分类号： G01N21/64 , G02B17/00
CPC分类号： G01N21/6456
摘要： A large-field fluorescence imaging apparatus couples an excitation beam produced by a high-power white light source to a sample with reflective optics to achieve high illumination intensity on the sample. The reflective optics includes a concave mirror which projects the filtered and collimated excitation beam from the white light source onto the sample surface. The concave mirror images a field stop onto the sample surface to define an illumination area which matches the field of view of the imaging optics. The fluorescent light generated in the sample is filtered and imaged on a charge coupled device. The combination of the high illumination intensity and the imaging efficiency allows the imaging apparatus to acquire fluorescent images at an improved rate. A sample-height alignment arrangement using fixed alignment stops allows the sample to be positioned quickly and repeatably in the focal plane of the imaging optics without the need for fine adjustments.
摘要翻译：大场荧光成像装置将由高功率白光源产生的激发光束与具有反射光学器件的样品耦合以实现样品上的高照明强度。反射光学器件包括凹透镜，其将经过滤波和准直的激发光束从白色光源投影到样品表面上。凹面镜将场停止图像映射到样品表面上以限定与成像光学器件的视场相匹配的照明区域。在样品中产生的荧光被过滤并在电荷耦合器件上成像。高照明强度和成像效率的组合允许成像装置以更高的速率获取荧光图像。使用固定对准止动件的样品高度对准布置允许样品快速且可重复地定位在成像光学元件的焦平面中，而不需要进行微调。

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