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    • 5. 发明公开
    • 다공성 키토산 구슬 및 그의 제조 방법
    • 多孔木质素珠及其制备方法
    • KR1020010063154A
    • 2001-07-09
    • KR1019990060034
    • 1999-12-21
    • 한국과학기술연구원
    • 정서영배은희권익찬최귀원
    • C12N1/00
    • C08J9/28C08B37/003C08J2201/0484C08J2305/08C08L5/08C12N5/0075C12N2533/72
    • PURPOSE: Provided are multi-porous chitosan bead whose pores are big and relatively constant in size and a preparation method thereof. The bead is used as a matrix for cell cultivation and for the study of alternative metabolic organ, bone and cartilage and protein, antibiotics, anti-cancer medicine, polysaccharide, biological active material, animal hormone, and plant hormone. CONSTITUTION: A multi-porous chitosan bead has a pore being 5-20 micrometer in a size at its inside and outside. It is prepared by the following steps of: (a) preparing chitosan solution by dissolving chitosan in acetic acid aqueous solution, water-soluble chitosan solution by dissolving water-soluble chitosan in deionized solution or mixed solution thereof; (b) making it in bead form by adding organic solvent of low temperature or liquid nitrogen; and (c) freeze-drying the resultant bead.
    • 目的:提供孔径大且尺寸相对恒定的多孔壳聚糖珠及其制备方法。 该珠被用作细胞培养的基质和用于替代代谢器官,骨和软骨和蛋白质,抗生素,抗癌药物,多糖,生物活性物质,动物激素和植物激素的研究。 构成:多孔壳聚糖珠的内部和外部具有5-20微米的孔径。 通过以下步骤制备:(a)通过将水溶性壳聚糖溶解在去离子溶液或其混合溶液中,通过将壳聚糖溶解在乙酸水溶液,水溶性壳聚糖溶液中制备壳聚糖溶液; (b)通过加入低温或液氮的有机溶剂使其呈珠粒形式; 和(c)冷冻干燥所得的珠粒。